-
1
-
-
0027986676
-
Epidermal growth factor-mediated apoptosis of MDA-MB-468 human breast cancer cells
-
Armstrong D.K., Kaufmann S.H., Ottaviano Y.L., Furuya Y., Buckley J.A., Isaacs J.T., Davidson N.E. Epidermal growth factor-mediated apoptosis of MDA-MB-468 human breast cancer cells. Cancer Res. 1994, 54:5280-5283.
-
(1994)
Cancer Res.
, vol.54
, pp. 5280-5283
-
-
Armstrong, D.K.1
Kaufmann, S.H.2
Ottaviano, Y.L.3
Furuya, Y.4
Buckley, J.A.5
Isaacs, J.T.6
Davidson, N.E.7
-
2
-
-
79960895769
-
The Ripoptosome: death decision in the cytosol
-
Bertrand M.J., Vandenabeele P. The Ripoptosome: death decision in the cytosol. Mol. Cell 2011, 43:323-325.
-
(2011)
Mol. Cell
, vol.43
, pp. 323-325
-
-
Bertrand, M.J.1
Vandenabeele, P.2
-
3
-
-
44949240664
-
CIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
-
Bertrand M.J., Milutinovic S., Dickson K.M., Ho W.C., Boudreault A., Durkin J., Gillard J.W., Jaquith J.B., Morris S.J., Barker P.A. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol. Cell 2008, 30:689-700.
-
(2008)
Mol. Cell
, vol.30
, pp. 689-700
-
-
Bertrand, M.J.1
Milutinovic, S.2
Dickson, K.M.3
Ho, W.C.4
Boudreault, A.5
Durkin, J.6
Gillard, J.W.7
Jaquith, J.B.8
Morris, S.J.9
Barker, P.A.10
-
4
-
-
2442676505
-
Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas
-
Biernat W., Huang H., Yokoo H., Kleihues P., Ohgaki H. Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas. Brain Pathol. 2004, 14:131-136.
-
(2004)
Brain Pathol.
, vol.14
, pp. 131-136
-
-
Biernat, W.1
Huang, H.2
Yokoo, H.3
Kleihues, P.4
Ohgaki, H.5
-
5
-
-
79953282304
-
NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling
-
Biton S., Ashkenazi A. NEMO and RIP1 control cell fate in response to extensive DNA damage via TNF-α feedforward signaling. Cell 2011, 145:92-103.
-
(2011)
Cell
, vol.145
, pp. 92-103
-
-
Biton, S.1
Ashkenazi, A.2
-
6
-
-
84866061138
-
EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway
-
Bonavia R., Inda M.M., Vandenberg S., Cheng S.Y., Nagane M., Hadwiger P., Tan P., Sah D.W., Cavenee W.K., Furnari F.B. EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway. Oncogene 2012, 31:4054-4066.
-
(2012)
Oncogene
, vol.31
, pp. 4054-4066
-
-
Bonavia, R.1
Inda, M.M.2
Vandenberg, S.3
Cheng, S.Y.4
Nagane, M.5
Hadwiger, P.6
Tan, P.7
Sah, D.W.8
Cavenee, W.K.9
Furnari, F.B.10
-
7
-
-
79951844223
-
NFKBIA deletion in glioblastomas
-
Bredel M., Scholtens D.M., Yadav A.K., Alvarez A.A., Renfrow J.J., Chandler J.P., Yu I.L., Carro M.S., Dai F., Tagge M.J., et al. NFKBIA deletion in glioblastomas. N.Engl. J. Med. 2011, 364:627-637.
-
(2011)
N.Engl. J. Med.
, vol.364
, pp. 627-637
-
-
Bredel, M.1
Scholtens, D.M.2
Yadav, A.K.3
Alvarez, A.A.4
Renfrow, J.J.5
Chandler, J.P.6
Yu, I.L.7
Carro, M.S.8
Dai, F.9
Tagge, M.J.10
-
8
-
-
67650638892
-
RIP kinases at the crossroads of cell death and survival
-
Declercq W., Vanden Berghe T., Vandenabeele P. RIP kinases at the crossroads of cell death and survival. Cell 2009, 138:229-232.
