Endoplasmic reticulum-associated degradation of the mouse PC1/3-N222D hypomorph and human PCSK1 mutations contributes to obesity

International Journal of Obesity

Volumn 40, Issue 6, 2016, Pages 973-981

  Stijnen, P ^a   Brouwers, B ^a   Dirkx, E ^a   Ramos Molina, B ^a   Van Lommel, L ^a   Schuit, F ^a   Thorrez, L ^a   Declercq, J ^a   Creemers, J W M ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; GLUCOSE REGULATED PROTEIN 78; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; PROOPIOMELANOCORTIN; PROPROTEIN CONVERTASE 1; SOMATOMEDIN C; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; PCSK1 PROTEIN, HUMAN; PCSK1 PROTEIN, MOUSE; PROINSULIN; PROTEASOME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; GENE; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HYPOPHYSIS; HYPOTHALAMUS; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 1 GENE; PROTEIN BINDING; ANIMAL; CYTOLOGY; FEMALE; GENETIC PREDISPOSITION; GENETICS; HEK293 CELL LINE; METABOLISM; MUTATION; PANCREAS ISLET; PATHOLOGY; PHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; UNFOLDED PROTEIN RESPONSE;

ANIMALS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HEAT-SHOCK PROTEINS; HEK293 CELLS; HUMANS; ISLETS OF LANGERHANS; MICE; MUTATION; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROINSULIN; PROPROTEIN CONVERTASE 1; PROTEASOME ENDOPEPTIDASE COMPLEX; UNFOLDED PROTEIN RESPONSE;

EID: 84959083192     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2016.3     Document Type: Article

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