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Volumn 68, Issue 1, 2016, Pages 127-138

Therapeutic strategies for Alzheimer's disease in clinical trials

Author keywords

Alzheimer's disease; Anti amyloid immunotherapy; Anti tau immunotherapy; Clinical trials; Secretase inhibitors

Indexed keywords

3 PHENYLSULFONYL 8 (1 PIPERAZINYL)QUINOLINE; 5,6 DIHYDRO 2 IMINO 3 METHYL 6 [4 [5 (1 PROPYNYL) 3 PYRIDINYL] 2 THIENYL] 4 PYRIMIDINONE; ABT 288; ALZHEIMER DISEASE VACCINE; AMARANTH; AVAGACESTAT; AZD 3293; AZELIRAGON; BAPINEUZUMAB; BEGACESTAT; BETA SECRETASE INHIBITOR; CRENEZUMAB; DONEPEZIL; ENCENICLINE; EPOTHILONE D; GANTENERUMAB; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; GSK 239512; IDALOPIRDINE; IMMUNOGLOBULIN; INSULIN; LIRAGLUTIDE; NILVADIPINE; PIOGLITAZONE; SEMAGACESTAT; SOLANEZUMAB; THALIDOMIDE; TIDEGLUSIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANUTIDE CRIDIFICAR; AMYLOID BETA PROTEIN; CHOLINESTERASE INHIBITOR; SECRETASE; TAU PROTEIN;

EID: 84953868005     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/j.pharep.2015.07.006     Document Type: Review
Times cited : (383)

References (103)
  • 1
    • 84886600387 scopus 로고    scopus 로고
    • Therapeutics of Alzheimer's disease: Past, present and future
    • R. Anand, K.D. Gill, and A.A. Mahdi Therapeutics of Alzheimer's disease: past, present and future Neuropharmacology 76 Part A 2014 27 50
    • (2014) Neuropharmacology , vol.76 , Issue.PART A , pp. 27-50
    • Anand, R.1    Gill, K.D.2    Mahdi, A.A.3
  • 3
    • 84872119357 scopus 로고    scopus 로고
    • Alzheimer Disease international. The worldwide economic impact of dementia 2010
    • e3
    • A. Wimo, L. Jonsson, J. Bond, M. Prince, and B. Winblad Alzheimer Disease international. The worldwide economic impact of dementia 2010 Alzheimers Dement 9 1 2013 1 11 e3
    • (2013) Alzheimers Dement , vol.9 , Issue.1 , pp. 1-11
    • Wimo, A.1    Jonsson, L.2    Bond, J.3    Prince, M.4    Winblad, B.5
  • 4
    • 79952574501 scopus 로고    scopus 로고
    • Epidemiology of Alzheimer disease
    • C. Reitz, C. Brayne, and R. Mayeux Epidemiology of Alzheimer disease Nat Rev Neurol 7 3 2011 137 152
    • (2011) Nat Rev Neurol , vol.7 , Issue.3 , pp. 137-152
    • Reitz, C.1    Brayne, C.2    Mayeux, R.3
  • 6
    • 84897954670 scopus 로고    scopus 로고
    • The complexities of the pathology-pathogenesis relationship in Alzheimer disease
    • R.J. Castellani, and G. Perry The complexities of the pathology-pathogenesis relationship in Alzheimer disease Biochem Pharmacol 88 4 2014 671 676
    • (2014) Biochem Pharmacol , vol.88 , Issue.4 , pp. 671-676
    • Castellani, R.J.1    Perry, G.2
  • 8
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer's disease
    • P. Davies, and A.J. Maloney Selective loss of central cholinergic neurons in Alzheimer's disease Lancet 2 8000 1976 1403
    • (1976) Lancet , vol.2 , Issue.8000 , pp. 1403
    • Davies, P.1    Maloney, A.J.2
  • 9
    • 33747423612 scopus 로고    scopus 로고
    • Memantine: A review of its use in Alzheimer's disease
    • D.M. Robinson, and G.M. Keating Memantine: a review of its use in Alzheimer's disease Drugs 66 11 2006 1515 1534
    • (2006) Drugs , vol.66 , Issue.11 , pp. 1515-1534
    • Robinson, D.M.1    Keating, G.M.2
  • 11
    • 84919882105 scopus 로고    scopus 로고
    • Diverse molecular targets for therapeutic strategies in Alzheimer's disease
    • S.H. Han, and I. Mook-Jung Diverse molecular targets for therapeutic strategies in Alzheimer's disease J Kor Med Sci 29 7 2014 893 902
    • (2014) J Kor Med Sci , vol.29 , Issue.7 , pp. 893-902
    • Han, S.H.1    Mook-Jung, I.2
  • 12
    • 84904702577 scopus 로고    scopus 로고
    • The battle of Alzheimer's Disease - The beginning of the future unleashing the potential of academic discoveries
    • J. Lundkvist, M.M. Halldin, J. Sandin, G. Nordvall, P. Forsell, S. Svensson, and et al. The battle of Alzheimer's Disease - the beginning of the future unleashing the potential of academic discoveries Front Pharmacol 5 2014 102
    • (2014) Front Pharmacol , vol.5 , pp. 102
    • Lundkvist, J.1    Halldin, M.M.2    Sandin, J.3    Nordvall, G.4    Forsell, P.5    Svensson, S.6
  • 13
    • 84895729886 scopus 로고    scopus 로고
    • Clinical trials and late-stage drug development for Alzheimer's disease: An appraisal from 1984 to 2014
