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Volumn 702, Issue 1, 2010, Pages 123-128

Prevention by l-carnitine of DNA damage induced by propionic and l-methylmalonic acids in human peripheral leukocytes in vitro

Author keywords

DNA damage; L Carnitine; Methylmalonic acid; Propionic acid

Indexed keywords

AMINO ACID; CARNITINE; ISOLEUCINE; METHIONINE; METHYLMALONIC ACID; PROPIONIC ACID; THREONINE; VALINE;

EID: 77956442345     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2010.07.008     Document Type: Article
Times cited : (49)

References (42)
  • 1
    • 0002911516 scopus 로고    scopus 로고
    • Disorders of propionate and methylmalonate metabolism
    • McGraw-Hill, New York, C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle (Eds.)
    • Fenton W.A., Gravel R.A., Rosenblatt D.S. Disorders of propionate and methylmalonate metabolism. The Metabolic and Molecular Bases of Inherited Disease 2001, 2165-2194. McGraw-Hill, New York. C.R. Scriver, A.L. Beaudet, W.S. Sly, D. Valle (Eds.).
    • (2001) The Metabolic and Molecular Bases of Inherited Disease , pp. 2165-2194
    • Fenton, W.A.1    Gravel, R.A.2    Rosenblatt, D.S.3
  • 3
    • 43649087986 scopus 로고    scopus 로고
    • Organic acidemias: a methylmalonic and propionic focus
    • Van Gosen L. Organic acidemias: a methylmalonic and propionic focus. J. Pediatr. Nurs. 2008, 23:225-233.
    • (2008) J. Pediatr. Nurs. , vol.23 , pp. 225-233
    • Van Gosen, L.1
  • 4
    • 33745017652 scopus 로고    scopus 로고
    • Lactate dehydrogenase activity is inhibited by methylmalonate in vitro
    • Saad L.O., Mirandola S.R., Maciel E.N., Castilho R.F. Lactate dehydrogenase activity is inhibited by methylmalonate in vitro. Neurochem. Res. 2006, 31:541-548.
    • (2006) Neurochem. Res. , vol.31 , pp. 541-548
    • Saad, L.O.1    Mirandola, S.R.2    Maciel, E.N.3    Castilho, R.F.4
  • 6
    • 0026568705 scopus 로고
    • Effect of methylmalonate on in vitro lactate release and carbon dioxide production by brain of suckling rats
    • Wajner M., Dutra J.C., Cardoso S.E., Wannmacher C.M., Motta E.R. Effect of methylmalonate on in vitro lactate release and carbon dioxide production by brain of suckling rats. J. Inherit. Metab. Dis. 1992, 15:92-96.
    • (1992) J. Inherit. Metab. Dis. , vol.15 , pp. 92-96
    • Wajner, M.1    Dutra, J.C.2    Cardoso, S.E.3    Wannmacher, C.M.4    Motta, E.R.5
  • 7
    • 0027510585 scopus 로고
    • Inhibition of succinate dehydrogenase and beta-hydroxybutyrate dehydrogenase activities by methylmalonate in brain and liver of developing rats
    • Dutra J.C., Dutra-Filho C.S., Cardozo S.E., Wannmacher C.M., Sarkis J.J., Wajner M. Inhibition of succinate dehydrogenase and beta-hydroxybutyrate dehydrogenase activities by methylmalonate in brain and liver of developing rats. J. Inherit. Metab. Dis. 1993, 16:147-153.
    • (1993) J. Inherit. Metab. Dis. , vol.16 , pp. 147-153
    • Dutra, J.C.1    Dutra-Filho, C.S.2    Cardozo, S.E.3    Wannmacher, C.M.4    Sarkis, J.J.5    Wajner, M.6
  • 8
    • 0029893660 scopus 로고    scopus 로고
    • Intrastriatal methylmalonic acid administration induces rotational behavior and convulsions through glutamatergic mechanisms
