Methylmalonate impairs mitochondrial respiration supported by NADH-linked substrates: Involvement of mitochondrial glutamate metabolism

Journal of Neuroscience Research

Volumn 90, Issue 6, 2012, Pages 1190-1199

  Melo, Daniela R ^a   Mirandola, Sandra R ^b   Assunção, Nilson A ^c   Castilho, Roger F ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

Author keywords

Brain mitochondria; Glutamate; Methylmalonic acidemia; Neurodegeneration; Oxidative metabolism

Indexed keywords

2 OXOGLUTARIC ACID; CITRIC ACID; GLUTAMIC ACID; ISOCITRIC ACID; MALIC ACID; METHYLMALONIC ACID; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ARTICLE; BRAIN MITOCHONDRION; CONTROLLED STUDY; ENZYME ASSAY; FEMALE; IN VIVO STUDY; INHIBITION KINETICS; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT;

AMINO ACID TRANSPORT SYSTEM X-AG; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; CARBOXY-LYASES; CITRATE (SI)-SYNTHASE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; KETOGLUTARATE DEHYDROGENASE COMPLEX; KETOGLUTARIC ACIDS; METHYLMALONIC ACID; MITOCHONDRIA; MULTIENZYME COMPLEXES; OXYGEN CONSUMPTION; PROSENCEPHALON; RATS; RATS, WISTAR;

EID: 84859383572     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23020     Document Type: Article

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