    • L.S. Schneider, F. Mangialasche, N. Andreasen, H. Feldman, E. Giacobini, R. Jones, and et al. Clinical trials and late-stage drug development for Alzheimer's disease: an appraisal from 1984 to 2014 J Intern Med 275 3 2014 251 283
    • (2014) J Intern Med , vol.275 , Issue.3 , pp. 251-283
    • Schneider, L.S.1    Mangialasche, F.2    Andreasen, N.3    Feldman, H.4    Giacobini, E.5    Jones, R.6
  • 14
    • 84922575690 scopus 로고    scopus 로고
    • New approaches to treating Alzheimer's disease
    • H. Zheng, M. Fridkin, and M. Youdim New approaches to treating Alzheimer's disease Perspect Med Chem 7 2015 1 8
    • (2015) Perspect Med Chem , vol.7 , pp. 1-8
    • Zheng, H.1    Fridkin, M.2    Youdim, M.3
  • 15
    • 84897954317 scopus 로고    scopus 로고
    • Immunotherapy for Alzheimer's disease
    • T. Wisniewski, and F. Goni Immunotherapy for Alzheimer's disease Biochem Pharmacol 88 4 2014 499 507
    • (2014) Biochem Pharmacol , vol.88 , Issue.4 , pp. 499-507
    • Wisniewski, T.1    Goni, F.2
  • 16
    • 84929051777 scopus 로고    scopus 로고
    • Potential therapeutic strategies for Alzheimer's disease targeting or beyond beta-amyloid: Insights from clinical trials
    • Q. Jia, Y. Deng, and H. Qing Potential therapeutic strategies for Alzheimer's disease targeting or beyond beta-amyloid: insights from clinical trials Biomed Res Int 2014 2014 837157
    • (2014) Biomed Res Int , vol.2014 , pp. 837157
    • Jia, Q.1    Deng, Y.2    Qing, H.3
  • 17
    • 84918591171 scopus 로고    scopus 로고
    • Ekavali. A review on Alzheimer's disease pathophysiology and its management: An update
    • A. Kumar, and A. Singh Ekavali. A review on Alzheimer's disease pathophysiology and its management: an update Pharmacol Rep 67 2 2015 195 203
    • (2015) Pharmacol Rep , vol.67 , Issue.2 , pp. 195-203
    • Kumar, A.1    Singh, A.2
  • 18
    • 84942363147 scopus 로고    scopus 로고
    • ATP leakage induces P2XR activation and contributes to acute synaptic excitotoxicity induced by soluble oligomers of beta-amyloid peptide in hippocampal neurons
    • F. Saez-Orellana, P.A. Godoy, C.Y. Bastidas, T. Silva-Grecchi, L. Guzman, L.G. Aguayo, and et al. ATP leakage induces P2XR activation and contributes to acute synaptic excitotoxicity induced by soluble oligomers of beta-amyloid peptide in hippocampal neurons Neuropharmacology 2015 10.1016/j.neuropharm.2015.04.005
    • (2015) Neuropharmacology
    • Saez-Orellana, F.1    Godoy, P.A.2    Bastidas, C.Y.3    Silva-Grecchi, T.4    Guzman, L.5    Aguayo, L.G.6
  • 20
    • 36048976686 scopus 로고    scopus 로고
    • The pathogenesis of Alzheimer's disease and the role of Abeta42
    • T.E. Golde The pathogenesis of Alzheimer's disease and the role of Abeta42 CNS Spectr 12 1 (Suppl. 1) 2007 4 6
    • (2007) CNS Spectr , vol.12 , pp. 4-6
    • Golde, T.E.1
  • 21
    • 84865529158 scopus 로고    scopus 로고
    • Clinical and biomarker changes in dominantly inherited Alzheimer's disease
    • R.J. Bateman, C. Xiong, T.L. Benzinger, A.M. Fagan, A. Goate, N.C. Fox, and et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease N Engl J Med 367 9 2012 795 804
    • (2012) N Engl J Med , vol.367 , Issue.9 , pp. 795-804
    • Bateman, R.J.1    Xiong, C.2    Benzinger, T.L.3    Fagan, A.M.4    Goate, A.5    Fox, N.C.6
  • 23
    • 84895729926 scopus 로고    scopus 로고
    • Amyloid-ss-directed immunotherapy for Alzheimer's disease
    • L. Lannfelt, N.R. Relkin, and E.R. Siemers Amyloid-ss-directed immunotherapy for Alzheimer's disease J Intern Med 275 3 2014 284 295
    • (2014) J Intern Med , vol.275 , Issue.3 , pp. 284-295
    • Lannfelt, L.1    Relkin, N.R.2    Siemers, E.R.3
  • 24
    • 84924614515 scopus 로고    scopus 로고
    • Effect of active Abeta immunotherapy on neurons in human Alzheimer's disease
    • C. Paquet, J. Amin, F. Mouton-Liger, M. Nasser, S. Love, F. Gray, and et al. Effect of active Abeta immunotherapy on neurons in human Alzheimer's disease J Pathol 235 5 2015 721 730
    • (2015) J Pathol , vol.235 , Issue.5 , pp. 721-730
    • Paquet, C.1    Amin, J.2    Mouton-Liger, F.3    Nasser, M.4    Love, S.5    Gray, F.6
  • 25
    • 84894033757 scopus 로고    scopus 로고
    • Is there still any hope for amyloid-based immunotherapy for Alzheimer's disease?
