Astragaloside IV improves the isoproterenol-induced vascular dysfunction via attenuating eNOS uncoupling-mediated oxidative stress and inhibiting ROS-NF-κB pathways

International Immunopharmacology

Volumn 33, Issue , 2016, Pages 119-127

  Xu, Chonghua ^a   Tang, Futian ^a   Lu, Meili ^a   Yang, Jing ^a   Han, Ronghui ^a   Mei, Meng ^a   Hu, Jin ^a   Zhou, Mingsheng ^a   Wang, Hongxin ^a  

^a JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Astragaloside IV; eNOS uncoupling; Isoproterenol; NF B; Tetrahydrobiopterin

Indexed keywords

ASTRAGALOSIDE IV; ENDOTHELIAL NITRIC OXIDE SYNTHASE; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; ISOPRENALINE; PEROXYNITRITE; PHENYLEPHRINE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SYNAPTOTAGMIN I; TETRAHYDROBIOPTERIN; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; ASTRAGALOSIDE A; CYTOKINE; SAPONIN; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOPLASM; DOWN REGULATION; ENDOTHELIAL DYSFUNCTION; ENZYME BLOOD LEVEL; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; MALE; NONHUMAN; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; THORACIC AORTA; VASOCONSTRICTION; ANIMAL; AORTA; ASTRAGALUS MEMBRANACEUS; CARDIOMEGALY; CHEMICALLY INDUCED; DRUG EFFECTS; HUMAN; IMMUNOLOGY; METABOLISM; OXIDATIVE COUPLING; PERIPHERAL VASCULAR DISEASES; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; AORTA; ASTRAGALUS MEMBRANACEUS; CARDIOMEGALY; CYTOKINES; HUMANS; ISOPROTERENOL; MALE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE COUPLING; PERIPHERAL VASCULAR DISEASES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SAPONINS; SIGNAL TRANSDUCTION; TRITERPENES;

EID: 84958964329     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2016.02.009     Document Type: Article

References (60)

