The kinase activity of ataxia-telangiectasia mutated interferes with adenovirus E4 mutant DNA replication

Journal of Virology

Volumn 87, Issue 15, 2013, Pages 8687-8696

  Gautam, Dipendra ^a   Bridge, Eileen ^a  

^a MIAMI UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; MRE11 PROTEIN; NIBRIN; RAD50 PROTEIN; VIRUS PROTEIN;

ADENOVIRUS; APOPTOSIS; ARTICLE; CELL CYCLE CHECKPOINT; COMPLEX FORMATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; VIRUS GENOME; VIRUS INHIBITION; VIRUS REPLICATION;

ADENOVIRIDAE; CELL CYCLE PROTEINS; CELL LINE; DNA REPLICATION; DNA, VIRAL; DNA-BINDING PROTEINS; HOST-PATHOGEN INTERACTIONS; HUMANS; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE DELETION; TUMOR SUPPRESSOR PROTEINS; VIRUS REPLICATION;

EID: 84880577366     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00376-13     Document Type: Article

References (31)

1. Weitzman MD, Ornelles DA. 2005. Inactivating intracellular antiviral responses during adenovirus infection. Oncogene 24:7686-7696.
2. Evans JD, Hearing P. 2005. Relocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replication.J. Virol. 79:6207-6215.
3. Lakdawala SS, Schwartz RA, Ferenchak K, Carson CT, McSharry BP, Wilkinson GW, Weitzman MD. 2008. Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation. J. Virol. 82:8362-8372.
4. Mathew SS, Bridge E. 2007. The cellular Mre11 protein interferes with adenovirus E4 mutant DNA replication. Virology 365:346-355.
5. Mathew SS, Bridge E. 2008. Nbs1-dependent binding of Mre11 to adenovirus E4 mutant viralDNAis important for inhibitingDNAreplication. Virology 374:11-22.
6. Blanchette P, Cheng CY, Yan Q, Ketner G, Ornelles DA, Dobner T, Conaway RC, Conaway JW, Branton PE. 2004. Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53. Mol. Cell. Biol. 24:9619-9629.
7. Cheng CY, Blanchette P, Branton PE. 2007. The adenovirus E4orf6 E3 ubiquitin ligase complex assembles in a novel fashion. Virology 364:36-44.
8. Querido E, Blanchette P, Yan Q, Kamura T, Morrison M, Boivin D, Kaelin WG, Conaway RC, Conaway JW, Branton PE. 2001. Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex. Genes Dev. 15:3104-3117.
9. Carson CT, Schwartz RA, Stracker TH, Lilley CE, Lee DV, Weitzman MD. 2003. The Mre11 complex is required for ATM activation and the G2/M checkpoint. EMBO J. 22:6610-6620.
10. Stracker TH, Carson CT, Weitzman MD. 2002. Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex. Nature 418:348-352
11. Baker A, Rohleder KJ, Hanakahi L, Ketner G. 2007. Adenovirus E4 34k and E1b 55k oncoproteins target host DNA ligase IV for proteasomal degradation. J. Virol. 81:7034-7040.
12. Karen KA, Hoey PJ, Young CS, Hearing P. 2009. Temporal regulation of the Mre11-Rad50-Nbs1 complex during adenovirus infection. J. Virol. 83:4565-4573.
13. Boyer J, Rohleder K, Ketner G. 1999. Adenovirus E4 34k and 11k inhibit double strand break repair and are physically associated with the cellular DNA-dependent protein kinase. Virology 263:307-312.
14. Harper JW, Elledge SJ. 2007. The DNA damage response: ten years after. Mol. Cell 28:739-745.
15. Karen KA, Hearing P. 2011. Adenovirus core protein VII protects the viral genome from a DNA damage response at early times after infection. J. Virol. 85:4135-4142.
16. Jayaram S, Bridge E. 2005. Genome concatenation contributes to the late gene expression defect of an adenovirus E4 mutant. Virology 342:286-296.
17. Weinberg DH, Ketner G. 1983. A cell line that supports the growth of a defective early region 4 deletion mutant of human adenovirus type 2. Proc.Natl. Acad. Sci. U. S. A. 80:5383-5386.
18. Cerosaletti K, Wright J, Concannon P. 2006. Active role for nibrin in the kinetics of Atm activation. Mol. Cell. Biol. 26:1691-1699.
19. Bridge E, Ketner G. 1989. Redundant control of adenovirus late gene expression by early region 4. J. Virol. 63:631-638.
20. Philipson L. 1961. Adenovirus assay by fluorescent cell counting procedure.Virology 15:263-268.
21. Prakash A, Jayaram S, Bridge E. 2012. Differential activation of cellular DNA damage responses by replication-defective and replicationcompetent adenovirus mutants. J. Virol. 86:13324-13333.
22. Pombo A, Ferreira J, Bridge E, Carmo-Fonseca M. 1994. Adenovirus replication and transcription sites are spatially separated in the nucleus of infected cells. EMBO J. 13:5075-5085.
23. Ziv Y, Bar-Shira A, Pecker I, Russell P, Jorgensen TJ, Tsarfati I, Shiloh Y. 1997. Recombinant ATM protein complements the cellular A-T phenotype. Oncogene 15:159-167.
24. Halbert DN, Cutt JR, Shenk T. 1985. Adenovirus early region 4 encodes functions required for efficientDNAreplication, late gene expression, and host cell shutoff. J. Virol. 56:250-257.
25. Weinberg DH, Ketner G. 1986. Adenoviral early region 4 is required for efficient viral DNA replication and for late gene expression. J. Virol. 57:833-838.
26. Thomas GP, Mathews MB. 1980. DNA replication and the early to late transition in adenovirus infection. Cell 22:523-533.
27. Golding SE, Rosenberg E, Valerie N, Hussaini I, Frigerio M, Hussaini I, Frigerio M, Cockcroft XF, Chong WY, Hummersone M, Rigoreau L, Menear KA, O'Connor MJ, Povirk LF, van Meter T, Valerie K. 2009. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol. Cancer Ther. 8:2894-2902.
28. You Z, Chahwan C, Bailis J, Hunter T, Russell P. 2005. ATM activation and its recruitment to damagedDNArequire binding to the C terminus of Nbs1. Mol. Cell. Biol. 25:5363-5379.
29. Block WD, Merkle D, Meek K, Lees-Miller SP. 2004. Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine. Nucleic Acids Res. 32:1967-1972.
30. Asaad NA, Zeng ZC, Guan J, Thacker J, Iliakis G. 2000. Homologous recombination as a potential target for caffeine radiosensitization in mammalian cells: reduced caffeine radio sensitization in XRCC2 and XRCC3 mutants. Oncogene 19:5788-5800.
31. Bekker-Jensen S, Mailand N. 2010. Assembly and function of DNA doublestrand break repair foci in mammalian cells. DNA Repair 9:1219-1228.