NO-donating aspirin isomers downregulate peroxisome proliferator-activated receptor (PPAR)δ expression in APCmin/+ mice proportionally to their tumor inhibitory effect: Implications for the role of PPARδ in carcinogenesis

Carcinogenesis

Volumn 27, Issue 2, 2006, Pages 232-239

  Ouyang, Nengtai ^a   Williams, Jennie L ^a   Rigas, Basil ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; APC PROTEIN; NITRIC OXIDE DONOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INCIDENCE; CELL PROLIFERATION; COLON CANCER; COLON CARCINOGENESIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; FEMALE; IMMUNOHISTOCHEMISTRY; ISOMER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; ASPIRIN; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHEMOPREVENTION; COLONIC NEOPLASMS; DOWN-REGULATION; FEMALE; MICE; MICE, INBRED C57BL; PPAR DELTA;

EID: 31544463796     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgi221     Document Type: Article

References (25)

1. Rigas,B. and Kashfi,K. (2004) Nitric-oxide-donating NSAIDs as agents for cancer prevention. Trends Mol. Med., 10, 324-330.
2. Robinson-Rechavi,M., Escriva Garcia,H. and Laudet,V. (2003) The nuclear receptor superfamily. J. Cell Sci., 116, 585-586.
3. Michalik,L., Desvergne,B. and Wahli,W. (2003) Peroxisome proliferator-activated receptors beta/delta: Emerging roles for a previously neglected third family member. Curr. Opin. Lipidol., 14, 129-135.
4. Tan,N.S., Michalik,L., Desvergne,B. and Wahli,W. (2003) Peroxisome proliferator-activated receptor (PPAR)-beta as a target for wound healing drugs: What is possible? Am. J. Clin. Dermatol., 4, 523-530.
5. Nahle,Z. (2004) PPAR trilogy from metabolism to cancer. Curr. Opin. Clin. Nutr. Metab. Care, 7, 397-402.
6. Peters,J.M., Aoyama,T., Cattley,R.C., Nobumitsu,U., Hashimoto,T. and Gonzalez,F.J. (1998) Role of peroxisome proliferator-activated receptor alpha in altered cell cycle regulation in mouse liver. Carcinogenesis, 19, 1989-1994.
7. He,T.C., Chan,T.A., Vogelstein,B. and Kinzler,K.W. (1999) PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell, 99, 335-345.
8. Park,B.H., Vogelstein,B. and Kinzler,K.W. (2001) Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells. Proc. Natl Acad. Sci. USA, 98, 2598-2603.
9. Gupta,R.A., Wang,D., Katkuri,S., Wang,H., Dey,S.K. and DuBois,R.N. (2004) Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-delta accelerates intestinal adenoma growth. Nat. Med., 10, 245-247.
10. Tan,N.S., Michalik,L., Di-Poi,N., Desvergne,B. and Wahli,W. (2004) Critical roles of the nuclear receptor PPARbeta (peroxisome-proliferator-activated receptor beta) in skin wound healing. Biochem. Soc. Trans., 32, 97-102.
11. Michalik,L., Desvergne,B., Tan,N.S. et al. (2001) Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J. Cell Biol., 154, 799-814.
12. Barak,Y., Liao,D., He,W., Ong,E.S., Nelson,M.C., Olefsky,J.M., Boland,R. and Evans,R.M. (2002) Effects of peroxisome proliferator-activated receptor delta on placentation, adiposity, and colorectal cancer. Proc. Natl Acad. Sci. USA, 99, 303-308.
13. Harman,F.S., Nicol,C.J., Marin,H.E., Ward,J.M., Gonzalez,F.J. and Peters,J.M. (2004) Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis. Nat. Med., 10, 481-483.
14. Reed,K.R., Sansom,O.J., Hayes,A.J., Gescher,A.J., Winton,D.J., Peters,J.M. and Clarke,A.R. (2004) PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine. Oncogene, 23, 8992-8996.
15. Kashfi,K., Borgo,S., Williams,J.L., Chen,J., Gao,J., Glekas,A., Benedini,F., Del Soldato,P. and Rigas,B. (2005) Positional isomerism markedly affects the growth inhibition of colon cancer cells by nitric oxide-donating aspirin in vitro and in vivo. J Pharmacol. Exp. Ther., 312, 978-988.
16. Kozoni,V., Tsioulias,G., Shiff,S. and Rigas,B. (2000) The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis: Differential effect on apoptosis in the presence of a colon carcinogen. Carcinogenesis, 21, 999-1005.
17. Moser,A.R., Shoemaker,A.R., Connelly,C.S., Clipson,L., Gould,K.A., Luongo,C., Dove,W.F., Siggers,P.H. and Gardner,R.L. (1995) Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation. Dev. Dyn., 203, 422-433.
18. Polakis,P. (1995) Mutations in the APC gene and their implications for protein structure and function. Curr. Opin. Genet. Dev., 5, 66-71.
19. Wang,D., Wang,H., Shi,Q., Katkuri,S., Walhi,W., Desvergne,B., Das,S.K., Dey,S.K. and DuBois,R.N. (2004) Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell, 6, 285-295.
20. Hao,C.M., Redha,R., Morrow,J. and Breyer,M.D. (2002) Peroxisome proliferator-activated receptor delta activation promotes cell survival following hypertonic stress. J. Biol. Chem., 277, 21341-21345.
21. Kashfi,K., Ryann,Y., Qiao,L.L., Williams,J.L., Chen,J., Del Soldato,P., Traganos,F. and Rigas,B. (2002) Nitric oxide-donating nonsteroidal anti-inflammatory drugs inhibit the growth of various cultured human cancer cells: Evidence of a tissue type-independent effect. J. Pharmacol. Exp. Ther., 303, 1273-1282.
22. Shureiqi,I., Jiang,W., Zuo,X., Wu,Y., Stimmel,J.B., Leesnitzer,L.M., Morris,J.S., Fan,H.Z., Fischer,S.M. and Lippman,S.M. (2003) The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells. Proc. Natl Acad. Sci. USA, 100, 9968-9973.
23. Assuncao Guimaraes,C. and Linden,R. (2004) Programmed cell deaths. Apoptosis and alternative deathstyles. Eur. J. Biochem., 271, 1638-1650.
24. Okada,H. and Mak,T.W. (2004) Pathways of apoptotic and non-apoptotic death in tumour cells. Nat. Rev. Cancer, 4, 592-603.
25. Ben-Sasson,S.A., Sherman,Y. and Gavrieli,Y. (1995) Identification of dying cells-in situ staining. Meth. Cell Biol., 46, 29-39.