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Volumn 4, Issue DEC, 2013, Pages

Glutamate pays its own way in astrocytes

Author keywords

Astrocytes; Glutamate; Glutamate dehydrogenase; Oxidative metabolism; Pyruvate recycling pathway

Indexed keywords

EXCITATORY AMINO ACID TRANSPORTER; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; HEXOKINASE; MITOCHONDRIAL PROTEIN; PYRUVIC ACID;

EID: 84892176412     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2013.00191     Document Type: Short Survey
Times cited : (159)

References (49)
  • 1
    • 0035001341 scopus 로고    scopus 로고
    • Glutamate uptake
    • doi:10.1016/S0301-0082(00)00067-8
    • Danbolt NC. Glutamate uptake. Prog Neurobiol (2001) 65:1-105. doi:10.1016/S0301-0082(00)00067-8.
    • (2001) Prog Neurobiol , vol.65 , pp. 1-105
    • Danbolt, N.C.1
  • 2
    • 84860599501 scopus 로고    scopus 로고
    • Aspects of astrocyte energy metabolism, amino acid neurotransmitter homeostasis and metabolic compartmentation
    • doi:10.1042/AN20120007
    • Kreft M, Bak LK, Waagepetersen HS, Schousboe A. Aspects of astrocyte energy metabolism, amino acid neurotransmitter homeostasis and metabolic compartmentation. ASN Neuro (2012) 4(3):e00086. doi:10.1042/AN20120007.
    • (2012) ASN Neuro , vol.4 , Issue.3
    • Kreft, M.1    Bak, L.K.2    Waagepetersen, H.S.3    Schousboe, A.4
  • 3
    • 35848947733 scopus 로고    scopus 로고
    • The glutamate-glutamine cycle is not stoichiometric: fates of glutamate in brain
    • doi:10.1002/jnr.21444
    • McKenna MC. The glutamate-glutamine cycle is not stoichiometric: fates of glutamate in brain. J Neurosci Res (2007) 85:3347-58. doi:10.1002/jnr.21444.
    • (2007) J Neurosci Res , vol.85 , pp. 3347-3358
    • McKenna, M.C.1
  • 4
    • 0033152742 scopus 로고    scopus 로고
    • Clearance of glutamate inside the synapse and beyond
    • doi:10.1016/S0959-4388(99)80043-9
    • Bergles DE, Diamond JS, Jahr CE. Clearance of glutamate inside the synapse and beyond. Curr Opin Neurobiol (1999) 9:293-8. doi:10.1016/S0959-4388(99)80043-9.
    • (1999) Curr Opin Neurobiol , vol.9 , pp. 293-298
    • Bergles, D.E.1    Diamond, J.S.2    Jahr, C.E.3
  • 5
    • 23844469720 scopus 로고    scopus 로고
    • High-concentration rapid transients of glutamate mediate neural-glial communication via ectopic release
    • doi:10.1523/JNEUROSCI.1927-05.2005
    • Matsui K, Jahr CE, Rubio ME. High-concentration rapid transients of glutamate mediate neural-glial communication via ectopic release. J Neurosci (2005) 25:7538-47. doi:10.1523/JNEUROSCI.1927-05.2005.
    • (2005) J Neurosci , vol.25 , pp. 7538-7547
    • Matsui, K.1    Jahr, C.E.2    Rubio, M.E.3
  • 6
    • 35548983491 scopus 로고    scopus 로고
    • The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex
    • doi:10.1523/JNEUROSCI.3404-07.2007
    • Lovatt D, Sonnewald U, Waagepetersen HS, Schousboe A, He W, Lin JH, et al. The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex. J Neurosci (2007) 27:12255-66. doi:10.1523/JNEUROSCI.3404-07.2007.
