Expression of normal sequence pathogenic proteins for neurodegenerative disease contributes to disease risk: 'Permissive templating' as a general mechanism underlying neurodegeneration

Biochemical Society Transactions

Volumn 33, Issue 4, 2005, Pages 578-581

  Hardy, J ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

synuclein; A ; Neurodegeneration; Permissive templating; Prion; Tau

Indexed keywords

ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; PRESENILIN 1; PRESENILIN 2; PRION PROTEIN;

ALZHEIMER DISEASE; CONCENTRATION RESPONSE; CONFERENCE PAPER; DEGENERATIVE DISEASE; GENE LOCUS; GENE MUTATION; GENETIC VARIABILITY; HUMAN; LEWY BODY; NERVE DEGENERATION; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; RISK FACTOR; TAUOPATHY;

ALZHEIMER DISEASE; GENE EXPRESSION REGULATION; HUMANS; NERVE DEGENERATION; TAU PROTEINS; TEMPLATES, GENETIC;

EID: 23844446448     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0330578     Document Type: Conference Paper

References (32)

1. Owen, F., Poulter, M., Lofthouse, R., Collinge, J., Crow, T.J., Risby, D., Baker, H.F., Ridley, R.M., Hsiao, K. and Prusiner, S.B. (1989) Lancet 1, 51-52
2. Singleton, A., Myers, A. and Hardy, J. (2004) Hum. Mol. Genet. 13, R123-R126
3. Collinge, J. (2001) Annu. Rev. Neurosci. 24, 519-550
4. Will, R.G. (2003) Br. Med. Bull. 66, 255-265
5. Prusiner, S.B. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 13363-13383
6. Palmer, M.S., Dryden, A.J., Hughes, J.T. and Collinge, J. (1991) Nature (London) 352, 340-342
7. Collinge, J., Palmer, M.S. and Dryden, A.J. (1991) Lancet 337, 1441-1442
8. Mead, S., Mahal, S.P., Beck, J., Campbell, T., Farrall, M., Fisher, E. and Collinge, J. (2001) Am. J. Hum. Genet. 69, 1225-1235
9. Bueler, H., Aguzzi, A., Sailer, A., Greiner, R.A., Autenried, P., Aguet, M. and Weissmann, C. (1993) Cell (Cambridge, Mass.) 73, 1339-1347
10. Bruce, M.E., McConnell, I., Fraser, H. and Dickinson, J. (1991) Gen. Virol. 72, 595-603
11. Wadsworth, J.D., Asante, E.A., Desbruslais, M., Linehan, J.M., Joiner, S., Gowland, I., Welch, J., Stone, L., Lloyd, S.E., Hill, A.F. et al. (2004) Science 306, 1793-1796
12. Rogaeva, E. (2002) Neuromol. Med. 2, 1-10
13. Wolfe, M.S., Xia, W., Ostaszewski, B.L., Diehl, T.S., Kimberly, W.T. and Selkoe, D.J. (1999) Nature (London) 398, 513-517
14. Younkin, S.G. (1995) Ann. Neurol. 37, 287-288
15. Kamboh, M.I. (2204) Ann. Hum. Genet. 68, 381-404
16. Holtzman, D.M. (2004) J. Mol. Neurosci. 23, 247-254
17. Myers, A.J. and Goate, A.M. (2001) Curr. Opin. Neurol. 14, 433-440
18. Wavrant-De Vrieze, F., Crook, R., Holmans, P., Kehoe, P., Owen, M.J., Williams, J., Roehl, K., Laliiri, D.K., Shears, S., Booth, J. et al. (1999) Neurosci. Lett. 269, 67-70
19. Hutton, M. (2000) Ann. Neurol. 47, 417-418
20. Spillantini, M.G. and Goedert, M. (1998) Trends Neurosci. 21, 428-433
21. Baker, M., Litvan, I., Houlden, H., Adamson, J., Dickson, D., Pérez-Tur, J., Hardy, J., Lynch, T., Bigio, E. and Hutton, M. (1999) Hum. Mol. Genet. 4, 711-715
22. Nussbaum, R.L. and Ellis, C.E. (2003) N. Engl. J. Med. 348, 1356-1364
23. Farrer, M., Maraganore, D.M., Lockhart, P., Singleton, A., Lesnick, T.G., de Andrade, M., West, A., de Silva, R., Hardy, J. and Hernandez, D. (2001) Hum. Mol. Genet. 10, 1847-1851
24. Chiba-Falek, O., Touchman, J.W. and Nussbaum, R.L. (2003) Hum. Genet. 113, 426-431
25. Singleton, A., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R. et al. (2003) Science 302, 841
26. Miller, D.W., Hague, S.M., Clarimon, J., Baptista, M., Gwinn-Hardy, K., Cookson, M.R. and Singleton, A.B. (2004) Neurology 62, 1835-1838
27. Sigurdsson, E.M., Wisniewski, T. and Frangione, B. (2002) Trends. Mol. Med. 8, 411-413
28. Baker, H.F., Ridley, R.M., Duchen, L.W., Crow, T.J. and Bruton, C.J. (1994) Mol. Neurobiol. 8, 25-39
29. Jucker, M. (2004) Swiss Society of Neuropathology XXth International Winter Meeting, St. Moritz, Switzerland 24-28 March 2004
30. Petkova, A.T., Leapman, R.D., Guo, Z., Yau, W.M., Mattson, M.P. and Tycko, R. (2005) Science 307, 262-265
31. Ashe, K.H. (2005) Biochem. Soc. Trans. 33, 591-594
32. Hardy, J. (1992) Trends Neurosci. 15, 200-201