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Volumn 12, Issue 4, 2010, Pages 267-287

Diabetes and obesity: Therapeutic targeting and risk reduction - a complex interplay

Author keywords

DPP 4; Exenatide; GLP 1 analogue; Human; Incretin; Liraglutide; Once daily; Type 2 diabetes mellitus

Indexed keywords

2,4 THIAZOLIDINEDIONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; ACARBOSE; ALPHA GLUCOSIDASE INHIBITOR; AMLODIPINE; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIDIABETIC AGENT; ANTIHYPERTENSIVE AGENT; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; EXENDIN 4; GLIMEPIRIDE; INCRETIN; INSULIN; LIRAGLUTIDE; MEGLITINIDE; METFORMIN; PIOGLITAZONE; PLACEBO; PLASMINOGEN ACTIVATOR INHIBITOR 1; RAMIPRIL; ROSIGLITAZONE; SITAGLIPTIN; SULFONYLUREA; THIAZIDE DIURETIC AGENT; VILDAGLIPTIN;

EID: 77954351422     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2009.01175.x     Document Type: Review
Times cited : (70)

References (274)
  • 1
    • 33846857559 scopus 로고    scopus 로고
    • Heart disease and stroke statistics - 2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Rosamond W, Flegal K, Friday G. Heart disease and stroke statistics - 2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2007, 115:e69-e171.
    • (2007) Circulation , vol.115
    • Rosamond, W.1    Flegal, K.2    Friday, G.3    et al4
  • 2
    • 60449094498 scopus 로고    scopus 로고
    • Heart Disease and Stroke Statistics - 2009 Update. A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Lloyd-Jones D, Adams R, Carnethon M. Heart Disease and Stroke Statistics - 2009 Update. A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2009, 119:480-486.
    • (2009) Circulation , vol.119 , pp. 480-486
    • Lloyd-Jones, D.1    Adams, R.2    Carnethon, M.3    et al4
  • 3
    • 0033553188 scopus 로고    scopus 로고
    • Diabetes and decline in heart disease mortality in US adults
    • Gu K, Cowie CC, Harris MI. Diabetes and decline in heart disease mortality in US adults. JAMA 1999, 281:1291-1297.
    • (1999) JAMA , vol.281 , pp. 1291-1297
    • Gu, K.1    Cowie, C.C.2    Harris, M.I.3
  • 4
    • 58849090589 scopus 로고    scopus 로고
    • Comparison of prognosis for men with type 2 diabetes mellitus and men with cardiovascular disease
    • Dagenais GR, St-Pierre A, Gilbert P. Comparison of prognosis for men with type 2 diabetes mellitus and men with cardiovascular disease. CMAJ 2009, 180:40-47.
    • (2009) CMAJ , vol.180 , pp. 40-47
    • Dagenais, G.R.1    St-Pierre, A.2    Gilbert, P.3    et al4
  • 5
    • 33745400514 scopus 로고    scopus 로고
    • Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study
    • Booth GL, Kapral MK, Fung K, Tu JV. Relation between age and cardiovascular disease in men and women with diabetes compared with non-diabetic people: a population-based retrospective cohort study. Lancet 2006, 368:29-36.
    • (2006) Lancet , vol.368 , pp. 29-36
    • Booth, G.L.1    Kapral, M.K.2    Fung, K.3    Tu, J.V.4
  • 7
    • 0034917709 scopus 로고    scopus 로고
    • Impact of overweight on the risk of developing common chronic diseases during a 10-year period
    • Field AE, Coakley EH, Must A. Impact of overweight on the risk of developing common chronic diseases during a 10-year period. Arch Intern Med 2001, 161:1581-1586.
    • (2001) Arch Intern Med , vol.161 , pp. 1581-1586
    • Field, A.E.1    Coakley, E.H.2    Must, A.3    et al4
  • 8
    • 0037407403 scopus 로고    scopus 로고
    • NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older
    • Alexander CM, Landsman PB, Teutsch SM, Haffner SM. NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes 2003, 52:1210-1214.
    • (2003) Diabetes , vol.52 , pp. 1210-1214
    • Alexander, C.M.1    Landsman, P.B.2    Teutsch, S.M.3    Haffner, S.M.4
  • 9
    • 0034289882 scopus 로고    scopus 로고
    • Redefining type 2 diabetes: 'diabesity' or 'obesity dependent diabetes mellitus'?
    • Astrup A, Finer N. Redefining type 2 diabetes: 'diabesity' or 'obesity dependent diabetes mellitus'? Obes Rev 2000, 1:57-59.
    • (2000) Obes Rev , vol.1 , pp. 57-59
    • Astrup, A.1    Finer, N.2
  • 10
    • 11844253332 scopus 로고    scopus 로고
    • Prevalence of overweight and obesity among adults with diagnosed diabetes - United States, 1988-1994 and 1999-2002
    • Prevalence of overweight and obesity among adults with diagnosed diabetes - United States, 1988-1994 and 1999-2002. MMWR Morb Mortal Wkly Rep 2004, 53:1066-1068.
    • (2004) MMWR Morb Mortal Wkly Rep , vol.53 , pp. 1066-1068
  • 11
    • 0030855615 scopus 로고    scopus 로고
    • Weight change and diabetes incidence: findings from a national cohort of US adults
    • Ford ES, Williamson DF, Liu S. Weight change and diabetes incidence: findings from a national cohort of US adults. Am J Epidemiol 1997, 146:214-222.
    • (1997) Am J Epidemiol , vol.146 , pp. 214-222
    • Ford, E.S.1    Williamson, D.F.2    Liu, S.3
  • 12
    • 0025134141 scopus 로고
    • Association of elevated fasting C-peptide level and increased intra-abdominal fat distribution with development of NIDDM in Japanese-American men
    • Bergstrom RW, Newell-Morris LL, Leonetti DL, Shuman WP, Wahl PW, Fujimoto WY. Association of elevated fasting C-peptide level and increased intra-abdominal fat distribution with development of NIDDM in Japanese-American men. Diabetes 1990, 39:104-111.
    • (1990) Diabetes , vol.39 , pp. 104-111
    • Bergstrom, R.W.1    Newell-Morris, L.L.2    Leonetti, D.L.3    Shuman, W.P.4    Wahl, P.W.5    Fujimoto, W.Y.6
  • 14
    • 40549114574 scopus 로고    scopus 로고
    • Prediabetes and its relationship with obesity in Mexican adults: The Mexican Diabetes Prevention (MexDiab) Study
    • Guerrero-Romero F, Rodriguez-Moran M, Perez-Fuentes R. Prediabetes and its relationship with obesity in Mexican adults: The Mexican Diabetes Prevention (MexDiab) Study. Metab Syndr Relat Disord 2008, 6:15-23.
    • (2008) Metab Syndr Relat Disord , vol.6 , pp. 15-23
    • Guerrero-Romero, F.1    Rodriguez-Moran, M.2    Perez-Fuentes, R.3    et al4
  • 15
    • 25144459980 scopus 로고    scopus 로고
    • The metabolic syndrome - a new worldwide definition
    • Alberti KG, Zimmet P, Shaw J. The metabolic syndrome - a new worldwide definition. Lancet 2005, 366:1059-1062.
    • (2005) Lancet , vol.366 , pp. 1059-1062
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 18
    • 33845370689 scopus 로고    scopus 로고
    • Initiation of therapy for patients with essential hypertension or comorbid conditions
    • Wexler R, Feldman D. Initiation of therapy for patients with essential hypertension or comorbid conditions. Prim Care 2006, 33:887-901.
    • (2006) Prim Care , vol.33 , pp. 887-901
    • Wexler, R.1    Feldman, D.2
  • 19
    • 33846422032 scopus 로고    scopus 로고
    • Obesity and diabetes in the developing world - a growing challenge
    • Hossain P, Kawar B, El NM. Obesity and diabetes in the developing world - a growing challenge. N Engl J Med 2007, 356:213-215.
    • (2007) N Engl J Med , vol.356 , pp. 213-215
    • Hossain, P.1    Kawar, B.2    El, N.M.3
  • 20
    • 79957651158 scopus 로고    scopus 로고
    • National diabetes statistics, 2007
    • National Institutes of Health, Available from URL:, Accessed 25 September 2009.
    • National diabetes statistics, 2007. http://diabetes.niddk.nih.gov/dm/pubs/statistics/index.htm, National Institutes of Health, Available from URL:, Accessed 25 September 2009.
  • 21
    • 0034732256 scopus 로고    scopus 로고
    • Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. Atherosclerosis Risk in Communities Study
    • Gress TW, Nieto FJ, Shahar E, Wofford MR, Brancati FL. Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. Atherosclerosis Risk in Communities Study. N Engl J Med 2000, 342:905-912.
    • (2000) N Engl J Med , vol.342 , pp. 905-912
    • Gress, T.W.1    Nieto, F.J.2    Shahar, E.3    Wofford, M.R.4    Brancati, F.L.5
  • 22
    • 0033664210 scopus 로고    scopus 로고
    • Obesity-hypertension: the effects on cardiovascular and renal systems
    • Zhang R, Reisin E. Obesity-hypertension: the effects on cardiovascular and renal systems. Am J Hypertens 2000, 13:1308-1314.
    • (2000) Am J Hypertens , vol.13 , pp. 1308-1314
    • Zhang, R.1    Reisin, E.2
  • 23
    • 27244455736 scopus 로고    scopus 로고
    • Effect of weight loss on blood pressure, arterial compliance, and insulin resistance in normotensive obese subjects
    • Schneider R, Golzman B, Turkot S, Kogan J, Oren S. Effect of weight loss on blood pressure, arterial compliance, and insulin resistance in normotensive obese subjects. Am J Med Sci 2005, 330:157-160.
    • (2005) Am J Med Sci , vol.330 , pp. 157-160
    • Schneider, R.1    Golzman, B.2    Turkot, S.3    Kogan, J.4    Oren, S.5
  • 24
    • 33745666035 scopus 로고    scopus 로고
    • Exercise effects on cardiac size and left ventricular diastolic function: relationships to changes in fitness, fatness, blood pressure and insulin resistance
    • Stewart KJ, Ouyang P, Bacher AC, Lima S, Shapiro EP. Exercise effects on cardiac size and left ventricular diastolic function: relationships to changes in fitness, fatness, blood pressure and insulin resistance. Heart 2006, 92:893-898.
    • (2006) Heart , vol.92 , pp. 893-898
    • Stewart, K.J.1    Ouyang, P.2    Bacher, A.C.3    Lima, S.4    Shapiro, E.P.5
  • 25
    • 0030025673 scopus 로고    scopus 로고
    • Hypertension and associated metabolic abnormalities - the role of insulin resistance and the sympathoadrenal system
    • Reaven GM, Lithell H, Landsberg L. Hypertension and associated metabolic abnormalities - the role of insulin resistance and the sympathoadrenal system. N Engl J Med 1996, 334:374-381.
    • (1996) N Engl J Med , vol.334 , pp. 374-381
    • Reaven, G.M.1    Lithell, H.2    Landsberg, L.3
  • 26
    • 0035050460 scopus 로고    scopus 로고
    • Diabetes, hypertension, and cardiovascular disease: an update
    • Sowers JR, Epstein M, Frohlich ED. Diabetes, hypertension, and cardiovascular disease: an update. Hypertension 2001, 37:1053-1059.
    • (2001) Hypertension , vol.37 , pp. 1053-1059
    • Sowers, J.R.1    Epstein, M.2    Frohlich, E.D.3
  • 27
    • 33847055005 scopus 로고    scopus 로고
    • Fat fuels the flame: triglyceride-rich lipoproteins and arterial inflammation
    • Libby P. Fat fuels the flame: triglyceride-rich lipoproteins and arterial inflammation. Circ Res 2007, 100:299-301.
    • (2007) Circ Res , vol.100 , pp. 299-301
    • Libby, P.1
  • 28
    • 0003687932 scopus 로고    scopus 로고
    • Cardiovascular disease statistics
    • American Heart Association, Available from URL:, Accessed 25 September
    • Cardiovascular disease statistics. 2009, http://www.americanheart.org/presenter.jhtml?identifier=4478, American Heart Association, Available from URL:, Accessed 25 September
    • (2009)
  • 29
    • 0032560807 scopus 로고    scopus 로고
    • Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction
    • Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998, 339:229-234.
    • (1998) N Engl J Med , vol.339 , pp. 229-234
    • Haffner, S.M.1    Lehto, S.2    Ronnemaa, T.3    Pyorala, K.4    Laakso, M.5
  • 30
    • 0037140211 scopus 로고    scopus 로고
    • Comparison of cardiovascular risk between patients with type 2 diabetes and those who had had a myocardial infarction: cross sectional and cohort studies
    • Evans JM, Wang J, Morris AD. Comparison of cardiovascular risk between patients with type 2 diabetes and those who had had a myocardial infarction: cross sectional and cohort studies. BMJ 2002, 324:939-942.
    • (2002) BMJ , vol.324 , pp. 939-942
    • Evans, J.M.1    Wang, J.2    Morris, A.D.3
  • 31
    • 0031819648 scopus 로고    scopus 로고
    • Drug treatment of hypertension complicating diabetes mellitus
    • MacLeod MJ, McLay J. Drug treatment of hypertension complicating diabetes mellitus. Drugs 1998, 56:189-202.
    • (1998) Drugs , vol.56 , pp. 189-202
    • MacLeod, M.J.1    McLay, J.2
  • 32
    • 0037157596 scopus 로고    scopus 로고
    • Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a prospective study
    • Norhammar A, Tenerz A, Nilsson G. Glucose metabolism in patients with acute myocardial infarction and no previous diagnosis of diabetes mellitus: a prospective study. Lancet 2002, 359:2140-2144.
    • (2002) Lancet , vol.359 , pp. 2140-2144
    • Norhammar, A.1    Tenerz, A.2    Nilsson, G.3    et al4
  • 33
    • 0037472879 scopus 로고    scopus 로고
    • Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes
    • Gaede P, Vedel P, Larsen N, Jensen GV, Parving HH, Pedersen O. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med 2003, 348:383-393.
