Adenovirus 12 E4orf6 inhibits ATR activation by promoting TOPBP1 degradation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 27, 2010, Pages 12251-12256

  Blackford, Andrew N ^a,d   Patel, Rakesh N ^a   Forrester, Natalie A ^a   Theil, Kathrin ^b   Groitl, Peter ^b   Stewart, Grant S ^a   Taylor, A Malcolm R ^a   Morgan, Iain M ^c   Dobner, Thomas ^b   Grand, Roger J A ^a   Turnell, Andrew S ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Cullin RING ubiquitin ligases; DNA damage; Proteasome

Indexed keywords

ATR PROTEIN; BINDING PROTEIN; CHECKPOINT KINASE 1; ELONGIN C; PROTEIN CUL2; PROTEIN E4ORF6; PROTEIN P53; PROTEIN RBX1; TOPOISOMERASE IIBETA BINDING PROTEIN 1; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADENOVIRUS 12; ADENOVIRUS 5; ADENOVIRUS INFECTION; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; VIRUS REPLICATION;

ADENOVIRIDAE; ADENOVIRUS E1B PROTEINS; BLOTTING, WESTERN; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CULLIN PROTEINS; DNA-BINDING PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE; HELA CELLS; HOST-PATHOGEN INTERACTIONS; HUMANS; MICROSCOPY, CONFOCAL; MUTATION; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; TRANSCRIPTION FACTORS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN-PROTEIN LIGASES; VIRAL PROTEINS;

ADENOVIRIDAE; HUMAN ADENOVIRUS TYPE 12;

EID: 77955448692     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0914605107     Document Type: Article

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