-
1
-
-
12244284000
-
Beta- And alpha-cell dysfunction in type 2 diabetes
-
Del Prato S, Marchetti P. Beta- and alpha-cell dysfunction in type 2 diabetes. Horm Metab Res 2004; 36: 775-781
-
(2004)
Horm Metab Res
, vol.36
, pp. 775-781
-
-
Del Prato, S.1
Marchetti, P.2
-
3
-
-
12244281854
-
Physiology of GIP - A lesson from GIP receptor knockout mice
-
DOI 10.1055/s-2004-826162
-
Yamada Y, Seino Y. Physiology of GIP - a lesson from GIP receptor knockout mice. Horm Metab Res 2004; 36: 771-774 (Pubitemid 40115898)
-
(2004)
Hormone and Metabolic Research
, vol.36
, Issue.11-12
, pp. 771-774
-
-
Yamada, Y.1
Seino, Y.2
-
4
-
-
12244270387
-
GIP as a potential therapeutic agent?
-
Meier JJ, Nauck MA. GIP as a potential therapeutic agent? Horm Metab Res 2004; 36: 859-866
-
(2004)
Horm Metab Res
, vol.36
, pp. 859-866
-
-
Meier, J.J.1
Ma, N.2
-
5
-
-
0037434991
-
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40
-
Itoh Y, Kawamata Y, Harada M, Kobayashi M, Fujii R, Fukusumi S, Ogi Jf, Hosoya M, Tanaka Y, Uejima H, Tanaka H, Maruyama M, Satoh R, Okubo S, Kizawa H, Komatsu H, Matsumura F, Noguchi Y, Shtn, Hinuma S, Fujisawa Y, Fujino M. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature 2003; 422: 173-176
-
(2003)
Nature
, vol.422
, pp. 173-176
-
-
Itoh, Y.1
Kawamata, Y.2
Harada, M.3
Kobayashi, M.4
Fujii, R.5
Fukusumi, S.6
Ogi, J.F.7
Hosoya, M.8
Tanaka, Y.9
Uejima, H.10
Tanaka, H.11
Maruyama, M.12
Satoh, R.13
Okubo, S.14
Kizawa, H.15
Komatsu, H.16
Matsumura, F.17
Noguchi, Y.18
Shinohara, T.19
Hinuma, Y.20
Fujisawa, Y.21
Fujino, M.22
more..
-
6
-
-
0037838892
-
The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids
-
Briscoe CP, Tadayyon M, Andrews JL, Benson WC, Chambers JK, Eifert MM, Ellis C, Elshourbagy NA, GoetzAS, Minnkk DT, Murdock PR, Sauls HR, Shabon U, Spinage LD, Strum JC, Szekeres PG, Tan KB, Way DM, Wilson S, Muir AL The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem 2003; 278: 11303-11311
-
(2003)
J Biol Chem
, vol.278
, pp. 11303-11311
-
-
Tadayyon M, C.P.1
Andrews, J.L.2
Benson, W.C.3
Chambers, J.K.4
Eifert, M.M.5
Ellis, C.6
Elshourbagy, N.A.7
Goetz, A.S.8
Minnkk, D.T.9
Murdock, P.R.10
Sauls, H.R.11
Shabon, U.12
Spinage, L.D.13
Strum, J.C.14
Szekeres, P.G.15
Tan, K.B.16
Way, D.M.17
Wilson, S.18
Muir, A.L.19
-
7
-
-
25144433441
-
Role of GPR40 in fatty acid action on the beta cell line INS-IE, Biochem.