    • (2003) N Engl J Med , vol.348 , pp. 383-393
    • Gaede, P.1    Vedel, P.2    Larsen, N.3    Jensen, G.V.4    Parving, H.H.5    Pedersen, O.6
  • 34
    • 38149140236 scopus 로고    scopus 로고
    • Trends in A1C concentrations among U.S. adults with diagnosed diabetes from 1999 to 2004
    • Ford ES, Li C, Little RR, Mokdad AH. Trends in A1C concentrations among U.S. adults with diagnosed diabetes from 1999 to 2004. Diabetes Care 2008, 31:102-104.
    • (2008) Diabetes Care , vol.31 , pp. 102-104
    • Ford, E.S.1    Li, C.2    Little, R.R.3    Mokdad, A.H.4
  • 35
    • 3042714557 scopus 로고    scopus 로고
    • The burden of treatment failure in type 2 diabetes
    • Brown JB, Nichols GA, Perry A. The burden of treatment failure in type 2 diabetes. Diabetes Care 2004, 27:1535-1540.
    • (2004) Diabetes Care , vol.27 , pp. 1535-1540
    • Brown, J.B.1    Nichols, G.A.2    Perry, A.3
  • 36
    • 40249120466 scopus 로고    scopus 로고
    • Standards of medical care in diabetes - 2008
    • American Diabetes Association
    • Standards of medical care in diabetes - 2008. Diabetes Care 2008, 31(Suppl. 1):S12-S54. American Diabetes Association
    • (2008) Diabetes Care , vol.31 , Issue.SUPPL. 1
  • 38
    • 0017585133 scopus 로고
    • Insulin secretion in obesity and diabetes: an illustrative case
    • Genuth SM. Insulin secretion in obesity and diabetes: an illustrative case. Ann Intern Med 1977, 87:714-716.
    • (1977) Ann Intern Med , vol.87 , pp. 714-716
    • Genuth, S.M.1
  • 39
    • 0037034257 scopus 로고    scopus 로고
    • Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    • Knowler WC, Barrett-Connor E, Fowler SE. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002, 346:393-403.
    • (2002) N Engl J Med , vol.346 , pp. 393-403
    • Knowler, W.C.1    Barrett-Connor, E.2    Fowler, S.E.3    et al4
  • 40
    • 34249864128 scopus 로고    scopus 로고
    • Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial
    • Pi-Sunyer X, Blackburn G, Brancati FL. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care 2007, 30:1374-1383.
    • (2007) Diabetes Care , vol.30 , pp. 1374-1383
    • Pi-Sunyer, X.1    Blackburn, G.2    Brancati, F.L.3    et al4
  • 42
    • 0035804277 scopus 로고    scopus 로고
    • Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group
    • Sacks FM, Svetkey LP, Vollmer WM. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH-Sodium Collaborative Research Group. N Engl J Med 2001, 344:3-10.
    • (2001) N Engl J Med , vol.344 , pp. 3-10
    • Sacks, F.M.1    Svetkey, L.P.2    Vollmer, W.M.3    et al4
  • 44
    • 0037715390 scopus 로고    scopus 로고
    • The management of the obese diabetic patient
    • Albu J, Raja-Khan N. The management of the obese diabetic patient. Prim Care 2003, 30:465-491.
    • (2003) Prim Care , vol.30 , pp. 465-491
    • Albu, J.1    Raja-Khan, N.2
  • 47
    • 34648836960 scopus 로고    scopus 로고
    • Weight-loss outcomes: a systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up
    • Franz MJ, VanWormer JJ, Crain AL. Weight-loss outcomes: a systematic review and meta-analysis of weight-loss clinical trials with a minimum 1-year follow-up. J Am Diet Assoc 2007, 107:1755-1767.
    • (2007) J Am Diet Assoc , vol.107 , pp. 1755-1767
    • Franz, M.J.1    VanWormer, J.J.2    Crain, A.L.3    et al4
  • 49
    • 37249083878 scopus 로고    scopus 로고
    • Long term pharmacotherapy for obesity and overweight: updated meta-analysis
    • Rucker D, Padwal R, Li SK, Curioni C, Lau DC. Long term pharmacotherapy for obesity and overweight: updated meta-analysis. BMJ 2007, 335:1194-1199.
    • (2007) BMJ , vol.335 , pp. 1194-1199
    • Rucker, D.1    Padwal, R.2    Li, S.K.3    Curioni, C.4    Lau, D.C.5
  • 50
    • 52949106040 scopus 로고    scopus 로고
    • Gastric banding or bypass? A systematic review comparing the two most popular bariatric procedures
    • Tice JA, Karliner L, Walsh J, Petersen AJ, Feldman MD. Gastric banding or bypass? A systematic review comparing the two most popular bariatric procedures. Am J Med 2008, 121:885-893.
    • (2008) Am J Med , vol.121 , pp. 885-893
    • Tice, J.A.1    Karliner, L.2    Walsh, J.3    Petersen, A.J.4    Feldman, M.D.5
  • 51
    • 38349136266 scopus 로고    scopus 로고
    • Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial
    • Dixon JB, O'Brien PE, Playfair J. Adjustable gastric banding and conventional therapy for type 2 diabetes: a randomized controlled trial. JAMA 2008, 299:316-323.
    • (2008) JAMA , vol.299 , pp. 316-323
    • Dixon, J.B.1    O'Brien, P.E.2    Playfair, J.3    et al4
  • 52
    • 47549118468 scopus 로고    scopus 로고
    • Long-long limb Roux-en-Y gastric bypass is more efficacious in treatment of type 2 diabetes and lipid disorders in super-obese patients
    • Pinheiro JS, Schiavon CA, Pereira PB, Correa JL, Noujaim P, Cohen R. Long-long limb Roux-en-Y gastric bypass is more efficacious in treatment of type 2 diabetes and lipid disorders in super-obese patients. Surg Obes Relat Dis 2008, 4:521-525.
    • (2008) Surg Obes Relat Dis , vol.4 , pp. 521-525
    • Pinheiro, J.S.1    Schiavon, C.A.2    Pereira, P.B.3    Correa, J.L.4    Noujaim, P.5    Cohen, R.6
  • 53
    • 18544384995 scopus 로고    scopus 로고
    • Laparoscopic adjustable gastric banding for the treatment of morbid (grade 3) obesity and its metabolic complications: a three-year study
    • Pontiroli AE, Pizzocri P, Librenti MC. Laparoscopic adjustable gastric banding for the treatment of morbid (grade 3) obesity and its metabolic complications: a three-year study. J Clin Endocrinol Metab 2002, 87:3555-3561.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3555-3561
    • Pontiroli, A.E.1    Pizzocri, P.2    Librenti, M.C.3    et al4
  • 54
    • 61549094077 scopus 로고    scopus 로고
    • Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis
    • Buchwald H, Estok R, Fahrbach K. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med 2009, 122:248-256.
    • (2009) Am J Med , vol.122 , pp. 248-256
    • Buchwald, H.1    Estok, R.2    Fahrbach, K.3    et al4
  • 55
    • 56549121016 scopus 로고    scopus 로고
    • Results and complications after Swedish adjustable gastric banding in older patients
    • Mittermair RP, Aigner F, Obermuller S. Results and complications after Swedish adjustable gastric banding in older patients. Obes Surg 2008, 18:1558-1562.
    • (2008) Obes Surg , vol.18 , pp. 1558-1562
    • Mittermair, R.P.1    Aigner, F.2    Obermuller, S.3
  • 56
    • 54449099834 scopus 로고    scopus 로고
    • Anemia following Roux-en-Y surgery for morbid obesity: a review
    • Marinella MA. Anemia following Roux-en-Y surgery for morbid obesity: a review. South Med J 2008, 101:1024-1031.
    • (2008) South Med J , vol.101 , pp. 1024-1031
    • Marinella, M.A.1
  • 57
  • 58
    • 43049115660 scopus 로고    scopus 로고
    • Seven cases of gastric perforation in Roux-en-Y gastric bypass patients: what lessons can we learn?
    • Sasse KC, Ganser J, Kozar M. Seven cases of gastric perforation in Roux-en-Y gastric bypass patients: what lessons can we learn? Obes Surg 2008, 18:530-534.
    • (2008) Obes Surg , vol.18 , pp. 530-534
    • Sasse, K.C.1    Ganser, J.2    Kozar, M.3    et al4
  • 59
    • 0015899849 scopus 로고
    • Diet therapy of diabetes: an analysis of failure
    • West KM. Diet therapy of diabetes: an analysis of failure. Ann Intern Med 1973, 79:425-434.
    • (1973) Ann Intern Med , vol.79 , pp. 425-434
    • West, K.M.1
  • 60
    • 0025083284 scopus 로고
    • Prospective Diabetes Study 7: response of fasting plasma glucose to diet therapy in newly presenting type II diabetic patients
    • UKPDS Group, UK
    • Prospective Diabetes Study 7: response of fasting plasma glucose to diet therapy in newly presenting type II diabetic patients. Metabolism 1990, 39:905-912. UKPDS Group, UK
    • (1990) Metabolism , vol.39 , pp. 905-912
  • 61
    • 64749100501 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009, 32:193-203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3    et al4
  • 62
    • 33947636649 scopus 로고    scopus 로고
    • Insulin detemir improves glycaemic control with less hypoglycaemia and no weight gain in patients with type 2 diabetes who were insulin naive or treated with NPH or insulin glargine: clinical practice experience from a German subgroup of the PREDICTIVE study
    • Meneghini LF, Rosenberg KH, Koenen C, Merilainen MJ, Luddeke HJ. Insulin detemir improves glycaemic control with less hypoglycaemia and no weight gain in patients with type 2 diabetes who were insulin naive or treated with NPH or insulin glargine: clinical practice experience from a German subgroup of the PREDICTIVE study. Diabetes Obes Metab 2007, 9:418-427.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 418-427
    • Meneghini, L.F.1    Rosenberg, K.H.2    Koenen, C.3    Merilainen, M.J.4    Luddeke, H.J.5
  • 63
    • 0034630441 scopus 로고    scopus 로고
    • Overweight, obesity, and health risk
    • National Task Force on the Prevention and Treatment of Obesity
    • Overweight, obesity, and health risk. Arch Intern Med 2000, 160:898-904. National Task Force on the Prevention and Treatment of Obesity
    • (2000) Arch Intern Med , vol.160 , pp. 898-904
  • 64
    • 0344604428 scopus 로고    scopus 로고
    • The challenge of diet, exercise and lifestyle modification in the management of the obese diabetic patient
    • Foreyt JP, Poston WS. The challenge of diet, exercise and lifestyle modification in the management of the obese diabetic patient. Int J Obes Relat Metab Disord 1999, 23(Suppl. 7):S5-S11.
    • (1999) Int J Obes Relat Metab Disord , vol.23 , Issue.SUPPL. 7
    • Foreyt, J.P.1    Poston, W.S.2
  • 65
    • 34548609993 scopus 로고    scopus 로고
    • Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus
    • Bolen S, Feldman L, Vassy J. Systematic review: comparative effectiveness and safety of oral medications for type 2 diabetes mellitus. Ann Intern Med 2007, 147:386-399.
    • (2007) Ann Intern Med , vol.147 , pp. 386-399
    • Bolen, S.1    Feldman, L.2    Vassy, J.3    et al4
  • 66
    • 36049005288 scopus 로고    scopus 로고
    • Short-term economic impact of body weight change among patients with type 2 diabetes treated with antidiabetic agents: analysis using claims, laboratory, and medical record data
    • Yu AP, Wu EQ, Birnbaum HG. Short-term economic impact of body weight change among patients with type 2 diabetes treated with antidiabetic agents: analysis using claims, laboratory, and medical record data. Curr Med Res Opin 2007, 23:2157-2169.
    • (2007) Curr Med Res Opin , vol.23 , pp. 2157-2169
    • Yu, A.P.1    Wu, E.Q.2    Birnbaum, H.G.3    et al4
  • 67
    • 34147109354 scopus 로고    scopus 로고
    • Relationship between patient medication adherence and subsequent clinical inertia in type 2 diabetes glycemic management
    • Grant R, Adams AS, Trinacty CM. Relationship between patient medication adherence and subsequent clinical inertia in type 2 diabetes glycemic management. Diabetes Care 2007, 30:807-812.
    • (2007) Diabetes Care , vol.30 , pp. 807-812
    • Grant, R.1    Adams, A.S.2    Trinacty, C.M.3    et al4
  • 68
    • 23944459590 scopus 로고    scopus 로고
    • Clinical inertia contributes to poor diabetes control in a primary care setting
    • Ziemer DC, Miller CD, Rhee MK. Clinical inertia contributes to poor diabetes control in a primary care setting. Diabetes Educ 2005, 31:564-571.
    • (2005) Diabetes Educ , vol.31 , pp. 564-571
    • Ziemer, D.C.1    Miller, C.D.2    Rhee, M.K.3    et al4
  • 69
    • 41949084607 scopus 로고    scopus 로고
    • The changing landscape of type 2 diabetes: the role of incretin-based therapies in managed care outcomes
    • Triplitt C, McGill JB, Porte D, Conner CS. The changing landscape of type 2 diabetes: the role of incretin-based therapies in managed care outcomes. J Manag Care Pharm 2007, 13:S2-S16.
    • (2007) J Manag Care Pharm , vol.13
    • Triplitt, C.1    McGill, J.B.2    Porte, D.3    Conner, C.S.4
  • 70
    • 0032511583 scopus 로고    scopus 로고
    • UKPDS Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UKPDS Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998, 352:837-853. UK Prospective Diabetes Study (UKPDS) Group
    • (1998) Lancet , vol.352 , pp. 837-853
  • 71
    • 45149133036 scopus 로고    scopus 로고
    • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    • Patel A, MacMahon S, Chalmers J. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008, 358:2560-2572.
    • (2008) N Engl J Med , vol.358 , pp. 2560-2572
    • Patel, A.1    MacMahon, S.2    Chalmers, J.3    et al4
  • 72
    • 45149131667 scopus 로고    scopus 로고
    • Effects of intensive glucose lowering in type 2 diabetes
    • Gerstein HC, Miller ME, Byington RP. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med 2008, 358:2545-2559.
