Synthesis of newer 1,2,3-triazole linked chalcone and flavone hybrid compounds and evaluation of their antimicrobial and cytotoxic activities

European Journal of Medicinal Chemistry

Volumn 113, Issue , 2016, Pages 34-49

  Kant, Rama ^a   Kumar, Dharmendra ^a   Agarwal, Drishti ^b   Gupta, Rinkoo Devi ^b   Tilak, Ragini ^a   Awasthi, Satish Kumar ^c   Agarwal, Alka ^a  

^a BANARAS HINDU UNIVERSITY   (India)

^b SOUTH ASIAN UNIVERSITY   (India)

^c UNIVERSITY OF DELHI   (India)

Author keywords

1,2,3 Triazole; Antibacterial activity; Antifungal activity; Antiplasmodial activity; Chalcone; Cytotoxicity

Indexed keywords

1 (2 HYDROXY 4,6 DIMETHOXYPHENYL) 3 [3 METHOXY 4 (PROP 2 YN 1 YLOXY)PHENYL]PROP 2 EN 1 ONE; 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL) 3 [4 METHOXY 3 (PROP 2 YN 1 YLOXY)PHENYL]PROP 2 EN 1 ONE; 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL)ETHAN 1 ONE; 1,2,3 TRIAZOLE DERIVATIVE; 2 [3,4 BIS(PROP 2 YN 1 YLOXY)PHENYL] 5,7 DIMETHOXY 4H CHROMEN 4 ONE; 3 HYDROXY 4 (PROP 2 YN 1 YLOXY)BENZALDEHYDE; 3 METHOXY 4 (PROP 2 YN 1 YLOXY)BENZALDEHYDE; 3 [3 [[1 (2 CHLORO 4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4 METHOXYPHENYL] 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [3 [[1 (2 CHLOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL] METHOXY] 4 METHOXYPHENYL] 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [3 [[1 (2,4 DIFLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL] METHOXY] 4 METHOXYPHENYL] 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [3 [[1 (3 CHLORO 4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 4 METHOXYPHENYL] 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [3 [[1 (4 CHLOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL] METHOXY] 4 METHOXYPHENYL] 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [3,4 BIS(PROP 2 YN 1 YLOXY)PHENYL] 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [3,4 BIS[[[1 (2 CHLORO 4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY]]PHENYL] 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [3,4 BIS[[[1 (3 CHLORO 4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY]]PHENYL] 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [4 [[1 (2 CHLORO 4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 4YL]METHOXY] 3 METHOXYPHENYL] 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [4 [[1 (2,4 DIFLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL] METHOXY] 3 METHOXYPHENYL] 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [4 [[1 (3 CHLORO 4 FLUOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 3 METHOXYPHENYL] 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3 [4 [[1 (4 CHLOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL] METHOXY] 3 METHOXYPHENYL] 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 3,4 BIS(PROP 2 YN 1 YLOXY)BENZALDEHYDE; 3[4 [[1 (2 CHLOROPHENYL) 1H 1,2,3 TRIAZOL 4 YL] METHOXY] 3 METHOXYPHENYL] 1 (2 HYDROXY 4,6 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 4 HYDROXY 3 (PROP 2 YN 1 YLOXY)BENZALDEHYDE; 4 METHOXY 3 (PROP 2 YN 1 YLOXY)BENZALDEHYDE; 5,7 DIMETHOXY 2 [3 METHOXY 4 (PROP 2 YN 1 YLOXY)PHENYL] 4H CHROMEN 4 ONE; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; CHALCONE DERIVATIVE; CYTOTOXIC AGENT; FLAVONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTIMALARIAL AGENT; CHALCONE; FLAVONE; TRIAZOLE DERIVATIVE;

ANALYTIC METHOD; ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIGER; CANDIDA ALBICANS; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CARBON NUCLEAR MAGNETIC RESONANCE; CARCINOMA CELL; CLICK CHEMISTRY; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DERMATOPHYTE; DRUG STRUCTURE; DRUG SYNTHESIS; ELEMENTAL ANALYSIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IC50; INFRARED SPECTROSCOPY; KLEBSIELLA PNEUMONIAE; LIVER CELL CARCINOMA; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PLASMODIUM FALCIPARUM 3D7; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; SHIGELLA BOYDII; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY; BACTERIUM; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SENSITIVITY; FUNGUS; MICROBIAL SENSITIVITY TEST; PLASMODIUM FALCIPARUM; SYNTHESIS; TUMOR CELL LINE;

ANTI-BACTERIAL AGENTS; ANTIFUNGAL AGENTS; ANTIMALARIALS; BACTERIA; CELL LINE, TUMOR; CHALCONE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONES; FUNGI; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84959138066     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2016.02.041     Document Type: Article

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