2-Methylcitric acid impairs glutamate metabolism and induces permeability transition in brain mitochondria

Journal of Neurochemistry

Volumn 137, Issue 1, 2016, Pages 62-75

  Amaral, Alexandre Umpierrez ^a   Cecatto, Cristiane ^a   Castilho, Roger Frigério ^b   Wajner, Moacir ^a,c  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSITY OF CAMPINAS   (Brazil)

^c HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

Author keywords

2 methylcitric acid; glutamate dehydrogenase; glutamate oxidative metabolism; mitochondrial permeability transition; mitochondrial respiration

Indexed keywords

2 METHYLCITRIC ACID; 2 OXOGLUTARIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ASPARTATE AMINOTRANSFERASE; CALCIUM ION; CITRIC ACID; CYCLOSPORIN A; GLUTAMATE AMMONIA LIGASE; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; MALIC ACID; PYRUVIC ACID; SUCCINIC ACID; UNCLASSIFIED DRUG; 2-METHYLCITRIC ACID; ALPHA-KETOGLUTARIC ACID; CALCIUM; CARRIER PROTEIN; CYCLOSPORIN; MALIC ACID DERIVATIVE; MITOCHONDRIAL PERMEABILITY TRANSITION PORE;

AEROBIC METABOLISM; AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GLUTAMATE TRANPORT; GLUTAMIC ACID METABOLISM; HOMEOSTASIS; KINETICS; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; NONHUMAN; OSMOSIS; OSMOTIC SWELLING; PRIORITY JOURNAL; RAT; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BRAIN; DISORDERS OF AMINO ACID AND PROTEIN METABOLISM; DRUG EFFECTS; ENERGY METABOLISM; HUMAN; METABOLISM; MITOCHONDRION; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PROPIONIC ACIDEMIA; WISTAR RAT;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINO ACID METABOLISM, INBORN ERRORS; ANIMALS; BRAIN; CALCIUM; CITRATES; CYCLOSPORINE; ENERGY METABOLISM; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; HUMANS; KETOGLUTARIC ACIDS; MALATES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PROPIONIC ACIDEMIA; PYRUVIC ACID; RATS; RATS, WISTAR;

EID: 84959142950     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13544     Document Type: Article

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