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Volumn 14, Issue 2, 2014, Pages 92-107

Paediatric and adult glioblastoma: Multiform (epi)genomic culprits emerge

(15)  Sturm, Dominik a,b   Bender, Sebastian a,b   Jones, David T W a   Lichter, Peter a   Grill, Jacques c   Becher, Oren d   Hawkins, Cynthia e   Majewski, Jacek f   Jones, Chris g   Costello, Joseph F h   Iavarone, Antonio i   Aldape, Kenneth j   Brennan, Cameron W k   Jabado, Nada f   Pfister, Stefan M a,b  


Author keywords

[No Author keywords available]

Indexed keywords

AGE FACTORS; EPIGENOMICS; GLIOBLASTOMA; HUMANS; NEOPLASMS, NERVE TISSUE;

EID: 84894573670     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3655     Document Type: Review
Times cited : (437)

References (224)
  • 2
    • 84868023931 scopus 로고    scopus 로고
    • CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2005-2009
    • Dolecek, T., Propp, J., Stroup, N. & Kruchko, C. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005-2009. Neuro Oncol. 14 (Suppl. 5), 49 (2012).
    • (2012) Neuro Oncol , vol.14 , Issue.SUPPL.5 , pp. 49
    • Dolecek, T.1    Propp, J.2    Stroup, N.3    Kruchko, C.4
  • 3
    • 34250877865 scopus 로고    scopus 로고
    • Genetic pathways to primary and secondary glioblastoma
    • Ohgaki, H. & Kleihues, P. Genetic pathways to primary and secondary glioblastoma. Am. J. Pathol. 170, 1445-1453 (2007).
    • (2007) Am. J. Pathol , vol.170 , pp. 1445-1453
    • Ohgaki, H.1    Kleihues, P.2
  • 4
    • 84857527038 scopus 로고    scopus 로고
    • Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomaS
    • Puget, S. et al. Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas. PLoS ONE 7, e30313 (2012).
    • (2012) PLoS ONE , vol.7
    • Puget, S.1
  • 5
    • 84865863019 scopus 로고    scopus 로고
    • K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomaS
    • Khuong-Quang, D. A. et al. K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas. Acta Neuropathol. 124, 439-447 (2012).
    • (2012) Acta Neuropathol , vol.124 , pp. 439-447
    • Khuong-Quang, D.A.1
  • 6
    • 84886029831 scopus 로고    scopus 로고
    • Diffuse intrinsic pontine glioma: Poised for progress
    • Warren, K. Diffuse intrinsic pontine glioma: poised for progress. Front. Oncol. 2, 205 (2012).
    • (2012) Front. Oncol , vol.2 , pp. 205
    • Warren, K.1
  • 7
    • 84880765927 scopus 로고    scopus 로고
    • Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children
    • Cage, T. et al. Feasibility, safety, and indications for surgical biopsy of intrinsic brainstem tumors in children. Child. Nerv. Syst. 29, 1313-1319 (2013).
    • (2013) Child. Nerv. Syst , vol.29 , pp. 1313-1319
    • Cage, T.1
  • 8
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp, R. et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N. Engl. J. Med. 352, 987-996 (2005).
    • (2005) N. Engl. J. Med , vol.352 , pp. 987-996
    • Stupp, R.1
  • 9
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • Stupp, R. et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 10, 459-466 (2009).
    • (2009) Lancet Oncol , vol.10 , pp. 459-466
    • Stupp, R.1
  • 10
    • 79955453343 scopus 로고    scopus 로고
    • Temozolomide in the treatment of high-grade gliomas in children: A report from the Children's Oncology Group
    • Cohen, K. J. et al. Temozolomide in the treatment of high-grade gliomas in children: a report from the Children's Oncology Group. Neuro Oncol. 13, 317-323 (2011).
    • (2011) Neuro Oncol , vol.13 , pp. 317-323
    • Cohen, K.J.1
  • 11
    • 33344464494 scopus 로고    scopus 로고
    • Diffuse brainstem glioma in children: Critical review of clinical trialS
    • Hargrave, D., Bartels, U. & Bouffet, E. Diffuse brainstem glioma in children: critical review of clinical trials. Lancet Oncol. 7, 241-248 (2006).
    • (2006) Lancet Oncol , vol.7 , pp. 241-248
    • Hargrave, D.1    Bartels, U.2    Bouffet, E.3
  • 12
    • 84872184811 scopus 로고    scopus 로고
    • Hypofractionation versus conventional radiation therapy for newly diagnosed diffuse intrinsic pontine glioma: A matched-cohort analysis
    • Janssens, G. et al. Hypofractionation versus conventional radiation therapy for newly diagnosed diffuse intrinsic pontine glioma: a matched-cohort analysis. Int. J. Radiat. Oncol. 85, 315-320 (2013).
    • (2013) Int. J. Radiat. Oncol , vol.85 , pp. 315-320
    • Janssens, G.1
  • 13
    • 84855913314 scopus 로고    scopus 로고
    • Diffuse intrinsic pontine gliomas: A systematic update on clinical trials and biology
    • Jansen, M. H., van Vuurden, D. G., Vandertop, W. P. & Kaspers, G. J. Diffuse intrinsic pontine gliomas: a systematic update on clinical trials and biology. Cancer Treat. Rev. 38, 27-35 (2012).
    • (2012) Cancer Treat. Rev , vol.38 , pp. 27-35
    • Jansen, M.H.1    Van Vuurden, D.G.2    Vandertop, W.P.3    Kaspers, G.J.4
  • 14
    • 0142157702 scopus 로고    scopus 로고
    • Classification of human astrocytic gliomas on the basis of gene expression: A correlated group of genes with angiogenic activity emerges as a strong predictor of subtypeS
    • Godard, S. et al. Classification of human astrocytic gliomas on the basis of gene expression: a correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes. Cancer Res. 63, 6613-6625 (2003).
    • (2003) Cancer Res , vol.63 , pp. 6613-6625
    • Godard, S.1
  • 15
    • 0042567193 scopus 로고    scopus 로고
    • Gene expression profiling identifies molecular subtypes of gliomaS
    • Shai, R. et al. Gene expression profiling identifies molecular subtypes of gliomas. Oncogene 22, 4918-4923 (2003).
    • (2003) Oncogene , vol.22 , pp. 4918-4923
    • Shai, R.1
  • 16
    • 33845807801 scopus 로고    scopus 로고
    • Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entitieS
    • Maher, E. et al. Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Res. 66, 11502-11513 (2006).
    • (2006) Cancer Res , vol.66 , pp. 11502-11513
    • Maher, E.1
  • 17
    • 31544467538 scopus 로고    scopus 로고
    • Distinct transcription profiles of primary and secondary glioblastoma subgroupS
    • Tso, C.-L. et al. Distinct transcription profiles of primary and secondary glioblastoma subgroups. Cancer Res. 66, 159-167 (2006).
    • (2006) Cancer Res , vol.66 , pp. 159-167
    • Tso, C.-L.1
  • 18
    • 34247131323 scopus 로고    scopus 로고
    • Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors
    • Faury, D. et al. Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors. J. Clin. Oncol. 25, 1196-1208 (2007).
    • (2007) J. Clin. Oncol , vol.25 , pp. 1196-1208
    • Faury, D.1
  • 19
    • 0037381008 scopus 로고    scopus 로고
    • Gene expression-based classification of malignant gliomas correlates better with survival than histological classification
    • Nutt, C. et al. Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. Cancer Res. 63, 1602-1607 (2003).
    • (2003) Cancer Res , vol.63 , pp. 1602-1607
    • Nutt, C.1
  • 20
    • 4644313275 scopus 로고    scopus 로고
    • Gene expression profiling of gliomas strongly predicts survival
    • Freije, W. et al. Gene expression profiling of gliomas strongly predicts survival. Cancer Res. 64, 6503-6510 (2004).
    • (2004) Cancer Res , vol.64 , pp. 6503-6510
    • Freije, W.1
  • 21
    • 37549007198 scopus 로고    scopus 로고
    • Gene expression-based molecular diagnostic system for malignant gliomas is superior to histological diagnosis
    • Shirahata, M. et al. Gene expression-based molecular diagnostic system for malignant gliomas is superior to histological diagnosis. Clin. Cancer Res. 13, 7341-7356 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 7341-7356
    • Shirahata, M.1
  • 22
    • 20244387732 scopus 로고    scopus 로고
    • Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme
    • Liang, Y. et al. Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Proc. Natl Acad. Sci. USA 102, 5814-5819 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 5814-5819
    • Liang, Y.1
  • 23
    • 33644820339 scopus 로고    scopus 로고
    • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesiS
    • Phillips, H. et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9, 157-173 (2006).
    • (2006) Cancer Cell , vol.9 , pp. 157-173
    • Phillips, H.1
  • 24
    • 71549126830 scopus 로고    scopus 로고
    • Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology
    • Gravendeel, L. et al. Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology. Cancer Res. 69, 9065-9072 (2009).
    • (2009) Cancer Res , vol.69 , pp. 9065-9072
    • Gravendeel, L.1
  • 25
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak, R. G. et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17, 98-110 (2010).
    • (2010) Cancer Cell , vol.17 , pp. 98-110
    • Verhaak, R.G.1
  • 26
    • 84885074034 scopus 로고    scopus 로고
    • The somatic genomic landscape of glioblastoma
    • Brennan, C. W. et al. The somatic genomic landscape of glioblastoma. Cell 155, 462-477 (2013).