    • (2008) N Engl J Med , vol.358 , pp. 2545-2559
    • Gerstein, H.C.1    Miller, M.E.2    Byington, R.P.3    et al4
  • 73
    • 45149118855 scopus 로고    scopus 로고
    • Intensive glycemic control in the ACCORD and ADVANCE trials
    • Dluhy RG, McMahon GT. Intensive glycemic control in the ACCORD and ADVANCE trials. N Engl J Med 2008, 358:2630-2633.
    • (2008) N Engl J Med , vol.358 , pp. 2630-2633
    • Dluhy, R.G.1    McMahon, G.T.2
  • 74
    • 45149119142 scopus 로고    scopus 로고
    • Redefining quality - implications of recent clinical trials
    • Krumholz HM, Lee TH. Redefining quality - implications of recent clinical trials. N Engl J Med 2008, 358:2537-2539.
    • (2008) N Engl J Med , vol.358 , pp. 2537-2539
    • Krumholz, H.M.1    Lee, T.H.2
  • 75
    • 65649106228 scopus 로고    scopus 로고
    • Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials
    • Ray KK, Seshasai SR, Wijesuriya S. Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials. Lancet 2009, 373:1765-1772.
    • (2009) Lancet , vol.373 , pp. 1765-1772
    • Ray, K.K.1    Seshasai, S.R.2    Wijesuriya, S.3    et al4
  • 76
    • 0037116638 scopus 로고    scopus 로고
    • Oral antihyperglycemic therapy for type 2 diabetes: scientific review
    • Inzucchi SE. Oral antihyperglycemic therapy for type 2 diabetes: scientific review. JAMA 2002, 287:360-372.
    • (2002) JAMA , vol.287 , pp. 360-372
    • Inzucchi, S.E.1
  • 77
    • 34347407551 scopus 로고    scopus 로고
    • Effect of rosiglitazone on factors related to endothelial dysfunction in patients with type 2 diabetes mellitus
    • Albertini JP, McMorn SO, Chen H, Mather RA, Valensi P. Effect of rosiglitazone on factors related to endothelial dysfunction in patients with type 2 diabetes mellitus. Atherosclerosis 2007, 195:e159-e166.
    • (2007) Atherosclerosis , vol.195
    • Albertini, J.P.1    McMorn, S.O.2    Chen, H.3    Mather, R.A.4    Valensi, P.5
  • 78
    • 0026659006 scopus 로고
    • Sulfonylureas in NIDDM
    • Groop LC. Sulfonylureas in NIDDM. Diabetes Care 1992, 15:737-754.
    • (1992) Diabetes Care , vol.15 , pp. 737-754
    • Groop, L.C.1
  • 80
    • 67650057935 scopus 로고    scopus 로고
    • A long-acting GLP-1 analogue attenuates induction of PAI-1 and vascular adhesion molecules
    • Liu H, Dear AE, Knudsen LB, Simpson RW. A long-acting GLP-1 analogue attenuates induction of PAI-1 and vascular adhesion molecules. J Endocrinol 2009, 201:59-66.
    • (2009) J Endocrinol , vol.201 , pp. 59-66
    • Liu, H.1    Dear, A.E.2    Knudsen, L.B.3    Simpson, R.W.4
  • 81
    • 2542479374 scopus 로고    scopus 로고
    • Repaglinide versus nateglinide monotherapy: a randomized, multicenter study
    • Rosenstock J, Hassman DR, Madder RD. Repaglinide versus nateglinide monotherapy: a randomized, multicenter study. Diabetes Care 2004, 27:1265-1270.
    • (2004) Diabetes Care , vol.27 , pp. 1265-1270
    • Rosenstock, J.1    Hassman, D.R.2    Madder, R.D.3    et al4
  • 82
    • 0033754530 scopus 로고    scopus 로고
    • Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: a 6-month randomized placebo-controlled dose-response study
    • The Pioglitazone 001 Study Group
    • Aronoff S, Rosenblatt S, Braithwaite S, Egan JW, Mathisen AL, Schneider RL. Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: a 6-month randomized placebo-controlled dose-response study. Diabetes Care 2000, 23:1605-1611. The Pioglitazone 001 Study Group
    • (2000) Diabetes Care , vol.23 , pp. 1605-1611
    • Aronoff, S.1    Rosenblatt, S.2    Braithwaite, S.3    Egan, J.W.4    Mathisen, A.L.5    Schneider, R.L.6
  • 83
    • 33845472504 scopus 로고    scopus 로고
    • Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
    • Aschner P, Kipnes MS, Lunceford JK, Sanchez M, Mickel C, Williams-Herman DE. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care 2006, 29:2632-2637.
    • (2006) Diabetes Care , vol.29 , pp. 2632-2637
    • Aschner, P.1    Kipnes, M.S.2    Lunceford, J.K.3    Sanchez, M.4    Mickel, C.5    Williams-Herman, D.E.6
  • 84
    • 33748442464 scopus 로고    scopus 로고
    • Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
    • Blonde L, Klein EJ, Han J. Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes Obes Metab 2006, 8:436-447.
    • (2006) Diabetes Obes Metab , vol.8 , pp. 436-447
    • Blonde, L.1    Klein, E.J.2    Han, J.3    et al4
  • 85
    • 34147093268 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    • Bosi E, Camisasca RP, Collober C, Rochotte E, Garber AJ. Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin. Diabetes Care 2007, 30:890-895.
    • (2007) Diabetes Care , vol.30 , pp. 890-895
    • Bosi, E.1    Camisasca, R.P.2    Collober, C.3    Rochotte, E.4    Garber, A.J.5
  • 86
    • 33845476757 scopus 로고    scopus 로고
    • Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
    • Charbonnel B, Karasik A, Liu J, Wu M, Meininger G. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care 2006, 29:2638-2643.
    • (2006) Diabetes Care , vol.29 , pp. 2638-2643
    • Charbonnel, B.1    Karasik, A.2    Liu, J.3    Wu, M.4    Meininger, G.5
  • 87
    • 0038455703 scopus 로고    scopus 로고
    • Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial
    • Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M. Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial. JAMA 2003, 290:486-494.
    • (2003) JAMA , vol.290 , pp. 486-494
    • Chiasson, J.L.1    Josse, R.G.2    Gomis, R.3    Hanefeld, M.4    Karasik, A.5    Laakso, M.6
  • 88
    • 50649110233 scopus 로고    scopus 로고
    • Beneficial effects of once-daily liraglutide, a human glucagon-like peptide-1 analogue, on cardiovascular risk biomarkers in patients with Type 2 diabetes
    • Courreges JP, Vilsboll T, Zdravkovic M. Beneficial effects of once-daily liraglutide, a human glucagon-like peptide-1 analogue, on cardiovascular risk biomarkers in patients with Type 2 diabetes. Diabet Med 2008, 25:1129-1132.
    • (2008) Diabet Med , vol.25 , pp. 1129-1132
    • Courreges, J.P.1    Vilsboll, T.2    Zdravkovic, M.3    et al4
  • 89
    • 0029099086 scopus 로고
    • Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus
    • The Multicenter Metformin Study Group
    • DeFronzo RA, Goodman AM. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. N Engl J Med 1995, 333:541-549. The Multicenter Metformin Study Group
    • (1995) N Engl J Med , vol.333 , pp. 541-549
    • DeFronzo, R.A.1    Goodman, A.M.2
  • 91
    • 38849168916 scopus 로고    scopus 로고
    • Improvement of glycaemic control by nateglinide decreases systolic blood pressure in drug-naive patients with type 2 diabetes
    • Gonzalez-Clemente JM. Improvement of glycaemic control by nateglinide decreases systolic blood pressure in drug-naive patients with type 2 diabetes. Eur J Clin Invest 2008, 38:174-179.
    • (2008) Eur J Clin Invest , vol.38 , pp. 174-179
    • Gonzalez-Clemente, J.M.1
  • 92
    • 12744274870 scopus 로고    scopus 로고
    • Lower within-subject variability of fasting blood glucose and reduced weight gain with insulin detemir compared to NPH insulin in patients with type 2 diabetes
    • Haak T, Tiengo A, Draeger E, Suntum M, Waldhausl W. Lower within-subject variability of fasting blood glucose and reduced weight gain with insulin detemir compared to NPH insulin in patients with type 2 diabetes. Diabetes Obes Metab 2005, 7:56-64.
    • (2005) Diabetes Obes Metab , vol.7 , pp. 56-64
    • Haak, T.1    Tiengo, A.2    Draeger, E.3    Suntum, M.4    Waldhausl, W.5
  • 93
    • 33746391488 scopus 로고    scopus 로고
    • A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes
    • Hermansen K, Davies M, Derezinski T, Martinez RG, Clauson P, Home P. A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes. Diabetes Care 2006, 29:1269-1274.
    • (2006) Diabetes Care , vol.29 , pp. 1269-1274
    • Hermansen, K.1    Davies, M.2    Derezinski, T.3    Martinez, R.G.4    Clauson, P.5    Home, P.6
  • 94
    • 0032929173 scopus 로고    scopus 로고
    • Efficacy of metformin in the treatment of NIDDM. Meta-analysis
    • Johansen K. Efficacy of metformin in the treatment of NIDDM. Meta-analysis. Diabetes Care 1999, 22:33-37.
    • (1999) Diabetes Care , vol.22 , pp. 33-37
    • Johansen, K.1
  • 96
    • 43149110575 scopus 로고    scopus 로고
    • Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes
    • Lund SS, Tarnow L, Stehouwer CD. Impact of metformin versus repaglinide on non-glycaemic cardiovascular risk markers related to inflammation and endothelial dysfunction in non-obese patients with type 2 diabetes. Eur J Endocrinol 2008, 158:631-641.
    • (2008) Eur J Endocrinol , vol.158 , pp. 631-641
    • Lund, S.S.1    Tarnow, L.2    Stehouwer, C.D.3    et al4
  • 97
    • 12844272095 scopus 로고    scopus 로고
    • Repaglinide administration improves brachial reactivity in type 2 diabetic patients
    • Manzella D, Grella R, Abbatecola AM, Paolisso G. Repaglinide administration improves brachial reactivity in type 2 diabetic patients. Diabetes Care 2005, 28:366-371.
    • (2005) Diabetes Care , vol.28 , pp. 366-371
    • Manzella, D.1    Grella, R.2    Abbatecola, A.M.3    Paolisso, G.4
  • 99
    • 0035312620 scopus 로고    scopus 로고
    • Improved endothelial function with metformin in type 2 diabetes mellitus
    • Mather KJ, Verma S, Anderson TJ. Improved endothelial function with metformin in type 2 diabetes mellitus. J Am Coll Cardiol 2001, 37:1344-1350.
    • (2001) J Am Coll Cardiol , vol.37 , pp. 1344-1350
    • Mather, K.J.1    Verma, S.2    Anderson, T.J.3
  • 100
    • 41849099939 scopus 로고    scopus 로고
    • Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild to moderate hypertension
    • Mistry GC, Maes AL, Lasseter KC. Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on blood pressure in nondiabetic patients with mild to moderate hypertension. J Clin Pharmacol 2008, 48:592-598.
    • (2008) J Clin Pharmacol , vol.48 , pp. 592-598
    • Mistry, G.C.1    Maes, A.L.2    Lasseter, K.C.3    et al4
  • 101
    • 51549095571 scopus 로고    scopus 로고
    • Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study
    • Moretto TJ, Milton DR, Ridge TD. Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 2008, 30:1448-1460.
    • (2008) Clin Ther , vol.30 , pp. 1448-1460
    • Moretto, T.J.1    Milton, D.R.2    Ridge, T.D.3    et al4
  • 102
    • 33846905487 scopus 로고    scopus 로고
    • Efficacy and tolerability of vildagliptin monotherapy in drug-naive patients with type 2 diabetes
    • Pi-Sunyer FX, Schweizer A, Mills D, Dejager S. Efficacy and tolerability of vildagliptin monotherapy in drug-naive patients with type 2 diabetes. Diabetes Res Clin Pract 2007, 76:132-138.
    • (2007) Diabetes Res Clin Pract , vol.76 , pp. 132-138
    • Pi-Sunyer, F.X.1    Schweizer, A.2    Mills, D.3    Dejager, S.4
  • 103
    • 33645823198 scopus 로고    scopus 로고
    • A meta-analysis of the effect of thiazolidinediones on blood pressure
    • Qayyum R, Adomaityte J. A meta-analysis of the effect of thiazolidinediones on blood pressure. J Clin Hypertens (Greenwich) 2006, 8:19-28.
    • (2006) J Clin Hypertens (Greenwich) , vol.8 , pp. 19-28
    • Qayyum, R.1    Adomaityte, J.2
  • 104
    • 33947302393 scopus 로고    scopus 로고
    • Insulin detemir results in less weight gain than NPH insulin when used in basal-bolus therapy for type 2 diabetes mellitus, and this advantage increases with baseline body mass index
    • Raslova K, Tamer SC, Clauson P, Karl D. Insulin detemir results in less weight gain than NPH insulin when used in basal-bolus therapy for type 2 diabetes mellitus, and this advantage increases with baseline body mass index. Clin Drug Investig 2007, 27:279-285.
    • (2007) Clin Drug Investig , vol.27 , pp. 279-285
    • Raslova, K.1    Tamer, S.C.2    Clauson, P.3    Karl, D.4
  • 105
    • 33846827085 scopus 로고    scopus 로고
    • Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes
    • Rosenstock J, Baron MA, Camisasca RP, Cressier F, Couturier A, Dejager S. Efficacy and tolerability of initial combination therapy with vildagliptin and pioglitazone compared with component monotherapy in patients with type 2 diabetes. Diabetes Obes Metab 2007, 9:175-185.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 175-185
    • Rosenstock, J.1    Baron, M.A.2    Camisasca, R.P.3    Cressier, F.4    Couturier, A.5    Dejager, S.6
  • 106
    • 38149096290 scopus 로고    scopus 로고
    • Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance
    • Rosenstock J, Foley JE, Rendell M. Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance. Diabetes Care 2008, 31:30-35.