    • (2007) J Neurosci , vol.27 , pp. 12255-12266
    • Lovatt, D.1    Sonnewald, U.2    Waagepetersen, H.S.3    Schousboe, A.4    He, W.5    Lin, J.H.6
  • 7
    • 33645843953 scopus 로고    scopus 로고
    • Glutamate, a neurotransmitter-and so much more.A synopsis of Wierzba III
    • doi:10.1016/j.neuint.2005.12.021
    • Hertz L. Glutamate, a neurotransmitter-and so much more. A synopsis of Wierzba III. Neurochem Int (2006) 48:416-25. doi:10.1016/j.neuint.2005.12.021.
    • (2006) Neurochem Int , vol.48 , pp. 416-425
    • Hertz, L.1
  • 8
    • 0346888681 scopus 로고    scopus 로고
    • Localized in vivo 13C NMR spectroscopy of the brain
    • doi:10.1002/nbm.841
    • Gruetter R, Adriany G, Choi IY, Henry PG, Lei H, Oz G. Localized in vivo 13C NMR spectroscopy of the brain. NMR Biomed (2003) 16:313-38. doi:10.1002/nbm.841.
    • (2003) NMR Biomed , vol.16 , pp. 313-338
    • Gruetter, R.1    Adriany, G.2    Choi, I.Y.3    Henry, P.G.4    Lei, H.5    Oz, G.6
  • 9
    • 0036180634 scopus 로고    scopus 로고
    • Tricarboxylic acid cycle of glia in the in vivo human brain
    • doi:10.1002/nbm.725
    • Bluml S, Moreno-Torres A, Shic F, Nguy CH, Ross BD. Tricarboxylic acid cycle of glia in the in vivo human brain. NMR Biomed (2002) 15:1-5. doi:10.1002/nbm.725.
    • (2002) NMR Biomed , vol.15 , pp. 1-5
    • Bluml, S.1    Moreno-Torres, A.2    Shic, F.3    Nguy, C.H.4    Ross, B.D.5
  • 10
    • 84855978539 scopus 로고    scopus 로고
    • Isotope-based quantitation of uptake, release, and metabolism of glutamate and glucose in cultured astrocytes
    • doi:10.1007/978-1-61779-452-0_20
    • Hertz L. Isotope-based quantitation of uptake, release, and metabolism of glutamate and glucose in cultured astrocytes. Methods Mol Biol (2012) 814:305-23. doi:10.1007/978-1-61779-452-0_20.
    • (2012) Methods Mol Biol , vol.814 , pp. 305-323
    • Hertz, L.1
  • 11
    • 84871458541 scopus 로고    scopus 로고
    • Substrate competition studies demonstrate oxidative metabolism of glucose, glutamate, glutamine, lactate and 3-hydroxybutyrate in cortical astrocytes from rat brain
    • doi:10.1007/s11064-012-0901-3
    • McKenna MC. Substrate competition studies demonstrate oxidative metabolism of glucose, glutamate, glutamine, lactate and 3-hydroxybutyrate in cortical astrocytes from rat brain. Neurochem Res (2012) 37:2613-26. doi:10.1007/s11064-012-0901-3.
    • (2012) Neurochem Res , vol.37 , pp. 2613-2626
    • McKenna, M.C.1
  • 12
    • 0027727915 scopus 로고
    • Regulation of energy metabolism in synaptic terminals and cultured rat brain astrocytes: differences revealed using aminooxyacetate
    • doi:10.1159/000111351
    • McKenna MC, Tildon JT, Stevenson JH, Boatright R, Huang S. Regulation of energy metabolism in synaptic terminals and cultured rat brain astrocytes: differences revealed using aminooxyacetate. Dev Neurosci (1993) 15:320-9. doi:10.1159/000111351.
    • (1993) Dev Neurosci , vol.15 , pp. 320-329
    • McKenna, M.C.1    Tildon, J.T.2    Stevenson, J.H.3    Boatright, R.4    Huang, S.5
  • 13
    • 0029829149 scopus 로고    scopus 로고
    • Astrocyte glucose metabolism under normal and pathological conditions in vitro
    • doi:10.1159/000111448
    • Swanson RA, Benington JH. Astrocyte glucose metabolism under normal and pathological conditions in vitro. Dev Neurosci (1996) 18:515-21. doi:10.1159/000111448.