    • (2013) Cell , vol.155 , pp. 462-477
    • Brennan, C.W.1
  • 27
    • 77952108366 scopus 로고    scopus 로고
    • Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
    • Noushmehr, H. et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 17, 510-522 (2010).
    • (2010) Cancer Cell , vol.17 , pp. 510-522
    • Noushmehr, H.1
  • 28
    • 79957905986 scopus 로고    scopus 로고
    • Molecular subclassification of diffuse gliomas: Seeing order in the chaos
    • Huse, J., Phillips, H. & Brennan, C. Molecular subclassification of diffuse gliomas: seeing order in the chaos. Glia 59, 1190-1199 (2011).
    • (2011) Glia , vol.59 , pp. 1190-1199
    • Huse, J.1    Phillips, H.2    Brennan, C.3
  • 29
    • 84856722847 scopus 로고    scopus 로고
    • Studying a complex tumor: Potential and pitfallS
    • Zheng, S., Chheda, M. G. & Verhaak, R. G. Studying a complex tumor: potential and pitfalls. Cancer J. 18, 107-114 (2012).
    • (2012) Cancer J , vol.18 , pp. 107-114
    • Zheng, S.1    Chheda, M.G.2    Verhaak, R.G.3
  • 30
    • 75149195336 scopus 로고    scopus 로고
    • The transcriptional network for mesenchymal transformation of brain tumourS
    • Carro, M. S. et al. The transcriptional network for mesenchymal transformation of brain tumours. Nature 463, 318-325 (2010).
    • (2010) Nature , vol.463 , pp. 318-325
    • Carro, M.S.1
  • 31
    • 84255160601 scopus 로고    scopus 로고
    • The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma
    • Bhat, K. et al. The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. Genes Dev. 25, 2594-2609 (2011).
    • (2011) Genes Dev , vol.25 , pp. 2594-2609
    • Bhat, K.1
  • 32
    • 84884996623 scopus 로고    scopus 로고
    • The integrated landscape of driver genomic alterations in glioblastoma
    • Frattini, V. et al. The integrated landscape of driver genomic alterations in glioblastoma. Nature Genet. 45, 1141-1149 (2013).
    • (2013) Nature Genet , vol.45 , pp. 1141-1149
    • Frattini, V.1
  • 33
    • 84882654308 scopus 로고    scopus 로고
    • RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation
    • Danussi, C. et al. RHPN2 drives mesenchymal transformation in malignant glioma by triggering RhoA activation. Cancer Res. 73, 5140-5150 (2013).
    • (2013) Cancer Res , vol.73 , pp. 5140-5150
    • Danussi, C.1
  • 34
    • 84883656941 scopus 로고    scopus 로고
    • Mesenchymal differentiation mediated by NF-kappaB promotes radiation resistance in glioblastoma
    • Bhat, K. P. et al. Mesenchymal differentiation mediated by NF-kappaB promotes radiation resistance in glioblastoma. Cancer Cell 24, 331-346 (2013).
    • (2013) Cancer Cell , vol.24 , pp. 331-346
    • Bhat, K.P.1
  • 35
    • 35948989714 scopus 로고    scopus 로고
    • Gene expression profiling from formalinfixed paraffin-embedded tumors of pediatric glioblastoma
    • Haque, T. et al. Gene expression profiling from formalinfixed paraffin-embedded tumors of pediatric glioblastoma. Clin. Cancer Res. 13, 6284-6292 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 6284-6292
    • Haque, T.1
  • 36
    • 77954596239 scopus 로고    scopus 로고
    • Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease
    • Paugh, B. S. et al. Integrated molecular genetic profiling of pediatric high-grade gliomas reveals key differences with the adult disease. J. Clin. Oncol. 28, 3061-3068 (2010).
    • (2010) J. Clin. Oncol , vol.28 , pp. 3061-3068
    • Paugh, B.S.1
  • 37
    • 80054771090 scopus 로고    scopus 로고
    • Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma
    • Paugh, B. S. et al. Genome-wide analyses identify recurrent amplifications of receptor tyrosine kinases and cell-cycle regulatory genes in diffuse intrinsic pontine glioma. J. Clin. Oncol. 29, 3999-4006 (2011).
    • (2011) J. Clin. Oncol , vol.29 , pp. 3999-4006
    • Paugh, B.S.1
  • 38
    • 77954240113 scopus 로고    scopus 로고
    • A distinct spectrum of copy number aberrations in paediatric high grade gliomas
    • Bax, D. A. et al. A distinct spectrum of copy number aberrations in paediatric high grade gliomas. Clin. Cancer Res. 16, 3368-3377 (2010).
    • (2010) Clin. Cancer Res , vol.16 , pp. 3368-3377
    • Bax, D.A.1
  • 39
    • 75849131906 scopus 로고    scopus 로고
    • Genome-wide profiling using singlenucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomaS
    • Qu, H. Q. et al. Genome-wide profiling using singlenucleotide polymorphism arrays identifies novel chromosomal imbalances in pediatric glioblastomas. Neuro Oncol. 12, 153-163 (2010).
    • (2010) Neuro Oncol , vol.12 , pp. 153-163
    • Qu, H.Q.1
  • 40
    • 84867606428 scopus 로고    scopus 로고
    • Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
    • Sturm, D. et al. Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell 22, 425-437 (2012).
    • (2012) Cancer Cell , vol.22 , pp. 425-437
    • Sturm, D.1
  • 41
    • 84862777348 scopus 로고    scopus 로고
    • Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
    • Schwartzentruber, J. et al. Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature 482, 226-231 (2012).
    • (2012) Nature , vol.482 , pp. 226-231
    • Schwartzentruber, J.1
  • 42
    • 84874469720 scopus 로고    scopus 로고
    • Chromatin remodeling defects in pediatric and young adult glioblastoma: A tale of a variant histone 3 tail
    • Fontebasso, A., Liu, X.-Y., Sturm, D. & Jabado, N. Chromatin remodeling defects in pediatric and young adult glioblastoma: a tale of a variant histone 3 tail. Brain Pathol. 23, 210-216 (2013).
    • (2013) Brain Pathol , vol.23 , pp. 210-216
    • Fontebasso, A.1    Liu, X.-Y.2    Sturm, D.3    Jabado, N.4
  • 43
    • 84877621282 scopus 로고    scopus 로고
    • Histone H3.3 mutations drive pediatric glioblastoma through upregulation of MYCN
    • Bjerke, L. et al. Histone H3.3 mutations drive pediatric glioblastoma through upregulation of MYCN. Cancer Discov. 3, 512-519 (2013).
    • (2013) Cancer Discov , vol.3 , pp. 512-519
    • Bjerke, L.1
  • 44
    • 84887617868 scopus 로고    scopus 로고
    • Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomaS
    • Bender, S. et al. Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell 24, 660-672 (2013).
    • (2013) Cancer Cell , vol.24 , pp. 660-672
    • Bender, S.1
  • 45
    • 0029967152 scopus 로고    scopus 로고
    • Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation
    • Costello, J., Berger, M., Huang, H. & Cavenee, W. Silencing of p16/CDKN2 expression in human gliomas by methylation and chromatin condensation. Cancer Res. 56, 2405-2410 (1996).
    • (1996) Cancer Res , vol.56 , pp. 2405-2410
    • Costello, J.1    Berger, M.2    Huang, H.3    Cavenee, W.4
  • 47
    • 0035133842 scopus 로고    scopus 로고
    • Promoter hypermethylation of the RB1 gene in glioblastomas
    • Nakamura, M., Yonekawa, Y., Kleihues, P. & Ohgaki, H. Promoter hypermethylation of the RB1 gene in glioblastomas. Lab. Invest. 81, 77-82 (2001).
    • (2001) Lab. Invest , vol.81 , pp. 77-82
    • Nakamura, M.1    Yonekawa, Y.2    Kleihues, P.3    Ohgaki, H.4
  • 49
    • 20144387913 scopus 로고    scopus 로고
    • EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma
    • Alaminos, M. et al. EMP3, a myelin-related gene located in the critical 19q13.3 region, is epigenetically silenced and exhibits features of a candidate tumor suppressor in glioma and neuroblastoma. Cancer Res. 65, 2565-2571 (2005).
    • (2005) Cancer Res , vol.65 , pp. 2565-2571
    • Alaminos, M.1
  • 50
    • 33846821916 scopus 로고    scopus 로고
    • High TGFß-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
    • Bruna, A. et al. High TGFß-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 11, 147-160 (2007).
    • (2007) Cancer Cell , vol.11 , pp. 147-160
    • Bruna, A.1
  • 51
    • 15744392240 scopus 로고    scopus 로고
    • Epigenetic silencing of the protocadherin family member PCDH-.-A11 in astrocytomas
    • Waha, A. et al. Epigenetic silencing of the protocadherin family member PCDH-.-A11 in astrocytomas. Neoplasia 7, 193-199 (2005).
    • (2005) Neoplasia , vol.7 , pp. 193-199
    • Waha, A.1
  • 52
    • 34247892414 scopus 로고    scopus 로고
    • Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme
    • Zhou, H. et al. Reciprocal regulation of SOCS 1 and SOCS3 enhances resistance to ionizing radiation in glioblastoma multiforme. Clin. Cancer Res. 13, 2344-2353 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 2344-2353
    • Zhou, H.1
  • 53
    • 0036844322 scopus 로고    scopus 로고
    • Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumorS
    • Zardo, G. et al. Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. Nature Genet. 32, 453-458 (2002).