    • (2008) Diabetes Care , vol.31 , pp. 30-35
    • Rosenstock, J.1    Foley, J.E.2    Rendell, M.3    et al4
  • 107
    • 68849126118 scopus 로고    scopus 로고
    • The once-daily human glucagon-like peptide-1 analog liraglutide reduces bodyweight in subjects with type 2 diabetes, irrespective of body mass index at baseline
    • Russell-Jones DS, Shaw J, Brandle M. The once-daily human glucagon-like peptide-1 analog liraglutide reduces bodyweight in subjects with type 2 diabetes, irrespective of body mass index at baseline. Diabetes 2008, 57:A593-A594.
    • (2008) Diabetes , vol.57
    • Russell-Jones, D.S.1    Shaw, J.2    Brandle, M.3    et al4
  • 108
    • 34249869806 scopus 로고    scopus 로고
    • Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes
    • Vilsboll T, Zdravkovic M, Le Thi T. Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes. Diabetes Care 2007, 30:1608-1610.
    • (2007) Diabetes Care , vol.30 , pp. 1608-1610
    • Vilsboll, T.1    Zdravkovic, M.2    Le Thi, T.3    et al4
  • 109
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber A, Henry R, Ratner R. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 2009, 373:473-481.
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3    et al4
  • 110
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial
    • Russell-Jones D, Vaag A, Schmitz O. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial. Diabetologia 2009, 52:2046-2055.
    • (2009) Diabetologia , vol.52 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3    et al4
  • 111
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • Buse JB, Henry RR, Han J, Kim DD, Fineman MS, Baron AD. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 2004, 27:2628-2635.
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 112
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 2005, 28:1092-1100.
    • (2005) Diabetes Care , vol.28 , pp. 1092-1100
    • DeFronzo, R.A.1    Ratner, R.E.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 113
    • 0028817815 scopus 로고
    • U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease
    • U.K. Prospective Diabetes Study Group (UKPDS)
    • U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes 1995, 44:1249-1258. U.K. Prospective Diabetes Study Group (UKPDS)
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 115
    • 2942605695 scopus 로고    scopus 로고
    • An increase in insulin sensitivity and basal beta-cell function in diabetic subjects treated with pioglitazone in a placebo-controlled randomized study
    • Wallace TM, Levy JC, Matthews DR. An increase in insulin sensitivity and basal beta-cell function in diabetic subjects treated with pioglitazone in a placebo-controlled randomized study. Diabet Med 2004, 21:568-576.
    • (2004) Diabet Med , vol.21 , pp. 568-576
    • Wallace, T.M.1    Levy, J.C.2    Matthews, D.R.3
  • 116
    • 54249106294 scopus 로고    scopus 로고
    • Effects of vildagliptin on glucose control in patients with type 2 diabetes inadequately controlled with a sulphonylurea
    • Garber AJ, Foley JE, Banerji MA. Effects of vildagliptin on glucose control in patients with type 2 diabetes inadequately controlled with a sulphonylurea. Diabetes Obes Metab 2008, 10:1047-1056.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 1047-1056
    • Garber, A.J.1    Foley, J.E.2    Banerji, M.A.3    et al4
  • 117
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study
    • Nauck M, Frid A, Hermansen K. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study. Diabetes Care 2009, 32:84-90.
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3    et al4
  • 118
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)
    • Marre M, Shaw J, Brandle M. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU). Diabet Med 2009, 26:268-278.
    • (2009) Diabet Med , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brandle, M.3    et al4
  • 119
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    • Zinman B, Gerich J, Buse JB. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care 2009, 32:1224-1230.
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3    et al4
  • 120
    • 8944248809 scopus 로고    scopus 로고
    • Effect of metformin on intact proinsulin and des 31,32 proinsulin concentrations in subjects with non-insulin-dependent (type 2) diabetes mellitus
    • Nagi DK, Ali VM, Yudkin JS. Effect of metformin on intact proinsulin and des 31,32 proinsulin concentrations in subjects with non-insulin-dependent (type 2) diabetes mellitus. Diabet Med 1996, 13:753-757.
    • (1996) Diabet Med , vol.13 , pp. 753-757
    • Nagi, D.K.1    Ali, V.M.2    Yudkin, J.S.3
  • 121
    • 33646941576 scopus 로고    scopus 로고
    • Long-term efficacy of sulfonylureas: a United Kingdom Prospective Diabetes Study perspective
    • Holman RR. Long-term efficacy of sulfonylureas: a United Kingdom Prospective Diabetes Study perspective. Metabolism 2006, 55:S2-S5.
    • (2006) Metabolism , vol.55
    • Holman, R.R.1
  • 122
    • 34347379097 scopus 로고    scopus 로고
    • Improvement of insulin sensitivity and beta-cell function by nateglinide and repaglinide in type 2 diabetic patients - a randomized controlled double-blind and double-dummy multicentre clinical trial
    • Li J, Tian H, Li Q. Improvement of insulin sensitivity and beta-cell function by nateglinide and repaglinide in type 2 diabetic patients - a randomized controlled double-blind and double-dummy multicentre clinical trial. Diabetes Obes Metab 2007, 9:558-565.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 558-565
    • Li, J.1    Tian, H.2    Li, Q.3    et al4
  • 123
    • 6044253702 scopus 로고    scopus 로고
    • Effect of lowering postprandial hyperglycemia on insulin secretion in older people with impaired glucose tolerance
    • Chang AM, Smith MJ, Bloem CJ, Galecki AT, Halter JB. Effect of lowering postprandial hyperglycemia on insulin secretion in older people with impaired glucose tolerance. Am J Physiol Endocrinol Metab 2004, 287:E906-E911.
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Chang, A.M.1    Smith, M.J.2    Bloem, C.J.3    Galecki, A.T.4    Halter, J.B.5
  • 124
    • 0025823825 scopus 로고
    • Therapeutic potentials of acarbose as first-line drug in NIDDM insufficiently treated with diet alone
    • Hanefeld M, Fischer S, Schulze J. Therapeutic potentials of acarbose as first-line drug in NIDDM insufficiently treated with diet alone. Diabetes Care 1991, 14:732-737.
    • (1991) Diabetes Care , vol.14 , pp. 732-737
    • Hanefeld, M.1    Fischer, S.2    Schulze, J.3    et al4
  • 125
    • 43849105857 scopus 로고    scopus 로고
    • Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial
    • Weng J, Li Y, Xu W. Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial. Lancet 2008, 371:1753-1760.
    • (2008) Lancet , vol.371 , pp. 1753-1760
    • Weng, J.1    Li, Y.2    Xu, W.3    et al4
  • 126
    • 34247259577 scopus 로고    scopus 로고
    • The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial
    • Zinman B, Hoogwerf BJ, Duran GS. The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial. Ann Intern Med 2007, 146:477-485.
    • (2007) Ann Intern Med , vol.146 , pp. 477-485
    • Zinman, B.1    Hoogwerf, B.J.2    Duran, G.S.3    et al4
  • 127
    • 34250636401 scopus 로고    scopus 로고
    • Antidiabetic medications in overweight/ obese patients with type 2 diabetes: drawbacks of current drugs and potential advantages of incretin-based treatment on body weight
    • Bonora E. Antidiabetic medications in overweight/ obese patients with type 2 diabetes: drawbacks of current drugs and potential advantages of incretin-based treatment on body weight. Int J Clin Pract Suppl 2007, 154:19-28.
    • (2007) Int J Clin Pract Suppl , vol.154 , pp. 19-28
    • Bonora, E.1
  • 128
    • 77954350889 scopus 로고    scopus 로고
    • Glucophage [package insert]. Princeton, NJ: Bristol-Myers Squibb;
    • 2008, Glucophage [package insert]. Princeton, NJ: Bristol-Myers Squibb;
    • (2008)
  • 129
    • 43749110965 scopus 로고    scopus 로고
    • Non-insulin antidiabetic therapy in cardiac patients: current problems and future prospects
    • Fisman EZ, Motro M, Tenenbaum A. Non-insulin antidiabetic therapy in cardiac patients: current problems and future prospects. Adv Cardiol 2008, 45:154-170.
    • (2008) Adv Cardiol , vol.45 , pp. 154-170
    • Fisman, E.Z.1    Motro, M.2    Tenenbaum, A.3
  • 130
    • 0032568257 scopus 로고    scopus 로고
    • Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus
    • Inzucchi SE, Maggs DG, Spollett GR. Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus. N Engl J Med 1998, 338:867-872.
    • (1998) N Engl J Med , vol.338 , pp. 867-872
    • Inzucchi, S.E.1    Maggs, D.G.2    Spollett, G.R.3    et al4
  • 131
    • 0033673203 scopus 로고    scopus 로고
    • Mechanism by which metformin reduces glucose production in type 2 diabetes
    • Hundal RS, Krssak M, Dufour S. Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes 2000, 49:2063-2069.
    • (2000) Diabetes , vol.49 , pp. 2063-2069
    • Hundal, R.S.1    Krssak, M.2    Dufour, S.3    et al4
  • 132
    • 9544247850 scopus 로고    scopus 로고
    • The effect of metformin on the metabolic abnormalities associated with upper-body fat distribution
    • BIGPRO Study Group
    • Fontbonne A, Charles MA, Juhan-Vague I. The effect of metformin on the metabolic abnormalities associated with upper-body fat distribution. Diabetes Care 1996, 19:920-926. BIGPRO Study Group
    • (1996) Diabetes Care , vol.19 , pp. 920-926
    • Fontbonne, A.1    Charles, M.A.2    Juhan-Vague, I.3    et al4
  • 133
    • 33747879300 scopus 로고    scopus 로고
    • Effects of metformin on microvascular function and exercise tolerance in women with angina and normal coronary arteries: a randomized, double-blind, placebo-controlled study
    • Jadhav S, Ferrell W, Greer IA, Petrie JR, Cobbe SM, Sattar N. Effects of metformin on microvascular function and exercise tolerance in women with angina and normal coronary arteries: a randomized, double-blind, placebo-controlled study. J Am Coll Cardiol 2006, 48:956-963.
    • (2006) J Am Coll Cardiol , vol.48 , pp. 956-963
    • Jadhav, S.1    Ferrell, W.2    Greer, I.A.3    Petrie, J.R.4    Cobbe, S.M.5    Sattar, N.6
  • 135
    • 45949085098 scopus 로고    scopus 로고
    • A comparison of select cardiovascular outcomes by antidiabetic prescription drug classes used to treat type 2 diabetes among Military Health System beneficiaries, fiscal year 2003-2006
    • Casscells SW, Granger E, Swedorske J. A comparison of select cardiovascular outcomes by antidiabetic prescription drug classes used to treat type 2 diabetes among Military Health System beneficiaries, fiscal year 2003-2006. Am J Ther 2008, 15:198-205.
    • (2008) Am J Ther , vol.15 , pp. 198-205
    • Casscells, S.W.1    Granger, E.2    Swedorske, J.3    et al4
  • 137
    • 34548603259 scopus 로고    scopus 로고
    • Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review
    • Eurich DT, McAlister FA, Blackburn DF. Benefits and harms of antidiabetic agents in patients with diabetes and heart failure: systematic review. BMJ 2007, 335:497.
    • (2007) BMJ , vol.335 , pp. 497
    • Eurich, D.T.1    McAlister, F.A.2    Blackburn, D.F.3    et al4
  • 138
    • 0036367614 scopus 로고    scopus 로고
    • Adherence to oral hypoglycaemic agents prior to insulin therapy in Type 2 diabetes
    • Evans JM, Donnan PT, Morris AD. Adherence to oral hypoglycaemic agents prior to insulin therapy in Type 2 diabetes. Diabet Med 2002, 19:685-688.
    • (2002) Diabet Med , vol.19 , pp. 685-688
    • Evans, J.M.1    Donnan, P.T.2    Morris, A.D.3
  • 140
    • 0020646930 scopus 로고
    • Malabsorption of vitamin B12 and intrinsic factor secretion during biguanide therapy
    • Adams JF, Clark JS, Ireland JT, Kesson CM, Watson WS. Malabsorption of vitamin B12 and intrinsic factor secretion during biguanide therapy. Diabetologia 1983, 24:16-18.
    • (1983) Diabetologia , vol.24 , pp. 16-18
    • Adams, J.F.1    Clark, J.S.2    Ireland, J.T.3    Kesson, C.M.4    Watson, W.S.5
  • 141
    • 0036369165 scopus 로고    scopus 로고
    • Insulin secretagogues
    • Davies MJ. Insulin secretagogues. Curr Med Res Opin 2002, 18(Suppl. 1):s22-s30.
    • (2002) Curr Med Res Opin , vol.18 , Issue.SUPPL. 1
    • Davies, M.J.1
  • 142
    • 49649098865 scopus 로고    scopus 로고
    • Is the combination of sulfonylureas and metformin associated with an increased risk of cardiovascular disease or all-cause mortality? A meta-analysis of observational studies
    • Rao AD, Kuhadiya N, Reynolds K, Fonseca VA. Is the combination of sulfonylureas and metformin associated with an increased risk of cardiovascular disease or all-cause mortality? A meta-analysis of observational studies. Diabetes Care 2008, 31:1672-1678.
    • (2008) Diabetes Care , vol.31 , pp. 1672-1678
    • Rao, A.D.1    Kuhadiya, N.2    Reynolds, K.3    Fonseca, V.A.4
  • 143
    • 63649097810 scopus 로고    scopus 로고
    • Effects of the alpha glucosidase inhibitor acarbose on endothelial function after a mixed meal in newly diagnosed type 2 diabetes
    • Pistrosch F, Schaper F, Passauer J, Koehler C, Bornstein SR, Hanefeld M. Effects of the alpha glucosidase inhibitor acarbose on endothelial function after a mixed meal in newly diagnosed type 2 diabetes. Horm Metab Res 2009, 41:104-108.
