Hypertension alters role of iNOS, COX-2, and oxidative stress in bradykinin relaxation impairment after LPS in rat cerebral arteries

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 287, Issue 1 56-1, 2004, Pages

  Hernanz, Raquel ^a   Briones, Ana M ^a   Alonso, María J ^c   Vila, Elisabet ^b   Salaices, Mercedes ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c UNIVERSIDAD REY JUAN CARLOS   (Spain)

Author keywords

Cyclooxygenase 2; Inducible nitric oxide synthase; Lipopolysaccharide; Rat; Reactive oxygen species

Indexed keywords

7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; BRADYKININ; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLOOXYGENASE 2; DIETHYLAMINE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MANGANESE SUPEROXIDE DISMUTASE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N(G) METHYLARGININE; NITRIC OXIDE DONOR; PROSTAGLANDIN H2; PROSTAGLANDIN H2 RECEPTOR ANTAGONIST; PROSTANOID; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE; SUPEROXIDE DISMUTASE; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ARTERY; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME SYNTHESIS; HYPERTENSION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION; RAT; SMOOTH MUSCLE RELAXATION; STRAIN IDENTIFICATION;

ANIMALS; BRADYKININ; CEREBRAL ARTERIES; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; HYDRAZINES; HYPERTENSION; ISOENZYMES; LIPOPOLYSACCHARIDES; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITROBENZENES; OXIDATIVE STRESS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, INBRED SHR; RATS, INBRED WKY; REACTIVE OXYGEN SPECIES; SULFONAMIDES; VASODILATION;

EID: 3042538208     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00548.2003     Document Type: Article

References (46)

