-
1
-
-
34347207046
-
-
Louis, D. N., Ohgaki, H., Wiestler, O. D. & Cavenee, W. K. WHO Classification of Tumors of the Central Nervous System (International Agency for Research on Cancer, 2007).
-
(2007)
WHO Classification of Tumors of the Central Nervous System (International Agency for Research on Cancer
-
-
Louis, D.N.1
Ohgaki, H.2
Wiestler, O.D.3
Cavenee, W.K.4
-
2
-
-
84868023931
-
CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2005-2009
-
Dolecek, T., Propp, J., Stroup, N. & Kruchko, C. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009. Neuro Oncol. 14 (Suppl. 5), 49 (2012).
-
(2012)
Neuro Oncol
, vol.14
, Issue.SUPPL.5
, pp. 49
-
-
Dolecek, T.1
Propp, J.2
Stroup, N.3
Kruchko, C.4
-
3
-
-
34250877865
-
Genetic pathways to primary and secondary glioblastoma
-
Ohgaki, H. & Kleihues, P. Genetic pathways to primary and secondary glioblastoma. Am. J. Pathol. 170, 1445-1453 (2007).
-
(2007)
Am. J. Pathol
, vol.170
, pp. 1445-1453
-
-
Ohgaki, H.1
Kleihues, P.2
-
4
-
-
84857527038
-
Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomaS
-
Puget, S. et al. Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas. PLoS ONE 7, e30313 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Puget, S.1
-
5
-
-
84865863019
-
K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomaS
-
Khuong-Quang, D. A. et al. K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol. 124, 439-447 (2012).
-
(2012)
Acta Neuropathol
, vol.124
, pp. 439-447
-
-
Khuong-Quang, D.A.1
-
6
-
-
84886029831
-
Diffuse intrinsic pontine glioma: Poised for progress
-
Warren, K. Diffuse intrinsic pontine glioma: poised for progress. Front. Oncol. 2, 205 (2012).
-
(2012)
Front. Oncol
, vol.2
, pp. 205
-
-
Warren, K.1
-
7
-
-
84880765927
-
Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children
-
Cage, T. et al. Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children. Child. Nerv. Syst. 29, 1313-1319 (2013).
-
(2013)
Child. Nerv. Syst
, vol.29
, pp. 1313-1319
-
-
Cage, T.1
-
8
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp, R. et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352, 987-996 (2005).
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 987-996
-
-
Stupp, R.1
-
9
-
-
65349121788
-
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
-
Stupp, R. et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 10, 459-466 (2009).
-
(2009)
Lancet Oncol
, vol.10
, pp. 459-466
-
-
Stupp, R.1
-
10
-
-
79955453343
-
Temozolomide in the treatment of high-grade gliomas in children: A report from the Children's Oncology Group
-
Cohen, K. J. et al. Temozolomide in the treatment of high-grade gliomas in children: a report from the Children's Oncology Group. Neuro Oncol. 13, 317-323 (2011).
-
(2011)
Neuro Oncol
, vol.13
, pp. 317-323
-
-
Cohen, K.J.1
-
11
-
-
33344464494
-
Diffuse brainstem glioma in children: Critical review of clinical trialS
-
Hargrave, D., Bartels, U. & Bouffet, E. Diffuse brainstem glioma in children: critical review of clinical trials. Lancet Oncol. 7, 241-248 (2006).
-
(2006)
Lancet Oncol
, vol.7
, pp. 241-248
-
-
Hargrave, D.1
Bartels, U.2
Bouffet, E.3
-
12
-
-
84872184811
-
Hypofractionation versus conventional radiation therapy for newly diagnosed diffuse intrinsic pontine glioma: A matched-cohort analysis
-
Janssens, G. et al. Hypofractionation versus conventional radiation therapy for newly diagnosed diffuse intrinsic pontine glioma: a matched-cohort analysis. Int. J. Radiat. Oncol. 85, 315-320 (2013).
-
(2013)
Int. J. Radiat. Oncol
, vol.85
, pp. 315-320
-
-
Janssens, G.1
-
13
-
-
84855913314
-
Diffuse intrinsic pontine gliomas: A systematic update on clinical trials and biology
-
Jansen, M. H., van Vuurden, D. G., Vandertop, W. P. & Kaspers, G. J. Diffuse intrinsic pontine gliomas: a systematic update on clinical trials and biology. Cancer Treat. Rev. 38, 27-35 (2012).
-
(2012)
Cancer Treat. Rev
, vol.38
, pp. 27-35
-
-
Jansen, M.H.1
Van Vuurden, D.G.2
Vandertop, W.P.3
Kaspers, G.J.4
-
14
-
-
0142157702
-
Classification of human astrocytic gliomas on the basis of gene expression: A correlated group of genes with angiogenic activity emerges as a strong predictor of subtypeS
-
Godard, S. et al. Classification of human astrocytic gliomas on the basis of gene expression: a correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes. Cancer Res. 63, 6613-6625 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 6613-6625
-
-
Godard, S.1
-
15
-
-
0042567193
-
Gene expression profiling identifies molecular subtypes of gliomaS
-
Shai, R. et al. Gene expression profiling identifies molecular subtypes of gliomas. Oncogene 22, 4918-4923 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 4918-4923
-
-
Shai, R.1
-
16
-
-
33845807801
-
Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entitieS
-
Maher, E. et al. Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Res. 66, 11502-11513 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 11502-11513
-
-
Maher, E.1
-
17
-
-
31544467538
-
Distinct transcription profiles of primary and secondary glioblastoma subgroupS
-
Tso, C.-L. et al. Distinct transcription profiles of primary and secondary glioblastoma subgroups. Cancer Res. 66, 159-167 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 159-167
-
-
Tso, C.-L.1
-
18
-
-
34247131323
-
Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors
-
Faury, D. et al. Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors. J. Clin. Oncol. 25, 1196-1208 (2007).
-
(2007)
J. Clin. Oncol
, vol.25
, pp. 1196-1208
-
-
Faury, D.1
-
19
-
-
0037381008
-
Gene expression-based classification of malignant gliomas correlates better with survival than histological classification
-
Nutt, C. et al. Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. Cancer Res. 63, 1602-1607 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 1602-1607
-
-
Nutt, C.1
-
20
-
-
4644313275
-
Gene expression profiling of gliomas strongly predicts survival
-
Freije, W. et al. Gene expression profiling of gliomas strongly predicts survival. Cancer Res. 64, 6503-6510 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 6503-6510
-
-
Freije, W.1
-
21
-
-
37549007198
-
Gene expression-based molecular diagnostic system for malignant gliomas is superior to histological diagnosis
-
Shirahata, M. et al. Gene expression-based molecular diagnostic system for malignant gliomas is superior to histological diagnosis. Clin. Cancer Res. 13, 7341-7356 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 7341-7356
-
-
Shirahata, M.1
-
22
-
-
20244387732
-
Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme
-
Liang, Y. et al. Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Proc. Natl Acad. Sci. USA 102, 5814-5819 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 5814-5819
-
-
Liang, Y.1
-
23
-
-
33644820339
-
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesiS
-
Phillips, H. et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9, 157-173 (2006).
-
(2006)
Cancer Cell
, vol.9
, pp. 157-173
-
-
Phillips, H.1
-
24
-
-
71549126830
-
Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology
-
Gravendeel, L. et al. Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology. Cancer Res. 69, 9065-9072 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 9065-9072
-
-
Gravendeel, L.1
-
25
-
-
73649123907
-
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
-
Verhaak, R. G. et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17, 98-110 (2010).
-
(2010)
Cancer Cell
, vol.17
, pp. 98-110
-
-
Verhaak, R.G.1
-
26
-
-
84885074034
-
The somatic genomic landscape of glioblastoma
-
Brennan, C. W. et al. The somatic genomic landscape of glioblastoma. Cell 155, 462-477 (2013).
-
(2013)
Cell
, vol.155
, pp. 462-477
-
-
Brennan, C.W.1
-
27
-
-
77952108366
-
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
-
Noushmehr, H. et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 17, 510-522 (2010).
-
(2010)
Cancer Cell
, vol.17
, pp. 510-522
-
-
Noushmehr, H.1
-
28
-
-
79957905986
-
Molecular subclassification of diffuse gliomas: Seeing order in the chaos
-
Huse, J., Phillips, H. & Brennan, C. Molecular subclassification of diffuse gliomas: seeing order in the chaos. Glia 59, 1190-1199 (2011).
