메뉴 건너뛰기




Volumn 72, Issue 10, 2015, Pages 1139-1147

Nerve growth factor gene therapy activation of neuronal responses in Alzheimer disease

Author keywords

[No Author keywords available]

Indexed keywords

NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR; PROTEIN P75; TAU PROTEIN; NGF PROTEIN, HUMAN;

EID: 84944076745     PISSN: 21686149     EISSN: 21686157     Source Type: Journal    
DOI: 10.1001/jamaneurol.2015.1807     Document Type: Article
Times cited : (225)

References (36)
  • 1
    • 62049083420 scopus 로고    scopus 로고
    • Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease
    • Nagahara AH, Merrill DA, Coppola G, et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med. 2009;15(3):331-337.
    • (2009) Nat Med. , vol.15 , Issue.3 , pp. 331-337
    • Nagahara, A.H.1    Merrill, D.A.2    Coppola, G.3
  • 2
    • 0028020905 scopus 로고
    • The aged monkey basal forebrain: Rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor
    • Kordower JH, Winn SR, Liu YT, et al. The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor. Proc Natl Acad Sci USA. 1994;91(23):10898-10902.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.23 , pp. 10898-10902
    • Kordower, J.H.1    Winn, S.R.2    Liu, Y.T.3
  • 3
    • 0025513602 scopus 로고
    • Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration
    • UHS
    • Tuszynski MH, UHS, Amaral DG, Gage FH. Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration. J Neurosci. 1990;10(11):3604-3614.
    • (1990) J Neurosci. , vol.10 , Issue.11 , pp. 3604-3614
    • Tuszynski, M.H.1    Amaral, D.G.2    Gage, F.H.3
  • 4
    • 0035852680 scopus 로고    scopus 로고
    • Nontropic actions of neurotrophins: Subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation
    • Conner JM, Darracq MA, Roberts J, Tuszynski MH. Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reverses age-related degeneration of primate cortical cholinergic innervation. Proc Natl Acad Sci USA. 2001;98(4):1941-1946.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.4 , pp. 1941-1946
    • Conner, J.M.1    Darracq, M.A.2    Roberts, J.3    Tuszynski, M.H.4
  • 5
    • 84884561405 scopus 로고    scopus 로고
    • Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice
    • Nagahara AH, Mateling M, Kovacs I, et al. Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. J Neurosci. 2013;33(39):15596-15602.
    • (2013) J Neurosci. , vol.33 , Issue.39 , pp. 15596-15602
    • Nagahara, A.H.1    Mateling, M.2    Kovacs, I.3
  • 6
    • 21044458854 scopus 로고    scopus 로고
    • A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
    • Tuszynski MH, Thal L, Pay M, et al. A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease. Nat Med. 2005;11(5):551-555.
    • (2005) Nat Med. , vol.11 , Issue.5 , pp. 551-555
    • Tuszynski, M.H.1    Thal, L.2    Pay, M.3
  • 7
    • 0024504222 scopus 로고
    • Nerve growth factor receptor mRNA distribution in human brain: Normal levels in basal forebrain in Alzheimer's disease
    • Goedert M, Fine A, Dawbarn D, Wilcock GK, Chao MV. Nerve growth factor receptor mRNA distribution in human brain: normal levels in basal forebrain in Alzheimer's disease. Brain Res Mol Brain Res. 1989;5(1):1-7.
    • (1989) Brain Res Mol Brain Res , vol.5 , Issue.1 , pp. 1-7
    • Goedert, M.1    Fine, A.2    Dawbarn, D.3    Wilcock, G.K.4    Chao, M.V.5
  • 8
    • 0029022112 scopus 로고
    • Nerve growth factor in Alzheimer's disease: Increased levels throughout the brain coupled with declines in nucleus basalis
    • Scott SA, Mufson EJ, Weingartner JA, Skau KA, Crutcher KA. Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. J Neurosci. 1995;15(9):6213-6221.
    • (1995) J Neurosci. , vol.15 , Issue.9 , pp. 6213-6221
    • Scott, S.A.1    Mufson, E.J.2    Weingartner, J.A.3    Skau, K.A.4    Crutcher, K.A.5
  • 9
    • 69449091994 scopus 로고    scopus 로고
    • Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease
    • Blurton-Jones M, Kitazawa M, Martinez-Coria H, et al. Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease. Proc Natl Acad Sci USA. 2009;106(32):13594-13599.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.32 , pp. 13594-13599
    • Blurton-Jones, M.1    Kitazawa, M.2    Martinez-Coria, H.3
  • 10
    • 0025816941 scopus 로고
    • Hypophagia is induced by intracerebroventricular administration of nerve growth factor
    • Williams LR. Hypophagia is induced by intracerebroventricular administration of nerve growth factor. Exp Neurol. 1991;113(1):31-37.
    • (1991) Exp Neurol. , vol.113 , Issue.1 , pp. 31-37
    • Williams, L.R.1
  • 11
    • 0031037424 scopus 로고    scopus 로고
    • Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor
    • Winkler J, Ramirez GA, Kuhn HG, et al. Reversible Schwann cell hyperplasia and sprouting of sensory and sympathetic neurites after intraventricular administration of nerve growth factor. Ann Neurol. 1997;41(1):82-93.
    • (1997) Ann Neurol. , vol.41 , Issue.1 , pp. 82-93
    • Winkler, J.1    Ramirez, G.A.2    Kuhn, H.G.3
  • 12
    • 0031104593 scopus 로고    scopus 로고
    • The nucleus basalis magnocellularis cholinergic system: One hundred years of progress
    • Wenk GL. The nucleus basalis magnocellularis cholinergic system: one hundred years of progress. Neurobiol Learn Mem. 1997;67(2):85-95.
    • (1997) Neurobiol Learn Mem , vol.67 , Issue.2 , pp. 85-95
    • Wenk, G.L.1
  • 13
    • 0037016848 scopus 로고    scopus 로고
    • Loss of basal forebrain P75NTR immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease
    • Mufson EJ, Ma SY, Dills J, et al. Loss of basal forebrain P75NTR immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease. J Comp Neurol. 2002;443(2):136-153.
    • (2002) J Comp Neurol. , vol.443 , Issue.2 , pp. 136-153
    • Mufson, E.J.1    Ma, S.Y.2    Dills, J.3
  • 14
    • 4644268336 scopus 로고    scopus 로고
    • Reduction of cortical TrkA but not p75NTR protein in early-stage Alzheimer's disease
    • Counts SE, Nadeem M, Wuu J, Ginsberg SD, Saragovi HU, Mufson EJ. Reduction of cortical TrkA but not p75NTR protein in early-stage Alzheimer's disease. Ann Neurol. 2004;56(4):520-531.
    • (2004) Ann Neurol. , vol.56 , Issue.4 , pp. 520-531
    • Counts, S.E.1    Nadeem, M.2    Wuu, J.3    Ginsberg, S.D.4    Saragovi, H.U.5    Mufson, E.J.6
  • 15
    • 77955175906 scopus 로고    scopus 로고
    • Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC
    • Hadaczek P, Eberling JL, Pivirotto P, Bringas J, Forsayeth J, Bankiewicz KS. Eight years of clinical improvement in MPTP-lesioned primates after gene therapy with AAV2-hAADC. Mol Ther. 2010;18(8):1458-1461.
    • (2010) Mol Ther , vol.18 , Issue.8 , pp. 1458-1461
    • Hadaczek, P.1    Eberling, J.L.2    Pivirotto, P.3    Bringas, J.4    Forsayeth, J.5    Bankiewicz, K.S.6
  • 16
    • 85027921807 scopus 로고    scopus 로고
    • A phase 1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease
    • Rafii MS, Baumann TL, Bakay RA, et al. A phase 1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease. Alzheimers Dement. 2014;10(5):571-581.
    • (2014) Alzheimers Dement , vol.10 , Issue.5 , pp. 571-581
    • Rafii, M.S.1    Baumann, T.L.2    Bakay, R.A.3
  • 17
    • 0026708320 scopus 로고
    • The localization of nerve growth factor-like immunoreactivity in the adult rat basal forebrain and hippocampal formation
    • Conner JM, Muir D, Varon S, Hagg T, Manthorpe M. The localization of nerve growth factor-like immunoreactivity in the adult rat basal forebrain and hippocampal formation. J Comp Neurol. 1992;319(3):454-462.
    • (1992) J Comp Neurol. , vol.319 , Issue.3 , pp. 454-462
    • Conner, J.M.1    Muir, D.2    Varon, S.3    Hagg, T.4    Manthorpe, M.5
  • 18
    • 0029997290 scopus 로고    scopus 로고