    • (2009) Horm Metab Res , vol.41 , pp. 104-108
    • Pistrosch, F.1    Schaper, F.2    Passauer, J.3    Koehler, C.4    Bornstein, S.R.5    Hanefeld, M.6
  • 144
    • 84878665051 scopus 로고    scopus 로고
    • University of Oxford Diabetes Trials Unit (DTU)
    • Acarbose Cardiovascular Evaluation (ACE) study, Available from URL:, Accessed 14 September
    • University of Oxford Diabetes Trials Unit (DTU). 2009, http://www.dtu.ox.ac.uk/index.php?maindoc=/ace/overview/php, Acarbose Cardiovascular Evaluation (ACE) study, Available from URL:, Accessed 14 September
    • (2009)
  • 147
    • 12344316682 scopus 로고    scopus 로고
    • Thiazolidinediones: a review of their mechanisms of insulin sensitization, therapeutic potential, clinical efficacy, and tolerability
    • Vasudevan AR, Balasubramanyam A. Thiazolidinediones: a review of their mechanisms of insulin sensitization, therapeutic potential, clinical efficacy, and tolerability. Diabetes Technol Ther 2004, 6:850-863.
    • (2004) Diabetes Technol Ther , vol.6 , pp. 850-863
    • Vasudevan, A.R.1    Balasubramanyam, A.2
  • 148
    • 33845537033 scopus 로고    scopus 로고
    • Weight changes following the initiation of new anti-hyperglycaemic therapies
    • Nichols GA, Gomez-Caminero A. Weight changes following the initiation of new anti-hyperglycaemic therapies. Diabetes Obes Metab 2007, 9:96-102.
    • (2007) Diabetes Obes Metab , vol.9 , pp. 96-102
    • Nichols, G.A.1    Gomez-Caminero, A.2
  • 149
    • 42749101870 scopus 로고    scopus 로고
    • Diabetes, TZDs, and bone: a review of the clinical evidence
    • Schwartz AV. Diabetes, TZDs, and bone: a review of the clinical evidence. PPAR Res 2006, 2006:24502.
    • (2006) PPAR Res , vol.2006 , pp. 24502
    • Schwartz, A.V.1
  • 150
    • 37749034527 scopus 로고    scopus 로고
    • Skeletal consequences of thiazolidinedione therapy
    • Grey A. Skeletal consequences of thiazolidinedione therapy. Osteoporos Int 2008, 19:129-137.
    • (2008) Osteoporos Int , vol.19 , pp. 129-137
    • Grey, A.1
  • 152
    • 3543018475 scopus 로고    scopus 로고
    • Troglitazone in combination with sulfonylurea restores glycemic control in patients with type 2 diabetes
    • The Troglitazone Study Group
    • Horton ES, Whitehouse F, Ghazzi MN, Venable TC, Whitcomb RW. Troglitazone in combination with sulfonylurea restores glycemic control in patients with type 2 diabetes. Diabetes Care 1998, 21:1462-1469. The Troglitazone Study Group
    • (1998) Diabetes Care , vol.21 , pp. 1462-1469
    • Horton, E.S.1    Whitehouse, F.2    Ghazzi, M.N.3    Venable, T.C.4    Whitcomb, R.W.5
  • 153
    • 21444460136 scopus 로고    scopus 로고
    • The effect of metformin and rosiglitazone on postprandial lipid metabolism in obese insulin-resistant subjects
    • James AP, Watts GF, Mamo JC. The effect of metformin and rosiglitazone on postprandial lipid metabolism in obese insulin-resistant subjects. Diabetes Obes Metab 2005, 7:381-389.
    • (2005) Diabetes Obes Metab , vol.7 , pp. 381-389
    • James, A.P.1    Watts, G.F.2    Mamo, J.C.3
  • 154
    • 21544466158 scopus 로고    scopus 로고
    • A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia
    • Goldberg RB, Kendall DM, Deeg MA. A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia. Diabetes Care 2005, 28:1547-1554.
    • (2005) Diabetes Care , vol.28 , pp. 1547-1554
    • Goldberg, R.B.1    Kendall, D.M.2    Deeg, M.A.3    et al4
  • 155
    • 34447643245 scopus 로고    scopus 로고
    • Differential effect of pioglitazone (PGZ) and rosiglitazone (RGZ) on postprandial glucose and lipid metabolism in patients with type 2 diabetes mellitus: a prospective, randomized crossover study
    • Chappuis B, Braun M, Stettler C. Differential effect of pioglitazone (PGZ) and rosiglitazone (RGZ) on postprandial glucose and lipid metabolism in patients with type 2 diabetes mellitus: a prospective, randomized crossover study. Diabetes Metab Res Rev 2007, 23:392-399.
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 392-399
    • Chappuis, B.1    Braun, M.2    Stettler, C.3    et al4
  • 156
    • 43249083632 scopus 로고    scopus 로고
    • Dissociation between the insulin-sensitizing effect of rosiglitazone and its effect on hepatic and intestinal lipoprotein production
    • Duez H, Lamarche B, Uffelman KD. Dissociation between the insulin-sensitizing effect of rosiglitazone and its effect on hepatic and intestinal lipoprotein production. J Clin Endocrinol Metab 2008, 93:1722-1729.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1722-1729
    • Duez, H.1    Lamarche, B.2    Uffelman, K.D.3    et al4
  • 157
    • 0036551421 scopus 로고    scopus 로고
    • A prospective, randomized comparison of the metabolic effects of pioglitazone or rosiglitazone in patients with type 2 diabetes who were previously treated with troglitazone
    • Khan MA, St PJ, Xue JL. A prospective, randomized comparison of the metabolic effects of pioglitazone or rosiglitazone in patients with type 2 diabetes who were previously treated with troglitazone. Diabetes Care 2002, 25:708-711.
    • (2002) Diabetes Care , vol.25 , pp. 708-711
    • Khan, M.A.1    St, P.J.2    Xue, J.L.3
  • 158
    • 0036203666 scopus 로고    scopus 로고
    • Effects of pioglitazone and rosiglitazone on blood lipid levels and glycemic control in patients with type 2 diabetes mellitus: a retrospective review of randomly selected medical records
    • Boyle PJ, King AB, Olansky L. Effects of pioglitazone and rosiglitazone on blood lipid levels and glycemic control in patients with type 2 diabetes mellitus: a retrospective review of randomly selected medical records. Clin Ther 2002, 24:378-396.
    • (2002) Clin Ther , vol.24 , pp. 378-396
    • Boyle, P.J.1    King, A.B.2    Olansky, L.3    et al4
  • 160
    • 0034126428 scopus 로고    scopus 로고
    • Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects
    • Kruszynska YT, Yu JG, Olefsky JM, Sobel BE. Effects of troglitazone on blood concentrations of plasminogen activator inhibitor 1 in patients with type 2 diabetes and in lean and obese normal subjects. Diabetes 2000, 49:633-639.
    • (2000) Diabetes , vol.49 , pp. 633-639
    • Kruszynska, Y.T.1    Yu, J.G.2    Olefsky, J.M.3    Sobel, B.E.4
  • 161
    • 33748349646 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma agonists: their role as vasoprotective agents in diabetes
    • Blaschke F, Caglayan E, Hsueh WA. Peroxisome proliferator-activated receptor gamma agonists: their role as vasoprotective agents in diabetes. Endocrinol Metab Clin North Am 2006, 35:ix-574.
    • (2006) Endocrinol Metab Clin North Am , vol.35
    • Blaschke, F.1    Caglayan, E.2    Hsueh, W.A.3
  • 162
    • 0037072826 scopus 로고    scopus 로고
    • Constitutive activation of peroxisome proliferator-activated receptor-gamma suppresses pro-inflammatory adhesion molecules in human vascular endothelial cells
    • Wang N, Verna L, Chen NG. Constitutive activation of peroxisome proliferator-activated receptor-gamma suppresses pro-inflammatory adhesion molecules in human vascular endothelial cells. J Biol Chem 2002, 277:34176-34181.
    • (2002) J Biol Chem , vol.277 , pp. 34176-34181
    • Wang, N.1    Verna, L.2    Chen, N.G.3    et al4
  • 163
    • 0035967470 scopus 로고    scopus 로고
    • Modulation of C-reactive protein-mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs
    • Pasceri V, Cheng JS, Willerson JT, Yeh ET. Modulation of C-reactive protein-mediated monocyte chemoattractant protein-1 induction in human endothelial cells by anti-atherosclerosis drugs. Circulation 2001, 103:2531-2534.
    • (2001) Circulation , vol.103 , pp. 2531-2534
    • Pasceri, V.1    Cheng, J.S.2    Willerson, J.T.3    Yeh, E.T.4
  • 164
    • 13344282090 scopus 로고    scopus 로고
    • Effect of pioglitazone on vascular reactivity in vivo and in vitro
    • Kotchen TA, Zhang HY, Reddy S, Hoffmann RG. Effect of pioglitazone on vascular reactivity in vivo and in vitro. Am J Physiol 1996, 270:R660-R666.
    • (1996) Am J Physiol , vol.270
    • Kotchen, T.A.1    Zhang, H.Y.2    Reddy, S.3    Hoffmann, R.G.4
  • 165
    • 0035146287 scopus 로고    scopus 로고
    • Control of vascular cell proliferation and migration by PPAR-gamma: a new approach to the macrovascular complications of diabetes
    • Hsueh WA, Jackson S, Law RE. Control of vascular cell proliferation and migration by PPAR-gamma: a new approach to the macrovascular complications of diabetes. Diabetes Care 2001, 24:392-397.
    • (2001) Diabetes Care , vol.24 , pp. 392-397
    • Hsueh, W.A.1    Jackson, S.2    Law, R.E.3
  • 166
    • 26244453309 scopus 로고    scopus 로고
    • Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial
    • Dormandy JA, Charbonnel B, Eckland DJ. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trial. Lancet 2005, 366:1279-1289.
    • (2005) Lancet , vol.366 , pp. 1279-1289
    • Dormandy, J.A.1    Charbonnel, B.2    Eckland, D.J.3    et al4
  • 167
    • 34548590934 scopus 로고    scopus 로고
    • Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials
    • Lincoff AM, Wolski K, Nicholls SJ, Nissen SE. Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials. JAMA 2007, 298:1180-1188.
    • (2007) JAMA , vol.298 , pp. 1180-1188
    • Lincoff, A.M.1    Wolski, K.2    Nicholls, S.J.3    Nissen, S.E.4
  • 168
    • 53349153475 scopus 로고    scopus 로고
    • Pioglitazone and cardiovascular risk. A comprehensive meta-analysis of randomized clinical trials
    • Mannucci E, Monami M, Lamanna C, Gensini GF, Marchionni N. Pioglitazone and cardiovascular risk. A comprehensive meta-analysis of randomized clinical trials. Diabetes Obes Metab 2008, 10:1221-1238.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 1221-1238
    • Mannucci, E.1    Monami, M.2    Lamanna, C.3    Gensini, G.F.4    Marchionni, N.5
  • 169
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen SE, Wolski K. Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007, 356:2457-2471.
    • (2007) N Engl J Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 170
    • 67149146438 scopus 로고    scopus 로고
    • Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial
    • Home PD, Pocock SJ, Beck-Nielsen H. Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial. Lancet 2009, 373:2125-2135.
    • (2009) Lancet , vol.373 , pp. 2125-2135
    • Home, P.D.1    Pocock, S.J.2    Beck-Nielsen, H.3
  • 171
    • 77954356742 scopus 로고    scopus 로고
    • Cardiac safety profile of rosiglitazone: a comprehensive meta-analysis of randomized clinical trials
    • DOI: 10.1016/j.ijcard.2009.01.064
    • Mannucci E, Monami M, Di Bari M. Cardiac safety profile of rosiglitazone: a comprehensive meta-analysis of randomized clinical trials. Int J Cardiol 2009 DOI: 10.1016/j.ijcard.2009.01.064
    • Int J Cardiol 2009
    • Mannucci, E.1    Monami, M.2    Di Bari, M.3    et al4
  • 172
    • 33747840046 scopus 로고    scopus 로고
    • Overcoming psychological barriers to insulin use in type 2 diabetes
    • Brunton SA, Davis SN, Renda SM. Overcoming psychological barriers to insulin use in type 2 diabetes. Clin Cornerstone 2006, 8(Suppl. 2):S19-S26.
    • (2006) Clin Cornerstone , vol.8 , Issue.SUPPL. 2
    • Brunton, S.A.1    Davis, S.N.2    Renda, S.M.3
  • 173
    • 47849108928 scopus 로고    scopus 로고
    • Combining insulins with oral antidiabetic agents: effect on hyperglycemic control, markers of cardiovascular risk and disease
    • Hermansen K, Mortensen LS, Hermansen ML. Combining insulins with oral antidiabetic agents: effect on hyperglycemic control, markers of cardiovascular risk and disease. Vasc Health Risk Manag 2008, 4:561-574.
    • (2008) Vasc Health Risk Manag , vol.4 , pp. 561-574
    • Hermansen, K.1    Mortensen, L.S.2    Hermansen, M.L.3
  • 174
    • 0242269000 scopus 로고    scopus 로고
    • The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients
    • Riddle MC, Rosenstock J, Gerich J. The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients. Diabetes Care 2003, 26:3080-3086.
    • (2003) Diabetes Care , vol.26 , pp. 3080-3086
    • Riddle, M.C.1    Rosenstock, J.2    Gerich, J.3
  • 175
    • 0027517779 scopus 로고
    • Intensive insulin therapy and weight gain in IDDM
    • Carlson MG, Campbell PJ. Intensive insulin therapy and weight gain in IDDM. Diabetes 1993, 42:1700-1707.
    • (1993) Diabetes , vol.42 , pp. 1700-1707
    • Carlson, M.G.1    Campbell, P.J.2
  • 176
    • 6344228104 scopus 로고    scopus 로고
    • The reality of glycaemic control in insulin treated diabetes: defining the clinical challenges
    • Davies M. The reality of glycaemic control in insulin treated diabetes: defining the clinical challenges. Int J Obes Relat Metab Disord 2004, 28(Suppl. 2):S14-S22.