-
(2009)
Cell
, vol.138
, pp. 229-232
-
-
Declercq, W.1
Vanden Berghe, T.2
Vandenabeele, P.3
-
9
-
-
42249102086
-
Identification of RIP1 kinase as a specific cellular target of necrostatins
-
Degterev A., Hitomi J., Germscheid M., Ch'en I.L., Korkina O., Teng X., Abbott D., Cuny G.D., Yuan C., Wagner G., et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat. Chem. Biol. 2008, 4:313-321.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 313-321
-
-
Degterev, A.1
Hitomi, J.2
Germscheid, M.3
Ch'en, I.L.4
Korkina, O.5
Teng, X.6
Abbott, D.7
Cuny, G.D.8
Yuan, C.9
Wagner, G.10
-
10
-
-
84861712290
-
Survival function of the FADD-CASPASE-8-cFLIP(L) complex
-
Dillon C.P., Oberst A., Weinlich R., Janke L.J., Kang T.B., Ben-Moshe T., Mak T.W., Wallach D., Green D.R. Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep. 2012, 1:401-407.
-
(2012)
Cell Rep.
, vol.1
, pp. 401-407
-
-
Dillon, C.P.1
Oberst, A.2
Weinlich, R.3
Janke, L.J.4
Kang, T.B.5
Ben-Moshe, T.6
Mak, T.W.7
Wallach, D.8
Green, D.R.9
-
11
-
-
33646034316
-
Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO
-
Ea C.K., Deng L., Xia Z.P., Pineda G., Chen Z.J. Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol. Cell 2006, 22:245-257.
-
(2006)
Mol. Cell
, vol.22
, pp. 245-257
-
-
Ea, C.K.1
Deng, L.2
Xia, Z.P.3
Pineda, G.4
Chen, Z.J.5
-
12
-
-
0025790916
-
Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas invivo
-
Ekstrand A.J., James C.D., Cavenee W.K., Seliger B., Pettersson R.F., Collins V.P. Genes for epidermal growth factor receptor, transforming growth factor alpha, and epidermal growth factor and their expression in human gliomas invivo. Cancer Res. 1991, 51:2164-2172.
-
(1991)
Cancer Res.
, vol.51
, pp. 2164-2172
-
-
Ekstrand, A.J.1
James, C.D.2
Cavenee, W.K.3
Seliger, B.4
Pettersson, R.F.5
Collins, V.P.6
-
13
-
-
79960922705
-
CIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms
-
Feoktistova M., Geserick P., Kellert B., Dimitrova D.P., Langlais C., Hupe M., Cain K., MacFarlane M., Häcker G., Leverkus M. cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell 2011, 43:449-463.
-
(2011)
Mol. Cell
, vol.43
, pp. 449-463
-
-
Feoktistova, M.1
Geserick, P.2
Kellert, B.3
Dimitrova, D.P.4
Langlais, C.5
Hupe, M.6
Cain, K.7
MacFarlane, M.8
Häcker, G.9
Leverkus, M.10
-
14
-
-
33847051539
-
RIP1, a kinase on the crossroads of a cell's decision to live or die
-
Festjens N., Vanden Berghe T., Cornelis S., Vandenabeele P. RIP1, a kinase on the crossroads of a cell's decision to live or die. Cell Death Differ. 2007, 14:400-410.
-
(2007)
Cell Death Differ.
, vol.14
, pp. 400-410
-
-
Festjens, N.1
Vanden Berghe, T.2
Cornelis, S.3
Vandenabeele, P.4
-
15
-
-
0034163550
-
Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas
-
Frederick L., Wang X.Y., Eley G., James C.D. Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res. 2000, 60:1383-1387.
-
(2000)
Cancer Res.
, vol.60
, pp. 1383-1387
-
-
Frederick, L.1
Wang, X.Y.2
Eley, G.3
James, C.D.4
-
16
-
-
0019861187
-
Increased phosphotyrosine content and inhibition of proliferation in EGF-treated A431 cells
-
Gill G.N., Lazar C.S. Increased phosphotyrosine content and inhibition of proliferation in EGF-treated A431 cells. Nature 1981, 293:305-307.
