Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-κB activation and adhesion molecule expression

Thrombosis and Haemostasis

Volumn 90, Issue 5, 2003, Pages 904-914

  Zhang, Wei Jian ^a,b   Hufnagl, Peter ^a   Binder, Bernd R ^a   Wojta, Johann ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b OREGON STATE UNIVERSITY   (United States)

Author keywords

Adhesion molecules; Cytokines; Endothelial cells; Inflammation; Lipopolysaccharide

Indexed keywords

ASTRAGALUS MEMBRANACEUS EXTRACT; CELL ADHESION MOLECULE; CYTOKINE; DNA; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; MESSENGER RNA; SAPONIN ASTRAGALOSIDE IV; SAPONIN OCTYL DEXTRO GLUCOPYRANOSIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASSAY; CELL ISOLATION; CELL LINE; CHINESE MEDICINE; DNA BINDING; DRUG EFFECT; DRUG INHIBITION; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLAMMATION; LEUKOCYTE; NEUTROPHIL; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICAL VEIN;

EID: 0242606426     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/th03-03-0136     Document Type: Article

References (40)

1. Carlos TM, Harlan JM. Leukocyte-endothelial adhesion molecules. Blood 1994; 84: 2068-101.
2. Rothlein, R, Dustin MI, Marlin SD, et al. A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 1986; 137: 1270-4.
3. Bevilacqua MP, Pober JS, Mendrick DL, et al. Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Nat Acad Sci USA 1987; 84: 9238-42.
4. Rice GE, Munro JM, Bevilacqua MP. Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes. A CD11/CD18-independent adhesion mechanism. J Exp Med 1990; 171: 1369-74.
5. Kukielka GL, Hawkins HK, Michael LL, et al. Regulation of intercellular adhesion molecule-1 (ICAM-1) expression in ischemic and reperfused myocardium. J Clin Invest 1993; 92: 1504-16.
6. Griffin RL, Krzesicki RF, Fidler SF, et al. Attenuation of oxidant-induced lung injury by 21-aminosteroids (lazaroids): Correlation with the mRNA expression for E-selectin, P-selectin, ICAM-1 and VCAM-1. Environ Health Perspect 1994; 102: 193-200.
7. Fries JW, Williams AJ, Atkins RC, et al. Expression of E-selectin and VCAM-1 in an in vivo model of endothelial activation. Am J Pathol 1993; 143: 725-37.
8. Montefort S, Gratziou C, Goulding D, et al. Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways. J Clin Invest 1994; 93: 1411-21.
9. Gonzalez-Amaro R, Sanchez-Madrid F. Cell adhesion molecules: Selectins and integrins. Crit Rev Immunol 1999; 19: 389-429.
10. Kubes P, Ward PA. Leukocyte recruitment and the acute inflammatory response. Brain Pathol 2000; 10: 127-35.
11. Zhang W, Wojta J, Binder BR. Effect of notoginsenoside R1 on the synthesis of tissue-type plasminogen activator and plasminogen activator inhibitor-1 in cultured human umbilical vein endothelial cells. Arterioscl Thromb 1994; 14: 1040-6.
12. Zhang WJ, Wojta J, Binder BR. Notoginsenoside R1 counteracts endotoxin-induced activation of endothelial cells in vitro and endotoxin-induced lethality in mice in vivo. Arterioscl Thromb Vasc Biol 1997; 17: 465-74.
13. Zhang WJ, Wojta J, Binder BR. Regulation of the fibrinolytic potential of cultured human umbilical vein endothelial cells: Astragaloside IV downregulates plasminogen activator inhibitor-1 and upregulates tissue-type plasminogen activator expression. J Vasc Res 1997; 34: 273-80.
14. Lei ZY, Wang SR. Effect of Astragalus membranaceus on cardiovascular system. Chin J Integrated Trad West Med 1993; 13: 443-6.
15. Su ZZ, He YY, Chen G. Clinical and experimental study on effects of man-shen-ling oral liquid in the treatment of 100 cases of chronic nephritis. Chin J Integrated Trad West Med 1993; 13: 259-60.
16. Zhou QJ. Chinese medicinal herbs in the treatment of viral hepatitis. In: Advances in Chinese Medical Materials Research. Chang HM, Yeung HW, Tso WW, Koo A, eds., World Scientific. Singapore, 1985; 215.
17. Zhang BZ, Ding F, Tan LW. Clinical and experimental study on Yi-gan-ning granule in treating chronic hepatitis B. Chin J Integrated Trad West Med 1993; 13: 597-9.