    • F. Panza, G. Logroscino, B.P. Imbimbo, and V. Solfrizzi Is there still any hope for amyloid-based immunotherapy for Alzheimer's disease? Curr Opin Psychiatry 27 2 2014 128 137
    • (2014) Curr Opin Psychiatry , vol.27 , Issue.2 , pp. 128-137
    • Panza, F.1    Logroscino, G.2    Imbimbo, B.P.3    Solfrizzi, V.4
  • 26
  • 27
    • 84862331908 scopus 로고    scopus 로고
    • Safety, tolerability, and antibody response of active Abeta immunotherapy with CAD106 in patients with Alzheimer's disease: Randomised, double-blind, placebo-controlled, first-in-human study
    • B. Winblad, N. Andreasen, L. Minthon, A. Floesser, G. Imbert, T. Dumortier, and et al. Safety, tolerability, and antibody response of active Abeta immunotherapy with CAD106 in patients with Alzheimer's disease: randomised, double-blind, placebo-controlled, first-in-human study Lancet Neurol 11 7 2012 597 604
    • (2012) Lancet Neurol , vol.11 , Issue.7 , pp. 597-604
    • Winblad, B.1    Andreasen, N.2    Minthon, L.3    Floesser, A.4    Imbert, G.5    Dumortier, T.6
  • 28
    • 84969294757 scopus 로고    scopus 로고
    • https://clinicaltrials.gov
  • 29
    • 84966690787 scopus 로고    scopus 로고
    • Safety, tolerability and immunogenicity of an immunotherapeutic vaccine (vanutide cridificar [ACC-001]) and the QS-21 adjuvant in Japanese individuals with mild-to-moderate Alzheimer's disease: A phase IIa, multicenter, randomized, adjuvant and placebo clinical trial
    • H. Arai, H. Suzuki, T. Yoshiyama, K. Lobello, Y. Peng, E. Liu, and et al. Safety, tolerability and immunogenicity of an immunotherapeutic vaccine (vanutide cridificar [ACC-001]) and the QS-21 adjuvant in Japanese individuals with mild-to-moderate Alzheimer's disease: a phase IIa, multicenter, randomized, adjuvant and placebo clinical trial Alzheimer's Dement 9 4 2013 282
    • (2013) Alzheimer's Dement , vol.9 , Issue.4 , pp. 282
    • Arai, H.1    Suzuki, H.2    Yoshiyama, T.3    Lobello, K.4    Peng, Y.5    Liu, E.6
  • 30
    • 84892748542 scopus 로고    scopus 로고
    • Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease
    • R.S. Doody, R.G. Thomas, M. Farlow, T. Iwatsubo, B. Vellas, S. Joffe, and et al. Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease N Engl J Med 370 4 2014 311 321
    • (2014) N Engl J Med , vol.370 , Issue.4 , pp. 311-321
    • Doody, R.S.1    Thomas, R.G.2    Farlow, M.3    Iwatsubo, T.4    Vellas, B.5    Joffe, S.6
  • 31
    • 84901049049 scopus 로고    scopus 로고
    • Modulation of beta-amyloid by a single dose of GSK933776 in patients with mild Alzheimer's disease: A phase I study
    • T. Leyhe, N. Andreasen, M. Simeoni, A. Reich, C.A. von Arnim, X. Tong, and et al. Modulation of beta-amyloid by a single dose of GSK933776 in patients with mild Alzheimer's disease: a phase I study Alzheimers Res Ther 6 2 2014 19
    • (2014) Alzheimers Res Ther , vol.6 , Issue.2 , pp. 19
    • Leyhe, T.1    Andreasen, N.2    Simeoni, M.3    Reich, A.4    Von Arnim, C.A.5    Tong, X.6
  • 32
    • 84905184129 scopus 로고    scopus 로고
    • Clinical trials of intravenous immunoglobulin for Alzheimer's disease
    • N. Relkin Clinical trials of intravenous immunoglobulin for Alzheimer's disease J Clin Immunol 34 Suppl 1 2014 74 79
    • (2014) J Clin Immunol , vol.34 , pp. 74-79
    • Relkin, N.1
  • 34
    • 84891834492 scopus 로고    scopus 로고
    • Potential novel targets for Alzheimer pharmacotherapy: II. Update on secretase inhibitors and related approaches
    • J.A. Mikulca, V. Nguyen, D.A. Gajdosik, S.G. Teklu, E.A. Giunta, E.A. Lessa, and et al. Potential novel targets for Alzheimer pharmacotherapy: II. Update on secretase inhibitors and related approaches J Clin Pharm Ther 39 1 2014 25 37
    • (2014) J Clin Pharm Ther , vol.39 , Issue.1 , pp. 25-37
    • Mikulca, J.A.1    Nguyen, V.2    Gajdosik, D.A.3    Teklu, S.G.4    Giunta, E.A.5    Lessa, E.A.6
  • 35
    • 79959636033 scopus 로고    scopus 로고
    • The many substrates of presenilin/gamma-secretase
    • A. Haapasalo, and D.M. Kovacs The many substrates of presenilin/gamma-secretase J Alzheimers Dis 25 1 2011 3 28
    • (2011) J Alzheimers Dis , vol.25 , Issue.1 , pp. 3-28
    • Haapasalo, A.1    Kovacs, D.M.2
  • 36
    • 84980052944 scopus 로고    scopus 로고
    • Neuropathological and biochemical assessments of an Alzheimer's disease patient treated with the gamma-secretase inhibitor semagacestat
    • A.E. Roher, C.L. Maarouf, T.A. Kokjohn, C.M. Whiteside, W.M. Kalback, G. Serrano, and et al. Neuropathological and biochemical assessments of an Alzheimer's disease patient treated with the gamma-secretase inhibitor semagacestat Am J Neurodegener Dis 3 3 2014 115 133
    • (2014) Am J Neurodegener Dis , vol.3 , Issue.3 , pp. 115-133
    • Roher, A.E.1    Maarouf, C.L.2    Kokjohn, T.A.3    Whiteside, C.M.4    Kalback, W.M.5    Serrano, G.6
  • 37
    • 84880712325 scopus 로고    scopus 로고
    • A phase 3 trial of semagacestat for treatment of Alzheimer's disease
