AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APPPS1 mice

Gene Therapy

Volumn 19, Issue 7, 2012, Pages 724-733

  Kiyota, T ^a,b   Ingraham, K L ^c   Swan, R J ^a,b   Jacobsen, M T ^a,b   Andrews, S J ^a,b   Ikezu, T ^a,b,c  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

amyloid; AAV; Alzheimer's disease; cytokines; neurogenesis; neuroimmunology

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; INTERLEUKIN 10; PARVOVIRUS VECTOR; PRESENILIN 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTOSIS; BRAIN NERVE CELL; CELL PROLIFERATION; COCULTURE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GLIOSIS; HIPPOCAMPUS; LEARNING; MAZE TEST; MEMORY; MOUSE; NERVE CELL DIFFERENTIATION; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SEROTYPE; SOMATIC GENE THERAPY; SPATIAL LEARNING; VIRAL GENE DELIVERY SYSTEM; VIRUS HYBRID;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; COCULTURE TECHNIQUES; COGNITION; DEPENDOVIRUS; GENETIC THERAPY; HIPPOCAMPUS; INTERLEUKIN-10; MAZE LEARNING; MICE; MICE, TRANSGENIC; MUTATION; NEURAL STEM CELLS; NEUROGENESIS; NEURONS; PRESENILIN-1;

ADENO-ASSOCIATED VIRUS; MUS;

EID: 84863717973     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2011.126     Document Type: Article

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