-
Shapiro H, Shachar S, Sekler I, Hershfinkel M, Walker MD. Role of GPR40 in fatty acid action on the beta cell line INS-IE, Biochem. Biophys Res Commun 2005; 335: 97-104
-
(2005)
Biophys Res Commun
, vol.335
, pp. 97-104
-
-
Shapiro, H.1
Shachar, S.2
Sekler, I.3
Hershfinkel, M.4
Walker, M.D.5
-
8
-
-
33751520308
-
Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from β-cells through activation of GPR40
-
DOI 10.1016/j.mce.2006.09.013, PII S0303720706004758
-
Schnell S, Schaefer M, Schofl C. Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from beta-cells through activation of GPR40. MoI Cell Endocrinol 2007; 263: 173-180 (Pubitemid 44834553)
-
(2007)
Molecular and Cellular Endocrinology
, vol.263
, Issue.1-2
, pp. 173-180
-
-
Schnell, S.1
Schaefer, M.2
Schofl, C.3
-
9
-
-
20944433543
-
The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
-
DOI 10.1016/j.cmet.2005.03.007, PII S1550413105000860
-
Steneberg P, Rubins N, Bartoov-Shifman R, Walker MD, Edlund H. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metab 2005; 1: 245258 (Pubitemid 43960613)
-
(2005)
Cell Metabolism
, vol.1
, Issue.4
, pp. 245-258
-
-
Steneberg, P.1
Rubins, N.2
Bartoov-Shifman, R.3
Walker, M.D.4
Edlund, H.5
-
10
-
-
59449084679
-
Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- And high-glucose concentrations
-
Bensellam M, Van Lommel L, Overbergh L, Schuit FC, Jonas JC. Cluster analysis of rat pancreatic islet gene mRNA levels after culture in low-, intermediate- and high-glucose concentrations. Diabetologia 2009; 52: 463-476
-
(2009)
Diabetologia
, vol.52
, pp. 463-476
-
-
Bensellam, M.1
Van Lommel, L.2
Overbergh, L.3
Schuit, F.C.4
Jonas, J.C.5
-
11
-
-
33745225026
-
AMP-activated protein kinase - Development of the energy sensor concept
-
DOI 10.1113/jphysiol.2006.108944
-
Hardie DG, Hawley SA, Scott JW. AMP-activated protein kinase-development of the energy sensor concept. J Physiol 2006; 574: 7-15 (Pubitemid 43905792)
-
(2006)
Journal of Physiology
, vol.574
, Issue.1
, pp. 7-15
-
-
Hardie, D.G.1
Hawley, S.A.2
Scott, J.W.3
-
12
-
-
0037268159
-
A novel pathway for regulation of glucosedependent insulinotropic polypeptide (G1P) receptor expression in beta cells
-
Lynn FC, Thompson SA, Pospisilik JA, Ehses JA, Hinke SA, Pamir N, Mcintosh CH, Pederson RA. A novel pathway for regulation of glucosedependent insulinotropic polypeptide (G1P) receptor expression in beta cells. FASEB J 2003; 17: 91-93
-
(2003)
FASEB J
, vol.17
, pp. 91-93
-
-
Lynn, F.C.1
Thompson, S.A.2
Pospisilik, J.A.3
Ehses, J.A.4
Hinke, S.A.5
Pamir, N.6
Mcintosh, Ch.7
Pederson, R.A.8
-
13
-
-
0029859966
-
Effects of chronically elevated glucose levels on the functional properties of rat pancreatic β-cells
-
Ling Z, Kiekens R, Mahler T, Schuit K, Pipeleers-Marichal M, Sener A, Klöppel G, Malaisse WJ, Pipeleers DG. Effects of chronically elevated glucose levels on the functional properties of rat pancreatic ß-cells. Diabetes 1996; 45:1774-1782 (Pubitemid 26398959)
-
(1996)
Diabetes
, vol.45
, Issue.12
, pp. 1774-1782
-
-
Ling, Z.1
Kiekens, R.2
Mahler, T.3
Schuit, F.C.4
Pipeleers-Marichal, M.5
Sener, A.6
Kloppel, G.7
Malaisse, W.J.8
Pipeleers, D.G.9
-
14
-
-
0842263986
-
Nuclear Protein P8 Is Associated with Glucose-induced Pancreatic Beta-cell Growth
-
Path G, Opel A, Knoll A, SeufertJ. Nuclear protein p8 is associated with glucose-induced pancreatic beta-cell growth. Diabetes 2004; 53 (Suppl 1): S82-S85