    • R.S. Doody, R. Raman, M. Farlow, T. Iwatsubo, B. Vellas, S. Joffe, and et al. A phase 3 trial of semagacestat for treatment of Alzheimer's disease N Engl J Med 369 4 2013 341 350
    • (2013) N Engl J Med , vol.369 , Issue.4 , pp. 341-350
    • Doody, R.S.1    Raman, R.2    Farlow, M.3    Iwatsubo, T.4    Vellas, B.5    Joffe, S.6
  • 38
    • 0033617522 scopus 로고    scopus 로고
    • Notch signaling: Cell fate control and signal integration in development
    • S. Artavanis-Tsakonas, M.D. Rand, and R.J. Lake Notch signaling: cell fate control and signal integration in development Science 284 5415 1999 770 776
    • (1999) Science , vol.284 , Issue.5415 , pp. 770-776
    • Artavanis-Tsakonas, S.1    Rand, M.D.2    Lake, R.J.3
  • 39
    • 84872319163 scopus 로고    scopus 로고
    • Exacerbation of psoriatic skin lesions in a patient with Alzheimer disease receiving gamma-secretase inhibitor
    • C.K. Hsu, C.C. Hsu, J.Y. Lee, Y.M. Kuo, and M.C. Pai Exacerbation of psoriatic skin lesions in a patient with Alzheimer disease receiving gamma-secretase inhibitor J Am Acad Dermatol 68 2 2013 e46 e48
    • (2013) J Am Acad Dermatol , vol.68 , Issue.2 , pp. e46-e48
    • Hsu, C.K.1    Hsu, C.C.2    Lee, J.Y.3    Kuo, Y.M.4    Pai, M.C.5
  • 40
    • 40349111175 scopus 로고    scopus 로고
    • Therapeutic potential of gamma-secretase inhibitors and modulators
    • B.P. Imbimbo Therapeutic potential of gamma-secretase inhibitors and modulators Curr Top Med Chem 8 1 2008 54 61
    • (2008) Curr Top Med Chem , vol.8 , Issue.1 , pp. 54-61
    • Imbimbo, B.P.1
  • 41
    • 33750455150 scopus 로고    scopus 로고
    • Control of peripheral nerve myelination by the beta-secretase BACE1
    • M. Willem, A.N. Garratt, B. Novak, M. Citron, S. Kaufmann, A. Rittger, and et al. Control of peripheral nerve myelination by the beta-secretase BACE1 Science 314 5799 2006 664 666
    • (2006) Science , vol.314 , Issue.5799 , pp. 664-666
    • Willem, M.1    Garratt, A.N.2    Novak, B.3    Citron, M.4    Kaufmann, S.5    Rittger, A.6
  • 43
    • 84894090892 scopus 로고    scopus 로고
    • Targeting the beta secretase BACE1 for Alzheimer's disease therapy
    • R. Yan, and R. Vassar Targeting the beta secretase BACE1 for Alzheimer's disease therapy Lancet Neurol 13 3 2014 319 329
    • (2014) Lancet Neurol , vol.13 , Issue.3 , pp. 319-329
    • Yan, R.1    Vassar, R.2
  • 44
    • 84928122845 scopus 로고    scopus 로고
    • BACE1 inhibitor drugs in clinical trials for Alzheimer's disease
    • 89-014-0089-7
    • R. Vassar BACE1 inhibitor drugs in clinical trials for Alzheimer's disease Alzheimers Res Ther 6 9 2014 89-014-0089-7
    • (2014) Alzheimers Res Ther , vol.6 , Issue.9
    • Vassar, R.1
  • 45
    • 84908254254 scopus 로고    scopus 로고
    • Lessons from a BACE1 inhibitor trial: Off-site but not off base
    • D.K. Lahiri, B. Maloney, J.M. Long, and N.H. Greig Lessons from a BACE1 inhibitor trial: off-site but not off base Alzheimers Dement 10 5 SUPPL 2014 S411 S419
    • (2014) Alzheimers Dement , vol.10 , pp. S411-S419
    • Lahiri, D.K.1    Maloney, B.2    Long, J.M.3    Greig, N.H.4
  • 46
    • 84864148410 scopus 로고    scopus 로고
    • Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons
    • P.H. Kuhn, K. Koroniak, S. Hogl, A. Colombo, U. Zeitschel, M. Willem, and et al. Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons EMBO J 31 14 2012 3157 3168
    • (2012) EMBO J , vol.31 , Issue.14 , pp. 3157-3168
    • Kuhn, P.H.1    Koroniak, K.2    Hogl, S.3    Colombo, A.4    Zeitschel, U.5    Willem, M.6
  • 47
    • 84864471159 scopus 로고    scopus 로고
    • A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
    • T. Jonsson, J.K. Atwal, S. Steinberg, J. Snaedal, P.V. Jonsson, S. Bjornsson, and et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline Nature 488 7409 2012 96 99
    • (2012) Nature , vol.488 , Issue.7409 , pp. 96-99
    • Jonsson, T.1    Atwal, J.K.2    Steinberg, S.3    Snaedal, J.4    Jonsson, P.V.5    Bjornsson, S.6
  • 48
    • 79953854897 scopus 로고    scopus 로고
    • Alzheimer's disease: The challenge of the second century
    • D.M. Holtzman, J.C. Morris, and A.M. Goate Alzheimer's disease: the challenge of the second century Sci Transl Med 3 77 2011 77sr1
    • (2011) Sci Transl Med , vol.3 , Issue.77 , pp. 77sr1
    • Holtzman, D.M.1    Morris, J.C.2    Goate, A.M.3
  • 49
    • 84927710653 scopus 로고    scopus 로고
    • Tau aggregation and its interplay with amyloid-beta
    • R.M. Nisbet, J.C. Polanco, L.M. Ittner, and J. Gotz Tau aggregation and its interplay with amyloid-beta Acta Neuropathol 129 2 2015 207 220
    • (2015) Acta Neuropathol , vol.129 , Issue.2 , pp. 207-220
    • Nisbet, R.M.1    Polanco, J.C.2    Ittner, L.M.3    Gotz, J.4
  • 52
    • 84884979769 scopus 로고    scopus 로고
    • Preclinical trials in autosomal dominant AD: Implementation of the DIAN-TU trial
    • S.M. Mills, J. Mallmann, A.M. Santacruz, A. Fuqua, M. Carril, P.S. Aisen, and et al. Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial Rev Neurol (Paris) 169 10 2013 737 743
