20-Hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IκB kinase-dependent endothelial nitric-oxide synthase uncoupling

Journal of Pharmacology and Experimental Therapeutics

Volumn 332, Issue 1, 2010, Pages 57-65

  Cheng, Jennifer ^a   Wu, Cheng Chia ^a   Gotlinger, Katherine H ^a   Zhang, Frank ^a   Falck, John R ^b   Narsimhaswamy, Dubasi ^b   Laniado Schwartzman, Michal ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

20 HYDROXY 5,8,11,14 ICOSATETRAENOIC ACID; 20 HYDROXYICOSATETRAENOIC ACID; ACETYLCHOLINE; CALCIMYCIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEAT SHOCK PROTEIN 90; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IONOPHORE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RENAL ARTERY; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; AORTA; CATTLE; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; HYDROXYEICOSATETRAENOIC ACIDS; I-KAPPA B KINASE; MALE; MICROCIRCULATION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; RENAL ARTERY; VASOCONSTRICTION;

EID: 73949153243     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.159863     Document Type: Article

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