1. P.B. Taylor, and Q. Tang Development of isoproterenol-induced cardiac hypertrophy Can. J. Physiol. Pharmacol. 62 1984 384 389
2. I.J. Benjamin, J.E. Jalil, L.B. Tan, K. Cho, K.T. Weber, and W.A. Clark Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis Circ. Res. 65 1989 657 670
3. Q. Xu, and et al. Myocardial oxidative stress contributes to transgenic beta(2)-adrenoceptor activation-induced cardiomyopathy and heart failure Br. J. Pharmacol. 162 2011 1012 1028
4. A.P. Davel, P.C. Brum, and L.V. Rossoni Isoproterenol induces vascular oxidative stress and endothelial dysfunction via a Gialpha-coupled beta2-adrenoceptor signaling pathway PLoS One 9 2014 e91877
5. A.P. Davel, E.M. Kawamoto, C. Scavone, D.V. Vassallo, and L.V. Rossoni Changes in vascular reactivity following administration of isoproterenol for 1 week: a role for endothelial modulation Br. J. Pharmacol. 148 2006 629 639
6. I. Fleming, and R. Busse Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase Am. J. Physiol. Regul. Integr. Comp. Physiol. 284 2003 R1 12
7. J. Bauersachs, A. Bouloumie, D. Fraccarollo, K. Hu, R. Busse, and G. Ertl Endothelial dysfunction in chronic myocardial infarction despite increased vascular endothelial nitric oxide synthase and soluble guanylate cyclase expression: role of enhanced vascular superoxide production Circulation 100 1999 292 298
8. M.J. Brosnan, C.A. Hamilton, D. Graham, C.A. Lygate, E. Jardine, and A.F. Dominiczak Irbesartan lowers superoxide levels and increases nitric oxide bioavailability in blood vessels from spontaneously hypertensive stroke-prone rats J. Hypertens. 20 2002 281 286
9. H. Li, and U. Forstermann Nitric oxide in the pathogenesis of vascular disease J. Pathol. 190 2000 244 254
10. U. Landmesser, and et al. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension J. Clin. Invest. 111 2003 1201 1209
11. M.J. Crabtree, C.L. Smith, G. Lam, M.S. Goligorsky, and S.S. Gross Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS Am. J. Physiol. Heart Circ. Physiol. 294 2008 H1530 H1540
12. 2+/calmodulin-dependent and tetrahydrobiopterin regulatory process J. Biol. Chem. 273 1998 25804 25808
13. A.P. Davel, and et al. Effects of isoproterenol treatment for 7 days on inflammatory mediators in the rat aorta Am. J. Physiol. Heart Circ. Physiol. 295 2008 H211 H219
14. U. Forstermann, and H. Li Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling Br. J. Pharmacol. 164 2011 213 223
15. U. Forstermann, and T. Munzel Endothelial nitric oxide synthase in vascular disease: from marvel to menace Circulation 113 2006 1708 1714
16. J. Vasquez-Vivar, P. Martasek, J. Whitsett, J. Joseph, and B. Kalyanaraman The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study Biochem. J. 362 2002 733 739
17. K.M. Channon Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease Trends Cardiovasc. Med. 14 2004 323 327
18. N.J. Alp, and K.M. Channon Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease Arterioscler. Thromb. Vasc. Biol. 24 2004 413 420
19. M.J. Crabtree, and et al. Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression J. Biol. Chem. 284 2009 1136 1144
20. J. Vasquez-Vivar Tetrahydrobiopterin, superoxide, and vascular dysfunction Free Radic. Biol. Med. 47 2009 1108 1119
21. S. Kossmann, and et al. Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin II J. Biol. Chem. 289 2014 27540 27550
22. E. Takimoto, and et al. Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load J. Clin. Invest. 115 2005 1221 1231
23. J. Yang, and et al. Astragaloside IV attenuates inflammatory cytokines by inhibiting TLR4/NF-small ka, CyrillicB signaling pathway in isoproterenol-induced myocardial hypertrophy J. Ethnopharmacol. 2013
24. 2+/CaN signaling pathway Planta Med. 80 2014 63 69
25. S. Zhang, and et al. Astragaloside IV protects against isoproterenol-induced cardiac hypertrophy by regulating NF-kappaB/PGC-1alpha signaling mediated energy biosynthesis PLoS One 10 2015 e0118759
26. M. Lu, and et al. Astragaloside IV attenuates injury caused by myocardial ischemia/reperfusion in rats via regulation of toll-like receptor 4/nuclear factor-kappaB signaling pathway Phytother. Res. 29 2015 599 606
27. C. Zhang, and et al. Mechanisms underlying vasorelaxant action of astragaloside IV in isolated rat aortic rings Clin. Exp. Pharmacol. Physiol. 34 2007 387 392
28. H. Li, and et al. Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats J. Am. Coll. Cardiol. 47 2006 2536 2544
29. M.R. de Oliveira, M.W. Oliveira, G.A. Behr, M.L. Hoff, R.F. da Rocha, and J.C. Moreira Evaluation of the effects of vitamin A supplementation on adult rat substantia nigra and striatum redox and bioenergetic states: mitochondrial impairment, increased 3-nitrotyrosine and alpha-synuclein, but decreased D2 receptor contents Prog. Neuro-Psychopharmacol. Biol. Psychiatry 33 2009 353 362
30. H. Zhao, and et al. Ischemic postconditioning relieves cerebral ischemia and reperfusion injury through activating T-LAK cell-originated protein kinase/protein kinase B pathway in rats Stroke 45 2014 2417 2424
