Erythropoietin increases bioavailability of tetrahydrobiopterin and protects cerebral microvasculature against oxidative stress induced by eNOS uncoupling

Journal of Neurochemistry

Volumn 131, Issue 4, 2014, Pages 521-529

  Santhanam, Anantha Vijay R ^a   D'Uscio, Livius V ^a   Katusic, Zvonimir S ^a  

^a MAYO CLINIC   (United States)

Author keywords

brain; cerebral microvessels; GTP cyclohydrolase I; hph1 mice; nitric oxide; superoxide

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; DIHYDROBIOPTERIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ERYTHROPOIETIN; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; MANGANESE SUPEROXIDE DISMUTASE; SMALL INTERFERING RNA; SUPEROXIDE; TETRAHYDROBIOPTERIN; BIOPTERIN; BMI1 PROTEIN; NITRIC OXIDE; PHC1 PROTEIN, HUMAN; SAPROPTERIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; BRAIN BLOOD VESSEL; BRAIN MICROVASCULAR ENDOTHELIUM CELL; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG PROTEIN BINDING; ENDOTHELIUM CELL; ENZYME DEFICIENCY; ENZYME INHIBITION; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I DEFICIENCY; HUMAN; HUMAN CELL; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; OXIDATION; OXIDATIVE COUPLING; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT DURATION; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECTS; GENETICS; IMMUNOLOGY; IN VITRO STUDY; METABOLISM; MICROVASCULATURE; MUTATION; TRANSGENIC MOUSE;

MUS;

ANIMALS; BIOPTERIN; CELLS, CULTURED; ENDOTHELIAL CELLS; ERYTHROPOIETIN; HUMANS; IN VITRO TECHNIQUES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROVESSELS; MUTATION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; POLYCOMB REPRESSIVE COMPLEX 1; RNA, SMALL INTERFERING;

EID: 84922393650     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12824     Document Type: Article

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