Puerarin protects pancreatic β-cell survival via PI3K/Akt signaling pathway

Journal of Molecular Endocrinology

Volumn 53, Issue 1, 2014, Pages 71-79

  Li, Zhipeng ^a,b   Shangguan, Zhaoshui ^a   Liu, Yijie ^a   Wang, Jihua ^a   Li, Xuejun ^a   Yang, Shuyu ^a   Liu, Suhuan ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Apoptosis; Diabetes; Pancreatic cell; PI3K Akt; Puerarin

Indexed keywords

COBALT CHLORIDE; GLUCOSE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN KINASE B; PUERARIN; REACTIVE OXYGEN METABOLITE; STREPTOZOCIN; ANTIDIABETIC AGENT; ISOFLAVONE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CULTURE; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CELL VOLUME; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RELEASE; MALE; MIN6 CELL LINE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; C57BL MOUSE; CELL LINE; CYTOLOGY; DIABETES MELLITUS, EXPERIMENTAL; DRUG EFFECTS; METABOLISM; PATHOLOGY;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; DIABETES MELLITUS, EXPERIMENTAL; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; ISOFLAVONES; MALE; MICE; MICE, INBRED C57BL; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 84903582995     PISSN: 09525041     EISSN: 14796813     Source Type: Journal    
DOI: 10.1530/JME-13-0302     Document Type: Article

References (30)