    • De Mello C.F., Begnini J., Jiménez-Bernal R.E., Rubin M.A., de Bastiani J., da Costa E., Wajner M. Intrastriatal methylmalonic acid administration induces rotational behavior and convulsions through glutamatergic mechanisms. Brain Res. 1996, 721:120-125.
    • (1996) Brain Res. , vol.721 , pp. 120-125
    • De Mello, C.F.1    Begnini, J.2    Jiménez-Bernal, R.E.3    Rubin, M.A.4    de Bastiani, J.5    da Costa, E.6    Wajner, M.7
  • 10
    • 0034647727 scopus 로고    scopus 로고
    • Methylmalonate administration decreases Na+, K+-ATPase activity in cerebral cortex of rats
    • Wyse A.T., Streck E.L., Barros S.V., Brusque A.M., Zugno A.L., Wajner M. Methylmalonate administration decreases Na+, K+-ATPase activity in cerebral cortex of rats. Neuroreport 2000, 11:2331-2334.
    • (2000) Neuroreport , vol.11 , pp. 2331-2334
    • Wyse, A.T.1    Streck, E.L.2    Barros, S.V.3    Brusque, A.M.4    Zugno, A.L.5    Wajner, M.6
  • 12
    • 0037177804 scopus 로고    scopus 로고
    • Neurodegeneration in methylmalonic aciduria involves inhibition of complex II and the tricarboxylic acid cycle, and synergistically acting excitotoxicity
    • Okun J.G., Hörster F., Farkas L.M., Feyh P., Hinz A., Sauer S., Hoffmann G.F., Unsicker K., Mayatepek E., Kölker S. Neurodegeneration in methylmalonic aciduria involves inhibition of complex II and the tricarboxylic acid cycle, and synergistically acting excitotoxicity. J. Biol. Chem. 2002, 277:14674-14680.
    • (2002) J. Biol. Chem. , vol.277 , pp. 14674-14680
    • Okun, J.G.1    Hörster, F.2    Farkas, L.M.3    Feyh, P.4    Hinz, A.5    Sauer, S.6    Hoffmann, G.F.7    Unsicker, K.8    Mayatepek, E.9    Kölker, S.10
  • 14
    • 33745091218 scopus 로고    scopus 로고
    • Nutrition therapy of organic acidaemias with amino acid-based formulas: emphasis on methylmalonic and propionic acidaemia
    • Yannicelli S. Nutrition therapy of organic acidaemias with amino acid-based formulas: emphasis on methylmalonic and propionic acidaemia. J. Inherit. Metab. Dis. 2006, 29:281-287.
    • (2006) J. Inherit. Metab. Dis. , vol.29 , pp. 281-287
    • Yannicelli, S.1
  • 15
    • 4344630828 scopus 로고    scopus 로고
    • The role of oxidative damage in the neuropathology of organic acidurias: insights from animal studies
    • Wajner M., Latini A., Wyse A.T., Dutra-Filho C.S. The role of oxidative damage in the neuropathology of organic acidurias: insights from animal studies. J. Inherit. Metab. Dis. 2004, 27:427-448.
    • (2004) J. Inherit. Metab. Dis. , vol.27 , pp. 427-448
    • Wajner, M.1    Latini, A.2    Wyse, A.T.3    Dutra-Filho, C.S.4
  • 18
    • 0001590580 scopus 로고    scopus 로고
    • Oxidative stress: adaptation, damage, repair and death
    • Oxford University Press, Oxford, B. Halliwell, J.M.C. Gutteridge (Eds.)
    • Halliwell B., Gutteridge J.M.C. Oxidative stress: adaptation, damage, repair and death. Free Radicals in Biology and Medicine 2001, 246-350. Oxford University Press, Oxford. B. Halliwell, J.M.C. Gutteridge (Eds.).
    • (2001) Free Radicals in Biology and Medicine , pp. 246-350
    • Halliwell, B.1    Gutteridge, J.M.C.2
  • 19
