The Adenovirus E4orf4 Protein Provides a Novel Mechanism for Inhibition of the DNA Damage Response

PLoS Pathogens

Volumn 12, Issue 2, 2016, Pages

  Brestovitsky, Anna ^a,b   Nebenzahl Sharon, Keren ^a   Kechker, Peter ^a,c   Sharf, Rakefet ^a   Kleinberger, Tamar ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c CLALIT HEALTH SERVICES   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS E4ORF4 PROTEIN; ANTINEOPLASTIC AGENT; ATM PROTEIN; ATR PROTEIN; DOXYCYCLINE; ETP 46464; HYDROXYUREA; KU 60019; PARVOVIRUS VECTOR; PHOSPHATIDYLINOSITOL KINASE; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEIN; ZINOSTATIN; ATM PROTEIN, HUMAN; ATR PROTEIN, HUMAN; E4ORF4 PROTEIN, ADENOVIRUS; VIRAL PROTEIN;

APOPTOSIS; ARTICLE; CANCER CELL; COLONY FORMATION; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FLUORESCENCE MICROSCOPY; GENOTOXICITY; HEK293 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; NEOPLASM; PLASMID; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL; VIRUS GENOME; VIRUS MUTATION; VIRUS REPLICATION; WESTERN BLOTTING; ADENOVIRUS INFECTION; CELL DEATH; DNA REPLICATION; GENETICS; HUMAN ADENOVIRUS C; METABOLISM; MUTATION; PHOSPHORYLATION; PHYSIOLOGY; TUMOR CELL LINE; VIROLOGY;

ADENOVIRIDAE INFECTIONS; ADENOVIRUSES, HUMAN; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELL DEATH; CELL LINE, TUMOR; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; HUMANS; MUTATION; PHOSPHORYLATION; SIGNAL TRANSDUCTION; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84959548383     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005420     Document Type: Article

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