Hydrogel-forming microneedle arrays exhibit antimicrobial properties: Potential for enhanced patient safety

International Journal of Pharmaceutics

Volumn 451, Issue 1-2, 2013, Pages 76-91

  Donnelly, Ryan F ^a   Singh, Thakur Raghu Raj ^a   Alkilani, Ahlam Zaid ^a,c   McCrudden, Maelíosa T C ^a   O'Neill, Shannon ^a   O'Mahony, Conor ^b   Armstrong, Keith ^d   McLoone, Nabla ^e   Kole, Prashant ^a   Woolfson, A David ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b UNIVERSITY COLLEGE CORK   (Ireland)

^c ZARQA UNIVERSITY   (Jordan)

^d ROYAL VICTORIA HOSPITAL   (United Kingdom)

^e ANTRIM AREA HOSPITAL   (United Kingdom)

Author keywords

Microneedle; Microorganism; Pharmacopoeial standards; Stability

Indexed keywords

ANIMAL TISSUE; ANTIMICROBIAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; DISEASE TRANSMISSION; HUMAN; HYDROGEL FORMING MICRONEEDLE; INFECTION RISK; ISOTOPE LABELING; MICROBIOLOGICAL EXAMINATION; NEEDLE; NONHUMAN; PATIENT SAFETY; PRIORITY JOURNAL; RISK ASSESSMENT; SKIN PENETRATION; STAPHYLOCOCCUS EPIDERMIDIS; STRATUM CORNEUM; SWINE; SYNTHESIS;

ADULT; ANIMALS; CANDIDA ALBICANS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; DRUG STORAGE; FEMALE; FOLLOW-UP STUDIES; HUMANS; HUMIDITY; HYDROGELS; MALE; NEEDLES; PERMEABILITY; POLYMERS; SKIN; STAPHYLOCOCCUS EPIDERMIDIS; SWINE; TIME FACTORS; YOUNG ADULT;

EID: 84878008698     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.04.045     Document Type: Article

References (28)