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 1
-
-
Path, G.1
Opel, A.2
Knoll, A.3
Seufert, J.4
-
15
-
-
0030876081
-
The pathogenesis of NIDDM involves a defective expression of the GIP receptor
-
DOI 10.1007/s001250050779
-
Hoist JJ, Gromada J, Nauck MA. The pathogenesis of NIDDM involves a defective expression of the GIP receptor. Diabetologia 1997; 40:984-986 (Pubitemid 27316583)
-
(1997)
Diabetologia
, vol.40
, Issue.8
, pp. 984-986
-
-
Holst, J.J.1
Gromada, J.2
Nauck, M.A.3
-
16
-
-
0035041250
-
Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats
-
Lynn FC, Pamir N, NgEH, Mcintosh CH, Kieffer TJ, Pederson RA. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes 2001; 50:1004-1011 (Pubitemid 32374530)
-
(2001)
Diabetes
, vol.50
, Issue.5
, pp. 1004-1011
-
-
Lynn, F.C.1
Pamir, N.2
Ng, E.H.C.3
McIntosh, C.H.S.4
Kieffer, T.J.5
Pederson, R.A.6
-
17
-
-
0027391607
-
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type- 2 diabetes mellitus
-
Nauck MA, Heimesaat MM, Orskov C, Hoist JJ, Ebert R, Creutzfeldt W. Preserved incretin activity of glucagon-like peptide 1 [7-36amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 1993; 91: 301-307 (Pubitemid 23037285)
-
(1993)
Journal of Clinical Investigation
, vol.91
, Issue.1
, pp. 301-307
-
-
Nauck, M.A.1
Heimesaat, M.M.2
Orskov, C.3
Holst, J.J.4
Ebert, R.5
Creutzfeldt, W.6
-
18
-
-
0037312821
-
The influence of GLP-1 on glucose-stimulated insulin secretion: Effects on beta-cell sensitivity in type 2 and nondiabetic subjects
-
Kjems LL, Hoist JJ, Volund A, Madsbad S. The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects. Diabetes 2003; 52: 380-386
-
(2003)
Diabetes
, vol.52
, pp. 380-386
-
-
Kjems, L.L.1
Hoist, J.J.2
Volund, A.3
Madsbad, S.4
-
19
-
-
2442473274
-
Bioactive GLP-1 in gut, receptor expression in pancreas, and insulin response to GLP-1 in diabetes-prone rats
-
DOI 10.1385/ENDO:23:1:77
-
Valverde I, Wang GS, Burghardt K, Kauri LM, Redondo A, Acitores A, Villanueva-Penacarrillo ML, Courtois P, Sener A, Cancelas J, Malaisse WJ, Scott FW. Bioactive GLP-1 in gut, receptor expression in pancreas and insulin response to GLP-1 in diabetes-prone rats. Endocrine 2004; 23: 77-84 (Pubitemid 38621642)
-
(2004)
Endocrine
, vol.23
, Issue.1
, pp. 77-84
-
-
Valverde, I.1
Wang, G.-S.2
Burghardt, K.3
Kauri, L.M.4
Redondo, A.5
Acitores, A.6
Villanueva-Penacarrillo, M.L.7
Courtois, P.8
Sener, A.9
Cancelas, J.10
Malaisse, W.J.11
Scott, F.W.12
-
20
-
-
34249724553
-
Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: Possible contribution to impaired incretin effects in diabetes
-
DOI 10.2337/db06-1033
-
Xu G, Kaneto H, Laybutt DR, Duvivier-Kali VF, Trivedi N, Suzuma K, King GL, Wer GC, Bonner-Weir S. Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes 2007; 56:1551-1558 (Pubitemid 46842610)
-
(2007)
Diabetes
, vol.56
, Issue.6
, pp. 1551-1558
-
-
Xu, G.1
Kaneto, H.2
Laybutt, D.R.3
Duvivier-Kali, V.F.4
Trivedi, N.5
Suzuma, K.6
King, G.L.7
Weir, G.C.8
Bonner-Weir, S.9
-
21
-
-
0038584871
-
Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression
-
Da S, X, Leclerc I, Varadi A, Tsuboi T, Moule SK, Rutter GA. Role for AMP-activated protein kinase in glucose-stimulated insulin secretion and preproinsulin gene expression. Biochem J 2003; 371: 761-774
-
(2003)
Biochem J
, vol.371
