-
1
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 1991;12:383-388.
-
(1991)
Trends Pharmacol Sci
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
3
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe DJ. Alzheimer's disease: Genes, proteins, and therapy. Physiol Rev 2001;81:741-766.
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
5
-
-
84923360271
-
Genetic diagnosis and prognosis of Alzheimer's disease: Challenges and opportunities
-
Reitz C. Genetic diagnosis and prognosis of Alzheimer's disease: Challenges and opportunities. Expert Rev Mol Diagn 2015;15:339-348.
-
(2015)
Expert Rev Mol Diagn
, vol.15
, pp. 339-348
-
-
Reitz, C.1
-
6
-
-
0029004341
-
Cloning of a gene bearing missense mutations in earlyonset familial Alzheimer's disease
-
Sherrington R, Rogaev EI, Liang Y, et al. Cloning of a gene bearing missense mutations in earlyonset familial Alzheimer's disease. Nature 1995; 375:754-760.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
-
7
-
-
0023103748
-
The genetic defect causing familial Alzheimer's disease maps on chromosome 21
-
St George-Hyslop PH, Tanzi RE, Polinsky RJ, et al. The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science 1987; 235:885-890.
-
(1987)
Science
, vol.235
, pp. 885-890
-
-
St George-Hyslop, P.H.1
Tanzi, R.E.2
Polinsky, R.J.3
-
9
-
-
0027031612
-
Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3
-
Van Broeckhoven C, Backhovens H, Cruts M, et al. Mapping of a gene predisposing to early-onset Alzheimer's disease to chromosome 14q24.3. Nat Genet 1992;2:335-339.
-
(1992)
Nat Genet
, vol.2
, pp. 335-339
-
-
Van Broeckhoven, C.1
Backhovens, H.2
Cruts, M.3
-
10
-
-
0027407565
-
Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
-
Strittmatter WJ, Saunders AM, Schmechel D, et al. Apolipoprotein E: High-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc Natl Acad Sci U S A 1993;90:1977-1981.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 1977-1981
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Schmechel, D.3
-
11
-
-
84901926343
-
Alzheimer's disease: The forgetting gene
-
Spinney L. Alzheimer's disease: The forgetting gene. Nature 2014;510:26-28.
-
(2014)
Nature
, vol.510
, pp. 26-28
-
-
Spinney, L.1
-
12
-
-
84920703987
-
Alzheimer's disease risk genes and mechanisms of disease pathogenesis
-
Karch CM, Goate AM. Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biol Psychiatry 2015;77:43-51.
-
(2015)
Biol Psychiatry
, vol.77
, pp. 43-51
-
-
Karch, C.M.1
Goate, A.M.2
-
13
-
-
40549105438
-
Association between genetic variants in SORL1 and autopsyconfirmed Alzheimer disease
-
Lee JH, Cheng R, Honig LS, et al. Association between genetic variants in SORL1 and autopsyconfirmed Alzheimer disease. Neurology 2008;70: 887-889.
-
(2008)
Neurology
, vol.70
, pp. 887-889
-
-
Lee, J.H.1
Cheng, R.2
Honig, L.S.3
-
14
-
-
33846613222
-
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
-
Rogaeva E, Meng Y, Lee JH, et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 2007; 39:168-177.
-
(2007)
Nat Genet
, vol.39
, pp. 168-177
-
-
Rogaeva, E.1
Meng, Y.2
Lee, J.H.3
-
15
-
-
32544435097
-
The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments
-
Offe K, Dodson SE, Shoemaker JT, et al. The lipoprotein receptor LR11 regulates amyloid beta production and amyloid precursor protein traffic in endosomal compartments. J Neurosci 2006;26:1596-1603.
-
(2006)
J Neurosci
, vol.26
, pp. 1596-1603
-
-
Offe, K.1
Dodson, S.E.2
Shoemaker, J.T.3
-
16
-
-
84888317489
-
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
-
Lambert JC, Ibrahim-Verbaas CA, Harold D, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet 2013;45:1452-1458.