    • (1996) Dev Neurosci , vol.18 , pp. 515-521
    • Swanson, R.A.1    Benington, J.H.2
  • 14
    • 0031732043 scopus 로고    scopus 로고
    • Comparison of lactate and glucose metabolism in cultured neocortical neurons and astrocytes using 13C-NMR spectroscopy
    • doi:10.1159/000017326
    • Waagepetersen HS, Bakken IJ, Larsson OM, Sonnewald U, Schousboe A. Comparison of lactate and glucose metabolism in cultured neocortical neurons and astrocytes using 13C-NMR spectroscopy. Dev Neurosci (1998) 20:310-20. doi:10.1159/000017326.
    • (1998) Dev Neurosci , vol.20 , pp. 310-320
    • Waagepetersen, H.S.1    Bakken, I.J.2    Larsson, O.M.3    Sonnewald, U.4    Schousboe, A.5
  • 15
    • 0346888682 scopus 로고    scopus 로고
    • Regulation of glial metabolism studied by 13C-NMR
    • doi:10.1002/nbm.850
    • Zwingmann C, Leibfritz D. Regulation of glial metabolism studied by 13C-NMR. NMR Biomed (2003) 16:370-99. doi:10.1002/nbm.850.
    • (2003) NMR Biomed , vol.16 , pp. 370-399
    • Zwingmann, C.1    Leibfritz, D.2
  • 16
    • 84882479655 scopus 로고    scopus 로고
    • Astrocytic energetics during excitatory neurotransmission: what are contributions of glutamate oxidation and glycolysis?
    • doi:10.1016/j.neuint.2013.06.015
    • Dienel GA. Astrocytic energetics during excitatory neurotransmission: what are contributions of glutamate oxidation and glycolysis? Neurochem Int (2013) 63:244-58. doi:10.1016/j.neuint.2013.06.015.
    • (2013) Neurochem Int , vol.63 , pp. 244-258
    • Dienel, G.A.1
  • 17
    • 0037727865 scopus 로고    scopus 로고
    • Cataplerotic TCA cycle flux determined as glutamate-sustained oxygen consumption in primary cultures of astrocytes
    • doi:10.1016/S0197-0186(03)00022-6
    • Hertz L, Hertz E. Cataplerotic TCA cycle flux determined as glutamate-sustained oxygen consumption in primary cultures of astrocytes. Neurochem Int (2003) 43:355-61. doi:10.1016/S0197-0186(03)00022-6.
    • (2003) Neurochem Int , vol.43 , pp. 355-361
    • Hertz, L.1    Hertz, E.2
  • 18
    • 0027338137 scopus 로고
    • Metabolism of [U-13C]glutamate in astrocytes studied by 13C NMR spectroscopy: incorporation of more label into lactate than into glutamine demonstrates the importance of the tricarboxylic acid cycle
    • doi:10.1111/j.1471-4159.1993.tb03641.x
    • Sonnewald U, Westergaard N, Petersen SB, Unsgard G, Schousboe A. Metabolism of [U-13C]glutamate in astrocytes studied by 13C NMR spectroscopy: incorporation of more label into lactate than into glutamine demonstrates the importance of the tricarboxylic acid cycle. J Neurochem (1993) 61:1179-82. doi:10.1111/j.1471-4159.1993.tb03641.x.
    • (1993) J Neurochem , vol.61 , pp. 1179-1182
    • Sonnewald, U.1    Westergaard, N.2    Petersen, S.B.3    Unsgard, G.4    Schousboe, A.5
  • 19
    • 84865735219 scopus 로고    scopus 로고
    • The glutamate transporter, GLAST, participates in a macromolecular complex that supports glutamate metabolism
    • doi:10.1016/j.neuint.2012.01.013
    • Bauer DE, Jackson JG, Genda EN, Montoya MM, Yudkoff M, Robinson MB. The glutamate transporter, GLAST, participates in a macromolecular complex that supports glutamate metabolism. Neurochem Int (2012) 61(4):566-74. doi:10.1016/j.neuint.2012.01.013.