    • (2002) Nature Genet , vol.32 , pp. 453-458
    • Zardo, G.1
  • 54
    • 0033557903 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia
    • Esteller, M., Hamilton, S., Burger, P., Baylin, S. & Herman, J. Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res. 59, 793-797 (1999).
    • (1999) Cancer Res , vol.59 , pp. 793-797
    • Esteller, M.1    Hamilton, S.2    Burger, P.3    Baylin, S.4    Herman, J.5
  • 55
    • 79958072588 scopus 로고    scopus 로고
    • Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomaS
    • Felsberg, J. et al. Promoter methylation and expression of MGMT and the DNA mismatch repair genes MLH1, MSH2, MSH6 and PMS2 in paired primary and recurrent glioblastomas. Int. J. Cancer 129, 659-670 (2011).
    • (2011) Int. J. Cancer , vol.129 , pp. 659-670
    • Felsberg, J.1
  • 56
    • 84863091424 scopus 로고    scopus 로고
    • Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: The NOA-08 randomised, phase 3 trial
    • Wick, W. et al. Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. Lancet Oncol. 13, 707-715 (2012).
    • (2012) Lancet Oncol , vol.13 , pp. 707-715
    • Wick, W.1
  • 57
    • 84865558322 scopus 로고    scopus 로고
    • Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: The Nordic randomised, phase 3 trial
    • Malmström, A. et al. Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial. Lancet Oncol. 13, 916-926 (2012).
    • (2012) Lancet Oncol , vol.13 , pp. 916-926
    • Malmström, A.1
  • 58
    • 0028227862 scopus 로고
    • Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells
    • Costello, J., Futscher, B., Tano, K., Graunke, D. & Pieper, R. Graded methylation in the promoter and body of the O6-methylguanine DNA methyltransferase (MGMT) gene correlates with MGMT expression in human glioma cells. J. Biol. Chem. 269, 17228-17237 (1994).
    • (1994) J. Biol. Chem , vol.269 , pp. 17228-17237
    • Costello, J.1    Futscher, B.2    Tano, K.3    Graunke, D.4    Pieper, R.5
  • 59
    • 0028108955 scopus 로고
    • Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines
    • Costello, J., Futscher, B., Kroes, R. & Pieper, R. Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines. Mol. Cell. Biol. 14, 6515-6521 (1994).
    • (1994) Mol. Cell. Biol , vol.14 , pp. 6515-6521
    • Costello, J.1    Futscher, B.2    Kroes, R.3    Pieper, R.4
  • 60
    • 0034626988 scopus 로고    scopus 로고
    • Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents
    • Esteller, M. et al. Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. N. Engl. J. Med. 343, 1350-1354 (2000).
    • (2000) N. Engl. J. Med , vol.343 , pp. 1350-1354
    • Esteller, M.1
  • 61
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi, M. E. et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N. Engl. J. Med. 352, 997-1003 (2005).
    • (2005) N. Engl. J. Med , vol.352 , pp. 997-1003
    • Hegi, M.E.1
  • 62
    • 82955233990 scopus 로고    scopus 로고
    • Prognostic and predictive value of epigenetic silencing of MGMT in patients with high grade gliomas: A systematic review and meta-analysiS
    • Olson, R., Brastianos, P. & Palma, D. Prognostic and predictive value of epigenetic silencing of MGMT in patients with high grade gliomas: a systematic review and meta-analysis. J. Neuro-Oncol. 105, 325-335 (2011).
    • (2011) J. Neuro-Oncol , vol.105 , pp. 325-335
    • Olson, R.1    Brastianos, P.2    Palma, D.3
  • 63
    • 33847364433 scopus 로고    scopus 로고
    • MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma
    • Donson, A., Addo-Yobo, S., Handler, M., Gore, L. & Foreman, N. MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma. Pediatr. Blood Cancer 48, 403-407 (2007).
    • (2007) Pediatr. Blood Cancer , vol.48 , pp. 403-407
    • Donson, A.1    Addo-Yobo, S.2    Handler, M.3    Gore, L.4    Foreman, N.5
  • 64
    • 77956183827 scopus 로고    scopus 로고
    • Evaluation status and prognostic significance of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in pediatric high grade gliomas
    • Buttarelli, F. et al. Evaluation status and prognostic significance of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation in pediatric high grade gliomas. Child. Nerv. Syst. 26, 1051-1056 (2010).
    • (2010) Child. Nerv. Syst , vol.26 , pp. 1051-1056
    • Buttarelli, F.1
  • 65
    • 78649326720 scopus 로고    scopus 로고
    • MGMT gene promoter methylation in pediatric glioblastomas
    • Srivastava, A. et al. MGMT gene promoter methylation in pediatric glioblastomas. Child. Nerv. Syst. 26, 1613-1618 (2010).
    • (2010) Child. Nerv. Syst , vol.26 , pp. 1613-1618
    • Srivastava, A.1
  • 66
    • 80054731119 scopus 로고    scopus 로고
    • MGMT promoter gene methylation in pediatric glioblastoma: Analysis using MS-MLPA
    • Lee, J. et al. MGMT promoter gene methylation in pediatric glioblastoma: analysis using MS-MLPA. Child. Nerv. Syst. 27, 1877-1883 (2011).
    • (2011) Child. Nerv. Syst , vol.27 , pp. 1877-1883
    • Lee, J.1
  • 67
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061-1068 (2008).
    • (2008) Nature , vol.455 , pp. 1061-1068
  • 68
    • 33749039999 scopus 로고    scopus 로고
    • Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation
    • Cadieux, B., Ching, T.-T., VandenBerg, S. & Costello, J. Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. Cancer Res. 66, 8469-8476 (2006).
    • (2006) Cancer Res , vol.66 , pp. 8469-8476
    • Cadieux, B.1    Ching, T.-T.2    Vandenberg, S.3    Costello, J.4
  • 69
    • 84878588603 scopus 로고    scopus 로고
    • Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using highdensity DNA methylation arrays
    • Hovestadt, V. et al. Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using highdensity DNA methylation arrays. Acta Neuropathol. 125, 913-916 (2013).
    • (2013) Acta Neuropathol , vol.125 , pp. 913-916
    • Hovestadt, V.1
  • 70
    • 84877113990 scopus 로고    scopus 로고
    • Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanismS
    • Malhotra, A. et al. Breakpoint profiling of 64 cancer genomes reveals numerous complex rearrangements spawned by homology-independent mechanisms. Genome Res. 23, 762-776 (2013).
    • (2013) Genome Res , vol.23 , pp. 762-776
    • Malhotra, A.1
  • 71
    • 84876895426 scopus 로고    scopus 로고
    • Age-specific signatures of glioblastoma at the genomic, genetic, and epigenetic levelS
    • Bozdag, S. et al. Age-specific signatures of glioblastoma at the genomic, genetic, and epigenetic levels. PLoS ONE 8, e62982 (2013).
    • (2013) PLoS ONE , vol.8
    • Bozdag, S.1
  • 72
    • 84863434843 scopus 로고    scopus 로고
    • Paediatric and adult malignant glioma: Close relatives or distant cousins?
    • Jones, C., Perryman, L. & Hargrave, D. Paediatric and adult malignant glioma: close relatives or distant cousins? Nature Rev. Clin. Oncol. 9, 400-413 (2012).
    • (2012) Nature Rev. Clin. Oncol , vol.9 , pp. 400-413
    • Jones, C.1    Perryman, L.2    Hargrave, D.3
  • 73
    • 84879764400 scopus 로고    scopus 로고
    • A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival
    • Zheng, S. et al. A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival. Genes Dev. 27, 1462-1472 (2013).
    • (2013) Genes Dev , vol.27 , pp. 1462-1472
    • Zheng, S.1
  • 74
    • 70349456789 scopus 로고    scopus 로고
    • EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines
    • Bax, D. et al. EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines. Clin. Cancer Res. 15, 5753-5761 (2009).
    • (2009) Clin. Cancer Res , vol.15 , pp. 5753-5761
    • Bax, D.1
  • 75
    • 84255170397 scopus 로고    scopus 로고
    • Glioblastoma-derived epidermal growth factor receptor carboxyl-terminal deletion mutants are transforming and are sensitive to EGFR-directed therapieS
    • Cho, J. et al. Glioblastoma-derived epidermal growth factor receptor carboxyl-terminal deletion mutants are transforming and are sensitive to EGFR-directed therapies. Cancer Res. 71, 7587-7596 (2011).
    • (2011) Cancer Res , vol.71 , pp. 7587-7596
    • Cho, J.1
  • 76
    • 84886089551 scopus 로고    scopus 로고
    • The epidermal growth factor receptor variant III (EGFRvIII): Where wild things are altered
    • Gan, H., Cvrljevic, A. & Johns, T. The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered. FEBS J. 280, 5350-5370 (2013).
    • (2013) FEBS J , vol.280 , pp. 5350-5370
    • Gan, H.1    Cvrljevic, A.2    Johns, T.3
  • 77
    • 2442676505 scopus 로고    scopus 로고
    • Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomaS
    • Biernat, W., Huang, H., Yokoo, H., Kleihues, P. & Ohgaki, H. Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas. Brain Pathol. 14, 131-136 (2004).
    • (2004) Brain Pathol , vol.14 , pp. 131-136
    • Biernat, W.1    Huang, H.2    Yokoo, H.3    Kleihues, P.4    Ohgaki, H.5
  • 78
    • 77957667714 scopus 로고    scopus 로고
    • PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomaS
    • Ozawa, T. et al. PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas. Genes Dev. 24, 2205-2218 (2010).