-
(2011)
Glia
, vol.59
, pp. 1190-1199
-
-
Huse, J.1
Phillips, H.2
Brennan, C.3
-
29
-
-
84856722847
-
Studying a complex tumor: Potential and pitfallS
-
Zheng, S., Chheda, M. G. & Verhaak, R. G. Studying a complex tumor: potential and pitfalls. Cancer J. 18, 107-114 (2012).
-
(2012)
Cancer J
, vol.18
, pp. 107-114
-
-
Zheng, S.1
Chheda, M.G.2
Verhaak, R.G.3
-
30
-
-
75149195336
-
The transcriptional network for mesenchymal transformation of brain tumourS
-
Carro, M. S. et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 463, 318-325 (2010).
-
(2010)
Nature
, vol.463
, pp. 318-325
-
-
Carro, M.S.1
-
31
-
-
84255160601
-
The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma
-
Bhat, K. et al. The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. Genes Dev. 25, 2594-2609 (2011).
-
(2011)
Genes Dev
, vol.25
, pp. 2594-2609
-
-
Bhat, K.1
-
32
-
-
84884996623
-
The integrated landscape of driver genomic alterations in glioblastoma
-
Frattini, V. et al. The integrated landscape of driver genomic alterations in glioblastoma. Nature Genet. 45, 1141-1149 (2013).
-
(2013)
Nature Genet
, vol.45
, pp. 1141-1149
-
-
Frattini, V.1
-
33
-
-
84882654308
-
RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation
-
Danussi, C. et al. RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation. Cancer Res. 73, 5140-5150 (2013).
-
(2013)
Cancer Res
, vol.73
, pp. 5140-5150
-
-
Danussi, C.1
-
34
-
-
84883656941
-
Mesenchymal differentiation mediated by NF-kappaB promotes radiation resistance in glioblastoma
-
Bhat, K. P. et al. Mesenchymal differentiation mediated by NF-kappaB promotes radiation resistance in glioblastoma. Cancer Cell 24, 331-346 (2013).
-
(2013)
Cancer Cell
, vol.24
, pp. 331-346
-
-
Bhat, K.P.1
-
35
-
-
35948989714
-
Gene expression profiling from formalinfixed paraffin-embedded tumors of pediatric glioblastoma
-
Haque, T. et al. Gene expression profiling from formalinfixed paraffin-embedded tumors of pediatric glioblastoma. Clin. Cancer Res. 13, 6284-6292 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 6284-6292
-
-
Haque, T.1
-
36
-
-
77954596239
-
Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease
-
Paugh, B. S. et al. Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease. J. Clin. Oncol. 28, 3061-3068 (2010).
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 3061-3068
-
-
Paugh, B.S.1
-
37
-
-
80054771090
-
Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma
-
Paugh, B. S. et al. Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma. J. Clin. Oncol. 29, 3999-4006 (2011).
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 3999-4006
-
-
Paugh, B.S.1
-
38
-
-
77954240113
-
A distinct spectrum of copy number aberrations in paediatric high grade gliomas
-
Bax, D. A. et al. A distinct spectrum of copy number aberrations in paediatric high grade gliomas. Clin. Cancer Res. 16, 3368-3377 (2010).
-
(2010)
Clin. Cancer Res
, vol.16
, pp. 3368-3377
-
-
Bax, D.A.1
-
39
-
-
75849131906
-
Genome-wide profiling using singlenucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomaS
-
Qu, H. Q. et al. Genome-wide profiling using singlenucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas. Neuro Oncol. 12, 153-163 (2010).
-
(2010)
Neuro Oncol
, vol.12
, pp. 153-163
-
-
Qu, H.Q.1
-
40
-
-
84867606428
-
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
-
Sturm, D. et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 22, 425-437 (2012).
-
(2012)
Cancer Cell
, vol.22
, pp. 425-437
-
-
Sturm, D.1
-
41
-
-
84862777348
-
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
-
Schwartzentruber, J. et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 482, 226-231 (2012).
-
(2012)
Nature
, vol.482
, pp. 226-231
-
-
Schwartzentruber, J.1
-
42
-
-
84874469720
-
Chromatin remodeling defects in pediatric and young adult glioblastoma: A tale of a variant histone 3 tail
-
Fontebasso, A., Liu, X.-Y., Sturm, D. & Jabado, N. Chromatin remodeling defects in pediatric and young adult glioblastoma: a tale of a variant histone 3 tail. Brain Pathol. 23, 210-216 (2013).
-
(2013)
Brain Pathol
, vol.23
, pp. 210-216
-
-
Fontebasso, A.1
Liu, X.-Y.2
Sturm, D.3
Jabado, N.4
-
43
-
-
84877621282
-
Histone H3.3 mutations drive pediatric glioblastoma through upregulation of MYCN
-
Bjerke, L. et al. Histone H3.3 mutations drive pediatric glioblastoma through upregulation of MYCN. Cancer Discov. 3, 512-519 (2013).
-
(2013)
Cancer Discov
, vol.3
, pp. 512-519
-
-
Bjerke, L.1
-
44
-
-
84887617868
-
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomaS
-
Bender, S. et al. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell 24, 660-672 (2013).
-
(2013)
Cancer Cell
, vol.24
, pp. 660-672
-
-
Bender, S.1
-
45
-
-
0029967152
-
Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation
-
Costello, J., Berger, M., Huang, H. & Cavenee, W. Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res. 56, 2405-2410 (1996).
-
(1996)
Cancer Res
, vol.56
, pp. 2405-2410
-
-
Costello, J.1
Berger, M.2
Huang, H.3
Cavenee, W.4
-
46
-
-
0142061145
-
PTEN methylation and expression in glioblastomaS
-
Baeza, N., Weller, M., Yonekawa, Y., Kleihues, P. & Ohgaki, H. PTEN methylation and expression in glioblastomas. Acta Neuropathol. 106, 479-485 (2003).
-
(2003)
Acta Neuropathol
, vol.106
, pp. 479-485
-
-
Baeza, N.1
Weller, M.2
Yonekawa, Y.3
Kleihues, P.4
Ohgaki, H.5
-
47
-
-
0035133842
-
Promoter hypermethylation of the RB1 gene in glioblastomas
-
Nakamura, M., Yonekawa, Y., Kleihues, P. & Ohgaki, H. Promoter hypermethylation of the RB1 gene in glioblastomas. Lab. Invest. 81, 77-82 (2001).
-
(2001)
Lab. Invest
, vol.81
, pp. 77-82
-
-
Nakamura, M.1
Yonekawa, Y.2
Kleihues, P.3
Ohgaki, H.4
-
48
-
-
24344509239
-
TP53 promoter methylation in human gliomaS
-
Amatya, V., Naumann, U., Weller, M. & Ohgaki, H. TP53 promoter methylation in human gliomas. Acta Neuropathol. 110, 178-184 (2005).
-
(2005)
Acta Neuropathol
, vol.110
, pp. 178-184
-
-
Amatya, V.1
Naumann, U.2
Weller, M.3
Ohgaki, H.4
-
49
-
-
20144387913
-
EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma
-
Alaminos, M. et al. EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma. Cancer Res. 65, 2565-2571 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 2565-2571
-
-
Alaminos, M.1
-
50
-
-
33846821916
-
High TGFß-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
-
Bruna, A. et al. High TGFß-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 11, 147-160 (2007).
-
(2007)
Cancer Cell
, vol.11
, pp. 147-160
-
-
Bruna, A.1
-
51
-
-
15744392240
-
Epigenetic silencing of the protocadherin family member PCDH-.-A11 in astrocytomas
-
Waha, A. et al. Epigenetic silencing of the protocadherin family member PCDH-.-A11 in astrocytomas. Neoplasia 7, 193-199 (2005).
-
(2005)
Neoplasia
, vol.7
, pp. 193-199
-
-
Waha, A.1
-
52
-
-
34247892414
-
Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme
-
Zhou, H. et al. Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme. Clin. Cancer Res. 13, 2344-2353 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 2344-2353
-
-
Zhou, H.1
-
53
-
-
0036844322
-
Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumorS
-
Zardo, G. et al. Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. Nature Genet. 32, 453-458 (2002).
-
(2002)
Nature Genet
, vol.32
, pp. 453-458
-
-
Zardo, G.1
-
54
-
-
0033557903
-
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
-
Esteller, M., Hamilton, S., Burger, P., Baylin, S. & Herman, J. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res. 59, 793-797 (1999).
-
(1999)
Cancer Res
, vol.59
, pp. 793-797
-
-
Esteller, M.1
Hamilton, S.2
Burger, P.3
Baylin, S.4
Herman, J.5
-
55
-
-
79958072588
-
Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomaS
-
Felsberg, J. et al. Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas. Int. J. Cancer 129, 659-670 (2011).
