Hepatic expression of Sonic Hedgehog induces liver fibrosis and promotes hepatocarcinogenesis in a transgenic mouse model

Journal of Hepatology

Volumn 64, Issue 3, 2016, Pages 618-627

  Chung, Sook In ^a   Moon, Hyuk ^a   Ju, Hye Lim ^b   Cho, Kyung Joo ^a   Kim, Do Young ^b   Han, Kwang Hyub ^b   Eun, Jung Woo ^c   Nam, Suk Woo ^c   Ribback, Silvia ^d   Dombrowski, Frank ^d   Calvisi, Diego F ^d   Ro, Simon Weonsang ^a,b  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c The Catholic University of Korea   (South Korea)

^d UNIVERSITY MEDICINE GREIFSWALD   (Germany)

Author keywords

Hepatic stellate cell; Hepatocellular carcinoma; Hydrodynamic transfection; Liver fibrosis; Sonic Hedgehog

Indexed keywords

K RAS PROTEIN; PROTEIN P53; SONIC HEDGEHOG PROTEIN; SHH PROTEIN, MOUSE; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HYDRODYNAMICS; INTRACELLULAR SIGNALING; LIVER ADENOMA; LIVER CARCINOGENESIS; LIVER FIBROSIS; LIVER INJURY; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; STELLATE CELL; TRANSGENIC MOUSE; UPREGULATION; ANIMAL; C57BL MOUSE; EPITHELIAL MESENCHYMAL TRANSITION; LIVER CIRRHOSIS, EXPERIMENTAL; LIVER NEOPLASMS, EXPERIMENTAL; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; EPITHELIAL-MESENCHYMAL TRANSITION; HEDGEHOG PROTEINS; LIVER CIRRHOSIS, EXPERIMENTAL; LIVER NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84958873649     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.10.007     Document Type: Article

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