-
(2013)
Nat Genet
, vol.45
, pp. 1452-1458
-
-
Lambert, J.C.1
Ibrahim-Verbaas, C.A.2
Harold, D.3
-
17
-
-
84964848239
-
The genetic landscape of Alzheimer disease: Clinical implications and perspectives
-
Epub ahead of print
-
Van Cauwenberghe C, Van Broeckhoven C, Sleegers K. The genetic landscape of Alzheimer disease: Clinical implications and perspectives. Genet Med 2015. doi: 10.1038/gim.2015.117. [Epub ahead of print]
-
(2015)
Genet Med
-
-
Van Cauwenberghe, C.1
Van Broeckhoven, C.2
Sleegers, K.3
-
18
-
-
77953518555
-
Alzheimer's disease: Clinical trials and drug development
-
Mangialasche F, Solomon A, Winblad B, et al. Alzheimer's disease: Clinical trials and drug development. Lancet Neurol 2010;9:702-716.
-
(2010)
Lancet Neurol
, vol.9
, pp. 702-716
-
-
Mangialasche, F.1
Solomon, A.2
Winblad, B.3
-
19
-
-
84953868005
-
Therapeutic strategies for Alzheimer's disease in clinical trials
-
Godyn J, Jonczyk J, Panek D, et al. Therapeutic strategies for Alzheimer's disease in clinical trials. Pharmacol Rep 2016;68:127-138.
-
(2016)
Pharmacol Rep
, vol.68
, pp. 127-138
-
-
Godyn, J.1
Jonczyk, J.2
Panek, D.3
-
20
-
-
84933047335
-
Pharmacological inhibition of BACE1 impairs synaptic plasticity and cognitive functions
-
Filser S, Ovsepian SV, Masana M, et al. Pharmacological inhibition of BACE1 impairs synaptic plasticity and cognitive functions. Biol Psychiatry 2015;77:729-739.
-
(2015)
Biol Psychiatry
, vol.77
, pp. 729-739
-
-
Filser, S.1
Ovsepian, S.V.2
Masana, M.3
-
21
-
-
27744588007
-
Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model
-
Singer O, Marr RA, Rockenstein E, et al. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci 2005;8:1343-1349.
-
(2005)
Nat Neurosci
, vol.8
, pp. 1343-1349
-
-
Singer, O.1
Marr, R.A.2
Rockenstein, E.3
-
22
-
-
84894090892
-
Targeting the beta secretase BACE1 for Alzheimer's disease therapy
-
Yan R, Vassar R. Targeting the beta secretase BACE1 for Alzheimer's disease therapy. Lancet Neurol 2014;13:319-329.
-
(2014)
Lancet Neurol
, vol.13
, pp. 319-329
-
-
Yan, R.1
Vassar, R.2
-
23
-
-
84909971843
-
Lessons from a failed gammasecretase Alzheimer trial
-
De Strooper B. Lessons from a failed gammasecretase Alzheimer trial. Cell 2014;159:721-726.
-
(2014)
Cell
, vol.159
, pp. 721-726
-
-
De Strooper, B.1
-
24
-
-
84973431448
-
Anti-Alzheimer therapeutic drugs targeting gamma-secretase
-
Tan Y, Zhang Q, Wong SG, et al. Anti-Alzheimer therapeutic drugs targeting gamma-secretase. Curr Top Med Chem 2016;16:549-557.
-
(2016)
Curr Top Med Chem
, vol.16
, pp. 549-557
-
-
Tan, Y.1
Zhang, Q.2
Wong, S.G.3
-
25
-
-
80054891306
-
Abetadegrading enzymes: Potential for treatment of Alzheimer disease
-
Miners JS, Barua N, Kehoe PG, et al. Abetadegrading enzymes: Potential for treatment of Alzheimer disease. J Neuropathol Exp Neurol 2011;70:944-959.
-
(2011)
J Neuropathol Exp Neurol
, vol.70
, pp. 944-959
-
-
Miners, J.S.1
Barua, N.2
Kehoe, P.G.3
-
26
-
-
50549103941
-
Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice
-
Carty NC, Nash K, Lee D, et al. Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice. Mol Ther 2008;16:1580-1586.
-
(2008)
Mol Ther
, vol.16
, pp. 1580-1586
-
-
Carty, N.C.1
Nash, K.2
Lee, D.3
-
27
-
-
84875499318
-
Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice
-
Carty N, Nash KR, Brownlow M, et al. Intracranial injection of AAV expressing NEP but not IDE reduces amyloid pathology in APP+PS1 transgenic mice. PLoS One 2013;8:e59626.
-
(2013)
PLoS One
, vol.8
, pp. e59626
-
-
Carty, N.1
Nash, K.R.2
Brownlow, M.3
-
28
-
-
84925279976
-
Immunotherapeutic approaches for Alzheimer's disease
-
Wisniewski T, Goni F. Immunotherapeutic approaches for Alzheimer's disease. Neuron 2015; 85:1162-1176.