-
(2011)
Int. J. Cancer
, vol.129
, pp. 659-670
-
-
Felsberg, J.1
-
56
-
-
84863091424
-
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: The NOA-08 randomised, phase 3 trial
-
Wick, W. et al. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. Lancet Oncol. 13, 707-715 (2012).
-
(2012)
Lancet Oncol
, vol.13
, pp. 707-715
-
-
Wick, W.1
-
57
-
-
84865558322
-
Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: The Nordic randomised, phase 3 trial
-
Malmström, A. et al. Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial. Lancet Oncol. 13, 916-926 (2012).
-
(2012)
Lancet Oncol
, vol.13
, pp. 916-926
-
-
Malmström, A.1
-
58
-
-
0028227862
-
Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells
-
Costello, J., Futscher, B., Tano, K., Graunke, D. & Pieper, R. Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. J. Biol. Chem. 269, 17228-17237 (1994).
-
(1994)
J. Biol. Chem
, vol.269
, pp. 17228-17237
-
-
Costello, J.1
Futscher, B.2
Tano, K.3
Graunke, D.4
Pieper, R.5
-
59
-
-
0028108955
-
Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines
-
Costello, J., Futscher, B., Kroes, R. & Pieper, R. Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines. Mol. Cell. Biol. 14, 6515-6521 (1994).
-
(1994)
Mol. Cell. Biol
, vol.14
, pp. 6515-6521
-
-
Costello, J.1
Futscher, B.2
Kroes, R.3
Pieper, R.4
-
60
-
-
0034626988
-
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
-
Esteller, M. et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N. Engl. J. Med. 343, 1350-1354 (2000).
-
(2000)
N. Engl. J. Med
, vol.343
, pp. 1350-1354
-
-
Esteller, M.1
-
61
-
-
20044372154
-
MGMT gene silencing and benefit from temozolomide in glioblastoma
-
Hegi, M. E. et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N. Engl. J. Med. 352, 997-1003 (2005).
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 997-1003
-
-
Hegi, M.E.1
-
62
-
-
82955233990
-
Prognostic and predictive value of epigenetic silencing of MGMT in patients with high grade gliomas: A systematic review and meta-analysiS
-
Olson, R., Brastianos, P. & Palma, D. Prognostic and predictive value of epigenetic silencing of MGMT in patients with high grade gliomas: a systematic review and meta-analysis. J. Neuro-Oncol. 105, 325-335 (2011).
-
(2011)
J. Neuro-Oncol
, vol.105
, pp. 325-335
-
-
Olson, R.1
Brastianos, P.2
Palma, D.3
-
63
-
-
33847364433
-
MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma
-
Donson, A., Addo-Yobo, S., Handler, M., Gore, L. & Foreman, N. MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma. Pediatr. Blood Cancer 48, 403-407 (2007).
-
(2007)
Pediatr. Blood Cancer
, vol.48
, pp. 403-407
-
-
Donson, A.1
Addo-Yobo, S.2
Handler, M.3
Gore, L.4
Foreman, N.5
-
64
-
-
77956183827
-
Evaluation status and prognostic significance of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in pediatric high grade gliomas
-
Buttarelli, F. et al. Evaluation status and prognostic significance of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in pediatric high grade gliomas. Child. Nerv. Syst. 26, 1051-1056 (2010).
-
(2010)
Child. Nerv. Syst
, vol.26
, pp. 1051-1056
-
-
Buttarelli, F.1
-
65
-
-
78649326720
-
MGMT gene promoter methylation in pediatric glioblastomas
-
Srivastava, A. et al. MGMT gene promoter methylation in pediatric glioblastomas. Child. Nerv. Syst. 26, 1613-1618 (2010).
-
(2010)
Child. Nerv. Syst
, vol.26
, pp. 1613-1618
-
-
Srivastava, A.1
-
66
-
-
80054731119
-
MGMT promoter gene methylation in pediatric glioblastoma: Analysis using MS-MLPA
-
Lee, J. et al. MGMT promoter gene methylation in pediatric glioblastoma: analysis using MS-MLPA. Child. Nerv. Syst. 27, 1877-1883 (2011).
-
(2011)
Child. Nerv. Syst
, vol.27
, pp. 1877-1883
-
-
Lee, J.1
-
67
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Cancer Genome Atlas Research Network
-
Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061-1068 (2008).
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
-
68
-
-
33749039999
-
Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation
-
Cadieux, B., Ching, T.-T., VandenBerg, S. & Costello, J. Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. Cancer Res. 66, 8469-8476 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 8469-8476
-
-
Cadieux, B.1
Ching, T.-T.2
Vandenberg, S.3
Costello, J.4
-
69
-
-
84878588603
-
Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using highdensity DNA methylation arrays
-
Hovestadt, V. et al. Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using highdensity DNA methylation arrays. Acta Neuropathol. 125, 913-916 (2013).
-
(2013)
Acta Neuropathol
, vol.125
, pp. 913-916
-
-
Hovestadt, V.1
-
70
-
-
84877113990
-
Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanismS
-
Malhotra, A. et al. Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms. Genome Res. 23, 762-776 (2013).
-
(2013)
Genome Res
, vol.23
, pp. 762-776
-
-
Malhotra, A.1
-
71
-
-
84876895426
-
Age-specific signatures of glioblastoma at the genomic, genetic, and epigenetic levelS
-
Bozdag, S. et al. Age-specific signatures of glioblastoma at the genomic, genetic, and epigenetic levels. PLoS ONE 8, e62982 (2013).
-
(2013)
PLoS ONE
, vol.8
-
-
Bozdag, S.1
-
72
-
-
84863434843
-
Paediatric and adult malignant glioma: Close relatives or distant cousins?
-
Jones, C., Perryman, L. & Hargrave, D. Paediatric and adult malignant glioma: close relatives or distant cousins? Nature Rev. Clin. Oncol. 9, 400-413 (2012).
-
(2012)
Nature Rev. Clin. Oncol
, vol.9
, pp. 400-413
-
-
Jones, C.1
Perryman, L.2
Hargrave, D.3
-
73
-
-
84879764400
-
A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival
-
Zheng, S. et al. A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival. Genes Dev. 27, 1462-1472 (2013).
-
(2013)
Genes Dev
, vol.27
, pp. 1462-1472
-
-
Zheng, S.1
-
74
-
-
70349456789
-
EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines
-
Bax, D. et al. EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines. Clin. Cancer Res. 15, 5753-5761 (2009).
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 5753-5761
-
-
Bax, D.1
-
75
-
-
84255170397
-
Glioblastoma-derived epidermal growth factor receptor carboxyl-terminal deletion mutants are transforming and are sensitive to EGFR-directed therapieS
-
Cho, J. et al. Glioblastoma-derived epidermal growth factor receptor carboxyl-terminal deletion mutants are transforming and are sensitive to EGFR-directed therapies. Cancer Res. 71, 7587-7596 (2011).
-
(2011)
Cancer Res
, vol.71
, pp. 7587-7596
-
-
Cho, J.1
-
76
-
-
84886089551
-
The epidermal growth factor receptor variant III (EGFRvIII): Where wild things are altered
-
Gan, H., Cvrljevic, A. & Johns, T. The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered. FEBS J. 280, 5350-5370 (2013).
-
(2013)
FEBS J
, vol.280
, pp. 5350-5370
-
-
Gan, H.1
Cvrljevic, A.2
Johns, T.3
-
77
-
-
2442676505
-
Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomaS
-
Biernat, W., Huang, H., Yokoo, H., Kleihues, P. & Ohgaki, H. Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas. Brain Pathol. 14, 131-136 (2004).
-
(2004)
Brain Pathol
, vol.14
, pp. 131-136
-
-
Biernat, W.1
Huang, H.2
Yokoo, H.3
Kleihues, P.4
Ohgaki, H.5
-
78
-
-
77957667714
-
PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomaS
-
Ozawa, T. et al. PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas. Genes Dev. 24, 2205-2218 (2010).
-
(2010)
Genes Dev
, vol.24
, pp. 2205-2218
-
-
Ozawa, T.1
-
79
-
-
84886028950
-
Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas
-
Paugh, B. et al. Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas. Cancer Res. 73, 6219-6229 (2013).
-
(2013)
Cancer Res
, vol.73
, pp. 6219-6229
-
-
Paugh, B.1
-
80
-
-
84885074156
-
Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons
-
Sanborn, J. et al. Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons. Cancer Res. 73, 6036-6045 (2013).
