Hydrogel-Forming Microneedle Arrays Made from Light-Responsive Materials for On-Demand Transdermal Drug Delivery

Molecular Pharmaceutics

Volumn 13, Issue 3, 2016, Pages 907-914

  Hardy, John G ^a   Larrañeta, Eneko ^a   Donnelly, Ryan F ^a   McGoldrick, Niamh ^a   Migalska, Katarzyna ^a   McCrudden, Maelíosa T C ^a   Irwin, Nicola J ^a   Donnelly, Louise ^a   McCoy, Colin P ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

hydrogel; light triggered; microneedle; stimuli responsive

Indexed keywords

2 HYDROXYETHYL METHACRYLATE; 3,5 DIMETHOXYBENZOIN; BENZOIN; ETHYLENE GLYCOL DIMETHACRYLATE; IBUPROFEN; POLYMER; UNCLASSIFIED DRUG; HYDROGEL; NONSTEROID ANTIINFLAMMATORY AGENT;

ARTICLE; CONJUGATE; DEVICE MATERIAL; DRUG DELIVERY SYSTEM; HUMAN; HYDROGEL; LIGHT; LIGHT RESPONSIVE MATERIAL; MICRONEEDLE; PATIENT CARE; PRIORITY JOURNAL; RAMAN SPECTROMETRY; TRANSDERMAL DRUG DELIVERY SYSTEM; CHEMISTRY; CUTANEOUS DRUG ADMINISTRATION; DEVICES; MATERIALS TESTING; METABOLISM; MICROINJECTION; NEEDLE; SKIN;

ADMINISTRATION, CUTANEOUS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DRUG DELIVERY SYSTEMS; HUMANS; HYDROGELS; IBUPROFEN; LIGHT; MATERIALS TESTING; MICROINJECTIONS; NEEDLES; POLYMERS; SKIN;

EID: 84960093107     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00807     Document Type: Article

References (46)

