Puerarin protects pancreatic β-cells in obese diabetic mice via activation of GLP-1R signaling

Molecular Endocrinology

Volumn 30, Issue 3, 2016, Pages 361-371

  Yang, Lei ^a,b   Yao, Dongdong ^a,b   Yang, Haiyuan ^c   Wei, Yingjie ^a,b   Peng, Yunru ^a,b   Ding, Yongfang ^a,b   Shu, Luan ^a,b  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b Jiangsu Province Academy of Traditional Chinese Medicine   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EXENDIN(9-39); GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE; HORMONE DERIVATIVE; PROTEIN KINASE B; PUERARIN; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; ISOFLAVONE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HOMEOBOX; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; OB/OB MOUSE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RECEPTOR UPREGULATION; WEIGHT GAIN; ANIMAL; C57BL MOUSE; CELL PROTECTION; CHEMISTRY; COMPLICATION; DRUG EFFECTS; EXPERIMENTAL DIABETES MELLITUS; HYPERGLYCEMIA; LIPID DIET; LIPID METABOLISM; METABOLISM; MOUSE MUTANT; PATHOLOGY; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CELL SURVIVAL; CYTOPROTECTION; DIABETES MELLITUS, EXPERIMENTAL; DIET, HIGH-FAT; GLUCAGON-LIKE PEPTIDE 1; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; GLUCOSE; HYPERGLYCEMIA; INSULIN-SECRETING CELLS; ISOFLAVONES; LIPID METABOLISM; MICE, INBRED C57BL; MICE, OBESE; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84959529226     PISSN: 08888809     EISSN: 19449917     Source Type: Journal    
DOI: 10.1210/me.2015-1213     Document Type: Article

References (40)