-
(2013)
Cancer Res
, vol.73
, pp. 6036-6045
-
-
Sanborn, J.1
-
81
-
-
3843101398
-
Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas
-
Vogt, N. et al. Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas. Proc. Natl Acad. Sci. USA 101, 11368-11373 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 11368-11373
-
-
Vogt, N.1
-
82
-
-
84865805666
-
Transforming fusions of FGFR and TACC genes in human glioblastoma
-
Singh, D. et al. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science 337, 1231-1235 (2012).
-
(2012)
Science
, vol.337
, pp. 1231-1235
-
-
Singh, D.1
-
83
-
-
84873347374
-
The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma
-
Parker, B. et al. The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. J. Clin. Invest. 123, 855-865 (2013).
-
(2013)
J. Clin. Invest
, vol.123
, pp. 855-865
-
-
Parker, B.1
-
84
-
-
84882247189
-
PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma
-
Phillips, J. et al. PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma. Brain Pathol. 23, 565-573 (2013).
-
(2013)
Brain Pathol
, vol.23
, pp. 565-573
-
-
Phillips, J.1
-
85
-
-
77950487385
-
Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor a and poly (ADP-ribose) polymerase as potential therapeutic targets
-
Zarghooni, M. et al. Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor a and poly (ADP-ribose) polymerase as potential therapeutic targets. J. Clin. Oncol. 28, 1337-1344 (2010).
-
(2010)
J. Clin. Oncol
, vol.28
, pp. 1337-1344
-
-
Zarghooni, M.1
-
86
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons, D. W. et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807-1812 (2008).
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
-
87
-
-
84871020024
-
Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutationS
-
Liu, X.-Y. et al. Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations. Acta Neuropathol. 124, 615-625 (2012).
-
(2012)
Acta Neuropathol
, vol.124
, pp. 615-625
-
-
Liu, X.-Y.1
-
88
-
-
84868625787
-
Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomaS
-
Jiao, Y. et al. Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. Oncotarget 3, 709-722 (2012).
-
(2012)
Oncotarget
, vol.3
, pp. 709-722
-
-
Jiao, Y.1
-
89
-
-
84863621527
-
Cancer epigenetics: From mechanism to therapy
-
Dawson, M. & Kouzarides, T. Cancer epigenetics: from mechanism to therapy. Cell 150, 12-27 (2012).
-
(2012)
Cell
, vol.150
, pp. 12-27
-
-
Dawson, M.1
Kouzarides, T.2
-
90
-
-
84875745673
-
Interplay between the cancer genome and epigenome
-
Shen, H. & Laird, P. Interplay between the cancer genome and epigenome. Cell 153, 38-55 (2013).
-
(2013)
Cell
, vol.153
, pp. 38-55
-
-
Shen, H.1
Laird, P.2
-
91
-
-
84876067164
-
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
-
Killela, P. et al. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc. Natl Acad. Sci. USA 110, 6021-6026 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 6021-6026
-
-
Killela, P.1
-
92
-
-
84881095932
-
Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q losS
-
Arita, H. et al. Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss. Acta Neuropathol. 126, 267-276 (2013).
-
(2013)
Acta Neuropathol
, vol.126
, pp. 267-276
-
-
Arita, H.1
-
93
-
-
84892603397
-
TERT promoter mutations in primary and secondary glioblastomaS
-
Nonoguchi, N. et al. TERT promoter mutations in primary and secondary glioblastomas. Acta Neuropathol. 126, 931-937 (2013).
-
(2013)
Acta Neuropathol
, vol.126
, pp. 931-937
-
-
Nonoguchi, N.1
-
94
-
-
84884524540
-
Frequency of TERT promoter mutations in human cancers
-
Vinagre, J. et al. Frequency of TERT promoter mutations in human cancers. Nature Commun. 4, 2185 (2013).
-
(2013)
Nature Commun
, vol.4
, pp. 2185
-
-
Vinagre, J.1
-
95
-
-
84892590846
-
Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous systeM
-
Koelsche, C. et al. Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system. Acta Neuropathol. 126, 907-915 (2013).
-
(2013)
Acta Neuropathol
, vol.126
, pp. 907-915
-
-
Koelsche, C.1
-
96
-
-
33747109928
-
Telomerase activity and hTERT mRNA expression in glial tumors
-
Boldrini, L. et al. Telomerase activity and hTERT mRNA expression in glial tumors. Int. J. Oncol. 28, 1555-1560 (2006).
-
(2006)
Int. J. Oncol
, vol.28
, pp. 1555-1560
-
-
Boldrini, L.1
-
97
-
-
79960700556
-
Altered telomeres in tumors with ATRX and DAXX mutations
-
Heaphy, C. et al. Altered telomeres in tumors with ATRX and DAXX mutations. Science 333, 425 (2011).
-
(2011)
Science
, vol.333
, pp. 425
-
-
Heaphy, C.1
-
98
-
-
33646256145
-
A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy
-
Hunter, C. et al. A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Cancer Res. 66, 3987-3991 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 3987-3991
-
-
Hunter, C.1
-
99
-
-
34247499001
-
Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment
-
Cahill, D. et al. Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment. Clin. Cancer Res. 13, 2038-2045 (2007).
-
(2007)
Clin. Cancer Res
, vol.13
, pp. 2038-2045
-
-
Cahill, D.1
-
100
-
-
68049095262
-
MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance
-
Yip, S. et al. MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance. Clin. Cancer Res. 15, 4622-4629 (2009).
-
(2009)
Clin. Cancer Res
, vol.15
, pp. 4622-4629
-
-
Yip, S.1
-
101
-
-
84862777410
-
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and nonbrainstem glioblastomaS
-
Wu, G. et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and nonbrainstem glioblastomas. Nature Genet. 44, 251-253 (2012).
-
(2012)
Nature Genet
, vol.44
, pp. 251-253
-
-
Wu, G.1
-
102
-
-
84861633881
-
The pediatric cancer genome project
-
Downing, J. et al. The Pediatric Cancer Genome Project. Nature Genet. 44, 619-622 (2012).
-
(2012)
Nature Genet
, vol.44
, pp. 619-622
-
-
Downing, J.1
-
103
-
-
84878723078
-
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomaS
-
Zhang, J. et al. Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nature Genet. 45, 602-612 (2013).
-
(2013)
Nature Genet
, vol.45
, pp. 602-612
-
-
Zhang, J.1
-
104
-
-
84880983541
-
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
-
Jones, D. T. W. et al. Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nature Genet. 45, 927-932 (2013).
-
(2013)
Nature Genet
, vol.45
, pp. 927-932
-
-
Jones, D.T.W.1
-
105
-
-
84882273357
-
Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomaS
-
Venneti, S. et al. Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas. Brain Pathol. 23, 558-564 (2013).
-
(2013)
Brain Pathol
, vol.23
, pp. 558-564
-
-
Venneti, S.1
-
106
-
-
84877785024
-
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma
-
Lewis, P. et al. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science 340, 857-861 (2013).
-
(2013)
Science
, vol.340
, pp. 857-861
-
-
Lewis, P.1
-
107
-
-
84877299145
-
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
-
Chan, K.-M. et al. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev. 27, 985-990 (2013).
-
(2013)
Genes Dev
, vol.27
, pp. 985-990
-
-
Chan, K.-M.1
-
108
-
-
84861399134
-
Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC
-
Swartling, F. J. et al. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. Cancer Cell 21, 601-613 (2012).
-
(2012)
Cancer Cell
, vol.21
, pp. 601-613
-
-
Swartling, F.J.1
-
109
-
-
84876033650
-
Targeting MYCN in neuroblastoma by BET bromodomain inhibition
-
Puissant, A. et al. Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 3, 308-323 (2013).
-
(2013)
Cancer Discov
, vol.3
, pp. 308-323
-
-
Puissant, A.1
-
110
-
-
84886712846
-
Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomaS
-
Fontebasso, A. et al. Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas. Acta Neuropathol. 125, 659-669 (2013).
-
(2013)
Acta Neuropathol
, vol.125
, pp. 659-669
-
-
Fontebasso, A.1
-
111
-
-
84876943255
-
The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSa
-
Li, F. et al. The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSa. Cell 153, 590-600 (2013).
-
(2013)
Cell
, vol.153
, pp. 590-600
-
-
Li, F.1
-
112
-
-
33746136947
-
Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma
-
Chen, Y.-J. et al. Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma. Cancer Res. 66, 6473-6476 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 6473-6476
-
-
Chen, Y.-J.1
-
113
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan, H. et al. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 360, 765-773 (2009).
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 765-773
-
-
Yan, H.1
-
114
-
-
68349116524
-
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomaS
-
Ichimura, K. et al. IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas. Neuro Oncol. 11, 341-347 (2009).