1. Bernard C, Merval R, Esposito B, and Tedgui A. Resistance to endotoxin shock in spontaneously hypertensive rats. Hypertension 31: 1350-1356, 1998.
2. Bishop-Bailey D, Larkin SW, Warner TD, Chen G, and Mitchell JA. Characterization of the induction of nitric oxide synthase and cyclooxygenase in rat aorta in organ culture. Br J Pharmacol 121: 125-133, 1997.
3. Brandes RP, Koddenberg G, Gwiner W, Kim DY, Kruse HJ, Busse R, and Mügge A. Role of increased production of superoxide anions by NAD(P)H oxidase and xanthine oxidase in prolonged endotoxemia. Hypertension 33: 1243-1249, 1999.
4. Brian JE Jr, Moore SA, and Faraci FM. Expression and vascular effects of cyclooxygenase-2 in brain. Stroke 29: 2600-2606, 1998.
5. Briones AM, Alonso MJ, Hernanz R, Miguel M, and Salaices M. Alterations of the nitric oxide pathway in cerebral arteries from spontaneously hypertensive rats. J Cardiovasc Pharmacol 39: 378-388, 2002.
6. Briones AM, Alonso MJ, Hernanz R, Tovar S, Vila E, and Salaices M. Hypertension alters the participation of contractile prostanoids and superoxide anions in lipopolysaccharide effects on small mesenteric arteries. Life Sci 71: 1997-2014, 2002.
7. Briones AM, Alonso MJ, Marín J, Balfagón G, and Salaices M. Influence of hypertension on nitric oxide synthase expression and vascular effects of lipopolysaccharide in rat mesenteric arteries. Br J Pharmacol 135: 185-194, 2000.
8. Buga GM, Griscavage JM, Rogers NE, and Ignarro LJ. Negative feedback regulation of endothelial cell function by nitric oxide. Circ Res 73: 808-812, 1993.
9. Chauhan SD, Seggara G, Vo PA, MacAllister RJ, Hobbs AJ, and Ahluwalia A. Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice. FASEB J 17: 773-775, 2003.
10. Chou TC, Yen MH, Li CY, and Ding YA. Alterations of nitric oxide synthase expression with aging and hypertension in rats. Hypertension 31: 643-648, 1998.
11. 2 antagonist SQ-29548 impair in vitro contractions of aortic rings of ex vivo-treated lipopolysaccharide rats. J Lipid Mediat Cell Signal 13: 177-187, 1996.
12. Ekström-Jodal B, Elfverson J, and Larsson LE. Early effects of E. coli endotoxin on superior sagittal sinus blood flow. An experimental study in dogs. Acta Anaesthesiol Scand 26: 171-174, 1982.
13. García-Cohen EC, Marín J, Díez-Picazo LD, Baena AB, Salaices M, and Rodríguez-Martínez MA. Oxidative stress induced by tert-butyl hydroperoxide causes vasoconstriction in the aorta from hypertensive and aged rats: role of cyclooxygenase-2 isoform. J Pharmacol Exp Ther 293: 75-81, 2000.
14. 2 in the SHR aorta. Circ Res 76: 1003-1010, 1995.
15. Gunnett CA, Lund DD, Howard MA, Chu Y, Faraci FM, and Heistad DD. Gene transfer of inducible nitric oxide synthase impairs relaxation in human and rabbit cerebral arteries. Stroke 33: 2292-2296, 2002.
16. Henrion D, Dechaux E, Dowell FJ, Maclour J, Samuel JL, Levy BI, and Michel JB. Alteration of flow-induced dilatation in mesenteric resistance arteries of L-NAME treated rats and its partial association with induction of cyclooxygenase-2. Br J Pharmacol 121: 83-90, 1997.
17. Hernanz R, Alonso MJ, Briones AM, Vila E, Simonsen U, and Salaices M. Mechanisms involved in the early increase of serotonin contraction evoked by endotoxin in rat middle cerebral arteries. Br J Pharmacol 140: 671-680, 2003.
18. 2 in aorta of the spontaneously hypertensive rat. J Cardiovasc Pharmacol 33: 605-610, 1999.
19. Ichihara A, Hayashi M, Navar G, and Saruta T. Inducible nitric oxide synthase attenuates endothelium-dependent renal microvascular vasodilation. J Am Soc Nephrol 11: 1807-1812, 2000.
20. Kulkarni M and Armstead WM. Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury. J Neurotrauma 19: 965-973, 2002.
21. Lagaud GJ, Skarsgard PL, Laher I, and van Breemen C. Heterogeneity of endothelium-dependent vasodilation in pressurized cerebral and small mesenteric resistance arteries of the rat. J Pharmacol Exp Ther 290: 832-839, 1999.
22. Leach M, Frank S, Olbrich A, Pfeilschifter J, and Thiemermann C. Decline in the expression of copper/zinc superoxide dismutase in the kidney of rats with endotoxic shock: effects of the superoxide anion radical scavenger, tempol, on organ injury. Br J Pharmacol 125: 817-825, 1998.
