Lenti-GDNF Gene Therapy Protects Against Alzheimer's Disease-Like Neuropathology in 3xTg-AD Mice and MC65 Cells

CNS Neuroscience and Therapeutics

Volumn 20, Issue 11, 2014, Pages 961-972

  Revilla, Susana ^a   Ursulet, Suzanna ^b   Álvarez López, María Jesús ^a   Castro Freire, Marco ^c   Perpiñá, Unai ^a   García Mesa, Yoelvis ^a   Bortolozzi, Analía ^a,c,d   Giménez Llort, Lydia ^e   Kaliman, Perla ^a   Cristòfol, Rosa ^a,c   Sarkis, Chamsy ^b   Sanfeliu, Coral ^a,c  

^a INST D INVESTIGACIONS B   (Spain)

^b NewVectys   (France)

^c INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^d CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

^e UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Alzheimer disease; Gene therapy; Glial cell line derived neurotrophic factor; Neuroblastoma; Transgenic mice

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; OLIGOMER; TAU PROTEIN; PRESENILIN 1; REACTIVE OXYGEN METABOLITE;

3XTG MOUSE; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN ATROPHY; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL LINE; CELL PROTECTION; COGNITION; CONTROLLED STUDY; GENE THERAPY; HIPPOCAMPUS; HUMAN; HUMAN CELL; LEARNING; MALE; MEMORY; MOUSE; NERVE CELL; NEUROBLASTOMA; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; UPREGULATION; VIRAL GENE THERAPY; VIRUS RECOMBINANT; ANIMAL; BIOSYNTHESIS; COGNITION DISORDERS; COMPLICATION; DISEASE MODEL; GENETICS; LENTIVIRINAE; MAZE TEST; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; PROCEDURES; TRANSGENIC MOUSE; TUMOR CELL LINE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CELL LINE, TUMOR; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; GENETIC THERAPY; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HIPPOCAMPUS; HUMANS; LENTIVIRUS; MALE; MAZE LEARNING; MICE; MICE, TRANSGENIC; MUTATION; NEUROBLASTOMA; PRESENILIN-1; REACTIVE OXYGEN SPECIES; TAU PROTEINS;

EID: 84911982234     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12312     Document Type: Article

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