-
(2009)
Neuro Oncol
, vol.11
, pp. 341-347
-
-
Ichimura, K.1
-
115
-
-
84883171570
-
IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma
-
Zhang, C., Moore, L., Li, X., Yung, W. & Zhang, W. IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma. Neuro Oncol. 15, 1114-1126 (2013).
-
(2013)
Neuro Oncol
, vol.15
, pp. 1114-1126
-
-
Zhang, C.1
Moore, L.2
Li, X.3
Yung, W.4
Zhang, W.5
-
116
-
-
84874091180
-
The definition of primary and secondary glioblastoma
-
Ohgaki, H. & Kleihues, P. The definition of primary and secondary glioblastoma. Clin. Cancer Res. 19, 764-772 (2013).
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 764-772
-
-
Ohgaki, H.1
Kleihues, P.2
-
117
-
-
34547432232
-
Incidence of gliomas by anatomic location
-
Larjavaara, S. et al. Incidence of gliomas by anatomic location. Neuro Oncol. 9, 319-325 (2007).
-
(2007)
Neuro Oncol
, vol.9
, pp. 319-325
-
-
Larjavaara, S.1
-
118
-
-
84858796263
-
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
-
This study was the first to show a causal link between mutations in IDH1 and the G-CIMP.
-
Turcan, S. et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 483, 479-483 (2012). This study was the first to show a causal link between mutations in IDH1 and the G-CIMP.
-
(2012)
Nature
, vol.483
, pp. 479-483
-
-
Turcan, S.1
-
119
-
-
84862999702
-
IDH mutations in human glioma
-
Kim, W. & Liau, L. IDH mutations in human glioma. Neurosurg. Clin. N. Am. 23, 471-480 (2012).
-
(2012)
Neurosurg. Clin. N. Am
, vol.23
, pp. 471-480
-
-
Kim, W.1
Liau, L.2
-
120
-
-
84865218876
-
Molecular pathogenesis of IDH mutations in gliomaS
-
Ichimura, K. Molecular pathogenesis of IDH mutations in gliomas. Brain Tumor Pathol. 29, 131-139 (2012).
-
(2012)
Brain Tumor Pathol
, vol.29
, pp. 131-139
-
-
Ichimura, K.1
-
121
-
-
84864192438
-
Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1-mutation as common tumor initiating event
-
Lass, U. et al. Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1-mutation as common tumor initiating event. PLoS ONE 7, e41298 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Lass, U.1
-
122
-
-
78651082266
-
Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: Implications for classification of gliomaS
-
Hartmann, C. et al. Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas. Acta Neuropathol. 120, 707-718 (2010).
-
(2010)
Acta Neuropathol
, vol.120
, pp. 707-718
-
-
Hartmann, C.1
-
123
-
-
84884582587
-
Longterm survival in primary glioblastoma with versus without isocitrate dehydrogenase mutations
-
Hartmann, C. et al. Longterm survival in primary glioblastoma with versus without isocitrate dehydrogenase mutations. Clin. Cancer Res. 19, 5146-5157 (2013).
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 5146-5157
-
-
Hartmann, C.1
-
124
-
-
77649305610
-
The common feature of leukemiaassociated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting a-ketoglutarate to 2-hydroxyglutarate
-
Ward, P. S. et al. The common feature of leukemiaassociated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting a-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 17, 225-234 (2010).
-
(2010)
Cancer Cell
, vol.17
, pp. 225-234
-
-
Ward, P.S.1
-
125
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang, L. et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462, 739-744 (2009).
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
-
126
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
Figueroa, M. et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18, 553-567 (2010).
-
(2010)
Cancer Cell
, vol.18
, pp. 553-567
-
-
Figueroa, M.1
-
127
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of a-ketoglutarate-dependent dioxygenaseS
-
Xu, W. et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of a-ketoglutarate-dependent dioxygenases. Cancer Cell 19, 17-30 (2011).
-
(2011)
Cancer Cell
, vol.19
, pp. 17-30
-
-
Xu, W.1
-
128
-
-
79955547561
-
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylaseS
-
Chowdhury, R. et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep. 12, 463-469 (2011).
-
(2011)
EMBO Rep
, vol.12
, pp. 463-469
-
-
Chowdhury, R.1
-
129
-
-
84885848576
-
Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2
-
Guilhamon, P. et al. Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2. Nature Commun. 4, 2166 (2013).
-
(2013)
Nature Commun
, vol.4
, pp. 2166
-
-
Guilhamon, P.1
-
130
-
-
84868128332
-
Transposon mutagenesis identifies genes that transform neural stem cells into gliomainitiating cells
-
Koso, H. et al. Transposon mutagenesis identifies genes that transform neural stem cells into gliomainitiating cells. Proc. Natl Acad. Sci. USA 109, E2998-E3007 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
-
-
Koso, H.1
-
131
-
-
57849109837
-
Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model
-
Alcantara Llaguno, S. et al. Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell 15, 45-56 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 45-56
-
-
Alcantara Llaguno, S.1
-
132
-
-
79960809488
-
Mosaic analysis with double markers reveals tumor cell of origin in glioma
-
Liu, C. et al. Mosaic analysis with double markers reveals tumor cell of origin in glioma. Cell 146, 209-221 (2011).
-
(2011)
Cell
, vol.146
, pp. 209-221
-
-
Liu, C.1
-
133
-
-
80052574196
-
Asymmetry-defective oligodendrocyte progenitors are glioma precursors
-
Sugiarto, S. et al. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell 20, 328-340 (2011).
-
(2011)
Cancer Cell
, vol.20
, pp. 328-340
-
-
Sugiarto, S.1
-
134
-
-
84869878282
-
Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice
-
Friedmann-Morvinski, D. et al. Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. Science 338, 1080-1084 (2012).
-
(2012)
Science
, vol.338
, pp. 1080-1084
-
-
Friedmann-Morvinski, D.1
-
135
-
-
79952717343
-
Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma
-
Monje, M. et al. Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc. Natl Acad. Sci. USA 108, 4453-4458 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 4453-4458
-
-
Monje, M.1
-
136
-
-
83355163405
-
Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin
-
Lai, A. et al. Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. J. Clin. Oncol. 29, 4482-4490 (2011).
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 4482-4490
-
-
Lai, A.1
-
137
-
-
80054993342
-
Spatio-temporal transcriptome of the human brain
-
Kang, H. et al. Spatio-temporal transcriptome of the human brain. Nature 478, 483-489 (2011).
-
(2011)
Nature
, vol.478
, pp. 483-489
-
-
Kang, H.1
-
138
-
-
0141922119
-
Expression of the oligodendroglial lineage-associated markers Olig1 and Olig2 in different types of human gliomas
-
Ohnishi, A. et al. Expression of the oligodendroglial lineage-associated markers Olig1 and Olig2 in different types of human gliomas. J. Neuropathol. Exp. Neurol. 62, 1052-1059 (2003).
-
(2003)
J. Neuropathol. Exp. Neurol
, vol.62
, pp. 1052-1059
-
-
Ohnishi, A.1
-
139
-
-
0035845569
-
Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors
-
Lu, Q. R. et al. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. Proc. Natl Acad. Sci. USA 98, 10851-10856 (2001).
-
(2001)
Proc. Natl Acad. Sci. USA
, vol.98
, pp. 10851-10856
-
-
Lu, Q.R.1
-
140
-
-
0035963934
-
OLIG2 as a specific marker of oligodendroglial tumour cells
-
Marie, Y. et al. OLIG2 as a specific marker of oligodendroglial tumour cells. Lancet 358, 298-300 (2001).
-
(2001)
Lancet
, vol.358
, pp. 298-300
-
-
Marie, Y.1
-
141
-
-
84855932131
-
Self-renewal does not predict tumor growth potential in mouse models of high-grade glioma
-
Barrett, L. E. et al. Self-renewal does not predict tumor growth potential in mouse models of high-grade glioma. Cancer Cell 21, 11-24 (2012).
-
(2012)
Cancer Cell
, vol.21
, pp. 11-24
-
-
Barrett, L.E.1
-
142
-
-
84864433702
-
Antagonistic modulation of gliomagenesis by Pax6 and Olig2 in PDGF-induced oligodendroglioma
-
Appolloni, I. et al. Antagonistic modulation of gliomagenesis by Pax6 and Olig2 in PDGF-induced oligodendroglioma. Int. J. Cancer 131, E1078-E1087 (2012).