-
(2015)
Neuron
, vol.85
, pp. 1162-1176
-
-
Wisniewski, T.1
Goni, F.2
-
29
-
-
33747178096
-
Anti-Abeta single-chain antibody delivery via adeno-associated virus for treatment of Alzheimer's disease
-
Fukuchi K, Tahara K, Kim HD, et al. Anti-Abeta single-chain antibody delivery via adeno-associated virus for treatment of Alzheimer's disease. Neurobiol Dis 2006;23:502-511.
-
(2006)
Neurobiol Dis
, vol.23
, pp. 502-511
-
-
Fukuchi, K.1
Tahara, K.2
Kim, H.D.3
-
30
-
-
84921830368
-
Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsalpha expression
-
Weyer SW, Zagrebelsky M, Herrmann U, et al. Comparative analysis of single and combined APP/APLP knockouts reveals reduced spine density in APP-KO mice that is prevented by APPsalpha expression. Acta Neuropathol Commun 2014;2:36.
-
(2014)
Acta Neuropathol Commun
, vol.2
, pp. 36
-
-
Weyer, S.W.1
Zagrebelsky, M.2
Herrmann, U.3
-
31
-
-
79957909084
-
APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP
-
Weyer SW, Klevanski M, Delekate A, et al. APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP. EMBO J 2011;30:2266-2280.
-
(2011)
EMBO J
, vol.30
, pp. 2266-2280
-
-
Weyer, S.W.1
Klevanski, M.2
Delekate, A.3
-
32
-
-
34447640166
-
The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice
-
Ring S, Weyer SW, Kilian SB, et al. The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci 2007;27:7817-7826.
-
(2007)
J Neurosci
, vol.27
, pp. 7817-7826
-
-
Ring, S.1
Weyer, S.W.2
Kilian, S.B.3
-
33
-
-
84862850617
-
Regulation of alphasecretase ADAM10 expression and activity
-
Endres K, Fahrenholz F. Regulation of alphasecretase ADAM10 expression and activity. Exp Brain Res 2012;217:343-352.
-
(2012)
Exp Brain Res
, vol.217
, pp. 343-352
-
-
Endres, K.1
Fahrenholz, F.2
-
34
-
-
34548688657
-
Alpha-secretase as a therapeutic target
-
Fahrenholz F. Alpha-secretase as a therapeutic target. Curr Alzheimer Res 2007;4:412-417.
-
(2007)
Curr Alzheimer Res
, vol.4
, pp. 412-417
-
-
Fahrenholz, F.1
-
35
-
-
84945186786
-
Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3beta signaling pathway
-
Deng J, Habib A, Obregon DF, et al. Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3beta signaling pathway. J Neurochem 2015;135:630-637.
-
(2015)
J Neurochem
, vol.135
, pp. 630-637
-
-
Deng, J.1
Habib, A.2
Obregon, D.F.3
-
36
-
-
84862889144
-
Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin
-
Prox J, Rittger A, Saftig P. Physiological functions of the amyloid precursor protein secretases ADAM10, BACE1, and presenilin. Exp Brain Res 2012;217:331-341.
-
(2012)
Exp Brain Res
, vol.217
, pp. 331-341
-
-
Prox, J.1
Rittger, A.2
Saftig, P.3
-
37
-
-
84954377011
-
Viral gene transfer of APPsalpha rescues synaptic failure in an Alzheimer's disease mouse model
-
Fol R, Braudeau J, Ludewig S, et al. Viral gene transfer of APPsalpha rescues synaptic failure in an Alzheimer's disease mouse model. Acta Neuropathol 2016;131:247-266.
-
(2016)
Acta Neuropathol
, vol.131
, pp. 247-266
-
-
Fol, R.1
Braudeau, J.2
Ludewig, S.3
-
38
-
-
62049083420
-
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
-
Nagahara AH, Merrill DA, Coppola G, et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med 2009;15:331-337.
-
(2009)
Nat Med
, vol.15
, pp. 331-337
-
-
Nagahara, A.H.1
Merrill, D.A.2
Coppola, G.3
-
39
-
-
0028020905
-
The agedmonkey basal forebrain: Rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor
-
Kordower JH,Winn SR, Liu YT, et al. The agedmonkey basal forebrain: Rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor. Proc Natl Acad Sci U S A 1994;91:10898-10902.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 10898-10902
-
-
Kordower, J.H.1
Winn, S.R.2
Liu, Y.T.3
-
40
-
-
4644268336
-
Reduction of cortical TrkA but not p75(NTR) protein in earlystage Alzheimer's disease
-
Counts SE, Nadeem M, Wuu J, et al. Reduction of cortical TrkA but not p75(NTR) protein in earlystage Alzheimer's disease. Ann Neurol 2004;56: 520-531.