    • (2004) Int J Obes Relat Metab Disord , vol.28 , Issue.SUPPL. 2
    • Davies, M.1
  • 177
    • 0036059959 scopus 로고    scopus 로고
    • The DAWN (Diabetes Attitudes, Wishes and Needs) study
    • DAWN
    • The DAWN (Diabetes Attitudes, Wishes and Needs) study. Pract Diab Int 2002, 19:22a-24a. DAWN
    • (2002) Pract Diab Int , vol.19
  • 178
    • 0036736185 scopus 로고    scopus 로고
    • When oral agents fail: practical barriers to starting insulin
    • Korytkowski M. When oral agents fail: practical barriers to starting insulin. Int J Obes Relat Metab Disord 2002, 26(Suppl. 3):S18-S24.
    • (2002) Int J Obes Relat Metab Disord , vol.26 , Issue.SUPPL. 3
    • Korytkowski, M.1
  • 179
    • 61449244692 scopus 로고    scopus 로고
    • Efficacy and safety of insulin analogues for the management of diabetes mellitus: a meta-analysis
    • Singh SR, Ahmad F, Lal A, Yu C, Bai Z, Bennett H. Efficacy and safety of insulin analogues for the management of diabetes mellitus: a meta-analysis. CMAJ 2009, 180:385-397.
    • (2009) CMAJ , vol.180 , pp. 385-397
    • Singh, S.R.1    Ahmad, F.2    Lal, A.3    Yu, C.4    Bai, Z.5    Bennett, H.6
  • 180
    • 47649100195 scopus 로고    scopus 로고
    • Long-acting insulin analogues versus NPH human insulin in type 2 diabetes: a meta-analysis
    • Monami M, Marchionni N, Mannucci E. Long-acting insulin analogues versus NPH human insulin in type 2 diabetes: a meta-analysis. Diabetes Res Clin Pract 2008, 81:184-189.
    • (2008) Diabetes Res Clin Pract , vol.81 , pp. 184-189
    • Monami, M.1    Marchionni, N.2    Mannucci, E.3
  • 181
    • 77950283292 scopus 로고    scopus 로고
    • Long-acting insulin analogues versus NPH insulin (human isophane insulin) for type 2 diabetes mellitus
    • Horvath K, Jeitler K, Berghold A. Long-acting insulin analogues versus NPH insulin (human isophane insulin) for type 2 diabetes mellitus. Cochrane Database Syst Rev 2007, CD005613.
    • (2007) Cochrane Database Syst Rev
    • Horvath, K.1    Jeitler, K.2    Berghold, A.3    et al4
  • 182
    • 0026655930 scopus 로고
    • Effect of insulin therapy on blood pressure in NIDDM patients with secondary failure
    • Randeree HA, Omar MA, Motala AA, Seedat MA. Effect of insulin therapy on blood pressure in NIDDM patients with secondary failure. Diabetes Care 1992, 15:1258-1263.
    • (1992) Diabetes Care , vol.15 , pp. 1258-1263
    • Randeree, H.A.1    Omar, M.A.2    Motala, A.A.3    Seedat, M.A.4
  • 183
    • 57849090023 scopus 로고    scopus 로고
    • Metabolic and antihypertensive effects of combined angiotension receptor blockers and diuretic therapy in prediabetic hypertensive patients with cardiometabolic syndrome
    • Zappe DH, Sowers JR, Hsueh WA. Metabolic and antihypertensive effects of combined angiotension receptor blockers and diuretic therapy in prediabetic hypertensive patients with cardiometabolic syndrome. J Clin Hypertens 2008, 10:894-903.
    • (2008) J Clin Hypertens , vol.10 , pp. 894-903
    • Zappe, D.H.1    Sowers, J.R.2    Hsueh, W.A.3    et al4
  • 184
    • 34548731369 scopus 로고    scopus 로고
    • Comparative effects of telmisartan and valsartan on insulin resistance in hypertensive patients with metabolic syndrome
    • Ichikawa Y. Comparative effects of telmisartan and valsartan on insulin resistance in hypertensive patients with metabolic syndrome. Intern Med 2007, 46:1331-1336.
    • (2007) Intern Med , vol.46 , pp. 1331-1336
    • Ichikawa, Y.1
  • 185
    • 33644898538 scopus 로고    scopus 로고
    • Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds
    • Grundy SM. Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds. J Am Coll Cardiol 2006, 47:1093-1100.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 1093-1100
    • Grundy, S.M.1
  • 186
    • 0032693603 scopus 로고    scopus 로고
    • Hyperglycemia and hyperinsulinemia at diagnosis of diabetes and their association with subsequent cardiovascular disease in the United Kingdom prospective diabetes study (UKPDS 47)
    • Adler AI, Neil HA, Manley SE, Holman RR, Turner RC. Hyperglycemia and hyperinsulinemia at diagnosis of diabetes and their association with subsequent cardiovascular disease in the United Kingdom prospective diabetes study (UKPDS 47). Am Heart J 1999, 138:S353-S359.
    • (1999) Am Heart J , vol.138
    • Adler, A.I.1    Neil, H.A.2    Manley, S.E.3    Holman, R.R.4    Turner, R.C.5
  • 187
    • 0024160877 scopus 로고
    • Banting lecture 1988. Role of insulin resistance in human disease
    • Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988, 37:1595-1607.
    • (1988) Diabetes , vol.37 , pp. 1595-1607
    • Reaven, G.M.1
  • 188
    • 35348978370 scopus 로고    scopus 로고
    • Circulating concentrations of insulin markers and coronary heart disease: a quantitative review of 19 Western prospective studies
    • Sarwar N, Sattar N, Gudnason V, Danesh J. Circulating concentrations of insulin markers and coronary heart disease: a quantitative review of 19 Western prospective studies. Eur Heart J 2007, 28:2491-2497.
    • (2007) Eur Heart J , vol.28 , pp. 2491-2497
    • Sarwar, N.1    Sattar, N.2    Gudnason, V.3    Danesh, J.4
  • 189
    • 0035658034 scopus 로고    scopus 로고
    • Insulin therapy may increase blood pressure levels in type 2 diabetes mellitus
    • Kanoun F, Ben AZ, Zouari B, Ben KF. Insulin therapy may increase blood pressure levels in type 2 diabetes mellitus. Diabetes Metab 2001, 27:695-700.
    • (2001) Diabetes Metab , vol.27 , pp. 695-700
    • Kanoun, F.1    Ben, A.Z.2    Zouari, B.3    Ben, K.F.4
  • 190
    • 50049096963 scopus 로고    scopus 로고
    • Reduced weight gain with insulin detemir compared to NPH insulin is not explained by a reduction in hypoglycemia
    • Davies MJ, Derezinski T, Pedersen CB, Clauson P. Reduced weight gain with insulin detemir compared to NPH insulin is not explained by a reduction in hypoglycemia. Diabetes Technol Ther 2008, 10:273-277.
    • (2008) Diabetes Technol Ther , vol.10 , pp. 273-277
    • Davies, M.J.1    Derezinski, T.2    Pedersen, C.B.3    Clauson, P.4
  • 191
    • 33845478593 scopus 로고    scopus 로고
    • Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea
    • Triplitt C, Glass L, Miyazaki Y. Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea. Diabetes Care 2006, 29:2371-2377.
    • (2006) Diabetes Care , vol.29 , pp. 2371-2377
    • Triplitt, C.1    Glass, L.2    Miyazaki, Y.3    et al4
  • 192
    • 0031818001 scopus 로고    scopus 로고
    • Insulin resistance and the effect of insulin on blood pressure in essential hypertension
    • Heise T, Magnusson K, Heinemann L, Sawicki PT. Insulin resistance and the effect of insulin on blood pressure in essential hypertension. Hypertension 1998, 32:243-248.
    • (1998) Hypertension , vol.32 , pp. 243-248
    • Heise, T.1    Magnusson, K.2    Heinemann, L.3    Sawicki, P.T.4
  • 193
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49)
    • UK Prospective Diabetes Study (UKPDS) Group
    • Turner RC, Cull CA, Frighi V, Holman RR. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). JAMA 1999, 281:2005-2012. UK Prospective Diabetes Study (UKPDS) Group
    • (1999) JAMA , vol.281 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3    Holman, R.R.4
  • 194
    • 0033139279 scopus 로고    scopus 로고
    • A comparison of preconstituted, fixed combinations of low-dose glyburide plus metformin versus high-dose glyburide alone in the treatment of type 2 diabetic patients
    • Erle G, Lovise S, Stocchiero C. A comparison of preconstituted, fixed combinations of low-dose glyburide plus metformin versus high-dose glyburide alone in the treatment of type 2 diabetic patients. Acta Diabetol 1999, 36:61-65.
    • (1999) Acta Diabetol , vol.36 , pp. 61-65
    • Erle, G.1    Lovise, S.2    Stocchiero, C.3    et al4
  • 196
    • 0034641550 scopus 로고    scopus 로고
    • Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study
    • Adler AI, Stratton IM, Neil HA. Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study. BMJ 2000, 321:412-419.
    • (2000) BMJ , vol.321 , pp. 412-419
    • Adler, A.I.1    Stratton, I.M.2    Neil, H.A.3    et al4
  • 197
    • 0037490085 scopus 로고    scopus 로고
    • Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials
    • Law MR, Wald NJ, Morris JK, Jordan RE. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials. BMJ 2003, 326:1427.
    • (2003) BMJ , vol.326 , pp. 1427
    • Law, M.R.1    Wald, N.J.2    Morris, J.K.3    Jordan, R.E.4
  • 198
    • 52049116541 scopus 로고    scopus 로고
    • The treatment of hypertension in obese patients
    • Wofford MR, Smith G, Minor DS. The treatment of hypertension in obese patients. Curr Hypertens Rep 2008, 10:143-150.
    • (2008) Curr Hypertens Rep , vol.10 , pp. 143-150
    • Wofford, M.R.1    Smith, G.2    Minor, D.S.3
  • 199
    • 41349095069 scopus 로고    scopus 로고
    • The effect of body mass index on fasting blood glucose after initiation of thiazide therapy in hypertensive patients
    • Siegel D, Meier J, Maas C, Lopez J, Swislocki AL. The effect of body mass index on fasting blood glucose after initiation of thiazide therapy in hypertensive patients. Am J Hypertens 2008, 21:438-442.
    • (2008) Am J Hypertens , vol.21 , pp. 438-442
    • Siegel, D.1    Meier, J.2    Maas, C.3    Lopez, J.4    Swislocki, A.L.5
  • 200
    • 16244375580 scopus 로고    scopus 로고
    • Manidipine versus enalapril monotherapy in patients with hypertension and type 2 diabetes mellitus: a multicenter, randomized, double-blind, 24-week study
    • Otero ML, Claros NM. Manidipine versus enalapril monotherapy in patients with hypertension and type 2 diabetes mellitus: a multicenter, randomized, double-blind, 24-week study. Clin Ther 2005, 27:166-173.
    • (2005) Clin Ther , vol.27 , pp. 166-173
    • Otero, M.L.1    Claros, N.M.2
  • 201
    • 0026067810 scopus 로고
    • Metabolic effects of isradipine versus hydrochlorothiazide in diabetes mellitus
    • Klauser R, Prager R, Gaube S. Metabolic effects of isradipine versus hydrochlorothiazide in diabetes mellitus. Hypertension 1991, 17:15-21.
    • (1991) Hypertension , vol.17 , pp. 15-21
    • Klauser, R.1    Prager, R.2    Gaube, S.3    et al4
  • 202
    • 34347360831 scopus 로고    scopus 로고
    • Differential effect of beta-blocker therapy on insulin resistance as a function of insulin sensitizer use: results from GEMINI
    • Fonseca V, Bakris GL, Bell DS. Differential effect of beta-blocker therapy on insulin resistance as a function of insulin sensitizer use: results from GEMINI. Diabet Med 2007, 24:759-763.
    • (2007) Diabet Med , vol.24 , pp. 759-763
    • Fonseca, V.1    Bakris, G.L.2    Bell, D.S.3    et al4
  • 203
    • 7644220156 scopus 로고    scopus 로고
    • The effect of irbesartan in reducing cardiovascular risk in hypertensive type 2 diabetic patients: an observational study in 16,600 patients in primary care
    • Bramlage P, Pittrow D, Kirch W. The effect of irbesartan in reducing cardiovascular risk in hypertensive type 2 diabetic patients: an observational study in 16,600 patients in primary care. Curr Med Res Opin 2004, 20:1625-1631.
    • (2004) Curr Med Res Opin , vol.20 , pp. 1625-1631
    • Bramlage, P.1    Pittrow, D.2    Kirch, W.3
  • 204
    • 33846414720 scopus 로고    scopus 로고
    • Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary
    • The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)
    • Ryden L, Standl E, Bartnik M. Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. Eur Heart J 2007, 28:88-136. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)
    • (2007) Eur Heart J , vol.28 , pp. 88-136
    • Ryden, L.1    Standl, E.2    Bartnik, M.3    et al4
  • 205
    • 42249095978 scopus 로고    scopus 로고
    • Concomitant calcium entry blockade and inhibition of the renin-angiotensin system: a rational and effective means for treating hypertension
    • Gojanovic B, Feihl F, Liaudet L, Waeber B. Concomitant calcium entry blockade and inhibition of the renin-angiotensin system: a rational and effective means for treating hypertension. J Renin Angiotensin Aldosterone Syst 2008, 9:1-9.
    • (2008) J Renin Angiotensin Aldosterone Syst , vol.9 , pp. 1-9
    • Gojanovic, B.1    Feihl, F.2    Liaudet, L.3    Waeber, B.4
  • 206
    • 44949104716 scopus 로고    scopus 로고
    • Comparison of angiotensin II type 1 receptor antagonists in the treatment of essential hypertension
    • Smith DH. Comparison of angiotensin II type 1 receptor antagonists in the treatment of essential hypertension. Drugs 2008, 68:1207-1225.
    • (2008) Drugs , vol.68 , pp. 1207-1225
    • Smith, D.H.1
  • 207
    • 0033034404 scopus 로고    scopus 로고
    • Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial
    • Hansson L, Lindholm LH, Niskanen L. Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial. Lancet 1999, 353:611-616.