    • (2010) Genes Dev , vol.24 , pp. 2205-2218
    • Ozawa, T.1
  • 79
    • 84886028950 scopus 로고    scopus 로고
    • Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas
    • Paugh, B. et al. Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas. Cancer Res. 73, 6219-6229 (2013).
    • (2013) Cancer Res , vol.73 , pp. 6219-6229
    • Paugh, B.1
  • 80
    • 84885074156 scopus 로고    scopus 로고
    • Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons
    • Sanborn, J. et al. Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons. Cancer Res. 73, 6036-6045 (2013).
    • (2013) Cancer Res , vol.73 , pp. 6036-6045
    • Sanborn, J.1
  • 81
    • 3843101398 scopus 로고    scopus 로고
    • Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas
    • Vogt, N. et al. Molecular structure of double-minute chromosomes bearing amplified copies of the epidermal growth factor receptor gene in gliomas. Proc. Natl Acad. Sci. USA 101, 11368-11373 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 11368-11373
    • Vogt, N.1
  • 82
    • 84865805666 scopus 로고    scopus 로고
    • Transforming fusions of FGFR and TACC genes in human glioblastoma
    • Singh, D. et al. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science 337, 1231-1235 (2012).
    • (2012) Science , vol.337 , pp. 1231-1235
    • Singh, D.1
  • 83
    • 84873347374 scopus 로고    scopus 로고
    • The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma
    • Parker, B. et al. The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. J. Clin. Invest. 123, 855-865 (2013).
    • (2013) J. Clin. Invest , vol.123 , pp. 855-865
    • Parker, B.1
  • 84
    • 84882247189 scopus 로고    scopus 로고
    • PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma
    • Phillips, J. et al. PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma. Brain Pathol. 23, 565-573 (2013).
    • (2013) Brain Pathol , vol.23 , pp. 565-573
    • Phillips, J.1
  • 85
    • 77950487385 scopus 로고    scopus 로고
    • Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor a and poly (ADP-ribose) polymerase as potential therapeutic targets
    • Zarghooni, M. et al. Whole-genome profiling of pediatric diffuse intrinsic pontine gliomas highlights platelet-derived growth factor receptor a and poly (ADP-ribose) polymerase as potential therapeutic targets. J. Clin. Oncol. 28, 1337-1344 (2010).
    • (2010) J. Clin. Oncol , vol.28 , pp. 1337-1344
    • Zarghooni, M.1
  • 86
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons, D. W. et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807-1812 (2008).
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1
  • 87
    • 84871020024 scopus 로고    scopus 로고
    • Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutationS
    • Liu, X.-Y. et al. Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations. Acta Neuropathol. 124, 615-625 (2012).
    • (2012) Acta Neuropathol , vol.124 , pp. 615-625
    • Liu, X.-Y.1
  • 88
    • 84868625787 scopus 로고    scopus 로고
    • Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomaS
    • Jiao, Y. et al. Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. Oncotarget 3, 709-722 (2012).
    • (2012) Oncotarget , vol.3 , pp. 709-722
    • Jiao, Y.1
  • 89
    • 84863621527 scopus 로고    scopus 로고
    • Cancer epigenetics: From mechanism to therapy
    • Dawson, M. & Kouzarides, T. Cancer epigenetics: from mechanism to therapy. Cell 150, 12-27 (2012).
    • (2012) Cell , vol.150 , pp. 12-27
    • Dawson, M.1    Kouzarides, T.2
  • 90
    • 84875745673 scopus 로고    scopus 로고
    • Interplay between the cancer genome and epigenome
    • Shen, H. & Laird, P. Interplay between the cancer genome and epigenome. Cell 153, 38-55 (2013).
    • (2013) Cell , vol.153 , pp. 38-55
    • Shen, H.1    Laird, P.2
  • 91
    • 84876067164 scopus 로고    scopus 로고
    • TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
    • Killela, P. et al. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc. Natl Acad. Sci. USA 110, 6021-6026 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 6021-6026
    • Killela, P.1
  • 92
    • 84881095932 scopus 로고    scopus 로고
    • Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q losS
    • Arita, H. et al. Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss. Acta Neuropathol. 126, 267-276 (2013).
    • (2013) Acta Neuropathol , vol.126 , pp. 267-276
    • Arita, H.1
  • 93
    • 84892603397 scopus 로고    scopus 로고
    • TERT promoter mutations in primary and secondary glioblastomaS
    • Nonoguchi, N. et al. TERT promoter mutations in primary and secondary glioblastomas. Acta Neuropathol. 126, 931-937 (2013).
    • (2013) Acta Neuropathol , vol.126 , pp. 931-937
    • Nonoguchi, N.1
  • 94
    • 84884524540 scopus 로고    scopus 로고
    • Frequency of TERT promoter mutations in human cancers
    • Vinagre, J. et al. Frequency of TERT promoter mutations in human cancers. Nature Commun. 4, 2185 (2013).
    • (2013) Nature Commun , vol.4 , pp. 2185
    • Vinagre, J.1
  • 95
    • 84892590846 scopus 로고    scopus 로고
    • Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous systeM
    • Koelsche, C. et al. Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system. Acta Neuropathol. 126, 907-915 (2013).
    • (2013) Acta Neuropathol , vol.126 , pp. 907-915
    • Koelsche, C.1
  • 96
    • 33747109928 scopus 로고    scopus 로고
    • Telomerase activity and hTERT mRNA expression in glial tumors
    • Boldrini, L. et al. Telomerase activity and hTERT mRNA expression in glial tumors. Int. J. Oncol. 28, 1555-1560 (2006).
    • (2006) Int. J. Oncol , vol.28 , pp. 1555-1560
    • Boldrini, L.1
  • 97
    • 79960700556 scopus 로고    scopus 로고
    • Altered telomeres in tumors with ATRX and DAXX mutations
    • Heaphy, C. et al. Altered telomeres in tumors with ATRX and DAXX mutations. Science 333, 425 (2011).
    • (2011) Science , vol.333 , pp. 425
    • Heaphy, C.1
  • 98
    • 33646256145 scopus 로고    scopus 로고
    • A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy
    • Hunter, C. et al. A hypermutation phenotype and somatic MSH6 mutations in recurrent human malignant gliomas after alkylator chemotherapy. Cancer Res. 66, 3987-3991 (2006).
    • (2006) Cancer Res , vol.66 , pp. 3987-3991
    • Hunter, C.1
  • 99
    • 34247499001 scopus 로고    scopus 로고
    • Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment
    • Cahill, D. et al. Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment. Clin. Cancer Res. 13, 2038-2045 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 2038-2045
    • Cahill, D.1
  • 100
    • 68049095262 scopus 로고    scopus 로고
    • MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance
    • Yip, S. et al. MSH6 mutations arise in glioblastomas during temozolomide therapy and mediate temozolomide resistance. Clin. Cancer Res. 15, 4622-4629 (2009).
    • (2009) Clin. Cancer Res , vol.15 , pp. 4622-4629
    • Yip, S.1
  • 101
    • 84862777410 scopus 로고    scopus 로고
    • Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and nonbrainstem glioblastomaS
    • Wu, G. et al. Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and nonbrainstem glioblastomas. Nature Genet. 44, 251-253 (2012).
    • (2012) Nature Genet , vol.44 , pp. 251-253
    • Wu, G.1
  • 102
    • 84861633881 scopus 로고    scopus 로고
    • The pediatric cancer genome project
    • Downing, J. et al. The Pediatric Cancer Genome Project. Nature Genet. 44, 619-622 (2012).
    • (2012) Nature Genet , vol.44 , pp. 619-622
    • Downing, J.1
  • 103
    • 84878723078 scopus 로고    scopus 로고
    • Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomaS
    • Zhang, J. et al. Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nature Genet. 45, 602-612 (2013).
    • (2013) Nature Genet , vol.45 , pp. 602-612
    • Zhang, J.1
  • 104
    • 84880983541 scopus 로고    scopus 로고
    • Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
    • Jones, D. T. W. et al. Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nature Genet. 45, 927-932 (2013).
    • (2013) Nature Genet , vol.45 , pp. 927-932
    • Jones, D.T.W.1
  • 105
    • 84882273357 scopus 로고    scopus 로고
    • Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomaS
    • Venneti, S. et al. Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas. Brain Pathol. 23, 558-564 (2013).
    • (2013) Brain Pathol , vol.23 , pp. 558-564
    • Venneti, S.1
  • 106
    • 84877785024 scopus 로고    scopus 로고
    • Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma
    • Lewis, P. et al. Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science 340, 857-861 (2013).
    • (2013) Science , vol.340 , pp. 857-861
    • Lewis, P.1
  • 107
    • 84877299145 scopus 로고    scopus 로고
    • The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression
    • Chan, K.-M. et al. The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression. Genes Dev. 27, 985-990 (2013).
    • (2013) Genes Dev , vol.27 , pp. 985-990
    • Chan, K.-M.1
  • 108
    • 84861399134 scopus 로고    scopus 로고
    • Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC
    • Swartling, F. J. et al. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. Cancer Cell 21, 601-613 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 601-613
    • Swartling, F.J.1
  • 109
    • 84876033650 scopus 로고    scopus 로고
    • Targeting MYCN in neuroblastoma by BET bromodomain inhibition
    • Puissant, A. et al. Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 3, 308-323 (2013).