23. 2 in responses of cerebral arterioles during chronic hypertension. Am J Physiol Heart Circ Physiol 262: H539-H543, 1992.
24. McIntyre M, Bohr DF, and Dominiczak AF. Endothelial dysfunction in hypertension. The role of superoxide anion. Hypertension 34: 539-545, 1999.
25. Miller FJ Jr, Gutterman DD, Rios CD, Heistad DD, and Davidson BL. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ Res 82: 1298-1305, 1998.
26. Mulvany MJ and Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 41: 19-26, 1977.
27. Okamoto H, Ito O, Roman RJ, and Hudetz AG. Role of inducible nitric oxide synthase and cyclooxygenase-2 in endotoxin-induced cerebral hyperemia. Stroke 29: 1209-1218, 1998.
28. Papapetropoulos A, Abou-Mohamed G, Marczin N, Murad F, Caldwell RW, and Catravas JD. Downregulation of nitrovasodilator-induced cyclic GMP accumulation in cells exposed to endotoxin or interleukin-1β. Br J Pharmacol 118: 1359-1366, 1996.
29. Parker JL and Emerson TE. Cerebral hemodynamics, vascular reactivity, and metabolism during canine endotoxin shock. Circ Shock 4: 41-53, 1977.
30. Pasquet JP, Zou MH, and Ullrich V. Peroxynitrite inhibition of nitric oxide synthases. Biochimie 78: 785-791, 1996.
31. Piepot HA, Boer C, Groeneveld ABJ, Lambalgen AA, and Sipkema P. Lipopolysaccharide impairs endothelial nitric oxide synthesis in rat renal arteries. Kidney Int 57: 2502-2510, 2000.
32. Pleiner J, Mittermayer F, Schaller G, MacAllister RJ, and Wolzt M. High doses of vitamin C reverse Escherichia coli endotoxin-induced hyporeactivity to acetylcholine in the human forearm. Circulation 106: 1460-1464, 2002.
33. Pu Q, Bordet R, Robin E, Puisieux F, Vallet B, and Dupuis B. Low dose of lipopolysaccharide induces a delayed enhanced nitric-oxide relaxation in rat aorta. Eur J Pharmacol 377: 209-214, 1999.
34. Puisieux F, Deplanque D, Pu Q, Souil E, Bastide M, and Bordet R. Differential role of nitric oxide pathway and heat shock protein in preconditioning and lipopolysaccharide-induced brain ischemic tolerance. Eur J Pharmacol 389: 71-78, 2000.
35. Rodríguez-Martínez MA, García-Cohen EC, Baena AB, González R, Salaices M, and Marín J. Contractile responses elicited by hydrogen peroxide in aorta from normotensive and hypertensive rats. Endothelial modulation and mechanism involved. Br J Pharmacol 125: 1329-1339, 1998.
36. Salvemini D, Settle SL, Masferrer JL, Seibert K, Currie MG, and Needleman P. Regulation of prostaglandin production by nitric oxide; an in vivo analysis. Br J Pharmacol 114: 1171-1178, 1995.
37. Scott WS and Nakayama DK. Escherichia coli lipopolysaccharide downregulates soluble guanylate cyclase in pulmonary artery smooth muscle. J Surg Res 80: 309-314, 1998.
38. Sessler CN and Shepherd W. New concepts in sepsis. Curr Opin Crit Care 8: 465-472, 2002.
39. Szabó C, Mitchell JA, Thiemermann C, and Vane JR. Nitric oxide-mediated hyporeactivity to noradrenaline precedes the induction of nitric oxide synthase in endotoxic shock. Br J Pharmacol 108: 786-792, 1993.
40. Tsuchida S, Hiraoka M, Sudo M, Kigoshi S, and Muramatsu I. Attenuation of sodium nitroprusside responses after prolonged incubation of rat aorta with endotoxin. Am J Physiol Heart Circ Physiol 267: H2305-H2310, 1994.
41. Ueno M and Lee TJ. Endotoxin decreases the contractile responses of the porcine basilar artery to vasoactive substances. J Cereb Blood Flow Metab 13: 712-719, 1993.
42. Virdis A and Schiffrin EL. Vascular inflammation: a role in vascular disease in hypertension? Curr Opin Nephrol Hypertens 12: 181-187, 2003.
43. Wu CC, Hong HJ, Chou TC, Ding YA, and Yen MH. Evidence for inducible nitric oxide synthase in spontaneously hypertensive rats. Biochem Biophys Res Commun 228: 459-466, 1996.
44. Wylam ME, Metkus AP, and Umans JG. Nitric oxide dependent and independent effects of in vitro incubation or endotoxin on vascular reactivity in rat aorta. Life Sci 69: 455-467, 2001.
45. Xia Y, Roman LD, Masters BS, and Zweier JL. Inducible nitric-oxide synthase generates superoxide from the reductase domain. J Biol Chem 273: 22635-22639, 1998.
46. Yen MH, Liu YC, Hong HJ, Shen JR, and Wu CC. Role of nitric oxide in lipopolysaccharide-induced mortality from spontaneously hypertensive rats. Life Sci 60: 1223-1230, 1997.