-
(2012)
Int. J. Cancer
, vol.131
-
-
Appolloni, I.1
-
143
-
-
65649142176
-
Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model
-
Wang, Y. et al. Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell 15, 514-526 (2009).
-
(2009)
Cancer Cell
, vol.15
, pp. 514-526
-
-
Wang, Y.1
-
144
-
-
59149086517
-
Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma
-
Prados, M. D. et al. Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. J. Clin. Oncol. 27, 579-584 (2009).
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 579-584
-
-
Prados, M.D.1
-
145
-
-
57149118473
-
Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177
-
Brown, P. D. et al. Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. J. Clin. Oncol. 26, 5603-5609 (2008).
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 5603-5609
-
-
Brown, P.D.1
-
146
-
-
62449150719
-
Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034
-
van den Bent, M. J. et al. Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034. J. Clin. Oncol. 27, 1268-1274 (2009).
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 1268-1274
-
-
Van Den Bent, M.J.1
-
147
-
-
27744506881
-
Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: Tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01
-
Lassman, A. B. et al. Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01. Clin. Cancer Res. 11, 7841-7850 (2005).
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 7841-7850
-
-
Lassman, A.B.1
-
148
-
-
34247218483
-
Gefitinib in patients with progressive high-grade gliomas: A multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)
-
Franceschi, E. et al. Gefitinib in patients with progressive high-grade gliomas: a multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO). Br. J. Cancer 96, 1047-1051 (2007).
-
(2007)
Br. J. Cancer
, vol.96
, pp. 1047-1051
-
-
Franceschi, E.1
-
149
-
-
69849112085
-
Stratified phase II trial of cetuximab in patients with recurrent high-grade glioma
-
Neyns, B. et al. Stratified phase II trial of cetuximab in patients with recurrent high-grade glioma. Ann. Oncol. 20, 1596-1603 (2009).
-
(2009)
Ann. Oncol
, vol.20
, pp. 1596-1603
-
-
Neyns, B.1
-
150
-
-
53749096014
-
Phase II study of imatinib in patients with recurrent gliomas of various histologies: A European Organisation for Research and Treatment of Cancer Brain Tumor Group Study
-
Raymond, E. et al. Phase II study of imatinib in patients with recurrent gliomas of various histologies: a European Organisation for Research and Treatment of Cancer Brain Tumor Group Study. J. Clin. Oncol. 26, 4659-4665 (2008).
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 4659-4665
-
-
Raymond, E.1
-
151
-
-
33748376520
-
Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08
-
Wen, P. Y. et al. Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin. Cancer Res. 12, 4899-4907 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 4899-4907
-
-
Wen, P.Y.1
-
152
-
-
71649102124
-
Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma
-
Reardon, D. A. et al. Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma. Br. J. Cancer 101, 1995-2004 (2009).
-
(2009)
Br. J. Cancer
, vol.101
, pp. 1995-2004
-
-
Reardon, D.A.1
-
153
-
-
75049085049
-
Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide
-
Dresemann, G. et al. Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide. J. Neurooncol. 96, 393-402 (2010).
-
(2010)
J. Neurooncol
, vol.96
, pp. 393-402
-
-
Dresemann, G.1
-
154
-
-
70350461699
-
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
-
Friedman, H. S. et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J. Clin. Oncol. 27, 4733-4740 (2009).
-
(2009)
J. Clin. Oncol
, vol.27
, pp. 4733-4740
-
-
Friedman, H.S.1
-
155
-
-
79951984402
-
Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme
-
Lai, A. et al. Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J. Clin. Oncol. 29, 142-148 (2011).
-
(2011)
J. Clin. Oncol
, vol.29
, pp. 142-148
-
-
Lai, A.1
-
156
-
-
84887116872
-
Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma
-
Batchelor, T. T. et al. Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma. J. Clin. Oncol. 31, 3212-3218 (2013).
-
(2013)
J. Clin. Oncol
, vol.31
, pp. 3212-3218
-
-
Batchelor, T.T.1
-
157
-
-
84871617507
-
Diagnostic and therapeutic avenues for glioblastoma: No longer a dead end?
-
Tanaka, S., Louis, D. N., Curry, W. T., Batchelor, T. T. & Dietrich, J. Diagnostic and therapeutic avenues for glioblastoma: no longer a dead end? Nature Rev. Clin. Oncol. 10, 14-26 (2013).
-
(2013)
Nature Rev. Clin. Oncol
, vol.10
, pp. 14-26
-
-
Tanaka, S.1
Louis, D.N.2
Curry, W.T.3
Batchelor, T.T.4
Dietrich, J.5
-
158
-
-
84861696508
-
Phase i study of panobinostat in combination with bevacizumab for recurrent highgrade glioma
-
Drappatz, J. et al. Phase I study of panobinostat in combination with bevacizumab for recurrent highgrade glioma. J. Neurooncol. 107, 133-138 (2012).
-
(2012)
J. Neurooncol
, vol.107
, pp. 133-138
-
-
Drappatz, J.1
-
159
-
-
84859538161
-
Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: A north central cancer treatment group study
-
Friday, B. B. et al. Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: a north central cancer treatment group study. Neuro. Oncol. 14, 215-221 (2012).
-
(2012)
Neuro. Oncol
, vol.14
, pp. 215-221
-
-
Friday, B.B.1
-
160
-
-
84880598419
-
Valproic acid use during radiation therapy for glioblastoma associated with improved survival
-
Barker, C. A., Bishop, A. J., Chang, M., Beal, K. & Chan, T. A. Valproic acid use during radiation therapy for glioblastoma associated with improved survival. Int. J. Radiat. Oncol. 86, 504-509 (2013).
-
(2013)
Int. J. Radiat. Oncol
, vol.86
, pp. 504-509
-
-
Barker, C.A.1
Bishop, A.J.2
Chang, M.3
Beal, K.4
Chan, T.A.5
-
161
-
-
80054705372
-
Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma
-
Weller, M. et al. Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma. Neurology 77, 1156-1164 (2011).
-
(2011)
Neurology
, vol.77
, pp. 1156-1164
-
-
Weller, M.1
-
162
-
-
84877632013
-
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cellS
-
Rohle, D. et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 340, 626-630 (2013).
-
(2013)
Science
, vol.340
, pp. 626-630
-
-
Rohle, D.1
-
164
-
-
84877620952
-
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
-
Wang, F. et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science 340, 622-626 (2013).
-
(2013)
Science
, vol.340
, pp. 622-626
-
-
Wang, F.1
-
165
-
-
84880291912
-
BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1
-
Tonjes, M. et al. BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1. Nature Med. 19, 901-908 (2013).
-
(2013)
Nature Med
, vol.19
, pp. 901-908
-
-
Tonjes, M.1
-
166
-
-
84870598190
-
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
-
Yang, W. et al. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biol. 14, 1295-1304 (2012).
-
(2012)
Nature Cell Biol
, vol.14
, pp. 1295-1304
-
-
Yang, W.1
-
167
-
-
84865266173
-
PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesiS
-
Yang, W. et al. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150, 685-696 (2012).
-
(2012)
Cell
, vol.150
, pp. 685-696
-
-
Yang, W.1
-
168
-
-
84863165348
-
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
-
McCabe, M. T. et al. Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc. Natl Acad. Sci. USA 109, 2989-2994 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 2989-2994
-
-
McCabe, M.T.1
-
169
-
-
83355173202
-
EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomaS
-
Ryan, R. J. et al. EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas. PLoS ONE 6, e28585 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Ryan, R.J.1
-
170
-
-
78650454078
-
Coordinated activities of wildtype plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
-
Sneeringer, C. J. et al. Coordinated activities of wildtype plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc. Natl Acad. Sci. USA 107, 20980-20985 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 20980-20985
-
-
Sneeringer, C.J.1
-
171
-
-
74949143829
-
The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumorinitiating cells leading to decreased proliferation and tumor growth
-
Marian, C. et al. The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumorinitiating cells leading to decreased proliferation and tumor growth. Clin. Cancer Res. 16, 154-163 (2010).
-
(2010)
Clin. Cancer Res
, vol.16
, pp. 154-163
-
-
Marian, C.1
-
172
-
-
84877097843
-
Inhibition of BET bromodomain targets genetically diverse glioblastoma
-
Cheng, Z. et al. Inhibition of BET bromodomain targets genetically diverse glioblastoma. Clin. Cancer Res. 19, 1748-1759 (2013).
-
(2013)
Clin. Cancer Res
, vol.19
, pp. 1748-1759
-
-
Cheng, Z.1
-
173
-
-
79958757490
-
Pathway analysis of glioblastoma tissue after preoperative treatment with the EGFR tyrosine kinase inhibitor gefitinib-A phase II trial
-
Hegi, M. et al. Pathway analysis of glioblastoma tissue after preoperative treatment with the EGFR tyrosine kinase inhibitor gefitinib-a phase II trial. Mol. Cancer Ther. 10, 1102-1112 (2011).
