Rational design, synthesis and anti-proliferative evaluation of novel 1,4-benzoxazine-[1,2,3]triazole hybrids

European Journal of Medicinal Chemistry

Volumn 89, Issue , 2015, Pages 138-146

  Bollu, Rajitha ^a   Palem, Jyothsna Devi ^a   Bantu, Rajashaker ^a   Guguloth, Vijayacharan ^a   Nagarapu, Lingaiah ^a   Polepalli, Sowjanya ^a   Jain, Nishant ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

1,2,3 Triazoles; 1,4 Benzoxazine; Anti proliferative; Apoptosis; Cell lines

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; 1,4 BENZOXAZINE[1,2,3]TRIAZOLE DERIVATIVE; 4 [3 (4 4 TOLYL 1H 1,2,3 TRIAZOL 1 YL)PROPYL] 2H BENZO[B][1,4]OXAZIN 3(4H) ONE; 4 [3 (4 BUTYL 1H 1,2,3 TRIAZOL 1 YL)PROPYL] 2H BENZO[B][1,4]OXAZIN 3(4H) ONE; 4 [3 (4 HEXYL 1H 1,2,3 TRIAZOL 1 YL)PROPYL] 2H BENZO[B][1,4]OXAZIN 3(4H) ONE; 4 [3 (4 PENTYLPHENYL 1H 1,2,3 TRIAZOL 1 YL)PROPYL] 2H BENZO[B][1,4]OXAZIN 3(4H) ONE; 4 [3 (4 PHENYL 1H 1,2,3 TRIAZOL 1 YL)PROPYL] 2H BENZO[B][1,4]OXAZIN 3(4H) ONE; 4 [3 (4 PROPYL 1H 1,2,3 TRIAZOL 1 YL)PROPYL] 2H BENZO[B][1,4]OXAZIN 3(4H) ONE; 4 [3 [4 (1 HYDROXYCYCLOHEXYL) 1H 1,2,3 TRIAZOL 1 YL]PROPYL) 2H BENZO[B][1,4] OXAZIN 3(4H) ONE; 4 [3 [4 (3 CHLOROPROPYL) 1H 1,2,3 TRIAZOL 1 YL]PROPYL] 2H BENZO[B][1,4]OXAZIN 3(4H) ONE; 4 [3 [4 (6 METHOXYNAPHTHALEN 1 YL) 1H 1,2,3 TRIAZOL 1 YL]PROPYL] 2H BENZO[B][1,4]OXACIN 3(4H) ONE; 4 [3 [4 (HYDROXYMETHYL) 1H 1,2,3 TRIAZOL 1 YL)PROPYL] 2H BENZO[B][1,4]OXAZIN 3(4H) ONE; 4 [3 [4 (METHOXYPHENYL) 1H 1,2,3 TRIAZOL 1 YL]PROPYL] 2H BENZO[B][1,4]OXAZIN 3(4H) ONE; 4 [3 [4 (PHENANTHREN 10 YL) 1H 1,2,3 TRIAZOL 1 YL]PROPYL] 2H BENZO[B][1,4]OXAZIN 3(4H)ONE; 4 [3 [4 (PYRIDIN 2 YL) 1H 1,2,3 TRIAZOL 1 YL]PROPYL] 2H BENZO[B][1,4]OXAZIN 3(4H) ONE; 4 [3 [4 (PYRIDIN 3 YL) 1H 1,2,3 TRIAZOL 1 YL]PROPYL] 2H BENZO[B][1,4]OXAZIN 3(4H) ONE; ANTINEOPLASTIC AGENT; DOXORUBICIN; PACLITAXEL; UNCLASSIFIED DRUG; 1,4-BENZOXAZINE-(1,2,3)TRIAZOLE; BENZOXAZINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER CELL LINE; CANCER CELL LINE; CANCER INHIBITION; CELL GROWTH; CELL PROLIFERATION ASSAY; CELL VIABILITY; CLICK CHEMISTRY; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; NEUROBLASTOMA CELL LINE; PANCREATIC CANCER CELL LINE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BENZOXAZINES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84908450736     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.10.051     Document Type: Article

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