    • (2012) Neurochem Int , vol.61 , Issue.4 , pp. 566-574
    • Bauer, D.E.1    Jackson, J.G.2    Genda, E.N.3    Montoya, M.M.4    Yudkoff, M.5    Robinson, M.B.6
  • 20
    • 83455179198 scopus 로고    scopus 로고
    • Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria
    • doi:10.1523/JNEUROSCI.3305-11.2011
    • Genda EN, Jackson JG, Sheldon AL, Locke SF, Greco TM, O'Donnell JC, et al. Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria. J Neurosci (2011) 31:18275-88. doi:10.1523/JNEUROSCI.3305-11.2011.
    • (2011) J Neurosci , vol.31 , pp. 18275-18288
    • Genda, E.N.1    Jackson, J.G.2    Sheldon, A.L.3    Locke, S.F.4    Greco, T.M.5    O'Donnell, J.C.6
  • 21
    • 33846423878 scopus 로고    scopus 로고
    • Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis
    • doi:10.1038/sj.jcbfm.9600343
    • Hertz L, Peng L, Dienel GA. Energy metabolism in astrocytes: high rate of oxidative metabolism and spatiotemporal dependence on glycolysis/glycogenolysis. J Cereb Blood Flow Metab (2007) 27:219-49. doi:10.1038/sj.jcbfm.9600343.
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 219-249
    • Hertz, L.1    Peng, L.2    Dienel, G.A.3
  • 22
    • 0029850061 scopus 로고    scopus 로고
    • Mass isotopomer study of glutamine oxidation and synthesis in primary culture of astrocytes
    • doi:10.1159/000111442
    • Lee WN, Edmond J, Bassilian S, Morrow JW. Mass isotopomer study of glutamine oxidation and synthesis in primary culture of astrocytes. Dev Neurosci (1996) 18:469-77. doi:10.1159/000111442.
    • (1996) Dev Neurosci , vol.18 , pp. 469-477
    • Lee, W.N.1    Edmond, J.2    Bassilian, S.3    Morrow, J.W.4
  • 23
    • 0023470792 scopus 로고
    • Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture
    • doi:10.1002/jnr.490180407
    • Edmond J, Robbins RA, Bergstrom JD, Cole RA, de Vellis J. Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture. J Neurosci Res (1987) 18:551-61. doi:10.1002/jnr.490180407.
    • (1987) J Neurosci Res , vol.18 , pp. 551-561
    • Edmond, J.1    Robbins, R.A.2    Bergstrom, J.D.3    Cole, R.A.4    de Vellis, J.5
  • 24
    • 0027767456 scopus 로고
    • NMR spectroscopic studies of 13C acetate and 13C glucose metabolism in neocortical astrocytes: evidence for mitochondrial heterogeneity
    • doi:10.1159/000111355
    • Sonnewald U, Westergaard N, Hassel B, Muller TB, Unsgard G, Fonnum F, et al. NMR spectroscopic studies of 13C acetate and 13C glucose metabolism in neocortical astrocytes: evidence for mitochondrial heterogeneity. Dev Neurosci (1993) 15:351-8. doi:10.1159/000111355.
    • (1993) Dev Neurosci , vol.15 , pp. 351-358
    • Sonnewald, U.1    Westergaard, N.2    Hassel, B.3    Muller, T.B.4    Unsgard, G.5    Fonnum, F.6
  • 25
    • 0023710552 scopus 로고
    • Effects of ammonia and beta-methylene-DL-aspartate on the oxidation of glucose and pyruvate by neurons and astrocytes in primary culture
    • doi:10.1111/j.1471-4159.1988.tb03087.x
    • Fitzpatrick SM, Cooper AJ, Hertz L. Effects of ammonia and beta-methylene-DL-aspartate on the oxidation of glucose and pyruvate by neurons and astrocytes in primary culture. J Neurochem (1988) 51:1197-203. doi:10.1111/j.1471-4159.1988.tb03087.x.
