Astragaloside IV attenuates inflammatory cytokines by inhibiting TLR4/NF-kB signaling pathway in isoproterenol-induced myocardial hypertrophy

Journal of Ethnopharmacology

Volumn 150, Issue 3, 2013, Pages 1062-1070

  Yang, Juan ^a   Wang, Hong Xin ^a   Zhang, Ying Jie ^a   Yang, Yu Hong ^a   Lu, Mei Li ^a   Zhang, Jing ^a   Li, Sheng Tao ^a   Zhang, Su Ping ^a   Li, Guang ^b  

^a JINZHOU MEDICAL UNIVERSITY   (China)

^b First Affiliated Hospital of Liaoning Medical College ^*  (China)

Author keywords

Astragaloside IV; Inflammatory effect; Isoproterenol; Myocardial hypertrophy; TLR4 NF kB

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ASTRAGALOSIDE IV; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; ISOPRENALINE; MESSENGER RNA; PROPRANOLOL; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL SIZE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HEART INDEX; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE MASS; HEART MUSCLE CELL; HEART PROTECTION; HEART RIGHT VENTRICLE; HEART VENTRICLE HYPERTROPHY; HEART WEIGHT; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ASTRAGALUS MEMBRANACEUS; RATTUS;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CARDIOTONIC AGENTS; CELLS, CULTURED; HYPERTROPHY, LEFT VENTRICULAR; INTERLEUKIN-6; ISOPROTERENOL; MALE; MYOCARDIUM; MYOCYTES, CARDIAC; NF-KAPPA B; RATS; RATS, SPRAGUE-DAWLEY; SAPONINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84889098202     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.10.017     Document Type: Article

References (35)

