Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission

Journal of Neurochemistry

Volumn 123, Issue 3, 2012, Pages 342-348

  Frigerio, Francesca ^a   Karaca, Melis ^a   De Roo, Mathias ^a   Mlynárik, Vladimír ^b   Skytt, Dorte M ^c   Carobbio, Stefania ^a   Pajȩcka, Kamilla ^c   Waagepetersen, Helle S ^c   Gruetter, Rolf ^b   Muller, Dominique ^a   Maechler, Pierre ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b EPFL   (Switzerland)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

astrocytes; central nervous system; Glud1; glutamate; glutamate dehydrogenase

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CARBON DIOXIDE; GLUTAMATE AMMONIA LIGASE; GLUTAMATE DEHYDROGENASE; GLUTAMATE DEHYDROGENASE 1; GLUTAMIC ACID; GLUTAMINASE; GLUTAMINE; GLUTAMINE TRANSPORTER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN LEVEL; CATABOLISM; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE; GENE DELETION; GENE EXPRESSION; GLUD 1 GENE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KNOCKOUT MOUSE; MALE; MOUSE; NERVE CELL PLASTICITY; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; SYNAPTIC TRANSMISSION; UPREGULATION;

ANIMALS; BRAIN; CELLS, CULTURED; FEMALE; GENE DELETION; GLUTAMIC ACID; GLUTAMINE; MALE; MICE; MICE, 129 STRAIN; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NEURAL PATHWAYS; ORGAN CULTURE TECHNIQUES; RECEPTORS, GLUTAMATE; SYNAPTIC TRANSMISSION;

ANIMALIA; MUS;

EID: 84867336558     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07933.x     Document Type: Article

References (25)

1. Bak L. K., Schousboe A., and, Waagepetersen H. S., (2006) The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer. J. Neurochem. 98, 641-653. (Pubitemid 44051266)
2. Bao X., Pal R., Hascup K. N., et al,. (2009) Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability. J. Neurosci. 29, 13929-13944.
3. Burbaeva G., Boksha I. S., Tereshkina E. B., Savushkina O. K., Starodubtseva L. I., and, Turishcheva M. S., (2005) Glutamate metabolizing enzymes in prefrontal cortex of Alzheimer's disease patients. Neurochem. Res. 30, 1443-1451. (Pubitemid 41784481)
4. Carobbio S., Ishihara H., Fernandez-Pascual S., Bartley C., Martin-Del-Rio R., and, Maechler P., (2004) Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets. Diabetologia 47, 266-276. (Pubitemid 38315363)
5. Carobbio S., Frigerio F., Rubi B., et al,. (2009) Deletion of Glutamate Dehydrogenase in Beta-Cells Abolishes Part of the Insulin Secretory Response Not Required for Glucose Homeostasis. J. Biol. Chem. 284, 921-929.
6. Fairman W. A., and, Amara S. G., (1999) Functional diversity of excitatory amino acid transporters: ion channel and transport modes. Am. J. Physiol. 277, F481-F486. (Pubitemid 29525985)
7. Frigerio F., Brun T., Bartley C., Usardi A., Bosco D., Ravnskjaer K., Mandrup S., and, Maechler P., (2010) Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism. Diabetologia 53, 331-340.
8. Gruetter R., and, Tkac I., (2000) Field mapping without reference scan using asymmetric echo-planar techniques. Magn. Reson. Med. 43, 319-323. (Pubitemid 30075458)
9. Hagglund M. G., Sreedharan S., Nilsson V. C., Shaik J. H., Almkvist I. M., Backlin S., Wrange O., and, Fredriksson R., (2011) Identification of SLC38A7 (SNAT7) protein as a glutamine transporter expressed in neurons. J. Biol. Chem. 286, 20500-20511.
10. Hertz L., Juurlink B. H. J., Hertz E., Fosmark H., and, Schousboe A., (1989) Preparation of primary cultures of mouse (rat) astrocytes, in A dissection and tissue culture manual of the nervous system, (, Shaher A., De Vellis J., Vernadakis A., and, Haber B., eds.), pp. 92-104. New York, Alan R. Liss, Inc.
11. Karaca M., Frigerio F., and, Maechler P., (2011) From pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis. Neurochem. Int. 59, 510-517.
12. Kim K., Lee S. G., Kegelman T. P., et al,. (2011) Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics. J. Cell. Physiol. 226, 2484-2493.
13. Malthankar-Phatak G. H., de Lanerolle N., Eid T., Spencer D. D., Behar K. L., Spencer S. S., Kim J. H., and, Lai J. C., (2006) Differential glutamate dehydrogenase (GDH) activity profile in patients with temporal lobe epilepsy. Epilepsia 47, 1292-1299. (Pubitemid 44200408)
14. Mastorodemos V., Zaganas I., Spanaki C., Bessa M., and, Plaitakis A., (2005) Molecular basis of human glutamate dehydrogenase regulation under changing energy demands. J. Neurosci. Res. 79, 65-73. (Pubitemid 40116419)
15. McKenna M. C., Sonnewald U., Huang X., Stevenson J., and, Zielke H. R., (1996) Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes. J. Neurochem. 66, 386-393. (Pubitemid 26010804)
16. Michaelidis T. M., Tzimagiorgis G., Moschonas N. K., and, Papamatheakis J., (1993) The human glutamate dehydrogenase gene family: gene organization and structural characterization. Genomics 16, 150-160. (Pubitemid 23123803)
17. Mlynarik V., Gambarota G., Frenkel H., and, Gruetter R., (2006) Localized short-echo-time proton MR spectroscopy with full signal-intensity acquisition. Magn. Reson. Med. 56, 965-970. (Pubitemid 44691337)
18. Owen J. B., Di Domenico F., Sultana R., Perluigi M., Cini C., Pierce W. M., and, Butterfield D. A., (2009) Proteomics-determined differences in the concanavalin-A-fractionated proteome of hippocampus and inferior parietal lobule in subjects with Alzheimer's disease and mild cognitive impairment: implications for progression of AD. J. Proteome Res. 8, 471-482.
19. Quintana P., Alberi S., Hakkoum D., and, Muller D., (2006) Glutamate receptor changes associated with transient anoxia/hypoglycaemia in hippocampal slice cultures. Eur. J. Neurosci. 23, 975-983. (Pubitemid 43344692)
20. Rothe F., Brosz M., and, Storm-Mathisen J., (1994) Quantitative ultrastructural localization of glutamate dehydrogenase in the rat cerebellar cortex. Neuroscience 62, 1133-1146. (Pubitemid 24335607)
21. Rothstein J. D., Dykes-Hoberg M., Pardo C. A., et al,. (1996) Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16, 675-686. (Pubitemid 26103145)
22. Tanaka K., Watase K., Manabe T., et al,. (1997) Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1. Science 276, 1699-1702. (Pubitemid 27421977)
23. Tkac I., Starcuk Z., Choi I. Y., and, Gruetter R., (1999) In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time. Magn. Reson. Med. 41, 649-656. (Pubitemid 29205710)
24. Tronche F., Kellendonk C., Kretz O., Gass P., Anlag K., Orban P. C., Bock R., Klein R., and, Schutz G., (1999) Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat. Genet. 23, 99-103. (Pubitemid 29418797)
25. Yu A. C., Schousboe A., and, Hertz L., (1982) Metabolic fate of 14C-labeled glutamate in astrocytes in primary cultures. J. Neurochem. 39, 954-960. (Pubitemid 13200014)