    • (2013) Cancer Discov , vol.3 , pp. 308-323
    • Puissant, A.1
  • 110
    • 84886712846 scopus 로고    scopus 로고
    • Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomaS
    • Fontebasso, A. et al. Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas. Acta Neuropathol. 125, 659-669 (2013).
    • (2013) Acta Neuropathol , vol.125 , pp. 659-669
    • Fontebasso, A.1
  • 111
    • 84876943255 scopus 로고    scopus 로고
    • The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSa
    • Li, F. et al. The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSa. Cell 153, 590-600 (2013).
    • (2013) Cell , vol.153 , pp. 590-600
    • Li, F.1
  • 112
    • 33746136947 scopus 로고    scopus 로고
    • Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma
    • Chen, Y.-J. et al. Association of mutant TP53 with alternative lengthening of telomeres and favorable prognosis in glioma. Cancer Res. 66, 6473-6476 (2006).
    • (2006) Cancer Res , vol.66 , pp. 6473-6476
    • Chen, Y.-J.1
  • 113
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • Yan, H. et al. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 360, 765-773 (2009).
    • (2009) N. Engl. J. Med , vol.360 , pp. 765-773
    • Yan, H.1
  • 114
    • 68349116524 scopus 로고    scopus 로고
    • IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomaS
    • Ichimura, K. et al. IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas. Neuro Oncol. 11, 341-347 (2009).
    • (2009) Neuro Oncol , vol.11 , pp. 341-347
    • Ichimura, K.1
  • 115
    • 84883171570 scopus 로고    scopus 로고
    • IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma
    • Zhang, C., Moore, L., Li, X., Yung, W. & Zhang, W. IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma. Neuro Oncol. 15, 1114-1126 (2013).
    • (2013) Neuro Oncol , vol.15 , pp. 1114-1126
    • Zhang, C.1    Moore, L.2    Li, X.3    Yung, W.4    Zhang, W.5
  • 116
    • 84874091180 scopus 로고    scopus 로고
    • The definition of primary and secondary glioblastoma
    • Ohgaki, H. & Kleihues, P. The definition of primary and secondary glioblastoma. Clin. Cancer Res. 19, 764-772 (2013).
    • (2013) Clin. Cancer Res , vol.19 , pp. 764-772
    • Ohgaki, H.1    Kleihues, P.2
  • 117
    • 34547432232 scopus 로고    scopus 로고
    • Incidence of gliomas by anatomic location
    • Larjavaara, S. et al. Incidence of gliomas by anatomic location. Neuro Oncol. 9, 319-325 (2007).
    • (2007) Neuro Oncol , vol.9 , pp. 319-325
    • Larjavaara, S.1
  • 118
    • 84858796263 scopus 로고    scopus 로고
    • IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
    • This study was the first to show a causal link between mutations in IDH1 and the G-CIMP.
    • Turcan, S. et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 483, 479-483 (2012). This study was the first to show a causal link between mutations in IDH1 and the G-CIMP.
    • (2012) Nature , vol.483 , pp. 479-483
    • Turcan, S.1
  • 119
    • 84862999702 scopus 로고    scopus 로고
    • IDH mutations in human glioma
    • Kim, W. & Liau, L. IDH mutations in human glioma. Neurosurg. Clin. N. Am. 23, 471-480 (2012).
    • (2012) Neurosurg. Clin. N. Am , vol.23 , pp. 471-480
    • Kim, W.1    Liau, L.2
  • 120
    • 84865218876 scopus 로고    scopus 로고
    • Molecular pathogenesis of IDH mutations in gliomaS
    • Ichimura, K. Molecular pathogenesis of IDH mutations in gliomas. Brain Tumor Pathol. 29, 131-139 (2012).
    • (2012) Brain Tumor Pathol , vol.29 , pp. 131-139
    • Ichimura, K.1
  • 121
    • 84864192438 scopus 로고    scopus 로고
    • Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1-mutation as common tumor initiating event
    • Lass, U. et al. Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1-mutation as common tumor initiating event. PLoS ONE 7, e41298 (2012).
    • (2012) PLoS ONE , vol.7
    • Lass, U.1
  • 122
    • 78651082266 scopus 로고    scopus 로고
    • Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: Implications for classification of gliomaS
    • Hartmann, C. et al. Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas. Acta Neuropathol. 120, 707-718 (2010).
    • (2010) Acta Neuropathol , vol.120 , pp. 707-718
    • Hartmann, C.1
  • 123
    • 84884582587 scopus 로고    scopus 로고
    • Longterm survival in primary glioblastoma with versus without isocitrate dehydrogenase mutations
    • Hartmann, C. et al. Longterm survival in primary glioblastoma with versus without isocitrate dehydrogenase mutations. Clin. Cancer Res. 19, 5146-5157 (2013).
    • (2013) Clin. Cancer Res , vol.19 , pp. 5146-5157
    • Hartmann, C.1
  • 124
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemiaassociated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting a-ketoglutarate to 2-hydroxyglutarate
    • Ward, P. S. et al. The common feature of leukemiaassociated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting a-ketoglutarate to 2-hydroxyglutarate. Cancer Cell 17, 225-234 (2010).
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1
  • 125
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    • Dang, L. et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462, 739-744 (2009).
    • (2009) Nature , vol.462 , pp. 739-744
    • Dang, L.1
  • 126
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa, M. et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell 18, 553-567 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.1
  • 127
    • 78651463452 scopus 로고    scopus 로고
    • Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of a-ketoglutarate-dependent dioxygenaseS
    • Xu, W. et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of a-ketoglutarate-dependent dioxygenases. Cancer Cell 19, 17-30 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 17-30
    • Xu, W.1
  • 128
    • 79955547561 scopus 로고    scopus 로고
    • The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylaseS
    • Chowdhury, R. et al. The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep. 12, 463-469 (2011).
    • (2011) EMBO Rep , vol.12 , pp. 463-469
    • Chowdhury, R.1
  • 129
    • 84885848576 scopus 로고    scopus 로고
    • Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2
    • Guilhamon, P. et al. Meta-analysis of IDH-mutant cancers identifies EBF1 as an interaction partner for TET2. Nature Commun. 4, 2166 (2013).
    • (2013) Nature Commun , vol.4 , pp. 2166
    • Guilhamon, P.1
  • 130
    • 84868128332 scopus 로고    scopus 로고
    • Transposon mutagenesis identifies genes that transform neural stem cells into gliomainitiating cells
    • Koso, H. et al. Transposon mutagenesis identifies genes that transform neural stem cells into gliomainitiating cells. Proc. Natl Acad. Sci. USA 109, E2998-E3007 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109
    • Koso, H.1
  • 131
    • 57849109837 scopus 로고    scopus 로고
    • Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model
    • Alcantara Llaguno, S. et al. Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell 15, 45-56 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 45-56
    • Alcantara Llaguno, S.1
  • 132
    • 79960809488 scopus 로고    scopus 로고
    • Mosaic analysis with double markers reveals tumor cell of origin in glioma
    • Liu, C. et al. Mosaic analysis with double markers reveals tumor cell of origin in glioma. Cell 146, 209-221 (2011).
    • (2011) Cell , vol.146 , pp. 209-221
    • Liu, C.1
  • 133
    • 80052574196 scopus 로고    scopus 로고
    • Asymmetry-defective oligodendrocyte progenitors are glioma precursors
    • Sugiarto, S. et al. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell 20, 328-340 (2011).
    • (2011) Cancer Cell , vol.20 , pp. 328-340
    • Sugiarto, S.1
  • 134
    • 84869878282 scopus 로고    scopus 로고
    • Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice
    • Friedmann-Morvinski, D. et al. Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice. Science 338, 1080-1084 (2012).
    • (2012) Science , vol.338 , pp. 1080-1084
    • Friedmann-Morvinski, D.1
  • 135
    • 79952717343 scopus 로고    scopus 로고
    • Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma
    • Monje, M. et al. Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc. Natl Acad. Sci. USA 108, 4453-4458 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 4453-4458
    • Monje, M.1
  • 136
    • 83355163405 scopus 로고    scopus 로고
    • Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin
    • Lai, A. et al. Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. J. Clin. Oncol. 29, 4482-4490 (2011).
    • (2011) J. Clin. Oncol , vol.29 , pp. 4482-4490
    • Lai, A.1
  • 137
    • 80054993342 scopus 로고    scopus 로고
    • Spatio-temporal transcriptome of the human brain
    • Kang, H. et al. Spatio-temporal transcriptome of the human brain. Nature 478, 483-489 (2011).
    • (2011) Nature , vol.478 , pp. 483-489
    • Kang, H.1
  • 138
    • 0141922119 scopus 로고    scopus 로고
    • Expression of the oligodendroglial lineage-associated markers Olig1 and Olig2 in different types of human gliomas
    • Ohnishi, A. et al. Expression of the oligodendroglial lineage-associated markers Olig1 and Olig2 in different types of human gliomas. J. Neuropathol. Exp. Neurol. 62, 1052-1059 (2003).
    • (2003) J. Neuropathol. Exp. Neurol , vol.62 , pp. 1052-1059
    • Ohnishi, A.1
  • 139
    • 0035845569 scopus 로고    scopus 로고
    • Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors
    • Lu, Q. R. et al. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. Proc. Natl Acad. Sci. USA 98, 10851-10856 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 10851-10856
    • Lu, Q.R.1
  • 140
    • 0035963934 scopus 로고    scopus 로고
    • OLIG2 as a specific marker of oligodendroglial tumour cells
    • Marie, Y. et al. OLIG2 as a specific marker of oligodendroglial tumour cells. Lancet 358, 298-300 (2001).