1. Bebrevska L, Foubert K, Hermans N, Chatterjee S, VanMarck E, DeMeyer G, Vlietinck A, Pieters L & Apers S 2010 In vivo antioxidative activity of a quantified Pueraria lobata root extract. Journal of Ethnopharmacology 127 112-117. (doi:10.1016/j.jep.2009.09.039)
2. Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M & Butler PC 2013 Marked expansion of exocrine and endocrine pancreas with incretin therapy in humans with increased exocrine pancreas dysplasia and the potential for glucagon-producing neuroendocrine tumors. Diabetes 62 2595-2604. (doi:10.2337/db12-1686)
3. Cernea S & Raz I 2011 Therapy in the early stage: incretins. Diabetes Care 34 (Suppl 2) S264-S271. (doi:10.2337/dc11-s223)
4. Chen YY, Chen J, Zhou XM, Meng XH, Jiang JP & Shen YL 2012 Puerarin protects human umbilical vein endothelial cells against high glucoseinduced apoptosis by upregulating heme oxygenase-1 and inhibiting calpain activation. Fundamental & Clinical Pharmacology 26 322-331. (doi:10.1111/j.1472-8206.2011.00926.x)
5. Cnop M, Welsh N, Jonas JC, Jorns A, Lenzen S & Eizirik DL 2005 Mechanisms of pancreatic b-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 54 (Suppl 2) S97-S107. (doi:10.2337/diabetes.54.suppl_2.S97)
6. Hao LN, Wang M, Ma JL & Yang T 2012 Puerarin decreases apoptosis of retinal pigment epithelial cells in diabetic rats by reducing peroxynitrite level and iNOS expression. Sheng Li Xue Bao 64 199-206.
7. Hsiang SW, Lee HC, Tsai FJ, Tsai CC, Yao CH & Chen YS 2011 Puerarin accelerates peripheral nerve regeneration. American Journal of Chinese Medicine 39 1207-1217. (doi:10.1142/S0192415X11009500)
8. Hsu FL, Liu IM, Kuo DH, Chen WC, Su HC & Cheng JT 2003 Antihyperglycemic effect of puerarin in streptozotocin-induced diabetic rats. Journal of Natural Products 66 788-792. (doi:10.1021/np0203887)
9. Huang F, Liu K, Du H, Kou J & Liu B 2012 Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKb/IRS-1-dependent manner. Biochimie 94 1143-1150. (doi:10.1016/ j.biochi.2012.01.018)
10. Hwang YP & Jeong HG 2008 Mechanism of phytoestrogen puerarinmediated cytoprotection following oxidative injury: estrogen receptordependent up-regulation of PI3K/Akt and HO-1. Toxicology and Applied Pharmacology 233 371-381. (doi:10.1016/j.taap.2008.09.006)
11. Hwang YP, Kim HG, Hien TT, Jeong MH, Jeong TC & Jeong HG 2011 Puerarin activates endothelial nitric oxide synthase through estrogen receptor-dependent PI3-kinase and calcium-dependent AMP-activated protein kinase. Toxicology and Applied Pharmacology 257 48-58. (doi:10.1016/j.taap.2011.08.017)
12. Jin SE, Son YK, Min BS, Jung HA & Choi JS 2012 Anti-inflammatory and antioxidant activities of constituents isolated from Pueraria lobata roots. Archives of Pharmacal Research 35 823-837. (doi:10.1007/s12272-012-0508-x)
13. Lee OH, Seo DH, Park CS & Kim YC 2010 Puerarin enhances adipocyte differentiation, adiponectin expression, and antioxidant response in 3T3-L1 cells. BioFactors 36 459-467. (doi:10.1002/biof.119)
14. Liang J, Chen H, PanW& Xu C 2012 Puerarin inhibits caspase-3 expression in osteoblasts of diabetic rats. Molecular Medicine Reports 5 1419-1422. (doi:10.3892/mmr.2012.854)
15. Liu S, Le May C, Wong WP, Ward RD, Clegg DJ, Marcelli M, Korach KS & Mauvais-Jarvis F 2009 Importance of extranuclear estrogen receptor-a and membrane G protein-coupled estrogen receptor in pancreatic islet survival. Diabetes 58 2292-2302. (doi:10.2337/db09-0257)
16. Liu CM, MaJQ&Sun YZ 2012 Puerarin protects rat kidney fromlead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway. Toxicology and Applied Pharmacology 258 330-342. (doi:10.1016/j.taap.2011.11.015)
17. Liu S, Kilic G, Meyers MS, Navarro G, Wang Y, Oberholzer J & Mauvais-Jarvis F 2013 Oestrogens improve human pancreatic islet transplantation in a mouse model of insulin deficient diabetes. Diabetologia 56 370-381. (doi:10.1007/s00125-012-2764-1)
18. Prasain JK, Peng N, Rajbhandari R & Wyss JM 2012 The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. Phytomedicine 20 17-23. (doi:10.1016/ j.phymed.2012.09.017)
19. Robertson RP 2010 Islet transplantation a decade later and strategies for filling a half-full glass. Diabetes 59 1285-1291. (doi:10.2337/ db09-1846)
20. Shen JG, Yao MF, Chen XC, Feng YF, Ye YH & Tong ZH 2009 Effects of puerarin on receptor for advanced glycation end products in nephridial tissue of streptozotocin-induced diabetic rats. Molecular Biology Reports 36 2229-2233. (doi:10.1007/s11033-008-9438-6)
21. Teng Y, Cui H, Yang M, Song H, Zhang Q, Su Y & Zheng J 2009 Protective effect of puerarin on diabetic retinopathy in rats. Molecular Biology Reports 36 1129-1133. (doi:10.1007/s11033-008-9288-2)
22. Wang Y, Wang WL, Xie WL, Li LZ, Sun J, Sun WJ & Gong HY 2013 Puerarin stimulates proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells via ER-dependent MEK/ERK and PI3K/Akt activation. Phytomedicine 20 787-796. (doi:10.1016/ j.phymed.2013.03.005)
23. Wong WP, Tiano JP, Liu S, Hewitt SC, Le May C, Dalle S, Katzenellenbogen JA, Katzenellenbogen BS, Korach KS & Mauvais-Jarvis F 2010 Extranuclear estrogen receptor-a stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis. PNAS 107 13057-13062. (doi:10.1073/pnas.0914501107)
24. Wu K, Liang T, Duan X, Xu L, Zhang K & Li R 2013 Anti-diabetic effects of puerarin, isolated from Pueraria lobata (Willd.), on streptozotocindiabetogenic mice through promoting insulin expression and ameliorating metabolic function. Food and Chemical Toxicology 60 341-347. (doi:10.1016/j.fct.2013.07.077)
25. Xing G, Dong M, Li X, Zou Y, Fan L, Wang X, Cai D, Li C, Zhou L, Liu J et al. 2011 Neuroprotective effects of puerarin against b-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway. Brain Research Bulletin 85 212-218. (doi:10.1016/ j.brainresbull.2011.03.024)
26. Xiong FL, Sun XH, Gan L, Yang XL & Xu HB 2006 Puerarin protects rat pancreatic islets from damage by hydrogen peroxide. European Journal of Pharmacology 529 1-7. (doi:10.1016/j.ejphar.2005.10.024)
27. Xu Y, Wang L, He J, Bi Y, Li M, Wang T, Wang L, Jiang Y, Dai M, Lu J et al. 2013 Prevalence and control of diabetes in Chinese adults. Journal of the American Medical Association 310 948-959. (doi:10.1001/jama.2013. 168118)
28. Zhang W, Liu CQ, Wang PW, Sun SY, Su WJ, Zhang HJ, Li XJ & Yang SY 2010 Puerarin improves insulin resistance and modulates adipokine expression in rats fed a high-fat diet. European Journal of Pharmacology 649 398-402. (doi:10.1016/j.ejphar.2010.09.054)
29. Zhang Q, Huang WD, Lv XY & Yang YM 2012 Puerarin protects differentiated PC12 cells from H(2)O(2)-induced apoptosis through the PI3K/Akt signalling pathway. Cell Biology International 36 419-426. (doi:10.1042/CBI20100900)
30. Zhu G, Wang X, Wu S & Li Q 2012 Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPPC-induced human neuroblastoma SH-SY5Y cell death. Neurochemistry International 60 400-408. (doi:10.1016/j.neuint.2012.01.003)