    • Characterization of antibodies to nerve growth factor: Assay-dependent variability in the cross-reactivity with other neurotrophins
    • Conner JM, Varon S. Characterization of antibodies to nerve growth factor: assay-dependent variability in the cross-reactivity with other neurotrophins. J Neurosci Methods. 1996;65(1):93-99.
    • (1996) J Neurosci Methods , vol.65 , Issue.1 , pp. 93-99
    • Conner, J.M.1    Varon, S.2
  • 20
    • 0028965223 scopus 로고
    • Somatic gene transfer of NGF to the aged brain: Behavioral and morphological amelioration
    • Chen KS, Gage FH. Somatic gene transfer of NGF to the aged brain: behavioral and morphological amelioration. J Neurosci. 1995;15(4):2819-2825.
    • (1995) J Neurosci. , vol.15 , Issue.4 , pp. 2819-2825
    • Chen, K.S.1    Gage, F.H.2
  • 21
    • 0029013323 scopus 로고
    • Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery
    • Tuszynski MH, Gage FH. Bridging grafts and transient nerve growth factor infusions promote long-term central nervous system neuronal rescue and partial functional recovery. Proc Natl Acad Sci USA. 1995;92:4621-4625.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 4621-4625
    • Tuszynski, M.H.1    Gage, F.H.2
  • 22
    • 33845993229 scopus 로고    scopus 로고
    • Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys
    • Kordower JH, Herzog CD, Dass B, et al. Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys. Ann Neurol. 2006;60(6):706-715.
    • (2006) Ann Neurol. , vol.60 , Issue.6 , pp. 706-715
    • Kordower, J.H.1    Herzog, C.D.2    Dass, B.3
  • 23
    • 0034044227 scopus 로고    scopus 로고
    • Neurotrophin signal transduction in the nervous system
    • Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol. 2000;10(3):381-391.
    • (2000) Curr Opin Neurobiol. , vol.10 , Issue.3 , pp. 381-391
    • Kaplan, D.R.1    Miller, F.D.2
  • 24
    • 0030002982 scopus 로고    scopus 로고
    • Gene therapy in the adult primate brain: Intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration
    • UHS
    • Tuszynski MH, Roberts J, Senut MC, UHS, Gage FH. Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene Ther. 1996;3(4):305-314.
    • (1996) Gene Ther , vol.3 , Issue.4 , pp. 305-314
    • Tuszynski, M.H.1    Roberts, J.2    Senut, M.C.3    Gage, F.H.4
  • 25
    • 0033044592 scopus 로고    scopus 로고
    • Nerve growth factor expressed in the medial septum following in vivo gene delivery using a recombinant adeno-associated viral vector protects cholinergic neurons from fimbria-fornix lesion-induced degeneration
    • Mandel RJ, Gage FH, Clevenger DG, Spratt SK, Snyder RO, Leff SE. Nerve growth factor expressed in the medial septum following in vivo gene delivery using a recombinant adeno-associated viral vector protects cholinergic neurons from fimbria-fornix lesion-induced degeneration. Exp Neurol. 1999;155(1):59-64.
    • (1999) Exp Neurol. , vol.155 , Issue.1 , pp. 59-64
    • Mandel, R.J.1    Gage, F.H.2    Clevenger, D.G.3    Spratt, S.K.4    Snyder, R.O.5    Leff, S.E.6
  • 26
    • 76549235314 scopus 로고
    • Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo
    • Levi-Montalcini R, Hamburger V. Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo. J Exp Zool. 1951;116(2):321-361.
    • (1951) J Exp Zool. , vol.116 , Issue.2 , pp. 321-361
    • Levi-Montalcini, R.1    Hamburger, V.2
  • 27
    • 84924375541 scopus 로고    scopus 로고
    • Neurite outgrowth in normal and injured primary sensory neurons reveals different regulation by nerve growth factor (NGF) and artemin
    • Wong AW, Yeung JK, Payne SC, Keast JR, Osborne PB. Neurite outgrowth in normal and injured primary sensory neurons reveals different regulation by nerve growth factor (NGF) and artemin. Mol Cell Neurosci. 2015;65:125-134.
    • (2015) Mol Cell Neurosci. , vol.65 , pp. 125-134
    • Wong, A.W.1    Yeung, J.K.2    Payne, S.C.3    Keast, J.R.4    Osborne, P.B.5