    • (2013) Rev Neurol (Paris) , vol.169 , Issue.10 , pp. 737-743
    • Mills, S.M.1    Mallmann, J.2    Santacruz, A.M.3    Fuqua, A.4    Carril, M.5    Aisen, P.S.6
  • 53
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • J. Hardy, and D. Allsop Amyloid deposition as the central event in the aetiology of Alzheimer's disease Trends Pharmacol Sci 12 10 1991 383 388
    • (1991) Trends Pharmacol Sci , vol.12 , Issue.10 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 54
    • 0035140975 scopus 로고    scopus 로고
    • Going new places using an old MAP: Tau, microtubules and human neurodegenerative disease
    • M.L. Garcia, and D.W. Cleveland Going new places using an old MAP: tau, microtubules and human neurodegenerative disease Curr Opin Cell Biol 13 1 2001 41 48
    • (2001) Curr Opin Cell Biol , vol.13 , Issue.1 , pp. 41-48
    • Garcia, M.L.1    Cleveland, D.W.2
  • 55
    • 84898059466 scopus 로고    scopus 로고
    • Tau-aggregation inhibitor therapy for Alzheimer's disease
    • C.M. Wischik, C.R. Harrington, and J.M. Storey Tau-aggregation inhibitor therapy for Alzheimer's disease Biochem Pharmacol 88 4 2014 529 539
    • (2014) Biochem Pharmacol , vol.88 , Issue.4 , pp. 529-539
    • Wischik, C.M.1    Harrington, C.R.2    Storey, J.M.3
  • 56
    • 84923037846 scopus 로고    scopus 로고
    • Invited review: Drug development for tauopathies
    • F. Gruninger Invited review: drug development for tauopathies Neuropathol Appl Neurobiol 41 1 2015 81 96
    • (2015) Neuropathol Appl Neurobiol , vol.41 , Issue.1 , pp. 81-96
    • Gruninger, F.1
  • 57
    • 19944429064 scopus 로고    scopus 로고
    • Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
    • B. Zhang, A. Maiti, S. Shively, F. Lakhani, G. McDonald-Jones, J. Bruce, and et al. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model Proc Natl Acad Sci U S A 102 1 2005 227 231
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.1 , pp. 227-231
    • Zhang, B.1    Maiti, A.2    Shively, S.3    Lakhani, F.4    McDonald-Jones, G.5    Bruce, J.6
  • 58
    • 78650945635 scopus 로고    scopus 로고
    • Tau vaccine: Active immunization with misfolded tau protein attenuates tau pathology in the transgenic rat model of tauopathy
    • M. Novak Tau vaccine: active immunization with misfolded tau protein attenuates tau pathology in the transgenic rat model of tauopathy Alzheimer's Dement 5 4 2009 93
    • (2009) Alzheimer's Dement , vol.5 , Issue.4 , pp. 93
    • Novak, M.1
  • 59
    • 84922479255 scopus 로고    scopus 로고
    • Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy
    • C. Theunis, N. Crespo-Biel, V. Gafner, M. Pihlgren, M.P. Lopez-Deber, P. Reis, and et al. Efficacy and safety of a liposome-based vaccine against protein Tau, assessed in tau.P301L mice that model tauopathy PLOS ONE 8 8 2013 72301
    • (2013) PLOS ONE , vol.8 , Issue.8 , pp. 72301
    • Theunis, C.1    Crespo-Biel, N.2    Gafner, V.3    Pihlgren, M.4    Lopez-Deber, M.P.5    Reis, P.6
  • 61
    • 68149150844 scopus 로고    scopus 로고
    • A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo
    • L. Sereno, M. Coma, M. Rodriguez, P. Sanchez-Ferrer, M.B. Sanchez, I. Gich, and et al. A novel GSK-3beta inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo Neurobiol Dis 35 3 2009 359 367
    • (2009) Neurobiol Dis , vol.35 , Issue.3 , pp. 359-367
    • Sereno, L.1    Coma, M.2    Rodriguez, M.3    Sanchez-Ferrer, P.4    Sanchez, M.B.5    Gich, I.6
  • 62
    • 84923008414 scopus 로고    scopus 로고
    • A phase II randomized, double-blind, parallel group, 26-week study of GSK-3 inhibitor tideglusib in Alzheimer's disease (argo trial)
    • T. del Ser, S. Lovestone, M. Boada-Rovira, B. Dubois, M. Hull, J. Rinne, and et al. A phase II randomized, double-blind, parallel group, 26-week study of GSK-3 inhibitor tideglusib in Alzheimer's disease (argo trial) Alzheimer's Dement 9 4 2013 P689 P690
    • (2013) Alzheimer's Dement , vol.9 , Issue.4 , pp. P689-P690
    • Del Ser, T.1    Lovestone, S.2    Boada-Rovira, M.3    Dubois, B.4    Hull, M.5    Rinne, J.6
  • 64
    • 84872431424 scopus 로고    scopus 로고
    • Intranasal insulin ameliorates tau hyperphosphorylation in a rat model of type 2 diabetes
    • Y. Yang, D. Ma, Y. Wang, T. Jiang, S. Hu, M. Zhang, and et al. Intranasal insulin ameliorates tau hyperphosphorylation in a rat model of type 2 diabetes J Alzheimers Dis 33 2 2013 329 338
    • (2013) J Alzheimers Dis , vol.33 , Issue.2 , pp. 329-338
    • Yang, Y.1    Ma, D.2    Wang, Y.3    Jiang, T.4    Hu, S.5    Zhang, M.6
  • 65
    • 84878864610 scopus 로고    scopus 로고
    • Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease
    • A. Claxton, L.D. Baker, C.W. Wilkinson, E.H. Trittschuh, D. Chapman, G.S. Watson, and et al. Sex and ApoE genotype differences in treatment response to two doses of intranasal insulin in adults with mild cognitive impairment or Alzheimer's disease J Alzheimers Dis 35 4 2013 789 797
