Methylmalonic acid induces excitotoxic neuronal damage in vitro

Journal of Inherited Metabolic Disease

Volumn 23, Issue 4, 2000, Pages 355-358

  Kolker S ^a,b   Ahlemeyer, B ^c   Krieglstein, J ^c   Hoffmann, G F ^a  

^a University Children's Hospital   (Germany)

^b University Children's Hospital   (Germany)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CREATINE; GLUTAMATE RECEPTOR ANTAGONIST; METHYLMALONIC ACID; METHYLMALONYL COENZYME A MUTASE; PYRUVATE DECARBOXYLASE; SUCCINATE DEHYDROGENASE;

ACIDURIA; ANIMAL CELL; BASAL GANGLION; CELL VIABILITY; CHICKEN; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME DEFICIENCY; LETHARGY; MYELINATION; NERVE CELL DEGENERATION; NEWBORN; NONHUMAN; SEIZURE;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ALANINE; ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CHICK EMBRYO; DIZOCILPINE MALEATE; EXCITATORY AMINO ACID ANTAGONISTS; METHYLMALONIC ACID; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; NG-NITROARGININE METHYL ESTER; PIPERIDINES;

EID: 0342424746     PISSN: 01418955     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005631230455     Document Type: Conference Paper

References (6)

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6. Wajner M, Coelho JC (1997) Neurological dysfunction in methylmalonic acidaemia is probably related to inhibitory effect of methylmalonate on brain energy production. J Inherit Metab Dis 20: 761-768.