    • (1988) J Neurochem , vol.51 , pp. 1197-1203
    • Fitzpatrick, S.M.1    Cooper, A.J.2    Hertz, L.3
  • 26
    • 0021288261 scopus 로고
    • Metabolic fate of [14C]-glutamine in mouse cerebral neurons in primary cultures
    • doi:10.1002/jnr.490110403
    • Yu AC, Fisher TE, Hertz E, Tildon JT, Schousboe A, Hertz L. Metabolic fate of [14C]-glutamine in mouse cerebral neurons in primary cultures. J Neurosci Res (1984) 11:351-7. doi:10.1002/jnr.490110403.
    • (1984) J Neurosci Res , vol.11 , pp. 351-357
    • Yu, A.C.1    Fisher, T.E.2    Hertz, E.3    Tildon, J.T.4    Schousboe, A.5    Hertz, L.6
  • 28
    • 0348109312 scopus 로고    scopus 로고
    • Glutamate metabolism in primary cultures of rat brain astrocytes: rationale and initial efforts toward developing a compartmental model
    • Novotny JA, Green MH, Boston RC, editors. Mathematical Modeling in Nutrition and the Health Sciences. New York: Kluwer Academic/Plenum Publishers.
    • McKenna MC. Glutamate metabolism in primary cultures of rat brain astrocytes: rationale and initial efforts toward developing a compartmental model. In: Novotny JA, Green MH, Boston RC, editors. Advances in Experimental Medicine and Biology (Vol. 537) Mathematical Modeling in Nutrition and the Health Sciences. New York: Kluwer Academic/Plenum Publishers (2003). p. 317-41.
    • (2003) Advances in Experimental Medicine and Biology , vol.537 , pp. 317-341
    • McKenna, M.C.1
  • 29
    • 0030061356 scopus 로고    scopus 로고
    • Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes
    • doi:10.1046/j.1471-4159.1996.66010386.x
    • McKenna MC, Sonnewald U, Huang X, Stevenson J, Zielke HR. Exogenous glutamate concentration regulates the metabolic fate of glutamate in astrocytes. J Neurochem (1996) 66:386-93. doi:10.1046/j.1471-4159.1996.66010386.x.
    • (1996) J Neurochem , vol.66 , pp. 386-393
    • McKenna, M.C.1    Sonnewald, U.2    Huang, X.3    Stevenson, J.4    Zielke, H.R.5
  • 30
    • 0029972176 scopus 로고    scopus 로고
    • New insights into the compartmentation of glutamate and glutamine in cultured rat brain astrocytes
    • doi:10.1159/000111431
    • McKenna MC, Tildon JT, Stevenson JH, Huang X. New insights into the compartmentation of glutamate and glutamine in cultured rat brain astrocytes. Dev Neurosci (1996) 18:380-90. doi:10.1159/000111431.
    • (1996) Dev Neurosci , vol.18 , pp. 380-390
    • McKenna, M.C.1    Tildon, J.T.2    Stevenson, J.H.3    Huang, X.4
  • 31
    • 0026668151 scopus 로고
    • Glutamate metabolism in rat cortical astrocyte cultures
    • doi:10.1111/j.1471-4159.1992.tb10068.x
    • Farinelli SE, Nicklas WJ. Glutamate metabolism in rat cortical astrocyte cultures. J Neurochem (1992) 58:1905-15. doi:10.1111/j.1471-4159.1992.tb10068.x.
