Synthesis and biological evaluation of allylated and prenylated mono-carbonyl analogs of curcumin as anti-inflammatory agents

European Journal of Medicinal Chemistry

Volumn 74, Issue , 2014, Pages 671-682

  Liu, Zhiguo ^a,c   Tang, Longguang ^a   Zou, Peng ^b   Zhang, Yali ^b   Wang, Zhe ^a   Fang, Qilu ^a   Jiang, Lili ^a   Chen, Gaozhi ^a   Xu, Zheng ^a   Zhang, Huajie ^a   Liang, Guang ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c Wenzhou Undersun Biotechnology Company   (China)

Author keywords

Anti inflammation; Curcumin; IL 6; Mono carbonyl analogs; QSAR; TNF

Indexed keywords

1 (3 ALLYL 4 HYDROXYPHENYL) 5 (3,4 DIMETHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 (3 ALLYL 4 HYDROXYPHENYL) 5 (4 NITROPHENYL)PENTA 1,4 DIEN 3 ONE; 1 (3 ALLYL 4 METHOXYPHENYL) 5 (3 BROMOPHENYL)PHENYL]PENTA 1,4 DIEN 3 ONE; 1 (3 ALLYL 4 METHOXYPHENYL) 5 (3,4 DIMETHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1 (3 ALLYL 4 METHOXYPHENYL) 5 (4 BROMOPHENYL)PHENYL]PENTA 1,4 DIEN 3 ONE; 1 (3 ALLYL 4 METHOXYPHENYL) 5 (4 MORPHOLINO PHENYL)PENTA 1,4 DIEN 3 ONE; 1 (3 ALLYL 4 METHOXYPHENYL) 5 [4 (DIMETHYLAMINO)PHENYL]PENTA 1,4 DIEN 3 ONE; 1 (3 ALLYL 4 METHOXYPHENYL) 5 [4 (PIPERIDIN 1 YL)PHENYL]PENTA 1,4 DIEN 3 ONE; 1 (3 ALLYL 4 METHOXYPHENYL) 5 [4 (TERT BUTOXY)PHENYL]PENTA 1,4 DIEN 3 ONE; 1 (3 ALLYL 4 METHOXYPHENYL) 5 [4 (TRIFLUOROMETHYL)PHENYL]PENTA 1,4 DIEN 3 ONE; 1 (3,4 DIMETHOXYPHENYL) 5 [4 [(3,4 METHYLBUT 2 EN 1 YL)OXY]PHENYL]PENTA 1,4 DIEN 3 ONE; 1 [4 (ALLYLOXY) 2 HYDROXYPHENYL) 5 ( 4 FLUOROPHENYL)PENTA 1,4 DIEN 3 ONE; 1 [4 (ALLYLOXY)PHENYL] 5 (3,4 DIMETHOXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1,5 BIS(3 ALLYL 4 HYDROXYPHENYL)PENTA 1,4 DIEN 3 ONE; 1,5 BIS[3 METHOXY 4 [(3 METHYLBUT 2 EN 1 YL)OXY]PHENYL]PENTA 1,4 DIEN 3 ONE; 1,5 BIS[4 (ALLYLOXY)PHENYL]PENTA 1,4 DIEN 3 ONE; 1,5 BIS[4 [(3 METHYLBUT 2 EN 1 YL)OXY]PHENYL]PENTA 1,4 DIEN 3 ONE; 2,5 BIS(3 ALLYL 4 HYDROXYBENZYLIDENE)CYCLOPENTANONE; 2,5 BIS[2 HYDROXY 4 [(3 METHYLBUT 2 EN 1 YL)OXY]BENZYLIDENE]CYCLOPENTA NONE; 2,5 BIS[3 ALLYL 4 [(TETRAHYDRO 2H PYRAN 2 YL)OXY]BENZYLIDENE]CYCLOPENTA NONE; 2,5 BIS[3 METHOXY 4 [(3 METHYLBUT 2 EN 1 YL)OXY]BENZYLIDENE]CYCLOPENTA NONE; 2,6-BIS[4 [(3 METHYLBUT 2 EN 1 YL)OXY]BENZYLIDENE]; ANTIINFLAMMATORY AGENT; CARBONYL DERIVATIVE; CURCUMIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONO CARBONYL DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALDOL REACTION; ALLYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; DRUG ABSORPTION; DRUG DESIGN; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; MORTALITY; MOUSE; NONHUMAN; PRENYLATION; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION;

ANTI-INFLAMMATION; CURCUMIN; IL-6; MONO-CARBONYL ANALOGS; QSAR; TNF-Α;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BASE SEQUENCE; BIOLOGICAL AVAILABILITY; CELL LINE; CURCUMIN; DNA PRIMERS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED C57BL; PRENYLATION; REAL-TIME POLYMERASE CHAIN REACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84895543431     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.061     Document Type: Article

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