    • (2001) Lancet , vol.358 , pp. 298-300
    • Marie, Y.1
  • 141
    • 84855932131 scopus 로고    scopus 로고
    • Self-renewal does not predict tumor growth potential in mouse models of high-grade glioma
    • Barrett, L. E. et al. Self-renewal does not predict tumor growth potential in mouse models of high-grade glioma. Cancer Cell 21, 11-24 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 11-24
    • Barrett, L.E.1
  • 142
    • 84864433702 scopus 로고    scopus 로고
    • Antagonistic modulation of gliomagenesis by Pax6 and Olig2 in PDGF-induced oligodendroglioma
    • Appolloni, I. et al. Antagonistic modulation of gliomagenesis by Pax6 and Olig2 in PDGF-induced oligodendroglioma. Int. J. Cancer 131, E1078-E1087 (2012).
    • (2012) Int. J. Cancer , vol.131
    • Appolloni, I.1
  • 143
    • 65649142176 scopus 로고    scopus 로고
    • Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model
    • Wang, Y. et al. Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model. Cancer Cell 15, 514-526 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 514-526
    • Wang, Y.1
  • 144
    • 59149086517 scopus 로고    scopus 로고
    • Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma
    • Prados, M. D. et al. Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. J. Clin. Oncol. 27, 579-584 (2009).
    • (2009) J. Clin. Oncol , vol.27 , pp. 579-584
    • Prados, M.D.1
  • 145
    • 57149118473 scopus 로고    scopus 로고
    • Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177
    • Brown, P. D. et al. Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. J. Clin. Oncol. 26, 5603-5609 (2008).
    • (2008) J. Clin. Oncol , vol.26 , pp. 5603-5609
    • Brown, P.D.1
  • 146
    • 62449150719 scopus 로고    scopus 로고
    • Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034
    • van den Bent, M. J. et al. Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034. J. Clin. Oncol. 27, 1268-1274 (2009).
    • (2009) J. Clin. Oncol , vol.27 , pp. 1268-1274
    • Van Den Bent, M.J.1
  • 147
    • 27744506881 scopus 로고    scopus 로고
    • Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: Tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01
    • Lassman, A. B. et al. Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01. Clin. Cancer Res. 11, 7841-7850 (2005).
    • (2005) Clin. Cancer Res , vol.11 , pp. 7841-7850
    • Lassman, A.B.1
  • 148
    • 34247218483 scopus 로고    scopus 로고
    • Gefitinib in patients with progressive high-grade gliomas: A multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)
    • Franceschi, E. et al. Gefitinib in patients with progressive high-grade gliomas: a multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO). Br. J. Cancer 96, 1047-1051 (2007).
    • (2007) Br. J. Cancer , vol.96 , pp. 1047-1051
    • Franceschi, E.1
  • 149
    • 69849112085 scopus 로고    scopus 로고
    • Stratified phase II trial of cetuximab in patients with recurrent high-grade glioma
    • Neyns, B. et al. Stratified phase II trial of cetuximab in patients with recurrent high-grade glioma. Ann. Oncol. 20, 1596-1603 (2009).
    • (2009) Ann. Oncol , vol.20 , pp. 1596-1603
    • Neyns, B.1
  • 150
    • 53749096014 scopus 로고    scopus 로고
    • Phase II study of imatinib in patients with recurrent gliomas of various histologies: A European Organisation for Research and Treatment of Cancer Brain Tumor Group Study
    • Raymond, E. et al. Phase II study of imatinib in patients with recurrent gliomas of various histologies: a European Organisation for Research and Treatment of Cancer Brain Tumor Group Study. J. Clin. Oncol. 26, 4659-4665 (2008).
    • (2008) J. Clin. Oncol , vol.26 , pp. 4659-4665
    • Raymond, E.1
  • 151
    • 33748376520 scopus 로고    scopus 로고
    • Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08
    • Wen, P. Y. et al. Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin. Cancer Res. 12, 4899-4907 (2006).
    • (2006) Clin. Cancer Res , vol.12 , pp. 4899-4907
    • Wen, P.Y.1
  • 152
    • 71649102124 scopus 로고    scopus 로고
    • Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma
    • Reardon, D. A. et al. Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma. Br. J. Cancer 101, 1995-2004 (2009).
    • (2009) Br. J. Cancer , vol.101 , pp. 1995-2004
    • Reardon, D.A.1
  • 153
    • 75049085049 scopus 로고    scopus 로고
    • Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide
    • Dresemann, G. et al. Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide. J. Neurooncol. 96, 393-402 (2010).
    • (2010) J. Neurooncol , vol.96 , pp. 393-402
    • Dresemann, G.1
  • 154
    • 70350461699 scopus 로고    scopus 로고
    • Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
    • Friedman, H. S. et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J. Clin. Oncol. 27, 4733-4740 (2009).
    • (2009) J. Clin. Oncol , vol.27 , pp. 4733-4740
    • Friedman, H.S.1
  • 155
    • 79951984402 scopus 로고    scopus 로고
    • Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme
    • Lai, A. et al. Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. J. Clin. Oncol. 29, 142-148 (2011).
    • (2011) J. Clin. Oncol , vol.29 , pp. 142-148
    • Lai, A.1
  • 156
    • 84887116872 scopus 로고    scopus 로고
    • Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma
    • Batchelor, T. T. et al. Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma. J. Clin. Oncol. 31, 3212-3218 (2013).
    • (2013) J. Clin. Oncol , vol.31 , pp. 3212-3218
    • Batchelor, T.T.1
  • 158
    • 84861696508 scopus 로고    scopus 로고
    • Phase i study of panobinostat in combination with bevacizumab for recurrent highgrade glioma
    • Drappatz, J. et al. Phase I study of panobinostat in combination with bevacizumab for recurrent highgrade glioma. J. Neurooncol. 107, 133-138 (2012).
    • (2012) J. Neurooncol , vol.107 , pp. 133-138
    • Drappatz, J.1
  • 159
    • 84859538161 scopus 로고    scopus 로고
    • Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: A north central cancer treatment group study
    • Friday, B. B. et al. Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: a north central cancer treatment group study. Neuro. Oncol. 14, 215-221 (2012).
    • (2012) Neuro. Oncol , vol.14 , pp. 215-221
    • Friday, B.B.1
  • 160
    • 84880598419 scopus 로고    scopus 로고
    • Valproic acid use during radiation therapy for glioblastoma associated with improved survival
    • Barker, C. A., Bishop, A. J., Chang, M., Beal, K. & Chan, T. A. Valproic acid use during radiation therapy for glioblastoma associated with improved survival. Int. J. Radiat. Oncol. 86, 504-509 (2013).
    • (2013) Int. J. Radiat. Oncol , vol.86 , pp. 504-509
    • Barker, C.A.1    Bishop, A.J.2    Chang, M.3    Beal, K.4    Chan, T.A.5
  • 161
    • 80054705372 scopus 로고    scopus 로고
    • Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma
    • Weller, M. et al. Prolonged survival with valproic acid use in the EORTC/NCIC temozolomide trial for glioblastoma. Neurology 77, 1156-1164 (2011).
    • (2011) Neurology , vol.77 , pp. 1156-1164
    • Weller, M.1
  • 162
    • 84877632013 scopus 로고    scopus 로고
    • An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cellS
    • Rohle, D. et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 340, 626-630 (2013).
    • (2013) Science , vol.340 , pp. 626-630
    • Rohle, D.1
  • 164
    • 84877620952 scopus 로고    scopus 로고
    • Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
    • Wang, F. et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science 340, 622-626 (2013).
    • (2013) Science , vol.340 , pp. 622-626
    • Wang, F.1
  • 165
    • 84880291912 scopus 로고    scopus 로고
    • BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1
    • Tonjes, M. et al. BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1. Nature Med. 19, 901-908 (2013).
    • (2013) Nature Med , vol.19 , pp. 901-908
    • Tonjes, M.1
  • 166
    • 84870598190 scopus 로고    scopus 로고
    • ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
    • Yang, W. et al. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biol. 14, 1295-1304 (2012).
    • (2012) Nature Cell Biol , vol.14 , pp. 1295-1304
    • Yang, W.1
  • 167
    • 84865266173 scopus 로고    scopus 로고
    • PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesiS
    • Yang, W. et al. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell 150, 685-696 (2012).
    • (2012) Cell , vol.150 , pp. 685-696
    • Yang, W.1
  • 168
    • 84863165348 scopus 로고    scopus 로고
    • Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)
    • McCabe, M. T. et al. Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27). Proc. Natl Acad. Sci. USA 109, 2989-2994 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 2989-2994
    • McCabe, M.T.1
  • 169
    • 83355173202 scopus 로고    scopus 로고
    • EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomaS
    • Ryan, R. J. et al. EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas. PLoS ONE 6, e28585 (2011).
    • (2011) PLoS ONE , vol.6
    • Ryan, R.J.1
  • 170
    • 78650454078 scopus 로고    scopus 로고
    • Coordinated activities of wildtype plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
    • Sneeringer, C. J. et al. Coordinated activities of wildtype plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas. Proc. Natl Acad. Sci. USA 107, 20980-20985 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 20980-20985
    • Sneeringer, C.J.1
  • 171
    • 74949143829 scopus 로고    scopus 로고
    • The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumorinitiating cells leading to decreased proliferation and tumor growth
    • Marian, C. et al. The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumorinitiating cells leading to decreased proliferation and tumor growth. Clin. Cancer Res. 16, 154-163 (2010).