-
(2011)
Mol. Cancer Ther
, vol.10
, pp. 1102-1112
-
-
Hegi, M.1
-
174
-
-
27744606737
-
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
-
Mellinghoff, I. et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N. Engl. J. Med. 353, 2012-2024 (2005).
-
(2005)
N. Engl. J. Med
, vol.353
, pp. 2012-2024
-
-
Mellinghoff, I.1
-
175
-
-
84865542459
-
Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240
-
Fenton, T. et al. Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc. Natl Acad. Sci. USA 109, 14164-14169 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 14164-14169
-
-
Fenton, T.1
-
176
-
-
84894579110
-
Inhibition of EGFR induces a c-MET driven stem cell population in glioblastoma
-
Jun, H., Bronson, R. & Charest, A. Inhibition of EGFR induces a c-MET driven stem cell population in glioblastoma. Stem Cells http://dx.doi.org/10. 1002/stem.1554 (2013).
-
(2013)
Stem Cells
-
-
Jun, H.1
Bronson, R.2
Charest, A.3
-
177
-
-
80051597880
-
Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRa/ß
-
Bielen, A. et al. Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRa/ß. Mol. Cancer Ther. 10, 1407-1418 (2011).
-
(2011)
Mol. Cancer Ther
, vol.10
, pp. 1407-1418
-
-
Bielen, A.1
-
178
-
-
84857397985
-
Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
-
Szerlip, N. et al. Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response. Proc. Natl Acad. Sci. USA 109, 3041-3046 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 3041-3046
-
-
Szerlip, N.1
-
179
-
-
84859376167
-
Receptor tyrosine kinase genes amplified in glioblastoma exhibit a mutual exclusivity in variable proportions reflective of individual tumor heterogeneity
-
Little, S. et al. Receptor tyrosine kinase genes amplified in glioblastoma exhibit a mutual exclusivity in variable proportions reflective of individual tumor heterogeneity. Cancer Res. 72, 1614-1620 (2012).
-
(2012)
Cancer Res
, vol.72
, pp. 1614-1620
-
-
Little, S.1
-
180
-
-
75549083303
-
Tumor heterogeneity: Causes and consequences
-
Marusyk, A. & Polyak, K. Tumor heterogeneity: causes and consequences. Biochim. Biophys. Acta 1805, 105-117 (2010).
-
(2010)
Biochim. Biophys. Acta
, vol.1805
, pp. 105-117
-
-
Marusyk, A.1
Polyak, K.2
-
181
-
-
0032532078
-
Intratumoral cytogenetic heterogeneity detected by comparative genomic hybridization and laser scanning cytometry in human gliomaS
-
Harada, K. et al. Intratumoral cytogenetic heterogeneity detected by comparative genomic hybridization and laser scanning cytometry in human gliomas. Cancer Res. 58, 4694-4700 (1998).
-
(1998)
Cancer Res
, vol.58
, pp. 4694-4700
-
-
Harada, K.1
-
182
-
-
0032850203
-
Evidence of focal genetic microheterogeneity in glioblastoma multiforme by area-specific CGH on microdissected tumor cells
-
Jung, V. et al. Evidence of focal genetic microheterogeneity in glioblastoma multiforme by area-specific CGH on microdissected tumor cells. J. Neuropath. Exp. Neur. 58, 993-999 (1999).
-
(1999)
J. Neuropath. Exp. Neur
, vol.58
, pp. 993-999
-
-
Jung, V.1
-
183
-
-
77955167915
-
Intratumoral patterns of genomic imbalance in glioblastomaS
-
Nobusawa, S. et al. Intratumoral patterns of genomic imbalance in glioblastomas. Brain Pathol. 20, 936-944 (2010).
-
(2010)
Brain Pathol
, vol.20
, pp. 936-944
-
-
Nobusawa, S.1
-
184
-
-
34948858931
-
Molecular genetic analysis of p53 intratumoral heterogeneity in human astrocytic brain tumors
-
Ren, Z.-P. et al. Molecular genetic analysis of p53 intratumoral heterogeneity in human astrocytic brain tumors. J. Neuropath. Exp. Neur. 66, 944-954 (2007).
-
(2007)
J. Neuropath. Exp. Neur
, vol.66
, pp. 944-954
-
-
Ren, Z.-P.1
-
185
-
-
51649117107
-
Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity
-
Hegi, M. et al. Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. J. Clin. Oncol. 26, 4189-4199 (2008).
-
(2008)
J. Clin. Oncol
, vol.26
, pp. 4189-4199
-
-
Hegi, M.1
-
186
-
-
84874598318
-
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
-
Sottoriva, A. et al. Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc. Natl Acad. Sci. USA 110, 4009-4014 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 4009-4014
-
-
Sottoriva, A.1
-
187
-
-
83455176258
-
Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma
-
Snuderl, M. et al. Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma. Cancer Cell 20, 810-817 (2011).
-
(2011)
Cancer Cell
, vol.20
, pp. 810-817
-
-
Snuderl, M.1
-
188
-
-
77955911497
-
Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma
-
Inda, M.-d.-M. et al. Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev. 24, 1731-1745 (2010).
-
(2010)
Genes Dev
, vol.24
, pp. 1731-1745
-
-
Inda, M.D.-M.1
-
189
-
-
35348822482
-
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapieS
-
Stommel, J. et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 318, 287-290 (2007).
-
(2007)
Science
, vol.318
, pp. 287-290
-
-
Stommel, J.1
-
190
-
-
84856013431
-
Clonal evolution in cancer
-
Greaves, M. & Maley, C. Clonal evolution in cancer. Nature 481, 306-313 (2012).
-
(2012)
Nature
, vol.481
, pp. 306-313
-
-
Greaves, M.1
Maley, C.2
-
191
-
-
33748891391
-
Cancer stem cells
-
Jordan, C., Guzman, M. & Noble, M. Cancer stem cells. N. Engl. J. Med. 355, 1253-1261 (2006).
-
(2006)
N. Engl. J. Med
, vol.355
, pp. 1253-1261
-
-
Jordan, C.1
Guzman, M.2
Noble, M.3
-
192
-
-
79957927593
-
Genetic modeling of gliomas in mice: New tools to tackle old problemS
-
Hambardzumyan, D., Parada, L., Holland, E. & Charest, A. Genetic modeling of gliomas in mice: new tools to tackle old problems. Glia 59, 1155-1168 (2011).
-
(2011)
Glia
, vol.59
, pp. 1155-1168
-
-
Hambardzumyan, D.1
Parada, L.2
Holland, E.3
Charest, A.4
-
193
-
-
84878139953
-
Vertebrate animal models of glioma: Understanding the mechanisms and developing new therapies
-
Chen, L., Zhang, Y., Yang, J., Hagan, J. & Li, M. Vertebrate animal models of glioma: understanding the mechanisms and developing new therapies. Biochim. Biophys. Acta 1836, 158-165 (2013).
-
(2013)
Biochim. Biophys. Acta
, vol.1836
, pp. 158-165
-
-
Chen, L.1
Zhang, Y.2
Yang, J.3
Hagan, J.4
Li, M.5
-
194
-
-
33646358694
-
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lineS
-
Lee, J. et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9, 391-403 (2006).
-
(2006)
Cancer Cell
, vol.9
, pp. 391-403
-
-
Lee, J.1
-
195
-
-
68849130180
-
Immunohistopathological and neuroimaging characterization of murine orthotopic xenograft models of glioblastoma multiforme recapitulating the most salient features of human disease
-
Radaelli, E. et al. Immunohistopathological and neuroimaging characterization of murine orthotopic xenograft models of glioblastoma multiforme recapitulating the most salient features of human disease. Histol. Histopathol. 24, 879-891 (2009).
-
(2009)
Histol. Histopathol
, vol.24
, pp. 879-891
-
-
Radaelli, E.1
-
196
-
-
77953194234
-
An extensive invasive intracranial human glioblastoma xenograft model: Role of high level matrix metalloproteinase 9
-
Zhao, Y. et al. An extensive invasive intracranial human glioblastoma xenograft model: role of high level matrix metalloproteinase 9. Am. J. Pathol. 176, 3032-3049 (2010).
-
(2010)
Am. J. Pathol
, vol.176
, pp. 3032-3049
-
-
Zhao, Y.1
-
197
-
-
84859553853
-
An in vivo patient-derived model of endogenous IDH1-mutant glioma
-
Luchman, H. et al. An in vivo patient-derived model of endogenous IDH1-mutant glioma. Neuro Oncol. 14, 184-191 (2012).