31. Y.C. Sun, and et al. Establishment of a sandwich ELISA using commercial antibody for plasma or serum 3-nitrotyrosine (3NT). Elevation in inflammatory diseases and complementary between 3NT and myeloperoxidase Clin. Chim. Acta 378 2007 175 180
32. R. Hernanz, A.M. Briones, M.J. Alonso, E. Vila, and M. Salaices Hypertension alters role of iNOS, COX-2, and oxidative stress in bradykinin relaxation impairment after LPS in rat cerebral arteries Am. J. Physiol. Heart Circ. Physiol. 287 2004 H225 H234
33. T.J. Guzik, and et al. Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase Circulation 105 2002 1656 1662
34. J. Cheng, and et al. 20-Hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling J. Pharmacol. Exp. Ther. 332 2010 57 65
35. J. Vasquez-Vivar, and et al. Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors Proc. Natl. Acad. Sci. U. S. A. 95 1998 9220 9225
36. A.V. Santhanam, L.V. d'Uscio, and Z.S. Katusic Erythropoietin increases bioavailability of tetrahydrobiopterin and protects cerebral microvasculature against oxidative stress induced by eNOS uncoupling J. Neurochem. 131 2014 521 529
37. R.M. Wever, T. van Dam, H.J. van Rijn, F. de Groot, and T.J. Rabelink Tetrahydrobiopterin regulates superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase Biochem. Biophys. Res. Commun. 237 1997 340 344
38. L.J. Ignarro Nitric oxide as a unique signaling molecule in the vascular system: a historical overview J. Physiol. Pharmacol. 53 2002 503 514
39. S. Gao, C.L. Long, R.H. Wang, and H. Wang K(ATP) activation prevents progression of cardiac hypertrophy to failure induced by pressure overload via protecting endothelial function Cardiovasc. Res. 83 2009 444 456
40. Y. Haruna, and et al. Endothelial dysfunction in rat adjuvant-induced arthritis: vascular superoxide production by NAD(P)H oxidase and uncoupled endothelial nitric oxide synthase Arthritis Rheum. 54 2006 1847 1855
41. L.V. d'Uscio, and et al. Mechanism of endothelial dysfunction in apolipoprotein E-deficient mice Arterioscler. Thromb. Vasc. Biol. 21 2001 1017 1022
42. H. Li, T. Wallerath, T. Munzel, and U. Forstermann Regulation of endothelial-type NO synthase expression in pathophysiology and in response to drugs Nitric Oxide 7 2002 149 164
43. M.H. Zou, C. Shi, and R.A. Cohen Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite J. Clin. Invest. 109 2002 817 826
44. M. Ozaki, and et al. Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice J. Clin. Invest. 110 2002 331 340
45. X.L. Ma, A.S. Weyrich, D.J. Lefer, and A.M. Lefer Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium Circ. Res. 72 1993 403 412
46. W.D. Zhang, and et al. Astragaloside IV dilates aortic vessels from normal and spontaneously hypertensive rats through endothelium-dependent and endothelium-independent ways Planta Med. 72 2006 621 626
47. N. Zhang, X.H. Wang, S.L. Mao, and F. Zhao Astragaloside IV improves metabolic syndrome and endothelium dysfunction in fructose-fed rats Molecules (Basel, Switzerland) 16 2011 3896 3907
48. L.H. Qiu, X.J. Xie, and B.Q. Zhang Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidation Biol. Pharm. Bull. 33 2010 641 646
49. A.L. Moens, and et al. Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy Circulation 117 2008 2626 2636
50. O. Malo, F. Desjardins, J.F. Tanguay, J.C. Tardif, M. Carrier, and L.P. Perrault Tetrahydrobiopterin and antioxidants reverse the coronary endothelial dysfunction associated with left ventricular hypertrophy in a porcine model Cardiovasc. Res. 59 2003 501 511
51. R. Kietadisorn, R.P. Juni, and A.L. Moens Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities Am. J. Physiol. Endocrinol. Metab. 302 2012 E481 E495
52. T.W. Yeo, and et al. Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria: association with disease severity, impaired microvascular function and increased endothelial activation PLoS Pathog. 11 2015 e1004667
53. T. Collins Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion Lab. Investig. 68 1993 499 508
54. 2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes Mol. Cell. Biol. 26 2006 140 154
55. W.J. Zhang, P. Hufnagl, B.R. Binder, and J. Wojta Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression Thromb. Haemost. 90 2003 904 914
56. J.F. Ndisang Role of heme oxygenase in inflammation, insulin-signalling, diabetes and obesity Mediat. Inflamm. 2010 2010 359732
57. E. Vila, and M. Salaices Cytokines and vascular reactivity in resistance arteries Am. J. Physiol. Heart Circ. Physiol. 288 2005 H1016 H1021
58. A.J. Patterson, and et al. Protecting the myocardium: a role for the beta2 adrenergic receptor in the heart Crit. Care Med. 32 2004 1041 1048
59. S.K. Banerjee, S. Sood, A.K. Dinda, T.K. Das, and S.K. Maulik Chronic oral administration of raw garlic protects against isoproterenol-induced myocardial necrosis in rat Comp. Biochem. Physiol. Toxicol. Pharmacol. 136 2003 377 386
60. D.R. Murray, and et al. Beta2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo J. Mol. Cell. Cardiol. 52 2012 206 218