SiRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate

Neurochemistry International

Volumn 61, Issue 4, 2012, Pages 490-497

  Skytt, Dorte M ^a   Klawonn, Anna M ^a   Stridh, Malin H ^a   Pajecka, Kamilla ^a   Patruss, Yasar ^a   Quintana Cabrera, Ruben ^b   Bolaños, Juan P ^b   Schousboe, Arne ^a   Waagepetersen, Helle S ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

15N; Alanine; Aspartate; Astrocyte; Glutamate; Glutamine; Homeostasis; Mass spectrometry; Metabolism; siRNA; TCA cycle

Indexed keywords

2 OXOGLUTARIC ACID; ALANINE; AMMONIUM CHLORIDE; ASPARTIC ACID; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; OXALOACETIC ACID; SMALL INTERFERING RNA;

AMINATION; ANIMAL CELL; ARTICLE; ASTROCYTE; CITRIC ACID CYCLE; DEAMINATION; ENZYME METABOLISM; ENZYME SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALS; ASPARTIC ACID; ASTROCYTES; BLOTTING, WESTERN; CELLS, CULTURED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENE KNOCKDOWN TECHNIQUES; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; MICE; RNA, SMALL INTERFERING;

EID: 84865720909     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2012.04.014     Document Type: Article

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