-
(1981)
Nature
, vol.293
, pp. 305-307
-
-
Gill, G.N.1
Lazar, C.S.2
-
17
-
-
0035937845
-
The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome
-
Habib A.A., Chatterjee S., Park S.K., Ratan R.R., Lefebvre S., Vartanian T. The epidermal growth factor receptor engages receptor interacting protein and nuclear factor-kappa B (NF-kappa B)-inducing kinase to activate NF-kappa B. Identification of a novel receptor-tyrosine kinase signalosome. J.Biol. Chem. 2001, 276:8865-8874.
-
(2001)
J.Biol. Chem.
, vol.276
, pp. 8865-8874
-
-
Habib, A.A.1
Chatterjee, S.2
Park, S.K.3
Ratan, R.R.4
Lefebvre, S.5
Vartanian, T.6
-
18
-
-
77956868654
-
Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance
-
Hatanpaa K.J., Burma S., Zhao D., Habib A.A. Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance. Neoplasia 2010, 12:675-684.
-
(2010)
Neoplasia
, vol.12
, pp. 675-684
-
-
Hatanpaa, K.J.1
Burma, S.2
Zhao, D.3
Habib, A.A.4
-
19
-
-
57649181391
-
Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway
-
Hitomi J., Christofferson D.E., Ng A., Yao J., Degterev A., Xavier R.J., Yuan J. Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway. Cell 2008, 135:1311-1323.
-
(2008)
Cell
, vol.135
, pp. 1311-1323
-
-
Hitomi, J.1
Christofferson, D.E.2
Ng, A.3
Yao, J.4
Degterev, A.5
Xavier, R.J.6
Yuan, J.7
-
21
-
-
77955911497
-
Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma
-
Inda M.M., Bonavia R., Mukasa A., Narita Y., Sah D.W., Vandenberg S., Brennan C., Johns T.G., Bachoo R., Hadwiger P., et al. Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev. 2010, 24:1731-1745.
-
(2010)
Genes Dev.
, vol.24
, pp. 1731-1745
-
-
Inda, M.M.1
Bonavia, R.2
Mukasa, A.3
Narita, Y.4
Sah, D.W.5
Vandenberg, S.6
Brennan, C.7
Johns, T.G.8
Bachoo, R.9
Hadwiger, P.10
-
22
-
-
0036546501
-
NF-kappaB in cancer: from innocent bystander to major culprit
-
Karin M., Cao Y., Greten F.R., Li Z.W. NF-kappaB in cancer: from innocent bystander to major culprit. Nat. Rev. Cancer 2002, 2:301-310.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 301-310
-
-
Karin, M.1
Cao, Y.2
Greten, F.R.3
Li, Z.W.4
-
23
-
-
3042581834
-
Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin
-
Li B., Yuan M., Kim I.A., Chang C.M., Bernhard E.J., Shu H.K. Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin. Oncogene 2004, 23:4594-4602.
-
(2004)
Oncogene
, vol.23
, pp. 4594-4602
-
-
Li, B.1
Yuan, M.2
Kim, I.A.3
Chang, C.M.4
Bernhard, E.J.5
Shu, H.K.6
-
24
-
-
4444263448
-
The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR
-
Luwor R.B., Zhu H.J., Walker F., Vitali A.A., Perera R.M., Burgess A.W., Scott A.M., Johns T.G. The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR. Oncogene 2004, 23:6095-6104.
-
(2004)
Oncogene
, vol.23
, pp. 6095-6104
-
-
Luwor, R.B.1
Zhu, H.J.2
Walker, F.3
Vitali, A.A.4
Perera, R.M.5
Burgess, A.W.6
Scott, A.M.7
Johns, T.G.8
-
25
-
-
14744299357
-
The RIP kinases: crucial integrators of cellular stress
-
Meylan E., Tschopp J. The RIP kinases: crucial integrators of cellular stress. Trends Biochem. Sci. 2005, 30:151-159.
-
(2005)
Trends Biochem. Sci.