1. Donnelly, R. F.; Singh, T. R. R.; Morrow, D. I. J.; Woolfson, A. D. Microneedle-mediated Transdermal and Intradermal Drug Delivery; Wiley: 2012.
2. Singh, T. R. R.; Garland, M. J.; Cassidy, C. M.; Migalska, K.; Demir, Y. K.; Abdelghany, S.; Ryan, E.; Woolfson, A. D.; Donnelly, R. F.; Singh, T. R. R. Microporation techniques for enhanced delivery of therapeutic agents Recent Pat. Drug Delivery Formulation 2010, 4, 1-17 10.2174/187221110789957174
3. Prausnitz, M. R.; Mitragotri, S.; Langer, R. Current status and future potential of transdermal drug delivery Nat. Rev. Drug Discovery 2004, 3, 115-124 10.1038/nrd1304
4. Kim, Y. C.; Park, J. H.; Prausnitz, M. R. Microneedles for drug and vaccine delivery Adv. Drug Delivery Rev. 2012, 64, 1547-1568 10.1016/j.addr.2012.04.005
5. Prausnitz, M. R. Microneedles for transdermal drug delivery Adv. Drug Delivery Rev. 2004, 56, 581-587 10.1016/j.addr.2003.10.023
6. Prausnitz, M. R.; Langer, R. Transdermal drug delivery Nat. Biotechnol. 2008, 26, 1261-1268 10.1038/nbt.1504
7. Birchall, J. C. Microneedle array technology: the time is right but is the science ready? Expert Rev. Med. Devices 2006, 3, 1-4 10.1586/17434440.3.1.1
8. Coulman, S.; Allender, C.; Birchall, J. Microneedles and other physical methods for overcoming the stratum corneum barrier for cutaneous gene therapy Crit. Rev. Ther. Drug Carrier Syst. 2006, 23, 205-258 10.1615/CritRevTherDrugCarrierSyst.v23.i3.20
9. Henry, S.; McAllister, D. V.; Allen, M. G.; Prausnitz, M. R. Microfabricated microneedles: a novel approach to transdermal drug delivery J. Pharm. Sci. 1998, 87, 922-925 10.1021/js980042+
10. Pierre, M. B. R.; Rossetti, F. C. Microneedle-based drug delivery systems for transdermal route Curr. Drug Targets 2014, 15, 281-291 10.2174/13894501113146660232
11. Tuan-Mahmood, T. M.; McCrudden, M. T.; Torrisi, B. M.; McAlister, E.; Garland, M. J.; Singh, T. R.; Donnelly, R. F. Microneedles for intradermal and transdermal drug delivery Eur. J. Pharm. Sci. 2013, 50, 623-637 10.1016/j.ejps.2013.05.005
12. Liu, S.; Jin, M. N.; Quan, Y. S.; Kamiyama, F.; Katsumi, H.; Sakane, T.; Yamamoto, A. The development and characteristics of novel microneedle arrays fabricated from hyaluronic acid, and their application in the transdermal delivery of insulin J. Controlled Release 2012, 161, 933-941 10.1016/j.jconrel.2012.05.030
13. Matsuo, K.; Yokota, Y.; Zhai, Y.; Quan, Y. S.; Kamiyama, F.; Mukai, Y.; Okada, N.; Nakagawa, S. A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens J. Controlled Release 2012, 161, 10-17 10.1016/j.jconrel.2012.01.033
14. Naito, S.; Ito, Y.; Kiyohara, T.; Kataoka, M.; Ochiai, M.; Takada, K. Antigen-loaded dissolving microneedle array as a novel tool for percutaneous vaccination Vaccine 2012, 30, 1191-1197 10.1016/j.vaccine.2011.11.111
15. Hong, X.; Wu, Z.; Chen, L.; Wu, F.; Wei, L.; Yuan, W. Hydrogel Microneedle Arrays for Transdermal Drug Delivery Nano-Micro Lett. 2014, 6, 191-199 10.1007/BF03353783
16. Donnelly, R. F.; Singh, T. R. R.; Garland, M. J.; Migalska, K.; Majithiya, R.; McCrudden, C. M.; Kole, P. L.; Mahmood, T. M. T.; McCarthy, H. O.; Woolfson, A. D. Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery Adv. Funct. Mater. 2012, 22, 4879-4890 10.1002/adfm.201200864
17. Kim, M.; Jung, B.; Park, J. H. Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin Biomaterials 2012, 33, 668-678 10.1016/j.biomaterials.2011.09.074
