Regulation of human glutamate dehydrogenases: Implications for glutamate, ammonia and energy metabolism in brain

Journal of Neuroscience Research

Volumn 66, Issue 5, 2001, Pages 899-908

  Plaitakis, Andreas ^a   Zaganas, Ioannis ^a  

^a UNIVERSITY OF CRETE   (Greece)

Author keywords

ADP; Glutamate dehydrogenase; GTP; L leucine; Recombinant

Indexed keywords

2 OXOGLUTARIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMMONIA; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; LEUCINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ASTROCYTE; CONFERENCE PAPER; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME MECHANISM; ENZYME REGULATION; HOUSEKEEPING GENE; HUMAN; HYDROLYSIS; KINETICS; PRIORITY JOURNAL;

ADENOSINE DIPHOSPHATE; AMMONIA; ANIMALS; BRAIN; ENERGY METABOLISM; GLUTAMATE DEHYDROGENASE; GLUTAMIC ACID; HUMANS; LEUCINE; PROTEIN ISOFORMS; RECOMBINANT PROTEINS;

EID: 0035577286     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10054     Document Type: Conference Paper

References (66)

1. Partially deficient glutamate dehydrogenase activity and attenuated oscillatory potentials in patients with spinocerebellar degeneration
2. Molecular cloning and nucleotide sequence of the cDNA for human liver glutamate dehydrogenase precursor
3. Glial glutamate dehydrogenase: Ultrastructural localization and regional distribution in relation to the mitochondrial enzyme, cytochrome oxidase
4. The purification and properties of rat brain glutamate dehydrogenase
5. Two soluble forms of glutamate dehydrogenase isoproteins from bovine brain
6. The time course of glutamate in the synaptic cleft
7. Purification and characterization of a soluble and a particulate glutamate dehydrogenase from rat brain
8. Biochemistry and physiology of brain ammonia
9. Three human glutamate dehydrogenase genes (GLUD1, GLUDP2, and GLUDP3) are located on chromosome 10q, but are not closely physically linked
10. Ontogenetic development of glutamate metabolizing enzymes in cultured cerebellar granule cells and in cerebellum in vivo
11. Glutamate dehydrogenase deficiency in patients with olivopontocerebellar atrophy
12. Low leucocyte glutamate dehydrogenase activity does not correlate with a particular type of multiple system atrophy
13. Stimulation of pancreatic islet metabolism and insulin release by a nonmetabolizable amino acid
14. Glutamate metabolism in rat cortical astrocyte cultures
15. J Neurochem
16. Comparison of the effects of leucine, non-metabolizable leucine analogues and other insulin secretagogues on the activity of glutamate dehydrogenase
17. Intracellular distribution of enzymes. XI. Glutamic dehydrogenase
18. L-Glutamate dehydrogenases: Distribution, properties and mechanism
19. Characterization of glutamate dehydrogenase isoproteins purified from the cerebellum of normal subjects and patients degenerative neurological disorders, and from human neoplastic cell lines
20. Lymphocyte glutamate dehydrogenase activity in normal ageing and neurological diseases
21. Partial amino acid sequence of the glutamate dehydrogenase of human liver and a revision of the sequence of the bovine enzyme
22. Assignment of the GDH loci to human chromosomes 10q23 and Xq24 by in situ hybridization
23. Decreased glutamate dehydrogenase protein in spinocerebellar degeneration
24. 15N nuclear magnetic resonance
25. Glutamate dehydrogenase and its isoenzyme activity in olivopontocerebellar atrophy
26. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome
27. Enzymatic degradation protects neurons from glutamate excitotoxicity
28. Isolation and characterization of cDNA clones encoding human liver glutamate dehydrogenase: Evidence for a small gene family
29. Exogenous concentration regulates the metabolic fate of glutamate in astrocytes
30. The human glutamate dehydrogenase gene family: Gene organization and structural characterization
31. Amino acid sequence of chicken liver glutamate dehydrogenase
32. Sequence of bovine liver glutamate dehydrogenase. VIII. Peptides produced by specific chemical cleavages; the complete sequence of the protein
33. Complete nucleotide sequence of human glutamate dehydrogenase cDNA
34. Newer aspects of glutamine/glutamate metabolism: The role of acute pH changes
35. Cytotoxic effects of acidic and sulfur containing aminoacids of the infant mouse central nervous system
36. The activities in different neural cell types of certain enzymes associated with the metabolic compartmentation of glutamate
37. Crystallization and characterization of bovine glutamate dehydrogenase
38. The structure of bovine glutamate dehydrogenase provides insights into the mechanism of allostery
39. Abnormal glutamate metabolism in an adult-onset degenerative neurological disorder
40. Neurological disorders associated with deficiency of glutamate dehydrogenase
41. Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: Implications for biologic function
42. Glutamate dehydrogenase deficiency in three patients with spinocerebellar syndrome
43. Glutamate transport and metabolism in dopaminergic neurons of substantia nigra: Implications for the pathogenesis of Parkinson disease
44. Immunohistochemical demonstration of glutamate dehydrogenase in the rat cerebellar cortex
45. Quantitative ultrastructural localization of glutamate dehydrogenase in the rat cerebellar cortex
46. Subcellular distribution of the enzymes of the glutamic acid, glutamine and α-aminobutyric acid cycles in rat brain
47. Novel missense mutations outside the allosteric domain of glutamate dehydrogenase are prevalent in European patients with the congenital hyperinsulinism-hyperammonemia syndrome
48. Cellular and regional expression of glutamate dehydrogenase in the rat nervous system: Non-radioactive in situ hybridization and comparative immunocytochemistry
49. L-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase
50. Stimulation of pancreatic islet metabolism and insulin release by a non-metabolizable amino acid
51. Nerve tissue-specific human glutamate dehydrogenase that is thermolabile and highly regulated by ADP
52. Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene
53. Glutamate dehydrogenase
54. The evolution of glutamate dehydrogenases and a hypothesis for the insertion or deletion of multiple residues in the interior of polypeptide chains
55. Structures of bovine glutamate dehydrogenase complexes elucidate the mechanism of purine regulation
56. Glutamate transport and metabolism in astrocytes
57. Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene
58. Structure and expression analysis of a member of the human glutamate dehydrogenase (GLUD) gene family mapped to chromosome 10p11.2
59. Molecular cloning, structure and expression analysis of a full length mouse brain glutamate dehydrogenase cDNA
60. A possible role of alanine for ammonia transfer between astrocytes and glutamatergic neurons
61. Exogenous glutamate is metabolized to glutamine and exported by rat primary astrocyte cultures
62. Immunocytochemical characterization of glutamate dehydrogenase in the cerebellum of the rat
63. Multiple sclerosis: Altered glutamate homeostasis in lesions correlates with oligodendrocyte and axonal damage
64. 13C]glutamate
65. Hyperinsulinism-hyperammonemia syndrome caused by mutant glutamate dehydrogenase accompanied by novel enzyme kinetics
66. Glutamate dehydrogenase reaction as a source of glutamic acid in synaptosomes