1. S. Al-Zahrani, M. Zaric, C. McCrudden, C. Scott, A. Kissenpfennig, and R.F. Donnelly Microneedle-mediated vaccine delivery: harnessing cutaneous immunobiology to improve efficacy Exp. Opin. Drug Deliv. 9 2012 541 550
2. S. Astner, N. Burnett, F. Rius-Díaz, A.G. Doukas, S. González, and E. Gonzalez Irritant contact dermatitis induced by a common household irritant: a noninvasive evaluation of ethnic variability in skin response J. Am. Acad. Dermatol. 54 2006 458 465
3. BBC Weather report, 2008. Available from: http://www.bbc.co.uk/weather/ world/city-guides/results.shtml?tt=TT003790 [accessed February 2008].
4. British Pharmacopoeia Appendix XVI C. Efficacy of antimicrobial preservatives in pharmaceutical products vol. V 2012 A454 A456
5. R.D. Boehm, P.R. Miller, R. Singh, A. Shah, S. Stafslien, and J. Daniels Indirect rapid prototyping of antibacterial acid anhydride copolymer microneedles Biofabrication 2012 10.1088/1758-5082/4/1/011002
6. K. Dawes, and L.C. Glover J.E. Mark, Physical Properties of Polymers Handbook 1996 American Institute of Physics Press Woodbury, NY
7. C.B. Del Mar, P.P. Glasziou, A.B. Spinks, and S.L. Sanders Is isopropyl alcohol swabbing before injection really necessary? Med. J. Aust. 174 2001 306
8. R.F. Donnelly, D.I.J. Morrow, T.R.R. Singh, K. Migalska, P.A. McCarron, and C. O'Mahony Processing difficulties and instability of carbohydrate microneedle arrays Drug Dev. Ind. Pharm. 35 2009 1242 1254
9. R.F. Donnelly, T.R.R. Singh, M.M. Tunney, D.I.J. Morrow, P.A. McCarron, and C. O'Mahony Microneedle arrays allow lower microbial penetration than hypodermic needles in vitro Pharm. Res. 26 2009 2513 2522
10. R.F. Donnelly, M.J. Garland, D.I.J. Morrow, K. Migalska, R.R.S. Thakur, R. Majithiya, and A.D. Woolfson Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution J. Control. Release 147 2010 333 341
11. R.F. Donnelly, R. Majithiya, T.R.R. Singh, D.I.J. Morrow, M.J. Garland, and Y. Demir Design and physicochemical characterisation of optimised polymeric microneedle arrays prepared by a novel laser-based micromoulding technique Pharm. Res. 28 2011 41 57
12. R.F. Donnelly, T.R.R. Singh, D.I.J. Morrow, and A.D. Woolfson Microneedle-mediated Transdermal and Intradermal Drug Delivery 2012 Wiley Online Library
13. R.F. Donnelly, T.R.R. Singh, M.J. Garland, K. Migalska, R. Majithiya, and C.M. McCrudden Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery Adv. Funct. Mater. 22 2012 4879 4890
14. P. Elsner Antimicrobials and the skin physiological and pathological flora Curr. Probl. Dermatol. Basel 33 (R) 2006 35
15. European Pharmacopoeia 6.5 Methods of analysis; 2.6.12 Microbiological examination of non-sterile products: Microbial Enumeration Tests 2007 European Pharmacopoeia 6.5 4769 4773
16. A. Fourtanier, and C. Berrebi Miniature pig as an animal model to study photoaging Photochem. Photobiol. 50 1989 771 784
17. Global Biotechnology Market to Surpass US$320 Billion by 2015 According to New Report by Global Industry Analysts 2012 Available from: www.prweb.com/releases/biotechnology/biotech-services-crops/prweb9128590.htm
18. Greystone Associates Microneedles in Medicine: Technology, Devices, Markets and Prospects 2012 Greystone Associates Amherst, NH
19. K. Migalska, D.I.J. Morrow, M.J. Garland, R.R.S. Thakur, A.D. Woolfson, and R.F. Donnelly Laser-engineered dissolving microneedle arrays for transdermal macromolecular drug delivery Pharm. Res. 28 2011 1919 1930
20. K. Moser, K. Kriwet, C. Froehlich, Y.N. Kalia, and R.H. Guy Supersaturation: enhancement of skin penetration and permeation of a lipophilic drug Pharm. Res. 18 2011 1006 1011
21. M. Pellett, M. Roberts, and J. Hadgraft Supersaturated solutions evaluated with an in vitro stratum corneum tape stripping technique Int. J. Pharm. 151 1997 91 98
22. D. Pittet, B. Allegranzi, H. Sax, S. Dharan, C.L. Pessoa-Silva, and L. Donaldson Evidence-based model for hand transmission during patient care and the role of improved practices Lancet Infect. Dis. 6 2006 641 652
23. Pharmaceutical and Medical Packaging News (PMPN) Magazine, 2012. Available from: http://www.pmpnews.com/pmpn-index ad.html?gotourl=http://www. pmpnews.com/news/transdermal-delivery-market-predicted reach-315-billion-2015- pharmalive-special-report (accessed October 2012).
24. D.V. Seal, R.J. Hay, and K.R. Middleton Skin and Wound Infection: Investigation and Treatment in Practice 2000 Martin Dunitz London 5 8
25. J. Seo, J. Kim, J. Lee, Y. Yoo, M.R. Kim, and K. Park Ovalbumin modified by gamma irradiation alters its immunological functions and allergic responses Int. Immunopharmacol. 7 2007 464 472
26. U. Ubaidulla, M.V.S. Reddy, K. Ruckmani, F.J. Ahmad, and R.K. Khar Transdermal therapeutic system of carvedilol: effect of hydrophilic and hydrophobic matrix on in vitro and in vivo characteristics AAPS PharmSciTech 8 2007 13 20
27. A.D. Woolfson, D.F. McCafferty, C.R. McCallion, E. McAdams, and J. Anderson Moisture-activated, electrically conducting bioadhesive hydrogels as interfaces for bioelectrodes: effect of film hydration on cutaneous adherence in wet environments J. Appl. Polym. Sci. 58 1995 1291 1296
28. World Health Organization, 2012. Available from: www.who.int/en (November 2012).