The role of aspirin in cancer prevention

Nature Reviews Clinical Oncology

Volumn 9, Issue 5, 2012, Pages 259-267

  Thun, Michael J ^a   Jacobs, Eric J ^a   Patrono, Carlo ^b  

^a AMERICAN CANCER SOCIETY   (United States)

^b CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO;

ARTERY THROMBOSIS; BRAIN HEMORRHAGE; BRAIN ISCHEMIA; BREAST CANCER; CANCER PREVENTION; CARDIOVASCULAR DISEASE; COLORECTAL CANCER; DIGESTIVE SYSTEM PERFORATION; DOSE RESPONSE; DRUG MECHANISM; DRUG METABOLISM; DRUG TARGETING; ESOPHAGUS CANCER; GASTROINTESTINAL HEMORRHAGE; HEART INFARCTION; HUMAN; LOW DRUG DOSE; LUNG CANCER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK BENEFIT ANALYSIS; RISK REDUCTION; STOMACH CANCER;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; HUMANS; NEOPLASMS;

EID: 84860386459     PISSN: 17594774     EISSN: 17594782     Source Type: Journal    
DOI: 10.1038/nrclinonc.2011.199     Document Type: Review

References (70)

1. US Preventive Services Task Force. Aspirin for the prevention of cardiovascular disease: U. S. Preventive Services Task Force recommendation statement. Ann. Intern. Med. 150, 396-404 (2009).
2. Graham, I. et al. European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur. J. Cardiovasc. Prev. Rehabil. 14 (Suppl. 2), S1-S113 (2007). (Pubitemid 47339826)
3. US Preventive Services Task Force. Routine aspirin or nonsteroidal anti-inflammatory drugs for the primary prevention of colourecolorectal cancer: U.S. Preventive Services Task Force recommendation statement. Ann. Intern. Med. 146, 361-364 (2007).
4. Patrono, C., Garcia Rodriguez, L. A., Landolfi, R. & Baigent, C. Low-dose aspirin for the prevention of atherothrombosis. N. Engl. J. Med. 353, 2373-2383 (2005). (Pubitemid 41713749)
5. Rothwell, P. M. et al. Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials. Lancet http://dx.doi.org/10.1016/S0140-6736(11)61720-0.
6. Rothwell, P. M. et al. Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials. Lancet 377, 31-41 (2011).
7. Rothwell, P. M. et al. Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials. Lancet http://dx.doi.org/10.1016/S0140-6736(12)60209-8.
8. Cook, N. R. et al. Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. JAMA 294, 47-55 (2005). (Pubitemid 41002838)
9. Smyth, E., Grosser, T. & FitzGerald, G. in Goodman & Gillman's The Pharmacological Basis of Therapeutics (eds Brunton, L. L., Chabner, B. A. & Knollmann, B. C.) 937-958 (McGraw-Hill, New York, 2011).
10. Chandrasekharan, N. V. et al. COX 3, a cyclooxygenase 1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc. Natl Acad. Sci. USA 99, 13926-13931 (2002). (Pubitemid 35215482)
11. Botting, R. M. Mechanism of action of acetaminophen: is there a cyclooxygenase 3? Clin. Infect. Dis. 31 (Suppl. 5), S202-S210 (2000). (Pubitemid 32291111)
12. Kis, B., Snipes, J. A. & Busija, D. W. Acetaminophen and the cyclooxygenase 3 puzzle: sorting out facts, fictions, and uncertainties. J. Pharmacol. Exp. Ther. 315, 1-7 (2005). (Pubitemid 41380491)
13. Hersh, E. V., Lally, E. T. & Moore, P. A. Update on cyclooxygenase inhibitors: has a third COX isoform entered the fray? Curr. Med. Res. Opin. 21, 1217-1226 (2005). (Pubitemid 41140725)
14. Pedersen, A. K. & FitzGerald, G. A. Dose-related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase. N. Engl. J. Med. 311, 1206-1211 (1984). (Pubitemid 14021923)
15. Zhou, G., Marathe, G. K., Willard, B. & McIntyre, T. M. Intracellular erythrocyte platelet-activating factor acetylhydrolase I inactivates aspirin in blood. J. Biol. Chem. 286, 34820-34829 (2011).
16. Thun, M., Henley, S. & Patrono, C. Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J. Natl Cancer Inst. 94, 252-266 (2002). (Pubitemid 34196319)
17. Chan, A. T. et al. Aspirin in the chemoprevention of colorectal neoplasia: an overview. Cancer Prev. Res. (Phila.) http://dx.doi.org/10.1158/ 1940-6207.CAPR-11-0391.
18. Kakarala, M. & Brenner, D. E. in Cancer: Principles & Practice of Oncology Ch. 55 (eds DeVita, V. T., Lawrence, T. S. & Rosenberg, S. A.) 573-580 (Lippincott Williams & Wilkins, Pennsylvania, 2011).
19. Chan, A. T., Ogino, S. & Fuchs, C. S. Aspirin and the risk of colorectal cancer in relation to the expression of COX 2. N. Engl. J. Med. 356, 2131-2142 (2007). (Pubitemid 47010839)