    • 0034796353 scopus 로고    scopus 로고
    • Role of free radicals in the neurodegenerative diseases
    • Halliwell B. Role of free radicals in the neurodegenerative diseases. Drugs Aging 2001, 18:685-716.
    • (2001) Drugs Aging , vol.18 , pp. 685-716
    • Halliwell, B.1
  • 20
    • 33344477525 scopus 로고    scopus 로고
    • The protective effect of l-carnitine in peripheral blood human lymphocytes exposed to oxidative agents
    • Garcia C.L., Filippi S., Mosesso P., Calvani M., Nicolai R., Mosconi L., Palitti F. The protective effect of l-carnitine in peripheral blood human lymphocytes exposed to oxidative agents. Mutagenesis 2006, 21:21-27.
    • (2006) Mutagenesis , vol.21 , pp. 21-27
    • Garcia, C.L.1    Filippi, S.2    Mosesso, P.3    Calvani, M.4    Nicolai, R.5    Mosconi, L.6    Palitti, F.7
  • 23
    • 77649193014 scopus 로고    scopus 로고
    • Reduction of lipid and protein damage in patients with disorders of propionate metabolism under treatment: a possible protective role of l-carnitine supplementation
    • Ribas G.S., Manfredini V., de Mari J.F., Wayhs C.Y., Vanzin C.S., Biancini G.B., Sitta A., Deon M., Wajner M., Vargas C.R. Reduction of lipid and protein damage in patients with disorders of propionate metabolism under treatment: a possible protective role of l-carnitine supplementation. Int. J. Dev. Neurosci. 2010, 28:127-132.
    • (2010) Int. J. Dev. Neurosci. , vol.28 , pp. 127-132
    • Ribas, G.S.1    Manfredini, V.2    de Mari, J.F.3    Wayhs, C.Y.4    Vanzin, C.S.5    Biancini, G.B.6    Sitta, A.7    Deon, M.8    Wajner, M.9    Vargas, C.R.10
  • 24
    • 0026783181 scopus 로고
    • Antiradical effects in l-propionyl carnitine protection of the heart against ischemia-reperfusion injury: the possible role of iron chelation
    • Reznick A.Z., Kagan V.E., Ramsey R., Tsuchiya M., Khwaja S., Serbinova E.A., Packer L. Antiradical effects in l-propionyl carnitine protection of the heart against ischemia-reperfusion injury: the possible role of iron chelation. Arch. Biochem. Biophys. 1992, 296:394-401.
    • (1992) Arch. Biochem. Biophys. , vol.296 , pp. 394-401
    • Reznick, A.Z.1    Kagan, V.E.2    Ramsey, R.3    Tsuchiya, M.4    Khwaja, S.5    Serbinova, E.A.6    Packer, L.7
  • 25
    • 33646828380 scopus 로고    scopus 로고
    • Oxidative stress-mediated macromolecular damage and dwindle in antioxidant status in aged rat brain regions: role of l-carnitine and dl-alpha-lipoic acid
    • Muthuswamy A.D., Vedagiri K., Ganesan M., Chinnakannu P. Oxidative stress-mediated macromolecular damage and dwindle in antioxidant status in aged rat brain regions: role of l-carnitine and dl-alpha-lipoic acid. Clin. Chim. Acta 2006, 368:84-92.
    • (2006) Clin. Chim. Acta , vol.368 , pp. 84-92
    • Muthuswamy, A.D.1    Vedagiri, K.2    Ganesan, M.3    Chinnakannu, P.4
  • 26
    • 30544455318 scopus 로고    scopus 로고
    • Antioxidant and antiradical activities of l-carnitine
    • Gülçin I. Antioxidant and antiradical activities of l-carnitine. Life Sci. 2006, 78:803-811.
    • (2006) Life Sci. , vol.78 , pp. 803-811
    • Gülçin, I.1
  • 27
    • 4844226348 scopus 로고    scopus 로고