18. Donnelly, R. F.; Singh, T. R.; Alkilani, A. Z.; McCrudden, M. T.; O'Neill, S.; O'Mahony, C.; Armstrong, K.; McLoone, N.; Kole, P.; Woolfson, A. D. Hydrogel-forming microneedle arrays exhibit antimicrobial properties: potential for enhanced patient safety Int. J. Pharm. 2013, 451, 76-91 10.1016/j.ijpharm.2013.04.045
19. Donnelly, R. F.; Morrow, D. I.; McCrudden, M. T.; Alkilani, A. Z.; Vicente-Pérez, E. M.; O'Mahony, C.; González-Vázquez, P.; McCarron, P. A.; Woolfson, A. D. Hydrogel-forming and dissolving microneedles for enhanced delivery of photosensitizers and precursors Photochem. Photobiol. 2014, 90, 641-647 10.1111/php.12209
20. Donnelly, R. F.; McCrudden, M. T. C.; Zaid Alkilani, A.; Larrañeta, E.; McAlister, E.; Courtenay, A. J.; Kearney, M.; Singh, T. R. R.; McCarthy, H. O.; Kett, V. L.; Caffarel-Salvador, E.; Al-Zahrani, S.; Woolfson, A. D. Hydrogel-Forming Microneedles Prepared from "Super Swelling" Polymers Combined with Lyophilised Wafers for Transdermal Drug Delivery PLoS One 2014, 9, e111547 10.1371/journal.pone.0111547
21. Garland, M. J.; Caffarel-Salvador, E.; Migalska, K.; Woolfson, A. D.; Donnelly, R. F. Dissolving polymeric microneedle arrays for electrically assisted transdermal drug delivery J. Controlled Release 2012, 159, 52-59 10.1016/j.jconrel.2012.01.003
22. Pawar, K. R.; Smith, F.; Kolli, C. S.; Babu, R. J. Effect of lipophilicity on microneedle-mediated iontophoretic transdermal delivery across human skin in vitro J. Pharm. Sci. 2013, 102, 3784-3791 10.1002/jps.23694
23. Wing, D.; Prausnitz, M. R.; Buono, M. J. Skin pretreatment with microneedles prior to pilocarpine iontophoresis increases sweat production Clin. Physiol. Funct. Imaging 2013, 33, 436-440 10.1111/cpf.12053
24. Singh, N. D.; Banga, A. K. Controlled delivery of ropinirole hydrochloride through skin using modulated iontophoresis and microneedles J. Drug Target 2013, 21, 354-366 10.3109/1061186X.2012.757768
25. Vemulapalli, V.; Bai, Y.; Kalluri, H.; Herwadkar, A.; Kim, H.; Davis, S. P.; Friden, P. M.; Banga, A. K. In vivo iontophoretic delivery of salmon calcitonin across microporated skin J. Pharm. Sci. 2012, 101, 2861-2869 10.1002/jps.23222
26. Chen, M. C.; Ling, M. H.; Wang, K. W.; Lin, Z. W.; Lai, B. H.; Chen, D. H. Near-infrared light-responsive composite microneedles for on-demand transdermal drug delivery Biomacromolecules 2015, 16, 1598-1607 10.1021/acs.biomac.5b00185
27. Cahill, E. M.; O'Cearbhaill, E. D. Toward Biofunctional Microneedles for Stimulus Responsive Drug Delivery Bioconjugate Chem. 2015, 26, 1289-1296 10.1021/acs.bioconjchem.5b00211
28. Huang, C. J.; Chen, Y. H.; Wang, C. H.; Chou, T. C.; Lee, G. B. Integrated microfluidic systems for automatic glucose sensing and insulin injection Sens. Actuators, B 2007, 122, 461-468 10.1016/j.snb.2006.06.015
29. McCoy, C. P.; Rooney, C.; Edwards, C. R.; Jones, D. S.; Gorman, S. P. Light-triggered molecule-scale drug dosing devices J. Am. Chem. Soc. 2007, 129, 9572 10.1021/ja073053q
30. McCoy, C. P.; Rooney, C.; Jones, D. S.; Gorman, S. P.; Nieuwenhuyzen, M. Rational design of a dual-mode optical and chemical prodrug Pharm. Res. 2007, 24, 194-200 10.1007/s11095-006-9145-8
31. Donnelly, R. F.; Majithiya, R.; Singh, T. R.; Morrow, D. I.; Garland, M. J.; Demir, Y. K.; Migalska, K.; Ryan, E.; Gillen, D.; Scott, C. J.; Woolfson, A. D. Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique Pharm. Res. 2011, 28, 41-57 10.1007/s11095-010-0169-8