    • (1992) J Neurochem , vol.58 , pp. 1905-1915
    • Farinelli, S.E.1    Nicklas, W.J.2
  • 32
    • 0025613128 scopus 로고
    • Effect of 8-bromo-cAMP and dexamethasone on glutamate metabolism in rat astrocytes
    • doi:10.1007/BF01101713
    • Zielke HR, Tildon JT, Landry ME, Max SR. Effect of 8-bromo-cAMP and dexamethasone on glutamate metabolism in rat astrocytes. Neurochem Res (1990) 15:1115-22. doi:10.1007/BF01101713.
    • (1990) Neurochem Res , vol.15 , pp. 1115-1122
    • Zielke, H.R.1    Tildon, J.T.2    Landry, M.E.3    Max, S.R.4
  • 33
    • 0023720157 scopus 로고
    • Energy metabolism in glutamatergic neurons, GABAergic neurons and astrocytes in primary cultures
    • doi:10.1007/BF00973275
    • Hertz L, Drejer J, Schousboe A. Energy metabolism in glutamatergic neurons, GABAergic neurons and astrocytes in primary cultures. Neurochem Res (1988) 13:605-10. doi:10.1007/BF00973275.
    • (1988) Neurochem Res , vol.13 , pp. 605-610
    • Hertz, L.1    Drejer, J.2    Schousboe, A.3
  • 34
    • 33947211245 scopus 로고    scopus 로고
    • Effect of fluorocitrate on cerebral oxidation of lactate and glucose in freely moving rats
    • doi:10.1111/j.1471-4159.2006.04335.x
    • Zielke HR, Zielke CL, Baab PJ, Tildon JT. Effect of fluorocitrate on cerebral oxidation of lactate and glucose in freely moving rats. J Neurochem (2007) 101:9-16. doi:10.1111/j.1471-4159.2006.04335.x.
    • (2007) J Neurochem , vol.101 , pp. 9-16
    • Zielke, H.R.1    Zielke, C.L.2    Baab, P.J.3    Tildon, J.T.4
  • 35
    • 0027759946 scopus 로고
    • Monitoring in vivo oxidation of 14C-labelled substrates to 14CO2 by brain microdialysis
    • doi:10.1159/000111339
    • Huang Y, Zielke CL, Tildon JT, Zielke HR. Monitoring in vivo oxidation of 14C-labelled substrates to 14CO2 by brain microdialysis. Dev Neurosci (1993) 15:233-9. doi:10.1159/000111339.
    • (1993) Dev Neurosci , vol.15 , pp. 233-239
    • Huang, Y.1    Zielke, C.L.2    Tildon, J.T.3    Zielke, H.R.4
  • 36
    • 0035577775 scopus 로고    scopus 로고
    • Differential expression of glutamate dehydrogenase in cultured neurons and astrocytes from mouse cerebellum and cerebral cortex
    • doi:10.1002/jnr.10058
    • Zaganas I, Waagepetersen HS, Georgopoulos P, Sonnewald U, Plaitakis A, Schousboe A. Differential expression of glutamate dehydrogenase in cultured neurons and astrocytes from mouse cerebellum and cerebral cortex. J Neurosci Res (2001) 66:909-13. doi:10.1002/jnr.10058.
    • (2001) J Neurosci Res , vol.66 , pp. 909-913
    • Zaganas, I.1    Waagepetersen, H.S.2    Georgopoulos, P.3    Sonnewald, U.4    Plaitakis, A.5    Schousboe, A.6
  • 37
    • 84865755077 scopus 로고    scopus 로고
    • Expression of human GLUD2 glutamate dehydrogenase in human tissues: functional implications
    • doi:10.1016/j.neuint.2012.06.007
    • Zaganas I, Spanaki C, Plaitakis A. Expression of human GLUD2 glutamate dehydrogenase in human tissues: functional implications. Neurochem Int (2012) 61:455-62. doi:10.1016/j.neuint.2012.06.007.