-
(2004)
Ann Neurol
, vol.56
, pp. 520-531
-
-
Counts, S.E.1
Nadeem, M.2
Wuu, J.3
-
41
-
-
84956909085
-
Alzheimer disease: NGF gene therapy activates neurons in the AD patient brain
-
Malkki H. Alzheimer disease: NGF gene therapy activates neurons in the AD patient brain. Nat Rev Neurol 2015;11:548.
-
(2015)
Nat Rev Neurol
, vol.11
, pp. 548
-
-
Malkki, H.1
-
42
-
-
85027921807
-
A phase 1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease
-
Rafii MS, Baumann TL, Bakay RA, et al. A phase 1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease. Alzheimers Dement 2014;10:571-581.
-
(2014)
Alzheimers Dement
, vol.10
, pp. 571-581
-
-
Rafii, M.S.1
Baumann, T.L.2
Bakay, R.A.3
-
43
-
-
84944076745
-
Nerve growth factor gene therapy: Activation of neuronal responses in Alzheimer disease
-
Tuszynski MH, Yang JH, Barba D, et al. Nerve growth factor gene therapy: Activation of neuronal responses in Alzheimer disease. JAMA Neurol 2015;72:1139-1147.
-
(2015)
JAMA Neurol
, vol.72
, pp. 1139-1147
-
-
Tuszynski, M.H.1
Yang, J.H.2
Barba, D.3
-
44
-
-
1842334441
-
Anterograde transport of brain-derived neurotrophic factor and its role in the brain
-
Altar CA, Cai N, Bliven T, et al. Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature 1997;389:856-860.
-
(1997)
Nature
, vol.389
, pp. 856-860
-
-
Altar, C.A.1
Cai, N.2
Bliven, T.3
-
45
-
-
0030451939
-
Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease
-
Narisawa-Saito M, Wakabayashi K, Tsuji S, et al. Regional specificity of alterations in NGF, BDNF and NT-3 levels in Alzheimer's disease. Neuroreport 1996;7:2925-2928.
-
(1996)
Neuroreport
, vol.7
, pp. 2925-2928
-
-
Narisawa-Saito, M.1
Wakabayashi, K.2
Tsuji, S.3
-
46
-
-
84911982234
-
Lenti-GDNF gene therapy protects against Alzheimer's disease-like neuropathology in 3xTg-AD mice and MC65 cells
-
Revilla S, Ursulet S, Alvarez-Lopez MJ, et al. Lenti-GDNF gene therapy protects against Alzheimer's disease-like neuropathology in 3xTg-AD mice and MC65 cells. CNS Neurosci Ther 2014;20:961-972.
-
(2014)
CNS Neurosci Ther
, vol.20
, pp. 961-972
-
-
Revilla, S.1
Ursulet, S.2
Alvarez-Lopez, M.J.3
-
47
-
-
84908135739
-
Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice
-
Pascual-Lucas M, Viana da Silva S, Di Scala M, et al. Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice. EMBO Mol Med 2014;6:1246-1262.
-
(2014)
EMBO Mol Med
, vol.6
, pp. 1246-1262
-
-
Pascual-Lucas, M.1
Viana Da Silva, S.2
Di Scala, M.3
-
48
-
-
84899621158
-
IGF2 ameliorates amyloidosis, increases cholinergic marker expression and raises BMP9 and neurotrophin levels in the hippocampus of the APPswePS1dE9 Alzheimer's disease model mice
-
Mellott TJ, Pender SM, Burke RM, et al. IGF2 ameliorates amyloidosis, increases cholinergic marker expression and raises BMP9 and neurotrophin levels in the hippocampus of the APPswePS1dE9 Alzheimer's disease model mice. PLoS One 2014;9:e94287.
-
(2014)
PLoS One
, vol.9
, pp. e94287
-
-
Mellott, T.J.1
Pender, S.M.2
Burke, R.M.3
-
49
-
-
70349482547
-
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mousemodel of Alzheimer's disease
-
Kanninen K, Heikkinen R, Malm T, et al. Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mousemodel of Alzheimer's disease. Proc Natl Acad Sci U S A 2009;106:16505-16510.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 16505-16510
-
-
Kanninen, K.1
Heikkinen, R.2
Malm, T.3
-
50
-
-
45749114895
-
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice
-
Pickford F, Masliah E, Britschgi M, et al. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest 2008;118:2190-2199.