    • (2013) J Alzheimers Dis , vol.35 , Issue.4 , pp. 789-797
    • Claxton, A.1    Baker, L.D.2    Wilkinson, C.W.3    Trittschuh, E.H.4    Chapman, D.5    Watson, G.S.6
  • 66
    • 47849123972 scopus 로고    scopus 로고
    • Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults
    • M.A. Reger, G.S. Watson, P.S. Green, L.D. Baker, B. Cholerton, M.A. Fishel, and et al. Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults J Alzheimers Dis 13 3 2008 323 331
    • (2008) J Alzheimers Dis , vol.13 , Issue.3 , pp. 323-331
    • Reger, M.A.1    Watson, G.S.2    Green, P.S.3    Baker, L.D.4    Cholerton, B.5    Fishel, M.A.6
  • 67
    • 40349091597 scopus 로고    scopus 로고
    • Intranasal insulin improves cognition and modulates beta-amyloid in early AD
    • M.A. Reger, G.S. Watson, P.S. Green, C.W. Wilkinson, L.D. Baker, B. Cholerton, and et al. Intranasal insulin improves cognition and modulates beta-amyloid in early AD Neurology 70 6 2008 440 448
    • (2008) Neurology , vol.70 , Issue.6 , pp. 440-448
    • Reger, M.A.1    Watson, G.S.2    Green, P.S.3    Wilkinson, C.W.4    Baker, L.D.5    Cholerton, B.6
  • 68
    • 77957108249 scopus 로고    scopus 로고
    • Signalling pathways associated with 5-HT6 receptors: Relevance for cognitive effects
    • B. Marcos, M. Cabero, M. Solas, B. Aisa, and M.J. Ramirez Signalling pathways associated with 5-HT6 receptors: relevance for cognitive effects Int J Neuropsychopharmacol 13 6 2010 775 784
    • (2010) Int J Neuropsychopharmacol , vol.13 , Issue.6 , pp. 775-784
    • Marcos, B.1    Cabero, M.2    Solas, M.3    Aisa, B.4    Ramirez, M.J.5
  • 70
    • 84907995546 scopus 로고    scopus 로고
    • Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): A randomised, double-blind, placebo-controlled phase 2 trial
    • D. Wilkinson, K. Windfeld, and E. Colding-Jorgensen Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial Lancet Neurol 13 11 2014 1092 1099
    • (2014) Lancet Neurol , vol.13 , Issue.11 , pp. 1092-1099
    • Wilkinson, D.1    Windfeld, K.2    Colding-Jorgensen, E.3
  • 71
    • 84907965476 scopus 로고    scopus 로고
    • Idalopirdine for Alzheimer's disease: Written in the stars
    • L.S. Schneider Idalopirdine for Alzheimer's disease: written in the stars Lancet Neurol 13 11 2014 1063 1065
    • (2014) Lancet Neurol , vol.13 , Issue.11 , pp. 1063-1065
    • Schneider, L.S.1
  • 72
    • 52949099850 scopus 로고    scopus 로고
    • Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat
    • B. Marcos, T.T. Chuang, F.J. Gil-Bea, and M.J. Ramirez Effects of 5-HT6 receptor antagonism and cholinesterase inhibition in models of cognitive impairment in the rat Br J Pharmacol 155 3 2008 434 440
    • (2008) Br J Pharmacol , vol.155 , Issue.3 , pp. 434-440
    • Marcos, B.1    Chuang, T.T.2    Gil-Bea, F.J.3    Ramirez, M.J.4
  • 73
    • 84969298569 scopus 로고    scopus 로고
    • A clinical phase II study of LU AE58054 added to stable donepezil treatment in patients with moderate Alzheimer's disease
    • D. Wilkinson, E. Colding-Jorgensen, and K. Windfeld A clinical phase II study of LU AE58054 added to stable donepezil treatment in patients with moderate Alzheimer's disease Alzheimer's Dement 9 4 2013 529
    • (2013) Alzheimer's Dement , vol.9 , Issue.4 , pp. 529
    • Wilkinson, D.1    Colding-Jorgensen, E.2    Windfeld, K.3
  • 74
    • 77957240989 scopus 로고    scopus 로고
    • Double-blind, controlled phase II study of a 5-HT6 receptor antagonist, SB-742457, in Alzheimer's disease
    • G. Maher-Edwards, M. Zvartau-Hind, A.J. Hunter, M. Gold, G. Hopton, G. Jacobs, and et al. Double-blind, controlled phase II study of a 5-HT6 receptor antagonist, SB-742457, in Alzheimer's disease Curr Alzheimer Res 7 5 2010 374 385
    • (2010) Curr Alzheimer Res , vol.7 , Issue.5 , pp. 374-385
    • Maher-Edwards, G.1    Zvartau-Hind, M.2    Hunter, A.J.3    Gold, M.4    Hopton, G.5    Jacobs, G.6
  • 75
    • 79953736827 scopus 로고    scopus 로고
    • The histaminergic system: A target for innovative treatments of cognitive deficits
    • M. Motawaj, A. Burban, E. Davenas, F. Gbahou, R. Faucard, S. Morisset, and et al. The histaminergic system: a target for innovative treatments of cognitive deficits Therapie 65 5 2010 415 422
    • (2010) Therapie , vol.65 , Issue.5 , pp. 415-422
    • Motawaj, M.1    Burban, A.2    Davenas, E.3    Gbahou, F.4    Faucard, R.5    Morisset, S.6
  • 77
    • 84866327781 scopus 로고    scopus 로고
    • Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist
    • T.A. Esbenshade, K.E. Browman, T.R. Miller, K.M. Krueger, V. Komater-Roderwald, M. Zhang, and et al. Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist J Pharmacol Exp Ther 343 1 2012 233 245
    • (2012) J Pharmacol Exp Ther , vol.343 , Issue.1 , pp. 233-245
    • Esbenshade, T.A.1    Browman, K.E.2    Miller, T.R.3    Krueger, K.M.4    Komater-Roderwald, V.5    Zhang, M.6
  • 78
    • 84901336206 scopus 로고    scopus 로고