18. Rui T, Yang Y, Zhao T, et al. Effect of Astragalus membranaceus on electrophysiological activities of acute experimental Coxsackie B-3 viral myocarditis in mice. Chin Med Sci J 1993; 8: 203-6.
19. Hong CY, Lo YC, Tan FC, et al. Astragalus membranaceus and Polygonum multiflorum protect rat heart mitochondria against lipid peroxidation. Am J Chin Med 1994; 22: 63-70.
20. Wojta J, Holzer M, Hufnagl P, et al. Hyperthermia stimulates plasminogen activator inhibitor type 1 expression in human umbilical vein endothelial cells in vitro. Amer J Pathol 1991; 139: 911-9.
21. Hoover RL, Folger R, Haering WA, et al. Adhesion of leukocytes to endothelium: Roles of divalent cations, surface charge, chemotactic agents and substrate. J Cell Sci 1980; 45: 73-86.
22. Wrighton CJ, Hofer-Warbinek R, Moll T, et al. Inhibition of endothelial cell activation by adenovirus-mediated expression of IκBα, an inhibitor of the transcription factor NF-κB. J Exp Med 1996; 183: 1013-22.
23. Osborn L, Kunkel S, Nabel GJ. Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc Natl Acad Sci USA 1989; 86: 2336-40.
24. Riedemann NC, Ward PA. Oxidized lipid protects against sepsis. Nat Med 2002; 8: 1084-5.
25. Bochkov VN, Kadl A, Huber J, et al. Protective role of phospholipid oxidation products in endotoxin-induced tissue damage. Nature 2002; 419: 77-81.
26. Bianchi E, Bender JR, Biasi F, et al. Through and beyond the wall: Late steps in leukocyte transendothelial migration. Immunol Today 1997; 18: 586-91.
27. Olofsson AM, Arfors KE, Ranezani L, et al. E-selectin mediates leukocyte rolling in interleukin-1-treated rabbit mesentery venules. Blood 1994; 84: 2749-58.
28. Alon R, Kassner PD, Carr MW, et al. The integrin VLA-4 supports tethering and rolling in flow on VCAM-1. J Cell Biol 1995; 128: 1243-53.
29. Cybulsky MI, Iiyama K, Li H, et al. A major role for VCAM-1, but not ICAM-1, in early atherosclerosis. J Clin Invest 2001; 107: 1255-1262.
30. Gerszten RE, Lim YC, Ding HT, et al. Adhesion of monocytes to vascular cell adhesion molecule-1-transduced human endothelial cells: Implications for atherogenesis. Circ Res 1998; 82: 871-8.
31. Mercurio F, Manning AM. Multiple signals converging on NF-κB. Curr Opinion Cell Biol 1999; 11: 226-32.
32. Weber C, Erl W, Pietsch A, et al. Antioxidants inhibit monocyte adhesion by suppressing nuclear factor-kappa B mobilization and induction of vascular cell adhesion molecule-1 in endothelial cells stimulated to generate radicals. Arterioscler Thromb 1994; 14: 1665-73.
33. Marui N, Offermann MK, Swerlick R, et al. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J Clin Invest 1993; 92: 1866-74.
34. Faruqi RM, Poptic EJ, Faruqi TR, et al. Distinct mechanisms for N-acetylcysteine inhibition of cytokine-induced E-selectin and VCAM-1 expression. Am J Physiol 1997; 273: H817-826.
35. Zapolska-Downar D, Zapolski-Downar A, Markiewski M, et al. Selective inhibition by alpha-tocopherol of vascular cell adhesion molecule-1 expression in human vascular endothelial cells. Biochem Biophys Res Commun 2000; 274: 609-15.
36. Pober JS, Slowik MR, De Luca LG, et al. Elevated cyclic AMP inhibits endothelial cell synthesis and expression of TNF-induced endothelial leukocyte adhesion molecule-1, and vascular cell adhesion molecule-1, but not intercellular adhesion molecule-1. J Immunol 1993; 150: 5114-23.
37. Yan W, Zhao K, Jiang Y, et al. Role of p38 MAPK in ICAM-1 expression of vascular endothelial cells induced by lipopolysaccharide. Shock 2002; 17: 433-8.
38. Wang N, Verna L, Liao HL, et al. Adenovirus-mediated overexpression of dominant-negative mutant of c-Jun prevents intercellular adhesion molecule-1 induction by LDL: A critical role for activator protein-1 in endothelial activation. Arterioscler Thromb Vasc Biol 2001; 21: 1414-20.
39. Fan H, Sun B, Gu Q, et al. Oxygen radicals trigger activation of NF-kappaB and AP-1 and upregulation of ICAM-1 in reperfused canine heart. Am J Physiol 2002; 282: H1778-1786.
40. Berendji-Grun D, Kolb-Bachofen V, Kroncke KD. Nitric oxide inhibits endothelial IL-1β-induced ICAM-1 gene expression at the transcriptional level decreasing Sp1 and AP-1 activity. Mol Med 2001; 7: 748-54.