-
(2008)
J Clin Invest
, vol.118
, pp. 2190-2199
-
-
Pickford, F.1
Masliah, E.2
Britschgi, M.3
-
51
-
-
13644253039
-
Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat
-
Maher FO, Nolan Y, Lynch MA. Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat. Neurobiol Aging 2005;26:717-728.
-
(2005)
Neurobiol Aging
, vol.26
, pp. 717-728
-
-
Maher, F.O.1
Nolan, Y.2
Lynch, M.A.3
-
52
-
-
77955814637
-
CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice
-
Kiyota T, Okuyama S, Swan RJ, et al. CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice. FASEB J 2010;24: 3093-3102.
-
(2010)
FASEB J
, vol.24
, pp. 3093-3102
-
-
Kiyota, T.1
Okuyama, S.2
Swan, R.J.3
-
53
-
-
84863717973
-
AAV serotype 2/1-mediated gene delivery of antiinflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice
-
Kiyota T, Ingraham KL, Swan RJ, et al. AAV serotype 2/1-mediated gene delivery of antiinflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice. Gene Ther 2012;19:724-733.
-
(2012)
Gene Ther
, vol.19
, pp. 724-733
-
-
Kiyota, T.1
Ingraham, K.L.2
Swan, R.J.3
-
54
-
-
85027946081
-
Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease
-
Jiang T, Tan L, Zhu XC, et al. Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease. Neuropsychopharmacology 2014;39:2949-2962.
-
(2014)
Neuropsychopharmacology
, vol.39
, pp. 2949-2962
-
-
Jiang, T.1
Tan, L.2
Zhu, X.C.3
-
55
-
-
12844273475
-
Gene delivery of human apolipoprotein e alters brain Abeta burden in a mouse model of Alzheimer's disease
-
Dodart JC, Marr RA, Koistinaho M, et al. Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 2005;102:1211-1216.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 1211-1216
-
-
Dodart, J.C.1
Marr, R.A.2
Koistinaho, M.3
-
56
-
-
84890365334
-
Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain
-
Hudry E, Dashkoff J, Roe AD, et al. Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain. Sci Transl Med 2013;5: 212ra161.
-
(2013)
Sci Transl Med
, vol.5
, pp. 212ra161
-
-
Hudry, E.1
Dashkoff, J.2
Roe, A.D.3
-
58
-
-
84881314432
-
Acat1 knockdown gene therapy decreases amyloid-beta in a mouse model of Alzheimer's disease
-
Murphy SR, Chang CC, Dogbevia G, et al. Acat1 knockdown gene therapy decreases amyloid-beta in a mouse model of Alzheimer's disease. Mol Ther 2013;21:1497-1506.
-
(2013)
Mol Ther
, vol.21
, pp. 1497-1506
-
-
Murphy, S.R.1
Chang, C.C.2
Dogbevia, G.3
-
59
-
-
58149396136
-
Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle
-
Ghribi O. Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle. Journal of Alzheimer's disease: JAD 2008;15:673-684.
-
(2008)
Journal of Alzheimer's Disease: JAD
, vol.15
, pp. 673-684
-
-
Ghribi, O.1
-
60
-
-
74149083432
-
Adenoassociated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease
-
Hudry E, Van Dam D, Kulik W, et al. Adenoassociated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. Mol Ther 2010;18:44-53.
-
(2010)
Mol Ther
, vol.18
, pp. 44-53
-
-
Hudry, E.1
Van Dam, D.2
Kulik, W.3
-
61
-
-
84949256198
-
Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology
-
Burlot MA, Braudeau J, Michaelsen-Preusse K, et al. Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology. Hum Mol Genet 2015;24:5965-5976.
-
(2015)
Hum Mol Genet
, vol.24
, pp. 5965-5976
-
-
Burlot, M.A.1
Braudeau, J.2
Michaelsen-Preusse, K.3
-
62
-
-
84940093906
-
CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease
-
Djelti F, Braudeau J, Hudry E, et al. CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease. Brain 2015;138:2383-2398.
-
(2015)
Brain
, vol.138
, pp. 2383-2398
-
-
Djelti, F.1
Braudeau, J.2
Hudry, E.3
|