1. Prentki M, Nolan CJ. Islet β cell failure in type 2 diabetes. J Clin Invest. 2006;116(7):1802–1812.
2. Robertson RP, Harmon J, Tran PO, Tanaka Y, Takahashi H. Glucose toxicity in β-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes. 2003;52(3):581–587.
3. Tosch W, Lanthaler K, Boote V, et al. Molecular species of phosphatidylethanolamine from continuous cultures of Saccharomyces pastorianus syn. carlsbergensis strains. Yeast. 2006;23(2):75–82.
4. Liu Q, Chen L, Hu L, Guo Y, Shen X. Small molecules from natural sources, targeting signaling pathways in diabetes. Biochim Biophys Acta. 2010;1799(10–12):854–865.
5. Liu YX, Si MM, Lu W, et al. Effects and molecular mechanisms of the antidiabetic fraction of Acorus calamus L. on GLP-1 expression and secretion in vivo and in vitro. J Ethnopharmacol. 2015;166: 168–175.
6. Xiong FL, Sun XH, Gan L, Yang XL, Xu HB. Puerarin protects rat pancreatic islets from damage by hydrogen peroxide. Eur J Pharmacol. 2006;529(1–3):1–7.
7. Zhang W, Liu CQ, Wang PW, et al. Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet. Eur J Pharmacol. 2010;649(1–3):398–402.
8. Wu K, Liang T, Duan X, Xu L, Zhang K, Li R. Anti-diabetic effects of puerarin, isolated from Pueraria lobata (Willd.), on streptozotocin-diabetogenic mice through promoting insulin expression and ameliorating metabolic function. Food Chem Toxicol. 2013;60: 341–347.
9. Li Z, Shangguan Z, Liu Y, et al. Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway. J Mol Endocrinol. 2014; 53(1):71–79.
10. Sauter NS, Schulthess FT, Galasso R, Castellani LW, Maedler K. The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia. Endocrinology. 2008;149(5):2208–2218.
11. Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K. Transcription factor 7-like 2 regulates β-cell survival and function in human pancreatic islets. Diabetes. 2008;57(3):645–653.
12. Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP-and GLP-1 receptors and impaired β-cell function. Hum Mol Genet. 2009;18(13): 2388–2399.
13. Zhao Z, Choi J, Zhao C, Ma ZA. FTY720 normalizes hyperglycemia by stimulating β-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57(KIP2). J Biol Chem. 2012;287(8): 5562–5573.
14. Han SJ, Choi SE, Yi SA, et al. β-Cell-protective effect of 2-aminobicyclo-(2, 2, 1)-heptane-2-carboxylic acid as a glutamate dehydrogenase activator in db/db mice. J Endocrinol. 2012;212(3):307–315.
15. Do GM, Jung UJ, Park HJ, et al. Resveratrol ameliorates diabetesrelated metabolic changes via activation of AMP-activated protein kinase and its downstream targets in db/db mice. Mol Nutr Food Res. 2012;56(8):1282–1291.
16. Bullock BP, Heller RS, Habener JF. Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology. 1996;137(7):2968–2978.
17. Welters HJ, Kulkarni RN. Wnt signaling: relevance to β-cell biology and diabetes. Trends Endocrinol Metab. 2008;19(10):349–355.
18. Jin T, Liu L. The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus. Mol Endocrinol. 2008;22(11):2383–2392.
19. Rajan S, Dickson LM, Mathew E, et al. Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase A. Mol Metab. 2015;4(4):265–276.
20. Li L, El-Kholy W, Rhodes CJ, Brubaker PL. Glucagon-like peptide-1 protects β cells from cytokine-induced apoptosis and necrosis: role of protein kinase B. Diabetologia. 2005;48(7):1339–1349.
21. Kitamura T, Nakae J, Kitamura Y, et al. The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth. J Clin Invest. 2002;110(12):1839–1847.
22. Sathananthan M, Farrugia LP, Miles JM, et al. Direct effects of exendin-(9, 39) and GLP-1-(9, 36)amide on insulin action, β–cell function, and glucose metabolism in nondiabetic subjects. Diabetes. 2013;62(8):2752–2756.
23. Patel VJ, Joharapurkar AA, Shah GB, Jain MR. Effect of GLP-1 based therapies on diabetic dyslipidemia. Curr Diabetes Rev. 2014; 10(4):238–250.
24. Baggio LL, Drucker DJ. Therapeutic approaches to preserve islet mass in type 2 diabetes. Annu Rev Med. 2006;57:265–281.
25. Kitamura T. The role of FOXO1in β-cell failure and type 2 diabetes mellitus. Nat Rev Endocrinol. 2013;9(10):615–623.
26. Wang X, Liu Y, Yang Z, et al. Glucose metabolism-related protein 1 (GMRP1) regulates pancreatic β cell proliferation and apoptosis via activation of Akt signalling pathway in rats and mice. Diabetologia. 2011;54(4):852–863.
27. Niswender K. Diabetes and obesity: therapeutic targeting and risk reduction-a complex interplay. Diabetes Obes Metab. 2010;12(4): 267–287.
28. King AJ. The use of animal models in diabetes research. Br J Pharmacol. 2012;166(3):877–894.
29. Newman DJ, Cragg GM. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod. 2012;75(3):311–335.
30. Tabatabaei-Malazy O, Larijani B, Abdollahi M. Targeting metabolic disorders by natural products. J Diabetes Metab Disord. 2015;14:57.
31. Fu Z, Zhang W, Zhen W, et al. Genistein induces pancreatic β-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice. Endocrinology. 2010; 151(7):3026–3037.
32. Koole C, Pabreja K, Savage EE, et al. Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function. Biochem Soc Trans. 2013;41(1):172–179.
33. Xu G, Kaneto H, Laybutt DR, et al. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes. 2007;56(6):1551–1558.
34. Pan QR, Li WH, Wang H, et al. Glucose, metformin, and AICAR regulate the expression of G protein-coupled receptor members in INS-1 β cell. Horm Metab Res. 2009;41(11):799–804.
35. de Sousa Abreu R, Penalva LO, Marcotte EM, Vogel C. Global signatures of protein and mRNA expression levels. Mol Biosyst. 2009;5(12):1512–1526.
36. Yi F, Brubaker PL, Jin T. TCF-4 mediates cell type-specific regulation of proglucagon gene expression by β-catenin and glycogen synthase kinase-3 β. J Biol Chem. 2005;280(2):1457–1464.
37. Liu Z, Habener JF. Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic β cell proliferation. J Biol Chem. 2008;283(13):8723–8735.
38. da Silva Xavier G, Mondragon A, Sun G, et al. Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice. Diabetologia. 2012;55(10):2667–2676.
39. Takamoto I, Kubota N, Nakaya K, et al. TCF7L2 in mouse pancreatic β cells plays a crucial role in glucose homeostasis by regulating β cell mass. Diabetologia. 2014;57(3):542–553.
40. Zhou Y, Park SY, Su J, et al. TCF7L2 is a master regulator of insulin production and processing. Hum Mol Genet. 2014;23(24):6419–6431.