    • (2012) Neurochem Int , vol.61 , pp. 455-462
    • Zaganas, I.1    Spanaki, C.2    Plaitakis, A.3
  • 38
    • 84863095997 scopus 로고    scopus 로고
    • Expression of mitochondrial branched-chain aminotransferase and alpha-keto-acid dehydrogenase in rat brain: implications for neurotransmitter metabolism
    • doi:10.3389/fnana.2012.00018
    • Cole JT, Sweatt AJ, Hutson SM. Expression of mitochondrial branched-chain aminotransferase and alpha-keto-acid dehydrogenase in rat brain: implications for neurotransmitter metabolism. Front Neuroanat (2012) 6:18. doi:10.3389/fnana.2012.00018.
    • (2012) Front Neuroanat , vol.6 , pp. 18
    • Cole, J.T.1    Sweatt, A.J.2    Hutson, S.M.3
  • 39
    • 33847709986 scopus 로고    scopus 로고
    • Widespread neuronal expression of branched-chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids
    • doi:10.1111/j.1471-4159.2006.04332.x
    • Garcia-Espinosa MA, Wallin R, Hutson SM, Sweatt AJ. Widespread neuronal expression of branched-chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids. J Neurochem (2007) 100:1458-68. doi:10.1111/j.1471-4159.2006.04332.x.
    • (2007) J Neurochem , vol.100 , pp. 1458-1468
    • Garcia-Espinosa, M.A.1    Wallin, R.2    Hutson, S.M.3    Sweatt, A.J.4
  • 40
    • 0035116897 scopus 로고    scopus 로고
    • Distribution of key enzymes of branched-chain amino acid metabolism in glial and neuronal cells in culture
    • doi:10.1177/002215540104900314
    • Bixel M, Shimomura Y, Hutson S, Hamprecht B. Distribution of key enzymes of branched-chain amino acid metabolism in glial and neuronal cells in culture. J Histochem Cytochem (2001) 49:407-18. doi:10.1177/002215540104900314.
    • (2001) J Histochem Cytochem , vol.49 , pp. 407-418
    • Bixel, M.1    Shimomura, Y.2    Hutson, S.3    Hamprecht, B.4
  • 41
    • 0030174754 scopus 로고    scopus 로고
    • Evaluation of the importance of transamination versus deamination in astrocytic metabolism of [U-13C]glutamate
    • doi:10.1002/(SICI)1098-1136(199606)17:2<160::AID-GLIA7>3.3.CO;2-S
    • Westergaard N, Drejer J, Schousboe A, Sonnewald U. Evaluation of the importance of transamination versus deamination in astrocytic metabolism of [U-13C]glutamate. Glia (1996) 17:160-8. doi:10.1002/(SICI)1098-1136(199606)17:2<160::AID-GLIA7>3.3.CO;2-S.
    • (1996) Glia , vol.17 , pp. 160-168
    • Westergaard, N.1    Drejer, J.2    Schousboe, A.3    Sonnewald, U.4
  • 42
    • 0036866554 scopus 로고    scopus 로고
    • Demonstration of pyruvate recycling in primary cultures of neocortical astrocytes but not in neurons
    • doi:10.1023/A:1021636102735
    • Waagepetersen HS, Qu H, Hertz L, Sonnewald U, Schousboe A. Demonstration of pyruvate recycling in primary cultures of neocortical astrocytes but not in neurons. Neurochem Res (2002) 27:1431-7. doi:10.1023/A:1021636102735.
    • (2002) Neurochem Res , vol.27 , pp. 1431-1437
    • Waagepetersen, H.S.1    Qu, H.2    Hertz, L.3    Sonnewald, U.4    Schousboe, A.5
  • 43
    • 33947611667 scopus 로고    scopus 로고
    • Pyruvate recycling in cultured neurons from cerebellum
    • doi:10.1002/jnr.21208
    • Olstad E, Olsen GM, Qu H, Sonnewald U. Pyruvate recycling in cultured neurons from cerebellum. J Neurosci Res (2007) 85:3318-25. doi:10.1002/jnr.21208.
