Hydrogel-forming microneedles prepared from "super swelling" polymers combined with lyophilised wafers for transdermal drug delivery

PLoS ONE

Volumn 9, Issue 10, 2014, Pages

  Donnelly, Ryan F ^a   McCrudden, Maelíosa T C ^a   Alkilani, Ahlam Zaid ^a,b   Larrañeta, Eneko ^a   McAlister, Emma ^a   Courtenay, Aaron J ^a   Kearney, Mary Carmel ^a   Raj Singh, Thakur Raghu ^a   McCarthy, Helen O ^a   Kett, Victoria L ^a   Caffarel Salvador, Ester ^a   Al Zahrani, Sharifa ^a   Woolfson, A David ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b ZARQA UNIVERSITY   (Jordan)

Author keywords

[No Author keywords available]

Indexed keywords

IBUPROFEN; OVALBUMIN; PHOSPHATE BUFFERED SALINE; POLYMER; CROSS LINKING REAGENT; HYDROGEL;

ANIMAL EXPERIMENT; ARTICLE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FREEZE DRYING; HYDROGEL; HYDROGEL FILM SWELLING; HYDROGEL FORMING MICRONEEDLE; IN VITRO STUDY; MAXIMUM PLASMA CONCENTRATION; MICRONEEDLE; MICROTECHNOLOGY; NEWBORN; NONHUMAN; PHARMACOLOGICAL PARAMETERS; RAT; RESERVOIR; SKIN SWELLING; SWINE; ANIMAL; CHEMISTRY; CHICKEN; DRUG DELIVERY SYSTEM; DRUG EFFECTS; INTRADERMAL DRUG ADMINISTRATION; MATERIALS TESTING; MICROINJECTION; NEEDLE; PERMEABILITY; PIG; PROCEDURES; SPRAGUE DAWLEY RAT;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANIMALS, NEWBORN; CHICKENS; CROSS-LINKING REAGENTS; DRUG DELIVERY SYSTEMS; FREEZE DRYING; HYDROGEL; IBUPROFEN; MATERIALS TESTING; MICROINJECTIONS; NEEDLES; PERMEABILITY; POLYMERS; RATS, SPRAGUE-DAWLEY; SUS SCROFA;

EID: 84910020396     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0111547     Document Type: Article

References (31)