    • The H3 antagonist ABT-288 is tolerated at significantly higher exposures in subjects with schizophrenia than in healthy volunteers
    • A.A. Othman, G. Haig, H. Florian, C. Locke, L. Gertsik, and S. Dutta The H3 antagonist ABT-288 is tolerated at significantly higher exposures in subjects with schizophrenia than in healthy volunteers Br J Clin Pharmacol 77 6 2014 965 974
    • (2014) Br J Clin Pharmacol , vol.77 , Issue.6 , pp. 965-974
    • Othman, A.A.1    Haig, G.2    Florian, H.3    Locke, C.4    Gertsik, L.5    Dutta, S.6
  • 79
    • 84907150288 scopus 로고    scopus 로고
    • A randomized study of H3 antagonist ABT-288 in mild-to-moderate Alzheimer's dementia
    • G.M. Haig, Y. Pritchett, A. Meier, A.A. Othman, C. Hall, L.M. Gault, and et al. A randomized study of H3 antagonist ABT-288 in mild-to-moderate Alzheimer's dementia J Alzheimers Dis 42 3 2014 959 971
    • (2014) J Alzheimers Dis , vol.42 , Issue.3 , pp. 959-971
    • Haig, G.M.1    Pritchett, Y.2    Meier, A.3    Othman, A.A.4    Hall, C.5    Gault, L.M.6
  • 80
    • 84891763528 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, 16-week study of the H3 receptor antagonist, GSK239512 as a monotherapy in subjects with mild-to-moderate Alzheimer's disease
    • R.A. Grove, C.M. Harrington, A. Mahler, I. Beresford, P. Maruff, M.T. Lowy, and et al. A randomized, double-blind, placebo-controlled, 16-week study of the H3 receptor antagonist, GSK239512 as a monotherapy in subjects with mild-to-moderate Alzheimer's disease Curr Alzheimer Res 11 1 2014 47 58
    • (2014) Curr Alzheimer Res , vol.11 , Issue.1 , pp. 47-58
    • Grove, R.A.1    Harrington, C.M.2    Mahler, A.3    Beresford, I.4    Maruff, P.5    Lowy, M.T.6
  • 82
    • 84855964150 scopus 로고    scopus 로고
    • EVP-6124, a novel and selective alpha7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of alpha7 nicotinic acetylcholine receptors
    • J. Prickaerts, N.P. van Goethem, R. Chesworth, G. Shapiro, F.G. Boess, C. Methfessel, and et al. EVP-6124, a novel and selective alpha7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of alpha7 nicotinic acetylcholine receptors Neuropharmacology 2 2012 1099 1110
    • (2012) Neuropharmacology , Issue.2 , pp. 1099-1110
    • Prickaerts, J.1    Van Goethem, N.P.2    Chesworth, R.3    Shapiro, G.4    Boess, F.G.5    Methfessel, C.6
  • 84
    • 84861411831 scopus 로고    scopus 로고
    • Early intervention with a small molecule inhibitor for tumor necrosis factor-alpha prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease
    • 99-2094-9-99
    • S.P. Gabbita, M.K. Srivastava, P. Eslami, M.F. Johnson, N.K. Kobritz, D. Tweedie, and et al. Early intervention with a small molecule inhibitor for tumor necrosis factor-alpha prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease J Neuroinflammation 9 2012 99-2094-9-99
    • (2012) J Neuroinflammation , vol.9
    • Gabbita, S.P.1    Srivastava, M.K.2    Eslami, P.3    Johnson, M.F.4    Kobritz, N.K.5    Tweedie, D.6
  • 85
    • 38449111448 scopus 로고    scopus 로고
    • The role of thalidomide in the management of erythema nodosum leprosum
    • S.L. Walker, M.F. Waters, and D.N. Lockwood The role of thalidomide in the management of erythema nodosum leprosum Lepr Rev 78 3 2007 197 215
    • (2007) Lepr Rev , vol.78 , Issue.3 , pp. 197-215
    • Walker, S.L.1    Waters, M.F.2    Lockwood, D.N.3
  • 86
    • 84929346786 scopus 로고    scopus 로고
    • Frontline therapy of multiple myeloma
    • P. Moreau, M. Attal, and T. Facon Frontline therapy of multiple myeloma Blood 125 20 2015 3076 3084
    • (2015) Blood , vol.125 , Issue.20 , pp. 3076-3084
    • Moreau, P.1    Attal, M.2    Facon, T.3
  • 87
    • 84864540510 scopus 로고    scopus 로고
    • Thalidomide chemistry, therapeutic potential and oxidative stress induced teratogenicity
    • N. Kumar, U. Sharma, C. Singh, and B. Singh Thalidomide chemistry, therapeutic potential and oxidative stress induced teratogenicity Curr Top Med Chem 12 13 2012 1436 1455
    • (2012) Curr Top Med Chem , vol.12 , Issue.13 , pp. 1436-1455
    • Kumar, N.1    Sharma, U.2    Singh, C.3    Singh, B.4
  • 90
    • 0141461415 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor is involved in learning and neuroprotection
    • M.J. During, L. Cao, D.S. Zuzga, J.S. Francis, H.L. Fitzsimons, X. Jiao, and et al. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection Nat Med 9 9 2003 1173 1179
    • (2003) Nat Med , vol.9 , Issue.9 , pp. 1173-1179
    • During, M.J.1    Cao, L.2    Zuzga, D.S.3    Francis, J.S.4    Fitzsimons, H.L.5    Jiao, X.6
  • 91
    • 69549138878 scopus 로고    scopus 로고
    • Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease
    • T. Abbas, E. Faivre, and C. Holscher Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease Behav Brain Res 205 1 2009 265 271
    • (2009) Behav Brain Res , vol.205 , Issue.1 , pp. 265-271
    • Abbas, T.1    Faivre, E.2    Holscher, C.3
  • 92
    • 84873266979 scopus 로고    scopus 로고
    • Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer s disease - Protocol for a controlled, randomized double-blinded trial
    • L. Egefjord, M. Gejl, A. Moller, H. Braendgaard, H. Gottrup, O. Antropova, and et al. Effects of liraglutide on neurodegeneration, blood flow and cognition in Alzheimer s disease - protocol for a controlled, randomized double-blinded trial Dan Med J 59 10 2012 A4519
    • (2012) Dan Med J , vol.59 , Issue.10 , pp. A4519
    • Egefjord, L.1    Gejl, M.2    Moller, A.3    Braendgaard, H.4    Gottrup, H.5    Antropova, O.6
  • 93
    • 84911435297 scopus 로고    scopus 로고
    • NILVAD protocol: A European multicentre double-blind placebo-controlled trial of nilvadipine in mild-to-moderate Alzheimer's disease
    • e006364-2014-006364
    • B. Lawlor, S. Kennelly, S. O'Dwyer, F. Cregg, C. Walsh, R. Coen, and et al. NILVAD protocol: a European multicentre double-blind placebo-controlled trial of nilvadipine in mild-to-moderate Alzheimer's disease BMJ Open 4 10 2014 e006364-2014-006364
    • (2014) BMJ Open , vol.4 , Issue.10
    • Lawlor, B.1    Kennelly, S.2    O'Dwyer, S.3    Cregg, F.4    Walsh, C.5    Coen, R.6
  • 94
    • 0027327267 scopus 로고
    • Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease
    • A.M. Saunders, W.J. Strittmatter, D. Schmechel, P.H. George-Hyslop, M.A. Pericak-Vance, S.H. Joo, and et al. Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease Neurology 43 8 1993 1467 1472
    • (1993) Neurology , vol.43 , Issue.8 , pp. 1467-1472
    • Saunders, A.M.1    Strittmatter, W.J.2    Schmechel, D.3    George-Hyslop, P.H.4    Pericak-Vance, M.A.5    Joo, S.H.6
  • 95
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • E.H. Corder, A.M. Saunders, W.J. Strittmatter, D.E. Schmechel, P.C. Gaskell, G.W. Small, and et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families Science 261 5123 1993 921 923
    • (1993) Science , vol.261 , Issue.5123 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5    Small, G.W.6
  • 96
    • 0032533647 scopus 로고    scopus 로고
    • A 4-Mb high-density single nucleotide polymorphism-based map around human APOE
    • E. Lai, J. Riley, I. Purvis, and A. Roses A 4-Mb high-density single nucleotide polymorphism-based map around human APOE Genomics 54 1 1998 31 38
    • (1998) Genomics , vol.54 , Issue.1 , pp. 31-38
    • Lai, E.1    Riley, J.2    Purvis, I.3    Roses, A.4
  • 98
    • 84863115245 scopus 로고    scopus 로고
    • Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons
    • H.K. Chen, Z. Liu, A. Meyer-Franke, J. Brodbeck, R.D. Miranda, J.G. McGuire, and et al. Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons J Biol Chem 287 8 2012 5253 5266
    • (2012) J Biol Chem , vol.287 , Issue.8 , pp. 5253-5266
    • Chen, H.K.1    Liu, Z.2    Meyer-Franke, A.3    Brodbeck, J.4    Miranda, R.D.5    McGuire, J.G.6
  • 100
    • 84857128928 scopus 로고    scopus 로고
    • Characterization of the poly-T variant in the TOMM40 gene in diverse populations
    • C. Linnertz, A.M. Saunders, M.W. Lutz, D.M. Crenshaw, I. Grossman, D.K. Burns, and et al. Characterization of the poly-T variant in the TOMM40 gene in diverse populations PLoS One 7 2 2012 e30994
    • (2012) PLoS One , vol.7 , Issue.2 , pp. e30994
    • Linnertz, C.1    Saunders, A.M.2    Lutz, M.W.3    Crenshaw, D.M.4    Grossman, I.5    Burns, D.K.6
  • 101
    • 84903539808 scopus 로고    scopus 로고
    • The Alzheimer's prevention initiative composite cognitive test score: Sample size estimates for the evaluation of preclinical Alzheimer's disease treatments in presenilin 1 E280A mutation carriers
    • N. Ayutyanont, J.B. Langbaum, S.B. Hendrix, K. Chen, A.S. Fleisher, M. Friesenhahn, and et al. The Alzheimer's prevention initiative composite cognitive test score: sample size estimates for the evaluation of preclinical Alzheimer's disease treatments in presenilin 1 E280A mutation carriers J Clin Psychiatry 75 6 2014 652 660
    • (2014) J Clin Psychiatry , vol.75 , Issue.6 , pp. 652-660
    • Ayutyanont, N.1    Langbaum, J.B.2    Hendrix, S.B.3    Chen, K.4    Fleisher, A.S.5    Friesenhahn, M.6
  • 102
    • 84903947419 scopus 로고    scopus 로고
    • Alzheimer's disease drug-development pipeline: Few candidates, frequent failures
    • J.L. Cummings, T. Morstorf, and K. Zhong Alzheimer's disease drug-development pipeline: few candidates, frequent failures Alzheimers Res Ther 6 4 2014 37
    • (2014) Alzheimers Res Ther , vol.6 , Issue.4 , pp. 37
    • Cummings, J.L.1    Morstorf, T.2    Zhong, K.3
  • 103
    • 84928684146 scopus 로고    scopus 로고
    • Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease
    • N. Guzior, A. Wieckowska, D. Panek, and B. Malawska Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease Curr Med Chem 22 3 2015 373 404
    • (2015) Curr Med Chem , vol.22 , Issue.3 , pp. 373-404
    • Guzior, N.1    Wieckowska, A.2    Panek, D.3    Malawska, B.4


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