20. Antiplatelet Trialists' Collaboration. Collaborative overview of randomised trials of antiplatelet therapy I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 308, 81-106 (1994).
21. Antithrombotic Trialists' Collaboration. Collaborative meta-analysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction and stroke in high risk patients. BMJ 324, 71-86 (2002).
22. Baigent, C. et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet 373, 1849-1860 (2009).
23. Patrono, C. et al. Antiplatelet agents for the treatment and prevention of atherothrombosis. Eur. Heart J. 32, 2922-2932 (2011).
24. Chan, F. K. et al. Celecoxib versus omeprazole and diclofenac in patients with osteoarthritis and rheumatoid arthritis (CONDOR): a randomised trial. Lancet 376, 173-179 (2010).
25. Baron, J. A. et al. A randomized trial of aspirin to prevent colorectal adenomas. N. Engl. J. Med. 348, 891-899 (2003). (Pubitemid 36297997)
26. Sandler, R. S. et al. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N. Engl. J. Med. 348, 883-890 (2003). (Pubitemid 36297996)
27. Logan, R. F., Grainge, M. J., Shepherd, V. C., Armitage, N. C. & Muir, K. R. Aspirin and folic acid for the prevention of recurrent colorectal adenomas. Gastroenterology 134, 29-38 (2008). (Pubitemid 350309319)
28. Cole, B. F. et al. Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials. J. Natl Cancer Inst. 101, 256-266 (2009).
29. Flossman, E. & Rothwell, P. M. Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies. Lancet 369, 1603-1613 (2007). (Pubitemid 46710123)
30. Rothwell, P. M. et al. Long-term effect of aspirin on colorectal cancer incidence and mortality: 20year follow-up of five randomised trials. Lancet 376, 1741-1750 (2010).
31. Burn, J. et al. Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomized controlled trial. Lancet http://dx.doi.org/10.1016/S0140-6736(11)61049-0.
32. Dube, C. et al. The use of aspirin for primary prevention of colorectal cancer: a systematic review prepared for the U. S. Preventive Services Task Force. Ann. Intern. Med. 146, 365-375 (2007). (Pubitemid 351650597)
33. Chan, A. T., Ogino, S. & Fuchs, C. S. Aspirin use and survival after diagnosis of colorectal cancer. JAMA 302, 649-658 (2009).
34. Gann, P., Manson, J., Glynn, R., Buring, J. & Hennekens, C. Low-dose aspirin and incidence of colorectal tumors in a randomized trial. J. Natl Cancer Inst. 85, 1220-1224 (1993). (Pubitemid 23223527)
35. Sturmer, T., Glynn, R., Lee, I., Buring, J. & Hennekens, C. Aspirin use and colorectal cancer: post-trial follow-up data from the Physicians' Health Study. Ann. Intern. Med. 128, 713-720 (1998). (Pubitemid 28204862)
36. Farrow, D. C. et al. Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer. Cancer Epidemiol. Biomarkers Prev. 7, 97-102 (1998). (Pubitemid 28109839)
37. Sharp, L. et al. Risk factors for squamous cell carcinoma of the oesophagus in women: a case control study. Br. J. Cancer 85, 1667-1670 (2001). (Pubitemid 34081510)
38. Funkhouser, E. & Sharp, G. Aspirin and reduced risk of esophageal carcinoma. Cancer 76, 1116-1119 (1995).
39. Abnet, C. C. et al. Non-steroidal anti-inflammatory drugs and risk of gastric and oesophageal adenocarcinomas: results from a cohort study and a meta-analysis. Br. J. Cancer 100, 551-557 (2009).
40. Zaridze, D., Borisova, E., Maximovitch, D. & Chkhikvadze, V. Aspirin protects against gastric cancer: results of a case-control study from Moscow, Russia. Int. J. Cancer 82, 473-476 (1999). (Pubitemid 29343443)
41. Schreinemachers, D. & Everson, R. Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology 5, 138-146 (1994). (Pubitemid 24073387)
42. Ratnasinghe, L. D. et al. Aspirin use and mortality from cancer in a prospective cohort study. Anticancer Res. 24, 3177-3184 (2004). (Pubitemid 39390970)
43. Capurso, G. et al. Meta-analysis: the use of non-steroidal anti-inflammatory drugs and pancreatic cancer risk for different exposure categories. Aliment. Pharmacol. Ther. 26, 1089-1099 (2007). (Pubitemid 47480965)
44. Oh, S. W., Myung, S. K., Park, J. Y., Lee, C. M. & Kwon, H. T. Aspirin use and risk for lung cancer: a meta-analysis. Ann. Oncol. 22, 2456-2465 (2011).