    • (2010) Clin. Cancer Res , vol.16 , pp. 154-163
    • Marian, C.1
  • 172
    • 84877097843 scopus 로고    scopus 로고
    • Inhibition of BET bromodomain targets genetically diverse glioblastoma
    • Cheng, Z. et al. Inhibition of BET bromodomain targets genetically diverse glioblastoma. Clin. Cancer Res. 19, 1748-1759 (2013).
    • (2013) Clin. Cancer Res , vol.19 , pp. 1748-1759
    • Cheng, Z.1
  • 173
    • 79958757490 scopus 로고    scopus 로고
    • Pathway analysis of glioblastoma tissue after preoperative treatment with the EGFR tyrosine kinase inhibitor gefitinib-A phase II trial
    • Hegi, M. et al. Pathway analysis of glioblastoma tissue after preoperative treatment with the EGFR tyrosine kinase inhibitor gefitinib-a phase II trial. Mol. Cancer Ther. 10, 1102-1112 (2011).
    • (2011) Mol. Cancer Ther , vol.10 , pp. 1102-1112
    • Hegi, M.1
  • 174
    • 27744606737 scopus 로고    scopus 로고
    • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
    • Mellinghoff, I. et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N. Engl. J. Med. 353, 2012-2024 (2005).
    • (2005) N. Engl. J. Med , vol.353 , pp. 2012-2024
    • Mellinghoff, I.1
  • 175
    • 84865542459 scopus 로고    scopus 로고
    • Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240
    • Fenton, T. et al. Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc. Natl Acad. Sci. USA 109, 14164-14169 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 14164-14169
    • Fenton, T.1
  • 176
    • 84894579110 scopus 로고    scopus 로고
    • Inhibition of EGFR induces a c-MET driven stem cell population in glioblastoma
    • Jun, H., Bronson, R. & Charest, A. Inhibition of EGFR induces a c-MET driven stem cell population in glioblastoma. Stem Cells http://dx.doi.org/10. 1002/stem.1554 (2013).
    • (2013) Stem Cells
    • Jun, H.1    Bronson, R.2    Charest, A.3
  • 177
    • 80051597880 scopus 로고    scopus 로고
    • Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRa/ß
    • Bielen, A. et al. Enhanced efficacy of IGF1R inhibition in pediatric glioblastoma by combinatorial targeting of PDGFRa/ß. Mol. Cancer Ther. 10, 1407-1418 (2011).
    • (2011) Mol. Cancer Ther , vol.10 , pp. 1407-1418
    • Bielen, A.1
  • 178
    • 84857397985 scopus 로고    scopus 로고
    • Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
    • Szerlip, N. et al. Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response. Proc. Natl Acad. Sci. USA 109, 3041-3046 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 3041-3046
    • Szerlip, N.1
  • 179
    • 84859376167 scopus 로고    scopus 로고
    • Receptor tyrosine kinase genes amplified in glioblastoma exhibit a mutual exclusivity in variable proportions reflective of individual tumor heterogeneity
    • Little, S. et al. Receptor tyrosine kinase genes amplified in glioblastoma exhibit a mutual exclusivity in variable proportions reflective of individual tumor heterogeneity. Cancer Res. 72, 1614-1620 (2012).
    • (2012) Cancer Res , vol.72 , pp. 1614-1620
    • Little, S.1
  • 180
    • 75549083303 scopus 로고    scopus 로고
    • Tumor heterogeneity: Causes and consequences
    • Marusyk, A. & Polyak, K. Tumor heterogeneity: causes and consequences. Biochim. Biophys. Acta 1805, 105-117 (2010).
    • (2010) Biochim. Biophys. Acta , vol.1805 , pp. 105-117
    • Marusyk, A.1    Polyak, K.2
  • 181
    • 0032532078 scopus 로고    scopus 로고
    • Intratumoral cytogenetic heterogeneity detected by comparative genomic hybridization and laser scanning cytometry in human gliomaS
    • Harada, K. et al. Intratumoral cytogenetic heterogeneity detected by comparative genomic hybridization and laser scanning cytometry in human gliomas. Cancer Res. 58, 4694-4700 (1998).
    • (1998) Cancer Res , vol.58 , pp. 4694-4700
    • Harada, K.1
  • 182
    • 0032850203 scopus 로고    scopus 로고
    • Evidence of focal genetic microheterogeneity in glioblastoma multiforme by area-specific CGH on microdissected tumor cells
    • Jung, V. et al. Evidence of focal genetic microheterogeneity in glioblastoma multiforme by area-specific CGH on microdissected tumor cells. J. Neuropath. Exp. Neur. 58, 993-999 (1999).
    • (1999) J. Neuropath. Exp. Neur , vol.58 , pp. 993-999
    • Jung, V.1
  • 183
    • 77955167915 scopus 로고    scopus 로고
    • Intratumoral patterns of genomic imbalance in glioblastomaS
    • Nobusawa, S. et al. Intratumoral patterns of genomic imbalance in glioblastomas. Brain Pathol. 20, 936-944 (2010).
    • (2010) Brain Pathol , vol.20 , pp. 936-944
    • Nobusawa, S.1
  • 184
    • 34948858931 scopus 로고    scopus 로고
    • Molecular genetic analysis of p53 intratumoral heterogeneity in human astrocytic brain tumors
    • Ren, Z.-P. et al. Molecular genetic analysis of p53 intratumoral heterogeneity in human astrocytic brain tumors. J. Neuropath. Exp. Neur. 66, 944-954 (2007).
    • (2007) J. Neuropath. Exp. Neur , vol.66 , pp. 944-954
    • Ren, Z.-P.1
  • 185
    • 51649117107 scopus 로고    scopus 로고
    • Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity
    • Hegi, M. et al. Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. J. Clin. Oncol. 26, 4189-4199 (2008).
    • (2008) J. Clin. Oncol , vol.26 , pp. 4189-4199
    • Hegi, M.1
  • 186
    • 84874598318 scopus 로고    scopus 로고
    • Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
    • Sottoriva, A. et al. Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc. Natl Acad. Sci. USA 110, 4009-4014 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 4009-4014
    • Sottoriva, A.1
  • 187
    • 83455176258 scopus 로고    scopus 로고
    • Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma
    • Snuderl, M. et al. Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma. Cancer Cell 20, 810-817 (2011).
    • (2011) Cancer Cell , vol.20 , pp. 810-817
    • Snuderl, M.1
  • 188
    • 77955911497 scopus 로고    scopus 로고
    • Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma
    • Inda, M.-d.-M. et al. Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev. 24, 1731-1745 (2010).
    • (2010) Genes Dev , vol.24 , pp. 1731-1745
    • Inda, M.D.-M.1
  • 189
    • 35348822482 scopus 로고    scopus 로고
    • Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapieS
    • Stommel, J. et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 318, 287-290 (2007).
    • (2007) Science , vol.318 , pp. 287-290
    • Stommel, J.1
  • 190
    • 84856013431 scopus 로고    scopus 로고
    • Clonal evolution in cancer
    • Greaves, M. & Maley, C. Clonal evolution in cancer. Nature 481, 306-313 (2012).
    • (2012) Nature , vol.481 , pp. 306-313
    • Greaves, M.1    Maley, C.2
  • 192
    • 79957927593 scopus 로고    scopus 로고
    • Genetic modeling of gliomas in mice: New tools to tackle old problemS
    • Hambardzumyan, D., Parada, L., Holland, E. & Charest, A. Genetic modeling of gliomas in mice: new tools to tackle old problems. Glia 59, 1155-1168 (2011).
    • (2011) Glia , vol.59 , pp. 1155-1168
    • Hambardzumyan, D.1    Parada, L.2    Holland, E.3    Charest, A.4
  • 193
    • 84878139953 scopus 로고    scopus 로고
    • Vertebrate animal models of glioma: Understanding the mechanisms and developing new therapies
    • Chen, L., Zhang, Y., Yang, J., Hagan, J. & Li, M. Vertebrate animal models of glioma: understanding the mechanisms and developing new therapies. Biochim. Biophys. Acta 1836, 158-165 (2013).
    • (2013) Biochim. Biophys. Acta , vol.1836 , pp. 158-165
    • Chen, L.1    Zhang, Y.2    Yang, J.3    Hagan, J.4    Li, M.5
  • 194
    • 33646358694 scopus 로고    scopus 로고
    • Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lineS
    • Lee, J. et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 9, 391-403 (2006).
    • (2006) Cancer Cell , vol.9 , pp. 391-403
    • Lee, J.1
  • 195
    • 68849130180 scopus 로고    scopus 로고
    • Immunohistopathological and neuroimaging characterization of murine orthotopic xenograft models of glioblastoma multiforme recapitulating the most salient features of human disease
    • Radaelli, E. et al. Immunohistopathological and neuroimaging characterization of murine orthotopic xenograft models of glioblastoma multiforme recapitulating the most salient features of human disease. Histol. Histopathol. 24, 879-891 (2009).
    • (2009) Histol. Histopathol , vol.24 , pp. 879-891
    • Radaelli, E.1
  • 196
    • 77953194234 scopus 로고    scopus 로고
    • An extensive invasive intracranial human glioblastoma xenograft model: Role of high level matrix metalloproteinase 9
    • Zhao, Y. et al. An extensive invasive intracranial human glioblastoma xenograft model: role of high level matrix metalloproteinase 9. Am. J. Pathol. 176, 3032-3049 (2010).