    • (1999) Lancet , vol.353 , pp. 611-616
    • Hansson, L.1    Lindholm, L.H.2    Niskanen, L.3    et al4
  • 208
    • 0035904369 scopus 로고    scopus 로고
    • Ramipril and the development of diabetes
    • Yusuf S, Gerstein H, Hoogwerf B. Ramipril and the development of diabetes. JAMA 2001, 286:1882-1885.
    • (2001) JAMA , vol.286 , pp. 1882-1885
    • Yusuf, S.1    Gerstein, H.2    Hoogwerf, B.3    et al4
  • 209
    • 33749590988 scopus 로고    scopus 로고
    • Effect of ramipril on the incidence of diabetes
    • Bosch J, Yusuf S, Gerstein HC. Effect of ramipril on the incidence of diabetes. N Engl J Med 2006, 355:1551-1562.
    • (2006) N Engl J Med , vol.355 , pp. 1551-1562
    • Bosch, J.1    Yusuf, S.2    Gerstein, H.C.3    et al4
  • 210
    • 34548610921 scopus 로고    scopus 로고
    • Effects of antihypertensives on glucose metabolism
    • Siegel D, Swislocki AL. Effects of antihypertensives on glucose metabolism. Metab Syndr Relat Disord 2007, 5:211-219.
    • (2007) Metab Syndr Relat Disord , vol.5 , pp. 211-219
    • Siegel, D.1    Swislocki, A.L.2
  • 211
    • 18844449196 scopus 로고    scopus 로고
    • Why blockade of the renin-angiotensin system reduces the incidence of new-onset diabetes
    • Jandeleit-Dahm KA, Tikellis C, Reid CM, Johnston CI, Cooper ME. Why blockade of the renin-angiotensin system reduces the incidence of new-onset diabetes. J Hypertens 2005, 23:463-473.
    • (2005) J Hypertens , vol.23 , pp. 463-473
    • Jandeleit-Dahm, K.A.1    Tikellis, C.2    Reid, C.M.3    Johnston, C.I.4    Cooper, M.E.5
  • 213
    • 84897552223 scopus 로고    scopus 로고
    • The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure
    • National Heart LaBI, Available from URL:, Accessed 25 September
    • The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. 2009, http://www.nhlbi.nih.gov/guidelines/hypertension/jnc7full.htm, National Heart LaBI, Available from URL:, Accessed 25 September
    • (2009)
  • 214
    • 0344373794 scopus 로고    scopus 로고
    • Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
    • ALLHAT Collaborative Research Group
    • Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002, 288:2981-2997. ALLHAT Collaborative Research Group
    • (2002) JAMA , vol.288 , pp. 2981-2997
  • 215
    • 0032513534 scopus 로고    scopus 로고
    • Influence of long-term, low-dose, diuretic-based, antihypertensive therapy on glucose, lipid, uric acid, and potassium levels in older men and women with isolated systolic hypertension: The Systolic Hypertension in the Elderly Program
    • SHEP Cooperative Research Group
    • Savage PJ, Pressel SL, Curb JD. Influence of long-term, low-dose, diuretic-based, antihypertensive therapy on glucose, lipid, uric acid, and potassium levels in older men and women with isolated systolic hypertension: The Systolic Hypertension in the Elderly Program. Arch Intern Med 1998, 158:741-751. SHEP Cooperative Research Group
    • (1998) Arch Intern Med , vol.158 , pp. 741-751
    • Savage, P.J.1    Pressel, S.L.2    Curb, J.D.3    et al4
  • 216
    • 11144228978 scopus 로고    scopus 로고
    • Long-term effect of diuretic-based therapy on fatal outcomes in subjects with isolated systolic hypertension with and without diabetes
    • Kostis JB, Wilson AC, Freudenberger RS, Cosgrove NM, Pressel SL, Davis BR. Long-term effect of diuretic-based therapy on fatal outcomes in subjects with isolated systolic hypertension with and without diabetes. Am J Cardiol 2005, 95:29-35.
    • (2005) Am J Cardiol , vol.95 , pp. 29-35
    • Kostis, J.B.1    Wilson, A.C.2    Freudenberger, R.S.3    Cosgrove, N.M.4    Pressel, S.L.5    Davis, B.R.6
  • 217
    • 33746367481 scopus 로고    scopus 로고
    • Antihypertensive medications and the risk of incident type 2 diabetes
    • Taylor EN, Hu FB, Curhan GC. Antihypertensive medications and the risk of incident type 2 diabetes. Diabetes Care 2006, 29:1065-1070.
    • (2006) Diabetes Care , vol.29 , pp. 1065-1070
    • Taylor, E.N.1    Hu, F.B.2    Curhan, G.C.3
  • 218
    • 77954375043 scopus 로고    scopus 로고
    • Body mass index and fasting blood glucose after initiation of thiazide therapy, Presented at:, American Heart Association Scientific Sessions, November 13-16,, Dallas, TX
    • Meier J, Maas C, Lopez J, Swislocki A, Siegel D. 2005, Body mass index and fasting blood glucose after initiation of thiazide therapy, Presented at:, American Heart Association Scientific Sessions, November 13-16,, Dallas, TX
    • (2005)
    • Meier, J.1    Maas, C.2    Lopez, J.3    Swislocki, A.4    Siegel, D.5
  • 219
    • 0027076111 scopus 로고
    • Effect of diuretics on the plasma lipid profile
    • Weidmann P, de Courten M, Ferrari P. Effect of diuretics on the plasma lipid profile. Eur Heart J 1992, (13 Suppl. G):61-67.
    • (1992) Eur Heart J , Issue.13 SUPPL. G , pp. 61-67
    • Weidmann, P.1    de Courten, M.2    Ferrari, P.3
  • 220
    • 0027089703 scopus 로고
    • Mechanisms of diuretic effects on carbohydrate tolerance, insulin sensitivity and lipid levels
    • Weinberger MH. Mechanisms of diuretic effects on carbohydrate tolerance, insulin sensitivity and lipid levels. Eur Heart J 1992, (13 Suppl. G):5-9.
    • (1992) Eur Heart J , Issue.13 SUPPL. G , pp. 5-9
    • Weinberger, M.H.1
  • 221
    • 0023553343 scopus 로고
    • Effects of calcium antagonists on glucose homeostasis and serum lipids in non-diabetic and diabetic subjects: a review
    • Trost BN, Weidmann P. Effects of calcium antagonists on glucose homeostasis and serum lipids in non-diabetic and diabetic subjects: a review. J Hypertens Suppl 1987, 5:S81-S104.
    • (1987) J Hypertens Suppl , vol.5
    • Trost, B.N.1    Weidmann, P.2
  • 222
    • 0023877391 scopus 로고
    • The effects of antihypertensive drugs on glucose intolerance in hypertensive nondiabetics and diabetics
    • Houston MC. The effects of antihypertensive drugs on glucose intolerance in hypertensive nondiabetics and diabetics. Am Heart J 1988, 115:640-656.
    • (1988) Am Heart J , vol.115 , pp. 640-656
    • Houston, M.C.1
  • 223
    • 33846294746 scopus 로고    scopus 로고
    • Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis
    • Elliott WJ, Meyer PM. Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis. Lancet 2007, 369:201-207.
    • (2007) Lancet , vol.369 , pp. 201-207
    • Elliott, W.J.1    Meyer, P.M.2
  • 224
    • 34347204082 scopus 로고    scopus 로고
    • The development of new-onset type 2 diabetes associated with choosing a calcium channel blocker compared to a diuretic or beta-blocker
    • Kuti EL, Baker WL, White CM. The development of new-onset type 2 diabetes associated with choosing a calcium channel blocker compared to a diuretic or beta-blocker. Curr Med Res Opin 2007, 23:1239-1244.
    • (2007) Curr Med Res Opin , vol.23 , pp. 1239-1244
    • Kuti, E.L.1    Baker, W.L.2    White, C.M.3
  • 225
    • 0026911129 scopus 로고
    • Metabolic effects of pindolol and propranolol in a double-blind cross-over study in hypertensive patients
    • Lithell H, Pollare T, Vessby B. Metabolic effects of pindolol and propranolol in a double-blind cross-over study in hypertensive patients. Blood Press 1992, 1:92-101.
    • (1992) Blood Press , vol.1 , pp. 92-101
    • Lithell, H.1    Pollare, T.2    Vessby, B.3
  • 226
    • 0024382752 scopus 로고
    • Metabolic effects of diltiazem and atenolol: results from a randomized, double-blind study with parallel groups
    • Pollare T, Lithell H, Morlin C, Prantare H, Hvarfner A, Ljunghall S. Metabolic effects of diltiazem and atenolol: results from a randomized, double-blind study with parallel groups. J Hypertens 1989, 7:551-559.
    • (1989) J Hypertens , vol.7 , pp. 551-559
    • Pollare, T.1    Lithell, H.2    Morlin, C.3    Prantare, H.4    Hvarfner, A.5    Ljunghall, S.6
  • 227
    • 0024598064 scopus 로고
    • Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients
    • Pollare T, Lithell H, Selinus I, Berne C. Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients. BMJ 1989, 298:1152-1157.
    • (1989) BMJ , vol.298 , pp. 1152-1157
    • Pollare, T.1    Lithell, H.2    Selinus, I.3    Berne, C.4
  • 228
    • 0032511601 scopus 로고    scopus 로고
    • Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39
    • UK Prospective Diabetes Study Group (UKPDS)
    • Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. BMJ 1998, 317:713-720. UK Prospective Diabetes Study Group (UKPDS)
    • (1998) BMJ , vol.317 , pp. 713-720
  • 229
    • 0025249863 scopus 로고
    • Long term propranolol treatment and changes in body weight after myocardial infarction
    • Rossner S, Taylor CL, Byington RP, Furberg CD. Long term propranolol treatment and changes in body weight after myocardial infarction. BMJ 1990, 300:902-903.
    • (1990) BMJ , vol.300 , pp. 902-903
    • Rossner, S.1    Taylor, C.L.2    Byington, R.P.3    Furberg, C.D.4
  • 230
    • 0037160968 scopus 로고    scopus 로고
    • Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol
    • Dahlof B, Devereux RB, Kjeldsen SE. Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 2002, 359:995-1003.
    • (2002) Lancet , vol.359 , pp. 995-1003
    • Dahlof, B.1    Devereux, R.B.2    Kjeldsen, S.E.3    et al4
  • 231
    • 56049122434 scopus 로고    scopus 로고
    • The Anglo-Scandinavian Cardiac Outcomes Trial: blood pressure-lowering limb: effects in patient with type II diabetes
    • Ostergren J, Poulter NR, Sever PS. The Anglo-Scandinavian Cardiac Outcomes Trial: blood pressure-lowering limb: effects in patient with type II diabetes. J Hypertens 2008, 26:2103-2111.
    • (2008) J Hypertens , vol.26 , pp. 2103-2111
    • Ostergren, J.1    Poulter, N.R.2    Sever, P.S.3    et al4
  • 232
    • 33645823854 scopus 로고    scopus 로고
    • Improvements in diabetes processes of care and intermediate outcomes: United States, 1988-2002
    • Saaddine JB, Cadwell B, Gregg EW. Improvements in diabetes processes of care and intermediate outcomes: United States, 1988-2002. Ann Intern Med 2006, 144:465-474.
    • (2006) Ann Intern Med , vol.144 , pp. 465-474
    • Saaddine, J.B.1    Cadwell, B.2    Gregg, E.W.3    et al4
  • 233
    • 34548450725 scopus 로고    scopus 로고
    • Why is blood pressure so hard to control in patients with type 2 diabetes?
    • Eguchi K, Pickering TG, Kario K. Why is blood pressure so hard to control in patients with type 2 diabetes? J Cardiometab Syndr 2007, 2:114-118.
    • (2007) J Cardiometab Syndr , vol.2 , pp. 114-118
    • Eguchi, K.1    Pickering, T.G.2    Kario, K.3
  • 234
    • 33646829645 scopus 로고    scopus 로고
    • Efficacy of lipid lowering drug treatment for diabetic and non-diabetic patients: meta-analysis of randomised controlled trials
    • Costa J, Borges M, David C, Vaz CA. Efficacy of lipid lowering drug treatment for diabetic and non-diabetic patients: meta-analysis of randomised controlled trials. BMJ 2006, 332:1115-1124.
    • (2006) BMJ , vol.332 , pp. 1115-1124
    • Costa, J.1    Borges, M.2    David, C.3    Vaz, C.A.4
  • 235
    • 77649091668 scopus 로고    scopus 로고
    • American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus
    • AACE Diabetes Mellitus Clinical Practice Guidelines Task Force
    • American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus. Endocr Pract 2007, 13(Suppl. 1):1-68. AACE Diabetes Mellitus Clinical Practice Guidelines Task Force
    • (2007) Endocr Pract , vol.13 , Issue.SUPPL. 1 , pp. 1-68
  • 236
    • 14644403669 scopus 로고    scopus 로고
    • Adherence to statin therapy and LDL cholesterol goal attainment by patients with diabetes and dyslipidemia
    • Parris ES, Lawrence DB, Mohn LA, Long LB. Adherence to statin therapy and LDL cholesterol goal attainment by patients with diabetes and dyslipidemia. Diabetes Care 2005, 28:595-599.
    • (2005) Diabetes Care , vol.28 , pp. 595-599
    • Parris, E.S.1    Lawrence, D.B.2    Mohn, L.A.3    Long, L.B.4
  • 237
    • 49649095014 scopus 로고    scopus 로고
    • Colesevelam HCl improves glycemic control and reduces LDL cholesterol in patients with inadequately controlled type 2 diabetes on sulfonylurea-based therapy
    • Fonseca VA, Rosenstock J, Wang AC, Truitt KE, Jones MR. Colesevelam HCl improves glycemic control and reduces LDL cholesterol in patients with inadequately controlled type 2 diabetes on sulfonylurea-based therapy. Diabetes Care 2008, 31:1479-1484.
    • (2008) Diabetes Care , vol.31 , pp. 1479-1484
    • Fonseca, V.A.1    Rosenstock, J.2    Wang, A.C.3    Truitt, K.E.4    Jones, M.R.5
  • 238
    • 33644618433 scopus 로고    scopus 로고
    • The biology of incretin hormones
    • Drucker DJ. The biology of incretin hormones. Cell Metab 2006, 3:153-165.