1. H.N. Althurwi, M.M. Tse, and G. Abdelhamid Soluble epoxide hydrolase inhibitor, tups, protects against isoproterenol-induced cardiac hypertrophy Br. J. Pharmacol. 168 2013 1794 1807
2. O. Avlas, R. Fallach, and A. Shainberg Toll-like receptor 4 stimulation initiates an inflammatory response that decreases cardiomyocyte contractility Antioxid. Redox Signal. 15 2011 1895 1909
3. B. Chandrasekar, F.M. Marelli-Berg, and M. Tone β-Adrenergic stimulation induces interleukin-18 expression via β2-AR, PI3K, Akt, IKK, and NF-κB Biochem. Biophys. Res. Commun. 319 2004 304 311 (Pubitemid 38725947)
4. P. Chen, Y. Xie, and E. Shen Astragaloside IV attenuates myocardial fibrosis by inhibiting TGF-β1 signaling in coxsackievirus B3-induced cardiomyopathy Eur. J. Pharmacol. 658 2011 168 174
5. X.J. Chen, D. Meng, and L. Feng Protective effect of astragalosides on myocardial injury by isoproterenol in SD rats Am. J. Chin. Med. 34 2006 1015 1025 (Pubitemid 44921246)
6. G. Condorelli, C. Morisco, and M.V. Latronico TNF-alpha signal transduction in rat neonatal cardiac myocytes: definition of pathways generating from the TNF-alpha receptor FASEB J. 16 2002 1732 1737 (Pubitemid 35340353)
7. H. Ehrentraut, C. Weber, and S. Ehrentraut The toll-like receptor 4-antagonist eritoran reduces murine cardiac hypertrophy Eur. J. Heart Fail. 13 2011 602 610
8. S. Frantz, J. Bauersachs, and G. Ertl Post-infarct remodelling: contribution of wound healing and inflammation Cardiovasc. Res. 81 2009 474 481
9. J.Y. Gu, H.X. Wang, and S.L. Zhao Astragaloside IV inhibits the tumor necrosis factor α-induced cardiomyocyte hypertrophy in neonatal rats Chin. J. Hypertens. 20 2012 838 842
10. B. Haas, F. Leonard, and I. Ernens Adenosine reduces cell surface expression of toll-like receptor 4 and inflammation in response tolipopolysaccharide and matrix products J. Cardiovasc. Transl. Res. 4 2011 790 800
11. S. Heymans, E. Hirsch, and S.D. Anker Inflammation as a therapeutic target in heart failure? A scientific statement from the Translational Research Committee of the Heart Failure Association of the European Society of Cardiology Eur. J. Heart Fail. 11 2009 119 129
12. Z.Q. Huang, N.P. Qin, and W. Ye Effect of Astragalus membranaceus on T-lymphocyte subsets in patients with viral myocarditis Zhongguo Zhong Xi Yi Jie He Za Zhi 15 1995 328 330
13. C. Jin, and R.H. Dai Effect of Astragalus membranaceus on erythrocyte sodium content and sodium transport in thecoronary heart disease Zhong Xi Yi Jie He Za Zhi 11 651-653 1991 643
14. Y.J. Kang Cardiac hypertrophy: a risk factor for QT-Prolongation and cardiac sudden death Toxicol. Pathol. 34 2006 58 66
15. J. Liu, H.B. Chen, and B.L. Guo Study of the relationship between genetics and geography in determining the quality of Astragali Radix Biol. Pharm. Bull. 34 2011 1404 1412
16. D.R. Murray, S.D. Prabhu, and B. Chandrasekar Chronic beta - adrenergic stimulation induces myocardial proinflammatory cytokine expression Circulation 101 2000 2338 2341 (Pubitemid 30329120)
17. A. Nicoletti, and J.B. Michel Cardiac fibrosis and inflammation: interaction with hemodynamic and hormonal factors Cardiovasc. Res. 41 1999 532 543 (Pubitemid 29130617)
18. M. Pokrzywnicka, L. Tymecki, and R. Koncki Low-cost optical detectors and flow systems for protein determination Talanta 96 2012 121 126
19. N. Reichek, R.B. Devereux, and R.A. Rocha Magnetic resonance imaging left ventricular mass reduction with fixed-dose angiotensin-converting enzyme inhibitor-based regimens in patients with high-risk hypertension Hypertension 54 2009 731 737
20. J. Ren, J. Avery, and H. Zhao β3 Integrin deficiency promotes cardiac hypertrophy and inflammation J. Mol. Cell. Cardiol. 42 2007 367 377 (Pubitemid 46135609)
21. L. Shang, Z. Qu, and L. Sun Astragaloside IV inhibits adenovirus replication and apoptosis in A549 cells in vitro J. Pharm. Pharmacol. 63 2011 688 694
22. H. Shi, C. Ma, and Y. Liu Inhibitory effect on activated renin-angiotensin system by astragaloside IV in rats with pressure-overload induced cardiac hypertrophy Zhongguo Zhong Yao Za Zhi 34 2009 3242 3246
23. P.J. Smeets, B.E. Teunissen, and A. Planavila Inflammatory pathways are activated during cardiomyocyte hypertrophy by Peroxisome proliferator-activated Receptors PPARalpha and PPARdelta J. Biol. Chem. 283 2008 29109 29118
24. J. Wang, J.H. Liu, and P. Yao Protective effect of astragaloside IV on isoproterenol induced myocardial injury J. Shanghai Jiao Tong Univ. (Med. Sci.) 27 2007 384 386
25. Wu X.; 2011. The Clinical Effect of Astragalus Infection on the Patients with CHD and the Experimental Research of Stimulating Angiogenesis. The Dissertation for the Master's Degree of Nanjing University of Chinese Medicine.
26. B Eur. J. Pharmacol. 595 2008 52 57
27. G.H. Xu, L. Yuan, and Y. Li Clinical observation of Astragalus Injection in treatment of renal injury in patients with primary hypertension Zhong Xi Yi Jie He Xue Bao 6 2008 530 532 (Pubitemid 351736686)
28. X.L. Xu, H. Ji, and S.Y. Gu Protective effects of astragaloside on isoproterenol induced cardiac hypertrophy in mice J. China Pharm. Univ. 38 2007 451 455 (Pubitemid 350081387)
29. Yang H.W.; 2005. Experimental and Clinic Studies on Curative Effect of Chronic Heart Failure and Prevent Digitalis Toxicity by Huangqi Injection. Guangzhou University of Traditional Chinese Medicine of the PhD thesis.
30. Q.Y. Yang, S. Lu, and H.R. Sun Effects of astragalus on cardiac function and serum tumor necrosis factor-alpha level in patients with chronic heart failure Zhongguo Zhong Xi Yi Jie He Za Zhi 30 2010 699 701
31. F. Yin, Y. Zhu, and P. Li Isoproterenlo-indcued activation of MAPK, NF-κB and JAK/STAT pathway in mouse myocardium Acta Physiol. Sin. 55 2003 449 453 (Pubitemid 37101604)
32. X.W. Yu, Q. Chen, and R.H. Kennedy Inhibition of sarcoplasmic reticular function by chronic interleukin-6 exposure via NOS in adult ventricular myocytes J. Physiol. 566 2005 327 340 (Pubitemid 41030543)
33. W.D. Zhang, C. Zhang, and X.H. Wang Astragaloside IV dilates aortic vessels from normal and spontaneously hypertensive rats through endothelium-dependent and endothelium-independent ways Planta Med. 72 2006 621 626
34. W.J. Zhang, P. Hufnagl, and B.R. Binder Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression Thromb. Haemost. 90 2003 904 914 (Pubitemid 37427861)
35. S.L. Zhao, H.X. Wang, and Z.H. Zhou Protective effects of Astragalus polysaccharides on isoproterenol induced myocardial hypertrophy in neonatal rats Chin. Pharmacol. Bull. 27 2011 1682 1686