  • 28
    • 84911374027 scopus 로고    scopus 로고
    • Neuronal degeneration associated with sympathosensory plexuses in the trigeminal ganglia of aged mice that overexpress nerve growth factor
    • Smithson LJ, Krol KM, Kawaja MD. Neuronal degeneration associated with sympathosensory plexuses in the trigeminal ganglia of aged mice that overexpress nerve growth factor. Neurobiol Aging. 2014;35(12):2812-2821.
    • (2014) Neurobiol Aging , vol.35 , Issue.12 , pp. 2812-2821
    • Smithson, L.J.1    Krol, K.M.2    Kawaja, M.D.3
  • 29
    • 84857917481 scopus 로고    scopus 로고
    • Experimental arthritis: NGF promotes synovial nerve sprouting
    • Killock D. Experimental arthritis: NGF promotes synovial nerve sprouting. Nat Rev Rheumatol. 2012;8(3):124.
    • (2012) Nat Rev Rheumatol. , vol.8 , Issue.3 , pp. 124
    • Killock, D.1
  • 30
    • 84900988611 scopus 로고    scopus 로고
    • Functional distinction between NGF-mediated plasticity and regeneration of nociceptive axons within the spinal cord
    • Lin CL, Heron P, Hamann SR, Smith GM. Functional distinction between NGF-mediated plasticity and regeneration of nociceptive axons within the spinal cord. Neuroscience. 2014;272:76-87.
    • (2014) Neuroscience , vol.272 , pp. 76-87
    • Lin, C.L.1    Heron, P.2    Hamann, S.R.3    Smith, G.M.4
  • 31
    • 0027742330 scopus 로고
    • Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration
    • Holtzman DM, Li Y, Chen K, Gage FH, Epstein CJ, Mobley WC. Nerve growth factor reverses neuronal atrophy in a Down syndrome model of age-related neurodegeneration. Neurology. 1993;43(12):2668-2673.
    • (1993) Neurology , vol.43 , Issue.12 , pp. 2668-2673
    • Holtzman, D.M.1    Li, Y.2    Chen, K.3    Gage, F.H.4    Epstein, C.J.5    Mobley, W.C.6
  • 32
    • 0029080919 scopus 로고
    • Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain
    • Martínez-Serrano A, Fischer W, Björklund A. Reversal of age-dependent cognitive impairments and cholinergic neuron atrophy by NGF-secreting neural progenitors grafted to the basal forebrain. Neuron. 1995;15(2):473-484.
    • (1995) Neuron , vol.15 , Issue.2 , pp. 473-484
    • Martínez-Serrano, A.1    Fischer, W.2    Björklund, A.3
  • 33
    • 78349247631 scopus 로고    scopus 로고
    • Gene delivery of AAV2-neurturin for Parkinson's disease: A double-blind, randomised, controlled trial
    • Marks WJ Jr, Bartus RT, Siffert J, et al. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol. 2010;9(12):1164-1172.
    • (2010) Lancet Neurol. , vol.9 , Issue.12 , pp. 1164-1172
    • Marks, W.J.1    Bartus, R.T.2    Siffert, J.3
  • 34
    • 33748083041 scopus 로고    scopus 로고
    • Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC
    • Bankiewicz KS, Forsayeth J, Eberling JL, et al. Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC. Mol Ther. 2006;14(4):564-570.
    • (2006) Mol Ther , vol.14 , Issue.4 , pp. 564-570
    • Bankiewicz, K.S.1    Forsayeth, J.2    Eberling, J.L.3
  • 35
    • 0023643241 scopus 로고
    • Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor
    • Fischer W, Wictorin K, Björklund A, Williams LR, Varon S, Gage FH. Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature. 1987;329(6134):65-68.
    • (1987) Nature , vol.329 , Issue.6134 , pp. 65-68
    • Fischer, W.1    Wictorin, K.2    Björklund, A.3    Williams, L.R.4    Varon, S.5    Gage, F.H.6
  • 36
    • 0027933176 scopus 로고
    • Human nerve growth factor improves spatial memory in aged but not in young rats
    • Markowska AL, Koliatsos VE, Breckler SJ, Price DL, Olton DS. Human nerve growth factor improves spatial memory in aged but not in young rats. J Neurosci. 1994;14(8):4815-4824.
    • (1994) J Neurosci. , vol.14 , Issue.8 , pp. 4815-4824
    • Markowska, A.L.1    Koliatsos, V.E.2    Breckler, S.J.3    Price, D.L.4    Olton, D.S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.