    • (2010) Am. J. Pathol , vol.176 , pp. 3032-3049
    • Zhao, Y.1
  • 197
    • 84859553853 scopus 로고    scopus 로고
    • An in vivo patient-derived model of endogenous IDH1-mutant glioma
    • Luchman, H. et al. An in vivo patient-derived model of endogenous IDH1-mutant glioma. Neuro Oncol. 14, 184-191 (2012).
    • (2012) Neuro Oncol , vol.14 , pp. 184-191
    • Luchman, H.1
  • 198
    • 75649109727 scopus 로고    scopus 로고
    • Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypeS
    • Jacques, T. et al. Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes. EMBO J. 29, 222-235 (2010).
    • (2010) EMBO J , vol.29 , pp. 222-235
    • Jacques, T.1
  • 199
    • 79952509861 scopus 로고    scopus 로고
    • Cooperativity within and among Pten, 53, and Rb pathways induces high-grade astrocytoma in adult brain
    • Chow, L. et al. Cooperativity within and among Pten, 53, and Rb pathways induces high-grade astrocytoma in adult brain. Cancer Cell 19, 305-316 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 305-316
    • Chow, L.1
  • 200
    • 0032418416 scopus 로고    scopus 로고
    • A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice
    • Holland, E., Hively, W., DePinho, R. & Varmus, H. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev. 12, 3675-3685 (1998).
    • (1998) Genes Dev , vol.12 , pp. 3675-3685
    • Holland, E.1    Hively, W.2    Depinho, R.3    Varmus, H.4
  • 201
    • 0037374550 scopus 로고    scopus 로고
    • Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model
    • Ding, H. et al. Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model. Cancer Res. 63, 1106-1113 (2003).
    • (2003) Cancer Res , vol.63 , pp. 1106-1113
    • Ding, H.1
  • 202
    • 0033960657 scopus 로고    scopus 로고
    • A mouse model for glioma: Biology, pathology, and therapeutic opportunities
    • Holland, E. A mouse model for glioma: biology, pathology, and therapeutic opportunities. Toxicol. Pathol. 28, 171-177 (2000).
    • (2000) Toxicol. Pathol , vol.28 , pp. 171-177
    • Holland, E.1
  • 203
    • 0037382205 scopus 로고    scopus 로고
    • Genetic determinants of malignancy in a mouse model for oligodendroglioma
    • Weiss, W. et al. Genetic determinants of malignancy in a mouse model for oligodendroglioma. Cancer Res. 63, 1589-1595 (2003).
    • (2003) Cancer Res , vol.63 , pp. 1589-1595
    • Weiss, W.1
  • 204
    • 33747885901 scopus 로고    scopus 로고
    • High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model
    • Wei, Q. et al. High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model. Cancer Res. 66, 7429-7437 (2006).
    • (2006) Cancer Res , vol.66 , pp. 7429-7437
    • Wei, Q.1
  • 205
    • 62449252775 scopus 로고    scopus 로고
    • Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis
    • Zhu, H. et al. Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc. Natl Acad. Sci. USA 106, 2712-2716 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 2712-2716
    • Zhu, H.1
  • 207
    • 69649103118 scopus 로고    scopus 로고
    • GFAP promoter driven transgenic expression of PDGFB in the mouse brain leads to glioblastoma in a Trp53 null background
    • Hede, S.-M. et al. GFAP promoter driven transgenic expression of PDGFB in the mouse brain leads to glioblastoma in a Trp53 null background. Glia 57, 1143-1153 (2009).
    • (2009) Glia , vol.57 , pp. 1143-1153
    • Hede, S.-M.1
  • 208
    • 79956361405 scopus 로고    scopus 로고
    • Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype
    • Lei, L. et al. Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype. PLoS ONE 6, e20041 (2011).
    • (2011) PLoS ONE , vol.6
    • Lei, L.1
  • 209
    • 33645736793 scopus 로고    scopus 로고
    • Genetically engineered models have advantages over xenografts for preclinical studieS
    • Becher, O. & Holland, E. Genetically engineered models have advantages over xenografts for preclinical studies. Cancer Res. 66, 3355 (2006).
    • (2006) Cancer Res , vol.66 , pp. 3355
    • Becher, O.1    Holland, E.2
  • 210
    • 77950232139 scopus 로고    scopus 로고
    • Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma
    • Becher, O. et al. Preclinical evaluation of radiation and perifosine in a genetically and histologically accurate model of brainstem glioma. Cancer Res. 70, 2548-2557 (2010).
    • (2010) Cancer Res , vol.70 , pp. 2548-2557
    • Becher, O.1
  • 211
    • 0033812187 scopus 로고    scopus 로고
    • Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effectS
    • Reilly, K., Loisel, D., Bronson, R., McLaughlin, M. & Jacks, T. Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects. Nature Genet. 26, 109-113 (2000).
    • (2000) Nature Genet , vol.26 , pp. 109-113
    • Reilly, K.1    Loisel, D.2    Bronson, R.3    McLaughlin, M.4    Jacks, T.5
  • 212
    • 0036293742 scopus 로고    scopus 로고
    • Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation
    • Bajenaru, M. et al. Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol. Cell. Biol. 22, 5100-5113 (2002).
    • (2002) Mol. Cell. Biol , vol.22 , pp. 5100-5113
    • Bajenaru, M.1
  • 213
    • 4444260352 scopus 로고    scopus 로고
    • Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects
    • Reilly, K. et al. Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects. Proc. Natl Acad. Sci. USA 101, 13008-13013 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 13008-13013
    • Reilly, K.1
  • 214
    • 23644443053 scopus 로고    scopus 로고
    • Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma
    • Zhu, Y. et al. Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. Cancer Cell 8, 119-130 (2005).
    • (2005) Cancer Cell , vol.8 , pp. 119-130
    • Zhu, Y.1
  • 215
    • 44849089702 scopus 로고    scopus 로고
    • Pten haploinsufficiency accelerates formation of high-grade astrocytomaS
    • Kwon, C.-H. et al. Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer Res. 68, 3286-3294 (2008).
    • (2008) Cancer Res , vol.68 , pp. 3286-3294
    • Kwon, C.-H.1
  • 216
    • 84866480031 scopus 로고    scopus 로고
    • D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function
    • Sasaki, M. et al. D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev. 26, 2038-2049 (2012).
    • (2012) Genes Dev , vol.26 , pp. 2038-2049
    • Sasaki, M.1
  • 217
    • 79951825581 scopus 로고    scopus 로고
    • Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomaS
    • Barrow, J. et al. Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas. Neuro Oncol. 13, 212-222 (2011).
    • (2011) Neuro Oncol , vol.13 , pp. 212-222
    • Barrow, J.1
  • 218
    • 0033398991 scopus 로고    scopus 로고
    • Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations
    • Raffel, C. et al. Analysis of oncogene and tumor suppressor gene alterations in pediatric malignant astrocytomas reveals reduced survival for patients with PTEN mutations. Clin. Cancer Res. 5, 4085-4090 (1999).
    • (1999) Clin. Cancer Res , vol.5 , pp. 4085-4090
    • Raffel, C.1
  • 219
    • 33845667568 scopus 로고    scopus 로고
    • Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: Results from the Children's Cancer Group 945 cohort
    • Pollack, I. F. et al. Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort. J. Neurosurg. 105, 418-424 (2006).
    • (2006) J. Neurosurg , vol.105 , pp. 418-424
    • Pollack, I.F.1
  • 220
    • 0035887141 scopus 로고    scopus 로고
    • Age and TP53 mutation frequency in childhood malignant gliomas: Results in a multi-institutional cohort
    • Pollack, I. et al. Age and TP53 mutation frequency in childhood malignant gliomas: results in a multi-institutional cohort. Cancer Res. 61, 7404-7407 (2001).
    • (2001) Cancer Res , vol.61 , pp. 7404-7407
    • Pollack, I.1
  • 221
    • 78951489314 scopus 로고    scopus 로고
    • IDH1 mutations are common in malignant gliomas arising in adolescents: A report from the Children's Oncology Group
    • Pollack, I. et al. IDH1 mutations are common in malignant gliomas arising in adolescents: a report from the Children's Oncology Group. Child. Nerv. Syst. 27, 87-94 (2011).
    • (2011) Child. Nerv. Syst , vol.27 , pp. 87-94
    • Pollack, I.1
  • 222
    • 33750596946 scopus 로고    scopus 로고
    • PIK3CA gene mutations in pediatric and adult glioblastoma multiforme
    • Gallia, G. et al. PIK3CA gene mutations in pediatric and adult glioblastoma multiforme. Mol. Cancer Res. 4, 709-714 (2006).
    • (2006) Mol. Cancer Res , vol.4 , pp. 709-714
    • Gallia, G.1
  • 223
    • 76549137130 scopus 로고    scopus 로고
    • Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomaS
    • Schiffman, J. et al. Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Cancer Res. 70, 512-519 (2010).
    • (2010) Cancer Res , vol.70 , pp. 512-519
    • Schiffman, J.1
  • 224
    • 84055212088 scopus 로고    scopus 로고
    • V600E malignant astrocytoma
    • Nicolaides, T. et al. Targeted therapy for BRAFV600E malignant astrocytoma. Clin. Cancer Res. 17, 7595-7604 (2011).
    • (2011) Clin. Cancer Res , vol.17 , pp. 7595-7604
    • Nicolaides, T.1


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