Defective transport of the obesity mutant PC1/3 N222D contributes to loss of function

Endocrinology

Volumn 155, Issue 7, 2014, Pages 2391-2401

  Prabhu, Yogikala ^a   Blanco, Elias H ^a   Liu, Ming ^b   Peinado, Juan R ^a,d   Wheeler, Matthew C ^c   Gekakis, Nicholas ^c,e   Arvan, Peter ^b   Lindberg, Iris ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^e SAN DIEGO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ENZYME PRECURSOR; MUTANT PROTEIN; PROINSULIN; PROPROTEIN CONVERTASE 1; PROTEASOME; UBIQUITIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; CYTOLOGY; ENDOCRINE CELL; ENDOPLASMIC RETICULUM; FEMALE; GENE MUTATION; GOLGI COMPLEX; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INSULIN SYNTHESIS; INTRACELLULAR TRANSPORT; KINETICS; LOSS OF FUNCTION MUTATION; MALE; MOUSE; MUTANT; NONHUMAN; OBESITY; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN TRANSPORT; SECRETORY CELL; SECRETORY PATHWAY; UBIQUITINATION; WILD TYPE;

ANIMALS; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM; FEMALE; GOLGI APPARATUS; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; INSULIN; ISLETS OF LANGERHANS; KINETICS; MALE; MICE; MICROSCOPY, CONFOCAL; MUTANT PROTEINS; MUTATION; OBESITY; PROPROTEIN CONVERTASE 1; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN TRANSPORT; PROTEOLYSIS; UBIQUITIN;

EID: 84903280912     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2013-1985     Document Type: Article

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