    • (2007) J Neurosci Res , vol.85 , pp. 3318-3325
    • Olstad, E.1    Olsen, G.M.2    Qu, H.3    Sonnewald, U.4
  • 44
    • 0029662102 scopus 로고    scopus 로고
    • Metabolism of [U-13C5] glutamine in cultured astrocytes studied by NMR spectroscopy: first evidence of astrocytic pyruvate recycling
    • doi:10.1046/j.1471-4159.1996.67062566.x
    • Sonnewald U, Westergaard N, Jones P, Taylor A, Bachelard HS, Schousboe A. Metabolism of [U-13C5] glutamine in cultured astrocytes studied by NMR spectroscopy: first evidence of astrocytic pyruvate recycling. J Neurochem (1996) 67:2566-72. doi:10.1046/j.1471-4159.1996.67062566.x.
    • (1996) J Neurochem , vol.67 , pp. 2566-2572
    • Sonnewald, U.1    Westergaard, N.2    Jones, P.3    Taylor, A.4    Bachelard, H.S.5    Schousboe, A.6
  • 45
    • 84860557551 scopus 로고    scopus 로고
    • Energy metabolism of the brain
    • Brady S, Price D, Siegal G. Basic Neurochemistry (Vol. 8). Waltham: Academic Press.
    • McKenna MC, Dienel GA, Waagepetersen HS, Schousboe A, Sonnewald U. Energy metabolism of the brain. In: Brady S, Price D, Siegal G. editors. Basic Neurochemistry (Vol. 8). Waltham: Academic Press (2012). p. 200-31.
    • (2012) editors , pp. 200-231
    • McKenna, M.C.1    Dienel, G.A.2    Waagepetersen, H.S.3    Schousboe, A.4    Sonnewald, U.5
  • 46
    • 0029858510 scopus 로고    scopus 로고
    • Excitatory amino acids stimulate aerobic glycolysis in astrocytes via an activation of the Na+/K+ ATPase
    • doi:10.1159/000111426
    • Pellerin L, Magistretti PJ. Excitatory amino acids stimulate aerobic glycolysis in astrocytes via an activation of the Na+/K+ ATPase. Dev Neurosci (1996) 18:336-42. doi:10.1159/000111426.
    • (1996) Dev Neurosci , vol.18 , pp. 336-342
    • Pellerin, L.1    Magistretti, P.J.2
  • 47
    • 0028080101 scopus 로고
    • Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
    • doi:10.1073/pnas.91.22.10625
    • Pellerin L, Magistretti PJ. Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci U S A (1994) 91:10625-9. doi:10.1073/pnas.91.22.10625.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 10625-10629
    • Pellerin, L.1    Magistretti, P.J.2
  • 48
    • 31444438575 scopus 로고    scopus 로고
    • Oxidative metabolism in cultured rat astroglia: effects of reducing the glucose concentration in the culture medium and of D-aspartate or potassium stimulation
    • doi:10.1038/sj.jcbfm.9600175
    • Abe T, Takahashi S, Suzuki N. Oxidative metabolism in cultured rat astroglia: effects of reducing the glucose concentration in the culture medium and of D-aspartate or potassium stimulation. J Cereb Blood Flow Metab (2006) 26:153-60. doi:10.1038/sj.jcbfm.9600175.
    • (2006) J Cereb Blood Flow Metab , vol.26 , pp. 153-160
    • Abe, T.1    Takahashi, S.2    Suzuki, N.3
  • 49
    • 84885998103 scopus 로고    scopus 로고
    • Inhibitors of glutamate dehydrogenase block sodium-dependent glutamate uptake in rat brain membranes
    • doi:10.3389/fendo.2013.00123
    • Whitelaw BS, Robinson MB. Inhibitors of glutamate dehydrogenase block sodium-dependent glutamate uptake in rat brain membranes. Front Endocrinol (Lausanne) (2013) 4:123. doi:10.3389/fendo.2013.00123.
    • (2013) Front Endocrinol (Lausanne) , vol.4 , pp. 123
    • Whitelaw, B.S.1    Robinson, M.B.2


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