, vol.30
, pp. 151-159
-
-
Meylan, E.1
Tschopp, J.2
-
26
-
-
8744234208
-
Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma
-
Nishikawa R., Sugiyama T., Narita Y., Furnari F., Cavenee W.K., Matsutani M. Immunohistochemical analysis of the mutant epidermal growth factor, deltaEGFR, in glioblastoma. Brain Tumor Pathol. 2004, 21:53-56.
-
(2004)
Brain Tumor Pathol.
, vol.21
, pp. 53-56
-
-
Nishikawa, R.1
Sugiyama, T.2
Narita, Y.3
Furnari, F.4
Cavenee, W.K.5
Matsutani, M.6
-
27
-
-
84867877809
-
NFκB and ubiquitination: partners in disarming RIPK1-mediated cell death
-
O'Donnell M.A., Ting A.T. NFκB and ubiquitination: partners in disarming RIPK1-mediated cell death. Immunol. Res. 2012, 54:214-226.
-
(2012)
Immunol. Res.
, vol.54
, pp. 214-226
-
-
O'Donnell, M.A.1
Ting, A.T.2
-
28
-
-
33847251527
-
Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling
-
O'Donnell M.A., Legarda-Addison D., Skountzos P., Yeh W.C., Ting A.T. Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. Curr. Biol. 2007, 17:418-424.
-
(2007)
Curr. Biol.
, vol.17
, pp. 418-424
-
-
O'Donnell, M.A.1
Legarda-Addison, D.2
Skountzos, P.3
Yeh, W.C.4
Ting, A.T.5
-
29
-
-
84864389178
-
NEMO inhibits programmed necrosis in an NFκB-independent manner by restraining RIP1
-
O'Donnell M.A., Hase H., Legarda D., Ting A.T. NEMO inhibits programmed necrosis in an NFκB-independent manner by restraining RIP1. PLoS One 2012, 7:e41238.
-
(2012)
PLoS One
, vol.7
-
-
O'Donnell, M.A.1
Hase, H.2
Legarda, D.3
Ting, A.T.4
-
31
-
-
66149128126
-
The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma
-
Park S., Hatanpaa K.J., Xie Y., Mickey B.E., Madden C.J., Raisanen J.M., Ramnarain D.B., Xiao G., Saha D., Boothman D.A., et al. The receptor interacting protein 1 inhibits p53 induction through NF-kappaB activation and confers a worse prognosis in glioblastoma. Cancer Res. 2009, 69:2809-2816.
-
(2009)
Cancer Res.
, vol.69
, pp. 2809-2816
-
-
Park, S.1
Hatanpaa, K.J.2
Xie, Y.3
Mickey, B.E.4
Madden, C.J.5
Raisanen, J.M.6
Ramnarain, D.B.7
Xiao, G.8
Saha, D.9
Boothman, D.A.10
-
32
-
-
35948994157
-
Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
-
Petersen S.L., Wang L., Yalcin-Chin A., Li L., Peyton M., Minna J., Harran P., Wang X. Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 2007, 12:445-456.
-
(2007)
Cancer Cell
, vol.12
, pp. 445-456
-
-
Petersen, S.L.1
Wang, L.2
Yalcin-Chin, A.3
Li, L.4
Peyton, M.5
Minna, J.6
Harran, P.7
Wang, X.8
-
33
-
-
31544454386
-
Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells
-
Ramnarain D.B., Park S., Lee D.Y., Hatanpaa K.J., Scoggin S.O., Otu H., Libermann T.A., Raisanen J.M., Ashfaq R., Wong E.T., et al. Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells. Cancer Res. 2006, 66:867-874.
-
(2006)
Cancer Res.
, vol.66
, pp. 867-874
-
-
Ramnarain, D.B.1
Park, S.2
Lee, D.Y.3
Hatanpaa, K.J.4
Scoggin, S.O.5
Otu, H.6
Libermann, T.A.7
Raisanen, J.M.8
Ashfaq, R.9
Wong, E.T.10
-
34
-
-
20444485232
-
Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer
-
Smith K., Gunaratnam L., Morley M., Franovic A., Mekhail K., Lee S. Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer. Cancer Res. 2005, 65:5221-5230.