45. Agrawal, A. & Fentiman, I. S. NSAIDs and breast cancer: a possible prevention and treatment strategy. Int. J. Clin. Pract. 62, 444-449 (2008). (Pubitemid 351197419)
46. Moysich, K. B., Beehler, G. P., Zirpoli, G., Choi, J. Y. & Baker, J. A. Use of common medications and breast cancer risk. Cancer Epidemiol. Biomarkers Prev. 17, 1564-1595 (2008).
47. Cuzick, J. et al. Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement. Lancet Oncol. 10, 501-507 (2008).
48. Zhao, Y. S. et al. Association between NSAIDs use and breast cancer risk: a systematic review and meta-analysis. Breast Cancer Res. Treat. 117, 141-150 (2009).
49. Holmes, M. D. et al. Aspirin intake and survival after breast cancer. J. Clin. Oncol. 28, 1467-1472 (2010).
50. Bosetti, C., Gallus, S. & La Vecchia, C. Aspirin and cancer risk: an updated quantitative review to 2005. Cancer Causes Control 17, 871-888 (2006). (Pubitemid 44081706)
51. Bosetti, C., Gallus, S. & La Vecchia, C. Aspirin and cancer risk: a summary review to 2007. Recent Results Cancer Res. 181, 231-251 (2009).
52. Prizment, A. E., Folsom, A. R. & Anderson, K. E. Nonsteroidal anti-inflammatory drugs and risk for ovarian and endometrial cancers in the Iowa Women's Health Study. Cancer Epidemiol. Biomarkers Prev. 19, 435-442 (2010).
53. Chang, E. T. et al. Aspirin and other nonsteroidal anti-inflammatory drugs in relation to Hodgkin lymphoma risk in northern Denmark. Cancer Epidemiol. Biomarkers Prev. 19, 59-64 (2010).
54. Chang, E. T. et al. Aspirin and the risk of Hodgkin's lymphoma in a population-based case control study. J. Natl Cancer Inst. 96, 305-315 (2004). (Pubitemid 38256275)
55. Zhang, Y., Coogan, P. F., Palmer, J. R., Strom, B. L. & Rosenberg, L. Risk of non-Hodgkin lymphoma and use of non-steroidal anti inflammatory drugs. Cancer Detect. Prev. 30, 99-101 (2006). (Pubitemid 43374509)
56. Daugherty, S. E. et al. Nonsteroidal antiinflammatory drugs and bladder cancer: a pooled analysis. Am. J. Epidemiol. 173, 721-730 (2011).
57. Tavani, A. et al. Aspirin and risk of renal cell cancer in Italy. Eur. J. Cancer Prev. 19, 272-274 (2010).
58. Benamouzig, R. et al. Daily soluble aspirin and prevention of colorectal adenoma recurrence: one-year results of the APACC trial. Gastroenterology 125, 328-336 (2003). (Pubitemid 36929412)
59. Charman, W. N. et al. Biopharmaceutical characterisation of a low-dose (75 mg) controlled-release aspirin formulation. Br. J. Clin. Pharmacol. 36, 470-473 (1993). (Pubitemid 23344160)
60. Hubner, R. A. et al. Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention. Clin. Cancer Res. 14, 2303-2309 (2008). (Pubitemid 351551061)
61. Patrono, C., Patrignani, P. & Garcia Rodriguez, L. A. Cyclooxygenase-selective inhibition of prostanoid formation: transducing biochemical selectivity into clinical readouts. J. Clin. Invest. 108, 7-13 (2001). (Pubitemid 32634915)
62. Dixon, D. A. et al. Expression of COX 2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. J. Clin. Invest. 116, 2727-2738 (2006). (Pubitemid 44511636)
63. Chulada, P. C. et al. Genetic disruption of Ptgs 1, as well as Ptgs 2, reduces intestinal tumorigenesis in Min mice. Cancer Res. 60, 4705-4708 (2000).
64. Baron, J. A. et al. A randomized trial of rofecoxib for the chemoprevention of colorectal adenomas. Gastroenterology 131, 1674-1682 (2006). (Pubitemid 44958508)
65. Bertagnolli, M. M. et al. Celecoxib for the prevention of sporadic colorectal adenomas. N. Engl. J. Med. 355, 873-884 (2006). (Pubitemid 44315980)
66. Arber, N. et al. Celecoxib for the prevention of colorectal adenomatous polyps. N. Engl. J. Med. 355, 885-895 (2006). (Pubitemid 44315981)
67. Gay, L. & Felding-Habermann, B. Contribution of platelets to tumour metastases. Nat. Rev. Cancer 11, 123-134 (2011).
68. Labelle, M., Begum, S. & Hynes, R. O. Direct signalling between platelets and cancer cells induces epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell 20, 576-590 (2011).
69. Altekruse, S. F., Kosary, C. L., Krapcho, M. et al. (eds). SEER Cancer Statistics Review, 1975-2007 [online], http://seer.cancer.gov/csr/1975-2007/ index.html (2010).
70. National Cancer Institute. Clinicaltrials.gov [online], http://clinicaltrials.gov/ct2/search (2011).