32. Rooney, C.; Hayes, G.; McCoy, C. P. Photolytic release of ibuprofen from a 3,5-dimethoxybenzoin ester within a p(HEMA-co-MMA) polymer matrix J. Pharm. Pharmacol. 2003, 55, S43
33. Ren, Y.; Matsushita, A.; Matsukawa, K.; Inoue, H.; Minami, Y.; Noda, I.; Ozaki, Y. Two-dimensional Fourier-transform-Raman and near-infrared correlation spectroscopy studies of poly(methyl methacrylate) blends Vib. Spectrosc. 2000, 23, 207-218 10.1016/S0924-2031(00)00063-1
34. Lutton, R. E. M.; Moore, J.; Larrañeta, E.; Ligett, S.; Woolfson, A. D.; Donnelly, R. F. Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation Drug Delivery Transl. Res. 2015, 5, 313-331 10.1007/s13346-015-0237-z
35. Larrañeta, E.; Moore, J.; Vicente-Pérez, E. M.; González-Vázquez, P.; Lutton, R.; Woolfson, A. D.; Donnelly, R. F. A proposed model membrane and test method for microneedle insertion studies Int. J. Pharm. 2014, 472, 65-73 10.1016/j.ijpharm.2014.05.042
36. Lutton, R. E. M.; Larrañeta, E.; Kearney, M. C.; Boyd, P.; Woolfson, A. D.; Donnelly, R. F. A novel scalable manufacturing process for the production of hydrogel-forming microneedle arrays Int. J. Pharm. 2015, 494, 417-429 10.1016/j.ijpharm.2015.08.049
37. Langer, R. Drug delivery. Drugs on target Science 2001, 293, 58-59 10.1126/science.1063273
38. Gillies, E. R.; Fréchet, J. M. J. Development of acid-sensitive copolymer micelles for drug delivery Pure Appl. Chem. 2004, 76, 1295-1307 10.1351/pac200476071295
39. Moreno, E.; Schwartz, J.; Larrañeta, E.; Nguewa, P. A.; Sanmartín, C.; Agüeros, M.; Irache, J. M.; Espuelas, S. Thermosensitive hydrogels of poly(methyl vinyl ether-co-maleic anhydride)-Pluronic(®) F127 copolymers for controlled protein release Int. J. Pharm. 2014, 459, 1-9 10.1016/j.ijpharm.2013.11.030
40. Sershen, S. R.; Mensing, G. A.; Ng, M.; Halas, N. J.; Beebe, D. J.; West, J. L. Independent Optical Control of Microfluidic Valves Formed from Optomechanically Responsive Nanocomposite Hydrogels Adv. Mater. 2005, 17, 1366 10.1002/adma.200401239
41. Li, S. K.; D'Emanuele, A. On-off transport through a thermoresponsive hydrogel composite membrane J. Controlled Release 2001, 75, 55-67 10.1016/S0168-3659(01)00365-0
42. Larrañeta, E.; Lutton, R. E. M.; Brady, A. J.; Vicente-Pérez, E. M.; Woolfson, A. D.; Thakur, R. R. S.; Donnelly, R. F. Microwave-Assisted Preparation of Hydrogel-Forming Microneedle Arrays for Transdermal Drug Delivery Applications Macromol. Mater. Eng. 2015, 300, 586-595 10.1002/mame.201500016
43. McCoy, C. P.; Gorman, S. P.; Jones, D. S. Drug delivery composition, U.S. Patent application 20110165114, July 7, 2011.
44. Pirrung, M. C.; Shuey, S. W. Photoremovable protecting groups for phosphorylation of chiral alcohols-asymmetric-synthesis of phosphotriesters of (-)-3′,5′-dimethoxybenzoin J. Org. Chem. 1994, 59, 3890-3897 10.1021/jo00093a021
45. Narayanan, D. L.; Saladi, R. N.; Fox, J. L. Review: Ultraviolet radiation and skin cancer Int. J. Dermatol. 2010, 49, 978-986 10.1111/j.1365-4632.2010.04474.x
46. Timko, B. P.; Arruebo, M.; Shankarappa, S. A.; McAlvin, J. B.; Okonkwo, O. S.; Mizrahi, B.; Stefanescu, C. F.; Gomez, L.; Zhu, J.; Zhu, A.; Santamaria, J.; Langer, R.; Kohane, D. S. Near-infrared-actuated devices for remotely controlled drug delivery Proc. Natl. Acad. Sci. U. S. A. 2014, 111, 1349-1354 10.1073/pnas.1322651111