-
(2012)
Neuro Oncol
, vol.14
, pp. 184-191
-
-
Luchman, H.1
-
198
-
-
75649109727
-
Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypeS
-
Jacques, T. et al. Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes. EMBO J. 29, 222-235 (2010).
-
(2010)
EMBO J
, vol.29
, pp. 222-235
-
-
Jacques, T.1
-
199
-
-
79952509861
-
Cooperativity within and among Pten, 53, and Rb pathways induces high-grade astrocytoma in adult brain
-
Chow, L. et al. Cooperativity within and among Pten, 53, and Rb pathways induces high-grade astrocytoma in adult brain. Cancer Cell 19, 305-316 (2011).
-
(2011)
Cancer Cell
, vol.19
, pp. 305-316
-
-
Chow, L.1
-
200
-
-
0032418416
-
A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice
-
Holland, E., Hively, W., DePinho, R. & Varmus, H. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev. 12, 3675-3685 (1998).
-
(1998)
Genes Dev
, vol.12
, pp. 3675-3685
-
-
Holland, E.1
Hively, W.2
Depinho, R.3
Varmus, H.4
-
201
-
-
0037374550
-
Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model
-
Ding, H. et al. Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model. Cancer Res. 63, 1106-1113 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 1106-1113
-
-
Ding, H.1
-
202
-
-
0033960657
-
A mouse model for glioma: Biology, pathology, and therapeutic opportunities
-
Holland, E. A mouse model for glioma: biology, pathology, and therapeutic opportunities. Toxicol. Pathol. 28, 171-177 (2000).
-
(2000)
Toxicol. Pathol
, vol.28
, pp. 171-177
-
-
Holland, E.1
-
203
-
-
0037382205
-
Genetic determinants of malignancy in a mouse model for oligodendroglioma
-
Weiss, W. et al. Genetic determinants of malignancy in a mouse model for oligodendroglioma. Cancer Res. 63, 1589-1595 (2003).
-
(2003)
Cancer Res
, vol.63
, pp. 1589-1595
-
-
Weiss, W.1
-
204
-
-
33747885901
-
High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model
-
Wei, Q. et al. High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model. Cancer Res. 66, 7429-7437 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 7429-7437
-
-
Wei, Q.1
-
205
-
-
62449252775
-
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis
-
Zhu, H. et al. Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc. Natl Acad. Sci. USA 106, 2712-2716 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 2712-2716
-
-
Zhu, H.1
-
206
-
-
70349291126
-
Modeling adult gliomas using RCAS/t-va technology
-
Hambardzumyan, D., Amankulor, N. M., Helmy, K. Y., Becher, O. J. & Holland, E. C. Modeling adult gliomas using RCAS/t-va technology. Transl. Oncol. 2, 89-95 (2009).
-
(2009)
Transl. Oncol
, vol.2
, pp. 89-95
-
-
Hambardzumyan, D.1
Amankulor, N.M.2
Helmy, K.Y.3
Becher, O.J.4
Holland, E.C.5
-
207
-
-
69649103118
-
GFAP promoter driven transgenic expression of PDGFB in the mouse brain leads to glioblastoma in a Trp53 null background
-
Hede, S.-M. et al. GFAP promoter driven transgenic expression of PDGFB in the mouse brain leads to glioblastoma in a Trp53 null background. Glia 57, 1143-1153 (2009).
-
(2009)
Glia
, vol.57
, pp. 1143-1153
-
-
Hede, S.-M.1
-
208
-
-
79956361405
-
Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype
-
Lei, L. et al. Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype. PLoS ONE 6, e20041 (2011).
-
(2011)
PLoS ONE
, vol.6
-
-
Lei, L.1
-
209
-
-
33645736793
-
Genetically engineered models have advantages over xenografts for preclinical studieS
-
Becher, O. & Holland, E. Genetically engineered models have advantages over xenografts for preclinical studies. Cancer Res. 66, 3355 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 3355
-
-
Becher, O.1
Holland, E.2
-
210
-
-
77950232139
-
Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma
-
Becher, O. et al. Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma. Cancer Res. 70, 2548-2557 (2010).
-
(2010)
Cancer Res
, vol.70
, pp. 2548-2557
-
-
Becher, O.1
-
211
-
-
0033812187
-
Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effectS
-
Reilly, K., Loisel, D., Bronson, R., McLaughlin, M. & Jacks, T. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nature Genet. 26, 109-113 (2000).
-
(2000)
Nature Genet
, vol.26
, pp. 109-113
-
-
Reilly, K.1
Loisel, D.2
Bronson, R.3
McLaughlin, M.4
Jacks, T.5
-
212
-
-
0036293742
-
Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation
-
Bajenaru, M. et al. Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol. Cell. Biol. 22, 5100-5113 (2002).
-
(2002)
Mol. Cell. Biol
, vol.22
, pp. 5100-5113
-
-
Bajenaru, M.1
-
213
-
-
4444260352
-
Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects
-
Reilly, K. et al. Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects. Proc. Natl Acad. Sci. USA 101, 13008-13013 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 13008-13013
-
-
Reilly, K.1
-
214
-
-
23644443053
-
Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
-
Zhu, Y. et al. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8, 119-130 (2005).
-
(2005)
Cancer Cell
, vol.8
, pp. 119-130
-
-
Zhu, Y.1
-
215
-
-
44849089702
-
Pten haploinsufficiency accelerates formation of high-grade astrocytomaS
-
Kwon, C.-H. et al. Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res. 68, 3286-3294 (2008).
-
(2008)
Cancer Res
, vol.68
, pp. 3286-3294
-
-
Kwon, C.-H.1
-
216
-
-
84866480031
-
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function
-
Sasaki, M. et al. D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev. 26, 2038-2049 (2012).
-
(2012)
Genes Dev
, vol.26
, pp. 2038-2049
-
-
Sasaki, M.1
-
217
-
-
79951825581
-
Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomaS
-
Barrow, J. et al. Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas. Neuro Oncol. 13, 212-222 (2011).
-
(2011)
Neuro Oncol
, vol.13
, pp. 212-222
-
-
Barrow, J.1
-
218
-
-
0033398991
-
Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations
-
Raffel, C. et al. Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations. Clin. Cancer Res. 5, 4085-4090 (1999).
-
(1999)
Clin. Cancer Res
, vol.5
, pp. 4085-4090
-
-
Raffel, C.1
-
219
-
-
33845667568
-
Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: Results from the Children's Cancer Group 945 cohort
-
Pollack, I. F. et al. Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort. J. Neurosurg. 105, 418-424 (2006).
-
(2006)
J. Neurosurg
, vol.105
, pp. 418-424
-
-
Pollack, I.F.1
-
220
-
-
0035887141
-
Age and TP53 mutation frequency in childhood malignant gliomas: Results in a multi-institutional cohort
-
Pollack, I. et al. Age and TP53 mutation frequency in childhood malignant gliomas: results in a multi-institutional cohort. Cancer Res. 61, 7404-7407 (2001).
-
(2001)
Cancer Res
, vol.61
, pp. 7404-7407
-
-
Pollack, I.1
-
221
-
-
78951489314
-
IDH1 mutations are common in malignant gliomas arising in adolescents: A report from the Children's Oncology Group
-
Pollack, I. et al. IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group. Child. Nerv. Syst. 27, 87-94 (2011).
-
(2011)
Child. Nerv. Syst
, vol.27
, pp. 87-94
-
-
Pollack, I.1
-
222
-
-
33750596946
-
PIK3CA gene mutations in pediatric and adult glioblastoma multiforme
-
Gallia, G. et al. PIK3CA gene mutations in pediatric and adult glioblastoma multiforme. Mol. Cancer Res. 4, 709-714 (2006).
-
(2006)
Mol. Cancer Res
, vol.4
, pp. 709-714
-
-
Gallia, G.1
-
223
-
-
76549137130
-
Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomaS
-
Schiffman, J. et al. Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Cancer Res. 70, 512-519 (2010).
-
(2010)
Cancer Res
, vol.70
, pp. 512-519
-
-
Schiffman, J.1
-
224
-
-
84055212088
-
V600E malignant astrocytoma
-
Nicolaides, T. et al. Targeted therapy for BRAFV600E malignant astrocytoma. Clin. Cancer Res. 17, 7595-7604 (2011).
-
(2011)
Clin. Cancer Res
, vol.17
, pp. 7595-7604
-
-
Nicolaides, T.1
|