, pp. 761-774
-
-
Da, S.X.1
Leclerc, I.2
Varadi, A.3
Tsuboi, T.4
Moule, S.K.5
Rutter, G.A.6
-
22
-
-
3042702709
-
Metfbrmin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis
-
Kefas BA, Cai Y, Kerckhofs K, Ling Z, Martens G, Heimberg H, Pipàeers D, Van de CM. Metfbrmin-induced stimulation of AMP-activated protein kinase in beta-cells impairs their glucose responsiveness and can lead to apoptosis. Biochem Pharmacol 2004; 68: 409-416
-
(2004)
Biochem Pharmacol
, vol.68
, pp. 409-416
-
-
Kefas, B.A.1
Cai, Y.2
Kerckhofs, K.3
Ling, Z.4
Martens, G.5
Heimberg, H.6
Pipàeers, D.7
Van De, C.M.8
-
23
-
-
0038363852
-
AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase
-
DOI 10.1677/jme.0.0300151
-
Kefas BA, Cai Y, Ling Z, Heimberg H, Hue L, Pipeleers D, Van de CM. AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase. J MoI Endocrinol 2003; 30:151-161 (Pubitemid 36592509)
-
(2003)
Journal of Molecular Endocrinology
, vol.30
, Issue.2
, pp. 151-161
-
-
Kefas, B.A.1
Cai, Y.2
Ling, Z.3
Heimberg, H.4
Hue, L.5
Pipeleers, D.6
Van De Casteele, M.7
-
24
-
-
0037301056
-
AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase
-
Kefas BA, Heimberg H, Voulant S, Meisse D, Hue L, Pipeleers D, Van de CM. AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase. Diabetologia 2003; 46: 250-254
-
(2003)
Diabetologia
, vol.46
, pp. 250-254
-
-
Kefas, B.A.1
Heimberg, H.2
Voulant, S.3
Meisse, D.4
Hue, L.5
Pipeleers, D.6
Van De, C.M.7
-
25
-
-
20144386698
-
Long-term AICAR administration and exercise prevents diabetes in ZDF rats
-
PoId R, Jensen LS, Jessen N, Buhl ES, Schmitz O, flyvbjerg A, Fujii N, Goodyear LJ, Gotjredsen CF, Brand CL, Lund S. Long-term AICAR administration and exercise prevents diabetes in ZDF rats. Diabetes 2005; 54: 928-934
-
(2005)
Diabetes
, vol.54
, pp. 928-934
-
-
Poid, R.1
Jensen, L.S.2
Jessen, N.3
Buhl, E.S.4
Schmitz, O.5
Flyvbjerg, A.6
Fujii, N.7
Goodyear, L.J.8
Gotjredsen, C.F.9
Brand, C.L.10
Lund, S.11
-
26
-
-
0031750277
-
Long-term exposure of β-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression
-
DOI 10.2337/diabetes.47.7.1086
-
Roche E, Farfari S, Witters LA, Assimacopoulos-Jeannet F, Thumelin S, Brun T, Corkey BE, SahaAK, Prentki M. Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression. Diabetes 1998; 47:1086-1094 (Pubitemid 28294551)
-
(1998)
Diabetes
, vol.47
, Issue.7
, pp. 1086-1094
-
-
Roche, E.1
Farfari, S.2
Witters, L.A.3
Assimacopoulos-Jeannet, F.4
Thumelin, S.5
Brun, T.6
Corkey, B.E.7
Saha, A.K.8
Prentki, M.9
-
27
-
-
20844451123
-
AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
-
DOI 10.1016/j.cmet.2004.12.003, PII S1550413104000099
-
Kahn BB, Alquier T, Carting D, Hardie DG. AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005; 1:15-25 (Pubitemid 43960587)
-
(2005)
Cell Metabolism
, vol.1
, Issue.1
, pp. 15-25
-
-
Kahn, B.B.1
Alquier, T.2
Carling, D.3
Hardie, D.G.4
-
28
-
-
33646142778
-
Glucose-induced repression of PPARalpha gene expression in pancreatic beta-cells involves PP2A activation and AMPK inactivation
-
Ravnskjaer K, Boergesen M, Dalgaard LT, Mandrup S. Glucose-induced repression of PPARalpha gene expression in pancreatic beta-cells involves PP2A activation and AMPK inactivation. J Mol Endocrinol 2006; 36: 289-299
-
(2006)
J Mol Endocrinol
, vol.36
, pp. 289-299
-
-
Ravnskjaer, K.1
Boergesen, M.2
Dalgaard, L.T.3
Mandrup, S.4
|