A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens

Journal of Controlled Release

Volumn 161, Issue 1, 2012, Pages 10-17

  Matsuo, Kazuhiko ^a   Yokota, Yayoi ^a   Zhai, You ^a   Quan, Ying Shu ^b   Kamiyama, Fumio ^b   Mukai, Yohei ^a   Okada, Naoki ^a   Nakagawa, Shinsaku ^a  

^a OSAKA UNIVERSITY   (Japan)

^b CosMED Pharmaceuticals Co Ltd ^*  (Japan)

Author keywords

Dissolving microneedle array; Particulate antigen; Skin; Soluble antigen; Transcutaneous immunization; Vaccine

Indexed keywords

HYALURONATE; IMMUNE RESPONSE; MICRONEEDLE ARRAYS; MICRONEEDLES; SKIN IRRITATION; STRATUM CORNEUM; TRANSCUTANEOUS;

ANTIGENS; IMMUNIZATION; IMMUNOLOGY; NEEDLES; SILVER; SKIN; VACCINES;

DISSOLUTION;

ADENOVIRUS VECTOR; GAMMA INTERFERON; HYALURONIC ACID; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 4; OVALBUMIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; APPLICATION SITE ERYTHEMA; APPLICATION SITE IRRITATION; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SOLUBILITY; EMBRYO; ENCAPSULATION; FEMALE; HUMAN; HUMAN CELL; HYDROGEL; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGLOBULIN PRODUCTION; MICRONEEDLE; MOUSE; NEEDLE; NONHUMAN; PRIORITY JOURNAL; RAT; SKIN IRRITATION; STRATUM CORNEUM; SUBCUTANEOUS DRUG ADMINISTRATION; TH1 TH2 BALANCE; TRANSCUTANEOUS IMMUNIZATION;

ADENOVIRIDAE; ADENOVIRIDAE INFECTIONS; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIGENS; CELL LINE; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; HYALURONIC ACID; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; OVALBUMIN; RATS; RATS, WISTAR; SKIN; TRANSDERMAL PATCH; VACCINATION;

EID: 84862629947     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.01.033     Document Type: Article

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