1. Chandrasekhar S, Iyer LK, Panchal JP, Topp EM, Cannon JB, et al. (2013) Microarrays and microneedle arrays for delivery of peptides, proteins, vaccines and other applications. Expert Opin Drug Deliv 10: 1155-1170.
2. Pierre MB, Rossetti FC (2014) Microneedle-based drug delivery systems for transdermal route. Curr Drug Targets 15: 281-291.
3. Gratieri T, Alberti I, Lapteva M, Kalia YN (2013) Next generation intra- and transdermal therapeutic systems: using non- and minimally-invasive technologies to increase drug delivery into and across the skin. Eur J Pharm Sci 50: 609-622.
4. Migalska K, Morrow DIJ., Garland MJ, Thakur RRS, Woolfson AD, et al. (2011) Laser-engineered dissolving microneedle arrays for transdermal macromolecular drug delivery. Pharm Res 28: 1919-1930.
5. Ito Y, Hirono M, Fukushima K, Sugioka N, Takada K (2012) Two-layered dissolving microneedles formulated with intermediate-acting insulin. Int J Pharm 436: 387-393
6. Hong X, Wei L, Wu F, Wu Z, Chen L, et al. (2013) Dissolving and biodegradable microneedle technologies for transdermal sustained delivery of drug and vaccine. Drug Des Devel Ther 7: 945-952.
7. Koutsonanos DG, Compans RW, Skountzou I (2013) Targeting the skin for microneedle delivery of influenza vaccine. Adv Exp Med Biol 785: 121-32.
8. McCrudden MTC, McCrudden C, McAlister E, Zaid Alkilani A, Woolfson AD, et al. (2014) Dissolving microneedle arrays for enhanced transdermal delivery of high dose low potency drug substances. J Cont Rel 180: 71-80.
9. Hirobe S, Azukizawa H, Matsuo K, Zhai Y, Quan YS, et al (2013) Development and clinical study of a self-dissolving microneedle patch for transcutaneous immunization device. Pharm Res 30: 2664-2674
10. Donnelly RF, Thakur RRS, Garland MJ, Migalska K, Majithiya R, et al. (2012) Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery. Adv Funct Mat 22: 4879-4890.
11. Donnelly RF, Morrow DI, McCrudden MT, Alkilani AZ, Vicente-Pérez EM, et al. (2014) Hydrogel-forming and dissolving microneedles for enhanced delivery of photosensitizers and precursors. Photochem Photobiol doi: 10.1111/php.12209.
12. Donnelly RF, Thakur RRS., McCrudden MTC., Zaid-Alkilani A, O'Mahony C, et al. (2013) Hydrogel-forming microneedle arrays exhibit antimicrobial properties: Potential for enhanced patient safety. Int J Pharm 451: 76-91.
13. Thakur RRS, McCarron PA, Woolfson AD, Donnelly RF (2009) Investigation of swelling and network parameters of poly (ethylene glycol)-crosslinked poly (methyl vinyl ether-co-maleic acid) hydrogels. Eur Polym J 45: 1239-1249.
14. Mikolajewska P, Donnelly RF, Garland MJ, Morrow DIJ, Iani V, et al. (2010) Microneedle pre-treatment of human skin improves 5-aminolevulininc acid (ALA) and 5-aminolevulinic acid methyl ester (MAL) induced PpIX production for topical photodynamic therapy without increase in pain or erythema. Pharm Res 27: 2213-2220.
15. McCarron PA, Woolfson AD, Donnelly RF, Andrews GP, Zawislak A, et al. (2004) Influence of plasticiser type and storage conditions on the properties of poly(methyl vinyl ether-co-maleic anhydride) bioadhesive films. J App Polym Sci 91: 1576-1589.
16. Peniche C, Cohen ME, Vázquez B, San Román J (1997) Water sorption of flexible networks based on 2-hydroxyethyl methacrylate-triethylenglycol dimethacrylate copolymers. Polymer 38: 5977-5982.
17. Peppas NA, Korsmeyer RW (1987) Dynamically swelling hydrogels in controlled release applications Hydrogels in Medicine and Pharmacy. Boca Raton, Florida: CRC Press Inc. 109-136 p.
18. Ritger PL, Peppas NA (1987) A simple equation for description of solute release II: Fickian and anomalous release from swellable devices. J Cont Rel 5: 37-42.
19. Bajpai S (2001) Swelling-deswelling behavior of poly(acrylamide-co-maleic acid) hydrogels. J Appl Polym Sci 80: 2782-2789.
20. Donnelly RF, Majithiya R, Thakur RRS, Morrow DIJ, Garland MJ, et al. (2011) Design and physicochemical characterisation of optimised polymeric microneedle arrays prepared by a novel laser-based micromoulding technique. Pharm Res 28: 41-57.
21. Fourtanier A, Berrebi C (1989) Miniature pig as an animal model to study photoaging. Photochem Photobiol 50: 771-784.
22. Woolfson AD, McCafferty DF, McCallion CR, McAdams E, Anderson J (1995) Moisture-activated, electrically conducting bioadhesive hydrogels as interfaces for bioelectrodes: Effect of film hydration on cutaneous adherence in wet environments. J Appl Polym Sci 58: 1291-1296.
23. Donnelly RF, Garland MJ, Morrow DIJ, Migalska K, Thakur RRS, et al. (2010) Optical coherence tomography is a valuable tool in the study of the effects of microneedle geometry on skin penetration characteristics and in-skin dissolution. J Cont Rel 147: 333-341.
24. The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) website. Available: http://www.ich.org/. Accessed 2013 Oct 4.
25. McCrudden MTC, Torrisi BM, Al-Zahrani S, McCrudden CM, Donnelly RF et al. (2014) Laser-engineered dissolving microneedle arrays for protein delivery: Potential for enhanced intradermal vaccination. J Pharm Pharmacol doi: 10.1111/jphp.12248.
26. Shevchenko LL (1963) Infrared spectra of salts and complexes of carboxylic acids and some of their derivatives. Russ Chem Rev 32: 201-207.
27. The British Pharmacopoeia 2013 website. Available: http://www.pharmacopoeia.co.uk/2013/. Accessed 2013 Oct 6.
28. Dollery C (1991) Therapeutic Drugs. London: Churchill Livingstone.
29. The National Health Service website. Available: http://www.nhs.uk/Livewell/healthy-living/Pages/height-weight-chart.aspx. Accessed 2013 Oct 5.
30. Nicotinell website. Available: http://www.nicotinell.co.uk/. Accessed 2013 Oct 14.
31. Duragesic website. Available: http://www.duragesic.com/. Accessed 2013 Oct 14.