-
(2005)
Cancer Res.
, vol.65
, pp. 5221-5230
-
-
Smith, K.1
Gunaratnam, L.2
Morley, M.3
Franovic, A.4
Mekhail, K.5
Lee, S.6
-
35
-
-
0032559962
-
Epidermal growth factor activation of NF-kappaB is mediated through IkappaBalpha degradation and intracellular free calcium
-
Sun L., Carpenter G. Epidermal growth factor activation of NF-kappaB is mediated through IkappaBalpha degradation and intracellular free calcium. Oncogene 1998, 16:2095-2102.
-
(1998)
Oncogene
, vol.16
, pp. 2095-2102
-
-
Sun, L.1
Carpenter, G.2
-
36
-
-
84860816141
-
Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance
-
Tanaka K., Babic I., Nathanson D., Akhavan D., Guo D., Gini B., Dang J., Zhu S., Yang H., De Jesus J., et al. Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance. Cancer Discov. 2011, 1:524-538.
-
(2011)
Cancer Discov.
, vol.1
, pp. 524-538
-
-
Tanaka, K.1
Babic, I.2
Nathanson, D.3
Akhavan, D.4
Guo, D.5
Gini, B.6
Dang, J.7
Zhu, S.8
Yang, H.9
De Jesus, J.10
-
37
-
-
79960921946
-
The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs
-
Tenev T., Bianchi K., Darding M., Broemer M., Langlais C., Wallberg F., Zachariou A., Lopez J., MacFarlane M., Cain K., Meier P. The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs. Mol. Cell 2011, 43:432-448.
-
(2011)
Mol. Cell
, vol.43
, pp. 432-448
-
-
Tenev, T.1
Bianchi, K.2
Darding, M.3
Broemer, M.4
Langlais, C.5
Wallberg, F.6
Zachariou, A.7
Lopez, J.8
MacFarlane, M.9
Cain, K.10
Meier, P.11
-
38
-
-
36048999753
-
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
-
Varfolomeev E., Blankenship J.W., Wayson S.M., Fedorova A.V., Kayagaki N., Garg P., Zobel K., Dynek J.N., Elliott L.O., Wallweber H.J., et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 2007, 131:669-681.
-
(2007)
Cell
, vol.131
, pp. 669-681
-
-
Varfolomeev, E.1
Blankenship, J.W.2
Wayson, S.M.3
Fedorova, A.V.4
Kayagaki, N.5
Garg, P.6
Zobel, K.7
Dynek, J.N.8
Elliott, L.O.9
Wallweber, H.J.10
-
39
-
-
36148954336
-
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
-
Vince J.E., Wong W.W., Khan N., Feltham R., Chau D., Ahmed A.U., Benetatos C.A., Chunduru S.K., Condon S.M., McKinlay M., et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 2007, 131:682-693.
-
(2007)
Cell
, vol.131
, pp. 682-693
-
-
Vince, J.E.1
Wong, W.W.2
Khan, N.3
Feltham, R.4
Chau, D.5
Ahmed, A.U.6
Benetatos, C.A.7
Chunduru, S.K.8
Condon, S.M.9
McKinlay, M.10
-
40
-
-
43049152912
-
TNF-alpha induces two distinct caspase-8 activation pathways
-
Wang L., Du F., Wang X. TNF-alpha induces two distinct caspase-8 activation pathways. Cell 2008, 133:693-703.
-
(2008)
Cell
, vol.133
, pp. 693-703
-
-
Wang, L.1
Du, F.2
Wang, X.3
-
42
-
-
84870885534
-
EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis
-
Yang W., Xia Y., Cao Y., Zheng Y., Bu W., Zhang L., You M.J., Koh M.Y., Cote G., Aldape K., et al. EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis. Mol. Cell 2012, 48:771-784.
-
(2012)
Mol. Cell
, vol.48
, pp. 771-784
-
-
Yang, W.1
Xia, Y.2
Cao, Y.3
Zheng, Y.4
Bu, W.5
Zhang, L.6
You, M.J.7
Koh, M.Y.8
Cote, G.9
Aldape, K.10
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