Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 9, 2016, Pages E1206-E1215

  Iljina, Marija ^a   Garcia, Gonzalo A ^a   Horrocks, Mathew H ^a   Tosatto, Laura ^a,b   Choi, Minee L ^c   Ganzinger, Kristina A ^a,d   Abramov, Andrey Y ^c   Gandhi, Sonia ^b   Wood, Nicholas W ^c   Cremades, Nunilo ^a,e   Dobson, Christopher M ^a   Knowles, Tuomas P J ^a   Klenerman, David ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CNR   (Italy)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^e UNIVERSITY OF ZARAGOZA   (Spain)

Author keywords

Amyloid aggregation; Kinetic analysis; Neurodegeneration; Prion like propagation; Templated seeding

Indexed keywords

ALPHA SYNUCLEIN; MONOMER; OLIGOMER; REACTIVE OXYGEN METABOLITE; PRION;

ARTICLE; ASTROCYTE; CONTROLLED STUDY; CYTOTOXICITY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HISTOGRAM; KINETICS; NERVE CELL; PREDICTION; PRION; PRIORITY JOURNAL; PROTEIN AGGREGATION; QUANTITATIVE ANALYSIS; QUANTITATIVE ASSAY; RATE CONSTANT; BIOLOGICAL MODEL; METABOLISM;

ALPHA-SYNUCLEIN; FLUORESCENCE RESONANCE ENERGY TRANSFER; KINETICS; MODELS, BIOLOGICAL; PRIONS; REACTIVE OXYGEN SPECIES;

EID: 84959569352     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1524128113     Document Type: Article

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