    • L-Carnitine protects gastric mucosa by decreasing ischemia-reperfusion induced lipid peroxidation
    • Derin N., Izgut-Uysal V.N., Agac A., Aliciguzel Y., Demir N. l-Carnitine protects gastric mucosa by decreasing ischemia-reperfusion induced lipid peroxidation. J. Physiol. Pharmacol. 2004, 55:595-606.
    • (2004) J. Physiol. Pharmacol. , vol.55 , pp. 595-606
    • Derin, N.1    Izgut-Uysal, V.N.2    Agac, A.3    Aliciguzel, Y.4    Demir, N.5
  • 28
    • 0023919963 scopus 로고
    • A simple technique for quantification of low levels of DNA damage in individuals cells
    • Singh N., McCoy M., Tice R., Schneider E. A simple technique for quantification of low levels of DNA damage in individuals cells. Exp. Cell Res. 1988, 175:184-191.
    • (1988) Exp. Cell Res. , vol.175 , pp. 184-191
    • Singh, N.1    McCoy, M.2    Tice, R.3    Schneider, E.4
  • 31
    • 65649138401 scopus 로고    scopus 로고
    • The comet assay: a sensitive method for detecting DNA damage in individual cells
    • Liao W., McNutt M.A., Zhu W.G. The comet assay: a sensitive method for detecting DNA damage in individual cells. Methods 2009, 48:46-53.
    • (2009) Methods , vol.48 , pp. 46-53
    • Liao, W.1    McNutt, M.A.2    Zhu, W.G.3
  • 32
    • 33745013111 scopus 로고    scopus 로고
    • Oxidative stress and neurodegeneration: where are we now?
    • Halliwell B. Oxidative stress and neurodegeneration: where are we now?. J. Neurochem. 2006, 97:1634-1658.
    • (2006) J. Neurochem. , vol.97 , pp. 1634-1658
    • Halliwell, B.1
  • 34
    • 47849100494 scopus 로고    scopus 로고
    • Mechanism of oxidative DNA damage repair and relevance to human pathology
    • D'Errico M., Parlanti E., Dogliotti E. Mechanism of oxidative DNA damage repair and relevance to human pathology. Mutat. Res. 2008, 659:4-14.
    • (2008) Mutat. Res. , vol.659 , pp. 4-14
    • D'Errico, M.1    Parlanti, E.2    Dogliotti, E.3
  • 39
    • 64849104137 scopus 로고    scopus 로고
    • L-Carnitine in the lipid and protein protection against ethanol-induced oxidative stress
    • Augustyniak A., Skrzydlewska E. l-Carnitine in the lipid and protein protection against ethanol-induced oxidative stress. Alcohol 2009, 43:217-223.
    • (2009) Alcohol , vol.43 , pp. 217-223
    • Augustyniak, A.1    Skrzydlewska, E.2
  • 40
    • 0037385059 scopus 로고    scopus 로고
    • The role of carnitine in normal and altered fatty acid metabolism
    • Hoppel C. The role of carnitine in normal and altered fatty acid metabolism. Am. J. Kidney Dis. 2003, 41:S4-12.
    • (2003) Am. J. Kidney Dis. , vol.41
    • Hoppel, C.1
  • 41
    • 0027374021 scopus 로고
    • The effect of l-carnitine and acetyl-l-carnitine on the disappearance of DNA single-strand breaks in human peripheral blood lymphocytes
    • Boerrigter M.E., Franceschi C., Arrigoni-Martelli E., Wei J.Y., Vijg J. The effect of l-carnitine and acetyl-l-carnitine on the disappearance of DNA single-strand breaks in human peripheral blood lymphocytes. Carcinogenesis 1993, 14:2131-2136.
    • (1993) Carcinogenesis , vol.14 , pp. 2131-2136
    • Boerrigter, M.E.1    Franceschi, C.2    Arrigoni-Martelli, E.3    Wei, J.Y.4    Vijg, J.5


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