Design, synthesis and antiproliferative activity of functionalized flavone-triazole-tetrahydropyran conjugates against human cancer cell lines

European Journal of Medicinal Chemistry

Volumn 82, Issue , 2014, Pages 552-564

  Ahmed, Naseem ^a   Konduru, Naveen Kumar ^a   Ahmad, Sarfaraz ^b   Owais, Mohammad ^b  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

^b ALIGARH MUSLIM UNIVERSITY   (India)

Author keywords

3 (2 Propynyloxy) flavone; 4 Azido tetrahydropyran; 5 Iodo and 5 H 1 tetrahydropyran 1,2,3 triazol 4 (3 methoxylflavone) derivatives; Antiproliferative activity; Click chemistry

Indexed keywords

ANTINEOPLASTIC AGENT; BENZENEBORONIC ACID; DOXORUBICIN; FLAVONE DERIVATIVE; TETRAHYDROPYRAN DERIVATIVE; TRIAZOLE DERIVATIVE; FLAVONE; PYRAN DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL LINE; CANCER INHIBITION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; CLICK CHEMISTRY; CRYSTAL STRUCTURE; CYCLIZATION; CYCLOADDITION; CYTOTOXICITY; DRUG CONJUGATION; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MITSUNOBU REACTION; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; SUZUKI REACTION; X RAY CRYSTALLOGRAPHY; X RAY DIFFRACTION; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HELA CELL LINE; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FLAVONES; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; PYRANS; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84902654418     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.06.009     Document Type: Article

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