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 239
    • 34147124852 scopus 로고    scopus 로고
    • Islet dysfunction: an underlying defect in the pathophysiology of type 2 diabetes
    • Pratley R. Islet dysfunction: an underlying defect in the pathophysiology of type 2 diabetes. Endocrinol Metab Clin North Am 2006, 35(Suppl. 1):6-11.
    • (2006) Endocrinol Metab Clin North Am , vol.35 , Issue.SUPPL. 1 , pp. 6-11
    • Pratley, R.1
  • 240
    • 0036216683 scopus 로고    scopus 로고
    • Evidence for early impairment of glucagon-like peptide 1-induced insulin secretion in human type 2 (non insulin-dependent) diabetes
    • Lugari R, Dei Cas A, Ugolotti D. Evidence for early impairment of glucagon-like peptide 1-induced insulin secretion in human type 2 (non insulin-dependent) diabetes. Horm Metab Res 2002, 34:150-154.
    • (2002) Horm Metab Res , vol.34 , pp. 150-154
    • Lugari, R.1    Dei Cas, A.2    Ugolotti, D.3    et al4
  • 241
    • 0001095690 scopus 로고    scopus 로고
    • Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
    • Vilsboll T, Krarup T, Deacon CF, Madsbad S, Holst JJ. Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 2001, 50:609-613.
    • (2001) Diabetes , vol.50 , pp. 609-613
    • Vilsboll, T.1    Krarup, T.2    Deacon, C.F.3    Madsbad, S.4    Holst, J.J.5
  • 242
    • 0141615898 scopus 로고    scopus 로고
    • Suppression of glucose production by GLP-1 independent of islet hormones: a novel extrapancreatic effect
    • Prigeon RL, Quddusi S, Paty B, D'Alessio DA. Suppression of glucose production by GLP-1 independent of islet hormones: a novel extrapancreatic effect. Am J Physiol Endocrinol Metab 2003, 285:E701-E707.
    • (2003) Am J Physiol Endocrinol Metab , vol.285
    • Prigeon, R.L.1    Quddusi, S.2    Paty, B.3    D'Alessio, D.A.4
  • 243
    • 2342599057 scopus 로고    scopus 로고
    • One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes
    • Degn KB, Juhl CB, Sturis J. One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes. Diabetes 2004, 53:1187-1194.
    • (2004) Diabetes , vol.53 , pp. 1187-1194
    • Degn, K.B.1    Juhl, C.B.2    Sturis, J.3    et al4
  • 244
    • 0141446228 scopus 로고    scopus 로고
    • Enhancing incretin action for the treatment of type 2 diabetes
    • Drucker DJ. Enhancing incretin action for the treatment of type 2 diabetes. Diabetes Care 2003, 26:2929-2940.
    • (2003) Diabetes Care , vol.26 , pp. 2929-2940
    • Drucker, D.J.1
  • 245
    • 70349107886 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analog, significantly improves β-cell function in subjects with type 2 diabetes
    • Matthews D, Marre M, Le-Thi T, Zdravkovic M, Simo R. Liraglutide, a once-daily human GLP-1 analog, significantly improves β-cell function in subjects with type 2 diabetes. Diabetes 2008, 57:A150-A151.
    • (2008) Diabetes , vol.57
    • Matthews, D.1    Marre, M.2    Le-Thi, T.3    Zdravkovic, M.4    Simo, R.5
  • 246
    • 39749143348 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic β-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus
    • Vilsboll T, Brock B, Perrild H. Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic β-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus. Diabet Med 2008, 25:152-156.
    • (2008) Diabet Med , vol.25 , pp. 152-156
    • Vilsboll, T.1    Brock, B.2    Perrild, H.3    et al4
  • 247
    • 0028889380 scopus 로고
    • Enteral enhancement of glucose disposition by both insulin-dependent and insulin-independent processes. A physiological role of glucagon-like peptide I
    • D'Alessio DA, Prigeon RL, Ensinck JW. Enteral enhancement of glucose disposition by both insulin-dependent and insulin-independent processes. A physiological role of glucagon-like peptide I. Diabetes 1995, 44:1433-1437.
    • (1995) Diabetes , vol.44 , pp. 1433-1437
    • D'Alessio, D.A.1    Prigeon, R.L.2    Ensinck, J.W.3
  • 248
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study
    • Zander M, Madsbad S, Madsen JL, Holst JJ. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study. Lancet 2002, 359:824-830.
    • (2002) Lancet , vol.359 , pp. 824-830
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 249
    • 0032966882 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2
    • Gutzwiller JP, Drewe J, Goke B. Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2. Am J Physiol 1999, 276:R1541-R1544.
    • (1999) Am J Physiol , vol.276
    • Gutzwiller, J.P.1    Drewe, J.2    Goke, B.3    et al4
  • 250
    • 84878634410 scopus 로고    scopus 로고
    • Mechanisms behind GLP-1 induced weight loss
    • (in press).
    • Larsen PJ. Mechanisms behind GLP-1 induced weight loss. Exp Clin Endocrinol Diabetes (in press).
    • Exp Clin Endocrinol Diabetes
    • Larsen, P.J.1
  • 251
    • 63849248275 scopus 로고    scopus 로고
    • Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety
    • Williams DL, Baskin DG, Schwartz MW. Evidence that intestinal glucagon-like peptide-1 plays a physiological role in satiety. Endocrinology 2009, 150:1680-1687.
    • (2009) Endocrinology , vol.150 , pp. 1680-1687
    • Williams, D.L.1    Baskin, D.G.2    Schwartz, M.W.3
  • 252
    • 0037667613 scopus 로고    scopus 로고
    • Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes
    • Meier JJ, Gallwitz B, Salmen S. Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes. J Clin Endocrinol Metab 2003, 88:2719-2725.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 2719-2725
    • Meier, J.J.1    Gallwitz, B.2    Salmen, S.3    et al4
  • 253
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007, 132:2131-2157.
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 254
    • 8544258807 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease
    • Nystrom T, Gutniak MK, Zhang Q. Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. Am J Physiol Endocrinol Metab 2004, 287:E1209-E1215.
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Nystrom, T.1    Gutniak, M.K.2    Zhang, Q.3    et al4
  • 255
    • 34249902025 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action
    • Drucker DJ. Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action. Diabetes Care 2007, 30:1335-1343.
    • (2007) Diabetes Care , vol.30 , pp. 1335-1343
    • Drucker, D.J.1
  • 256
    • 69949129023 scopus 로고    scopus 로고
    • The once-daily human glucagon-like peptide-1 analog liraglutide reduces systolic blood pressure in patients with type 2 diabetes
    • Colagiuri S, Frid A, Zdravkovic M, Le-Thi TDL, Vaag A. The once-daily human glucagon-like peptide-1 analog liraglutide reduces systolic blood pressure in patients with type 2 diabetes. Diabetes 2008, 57:A164-A165.
    • (2008) Diabetes , vol.57
    • Colagiuri, S.1    Frid, A.2    Zdravkovic, M.3    Le-Thi, T.D.L.4    Vaag, A.5
  • 257
    • 77954353052 scopus 로고    scopus 로고
    • Byetta [package insert]. San Diego, CA: Amylin Pharmaceuticals, Inc;
    • 2007, Byetta [package insert]. San Diego, CA: Amylin Pharmaceuticals, Inc;
    • (2007)
  • 258
    • 0347360186 scopus 로고    scopus 로고
    • Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes
    • Nielsen LL, Young AA, Parkes DG. Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes. Regul Pept 2004, 117:77-88.
    • (2004) Regul Pept , vol.117 , pp. 77-88
    • Nielsen, L.L.1    Young, A.A.2    Parkes, D.G.3
  • 259
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall DM, Riddle MC, Rosenstock J. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 2005, 28:1083-1091.
    • (2005) Diabetes Care , vol.28 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3    et al4
  • 260
    • 33947156808 scopus 로고    scopus 로고
    • Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: an interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials
    • Buse JB, Klonoff DC, Nielsen LL. Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: an interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials. Clin Ther 2007, 29:139-153.
    • (2007) Clin Ther , vol.29 , pp. 139-153
    • Buse, J.B.1    Klonoff, D.C.2    Nielsen, L.L.3    et al4
  • 261
    • 0034108646 scopus 로고    scopus 로고
    • Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration
    • Knudsen LB, Nielsen PF, Huusfeldt PO. Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration. J Med Chem 2000, 43:1664-1669.
    • (2000) J Med Chem , vol.43 , pp. 1664-1669
    • Knudsen, L.B.1    Nielsen, P.F.2    Huusfeldt, P.O.3    et al4
  • 262
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse JB, Rosenstock J, Sesti G. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009, 374:39-47.
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3    et al4
  • 263
    • 73249129055 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analog, reduces fat percentage, visceral and subcutaneous adipose tissue and hepatic steatosis compared with glimepiride when added to metformin in subjects with type 2 diabetes
    • Jendle J, Nauck M, Matthews D. Liraglutide, a once-daily human GLP-1 analog, reduces fat percentage, visceral and subcutaneous adipose tissue and hepatic steatosis compared with glimepiride when added to metformin in subjects with type 2 diabetes. Diabetes 2008, 57:A32-A33.
    • (2008) Diabetes , vol.57
    • Jendle, J.1    Nauck, M.2    Matthews, D.3    et al4
  • 264
    • 77954367645 scopus 로고    scopus 로고
    • Januvia [package insert]. Whitehouse Station, NJ: Merck & Co, Inc;
    • 2007, Januvia [package insert]. Whitehouse Station, NJ: Merck & Co, Inc;
    • (2007)
  • 265
    • 34547660561 scopus 로고    scopus 로고
    • Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes
    • Goldstein BJ, Feinglos MN, Lunceford JK, Johnson J, Williams-Herman DE. Effect of initial combination therapy with sitagliptin, a dipeptidyl peptidase-4 inhibitor, and metformin on glycemic control in patients with type 2 diabetes. Diabetes Care 2007, 30:1979-1987.
    • (2007) Diabetes Care , vol.30 , pp. 1979-1987
    • Goldstein, B.J.1    Feinglos, M.N.2    Lunceford, J.K.3    Johnson, J.4    Williams-Herman, D.E.5
  • 266
    • 84878627853 scopus 로고    scopus 로고
    • Approval in the United States is pending additional trials in patients with renal dysfunction
    • Available from URL:, Accessed 30 July
    • Approval in the United States is pending additional trials in patients with renal dysfunction. 2009, http://www.novartis.com/newsroom/mediareleases/en/2007/1153741.shtml, Available from URL:, Accessed 30 July
    • (2009)
  • 267
    • 67649377847 scopus 로고    scopus 로고
    • Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA1c without increasing weight gain or hypoglycemia
    • Rosenstock J, Rendell M, Gross J, Fleck P, Wilson C, Mekki Q. Alogliptin added to insulin therapy in patients with type 2 diabetes reduces HbA1c without increasing weight gain or hypoglycemia. Diabetes 2008, 57(Suppl. 1):A132.
    • (2008) Diabetes , vol.57 , Issue.SUPPL. 1
    • Rosenstock, J.1    Rendell, M.2    Gross, J.3    Fleck, P.4    Wilson, C.5    Mekki, Q.6
  • 268
    • 34447267513 scopus 로고    scopus 로고
    • Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis
    • Amori RE, Lau J, Pittas AG. Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. JAMA 2007, 298:194-206.
    • (2007) JAMA , vol.298 , pp. 194-206
    • Amori, R.E.1    Lau, J.2    Pittas, A.G.3
  • 269
    • 33846006173 scopus 로고    scopus 로고
    • The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    • Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006, 368:1696-1705.
    • (2006) Lancet , vol.368 , pp. 1696-1705
    • Drucker, D.J.1    Nauck, M.A.2
  • 270
    • 67649304917 scopus 로고    scopus 로고
    • Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide
    • Dore DD, Seeger JD, Arnold CK. Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide. Curr Med Res Opin 2009, 25:1019-1027.
    • (2009) Curr Med Res Opin , vol.25 , pp. 1019-1027
    • Dore, D.D.1    Seeger, J.D.2    Arnold, C.K.3
  • 271
    • 74049150996 scopus 로고    scopus 로고
    • Increased risk of acute pancreatitis observed in patients with type 2 diabetes
    • Noel R, Braun D, Patterson R, Bloomgren G. Increased risk of acute pancreatitis observed in patients with type 2 diabetes. Pancreas 2008, 37:487.
    • (2008) Pancreas , vol.37 , pp. 487
    • Noel, R.1    Braun, D.2    Patterson, R.3    Bloomgren, G.4
  • 272
    • 77952468685 scopus 로고    scopus 로고
    • FDA briefing materials: liraglutide
    • FDA, April 2, 2009. Available from URL:, Accessed 30 July 2009.
    • FDA briefing materials: liraglutide. http://www.fda.gov/ohrms/dockets/ac/09/briefing/2009-4422b2-01-FDA.pdf, FDA, April 2, 2009. Available from URL:, Accessed 30 July 2009.
  • 273
    • 84878625522 scopus 로고    scopus 로고
    • Novo Nordisk. Liraglutide (injection) NDA22-34
    • Endocrine and Metabolic Drug Advisory Committee, April 2, 2009. Available from URL:, Accessed 30 July 2009.
    • Novo Nordisk. Liraglutide (injection) NDA22-34. http://www.fda.gov/ohrms/dockets/ac/09/briefing/2009-4422b2-02-NovoNordisk.pdf, Endocrine and Metabolic Drug Advisory Committee, April 2, 2009. Available from URL:, Accessed 30 July 2009.
  • 274
    • 40149108459 scopus 로고    scopus 로고
    • The impact of diabetes and associated cardiometabolic risk factors on members: strategies for optimizing outcomes
    • Hoerger TJ, Ahmann AJ. The impact of diabetes and associated cardiometabolic risk factors on members: strategies for optimizing outcomes. J Manag Care Pharm 2008, 14:S2-S14.
    • (2008) J Manag Care Pharm , vol.14
    • Hoerger, T.J.1    Ahmann, A.J.2


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