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Volumn 18, Issue 8, 2012, Pages 727-735

Role of cytokines and chemokines in non-alcoholic fatty liver disease

Author keywords

Chemokine; Cytokine; Inflammation; Non alcoholic fatty liver disease

Indexed keywords

ALPHA TOCOPHEROL; AMINOTRANSFERASE; CHEMOKINE; CXCL9 CHEMOKINE; CYTOKINE; ETANERCEPT; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PENTOXIFYLLINE; RANTES; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

EID: 84857550029     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v18.i8.727     Document Type: Review
Times cited : (285)

References (109)
  • 1
    • 79952680445 scopus 로고    scopus 로고
    • Relationship between nonalcoholic fatty liver disease and metabolic syndrome
    • Chen SH, He F, Zhou HL, Wu HR, Xia C, Li YM. Relationship between nonalcoholic fatty liver disease and metabolic syndrome. J Dig Dis 2011; 12: 125-130
    • (2011) J Dig Dis , vol.12 , pp. 125-130
    • Chen, S.H.1    He, F.2    Zhou, H.L.3    Wu, H.R.4    Xia, C.5    Li, Y.M.6
  • 2
    • 0021272756 scopus 로고
    • The liver in consecutive patients with morbid obesity: A clinical, morphological, and biochemical study
    • Andersen T, Christoffersen P, Gluud C. The liver in consecutive patients with morbid obesity: a clinical, morphological, and biochemical study. Int J Obes 1984; 8: 107-115
    • (1984) Int J Obes , vol.8 , pp. 107-115
    • Andersen, T.1    Christoffersen, P.2    Gluud, C.3
  • 4
    • 36549070161 scopus 로고    scopus 로고
    • Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004
    • Fraser A, Longnecker MP, Lawlor DA. Prevalence of elevated alanine aminotransferase among US adolescents and associated factors: NHANES 1999-2004. Gastroenterology 2007; 133: 1814-1820
    • (2007) Gastroenterology , vol.133 , pp. 1814-1820
    • Fraser, A.1    Longnecker, M.P.2    Lawlor, D.A.3
  • 5
    • 0034089687 scopus 로고    scopus 로고
    • Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents
    • Strauss RS, Barlow SE, Dietz WH. Prevalence of abnormal serum aminotransferase values in overweight and obese adolescents. J Pediatr 2000; 136: 727-733
    • (2000) J Pediatr , vol.136 , pp. 727-733
    • Strauss, R.S.1    Barlow, S.E.2    Dietz, W.H.3
  • 9
    • 79957504753 scopus 로고    scopus 로고
    • Diagnosing steatohepatitis and predicting liver-related mortality in patients with NAFLD: Two distinct concepts
    • Angulo P. Diagnosing steatohepatitis and predicting liver-related mortality in patients with NAFLD: two distinct concepts. Hepatology 2011; 53: 1792-1794
    • (2011) Hepatology , vol.53 , pp. 1792-1794
    • Angulo, P.1
  • 10
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med2002; 346: 1221-1231
    • N Engl J Med2002 , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 11
    • 78049503241 scopus 로고    scopus 로고
    • Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance
    • Tarantino G, Savastano S, Colao A. Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance. World J Gastroenterol 2010; 16: 4773-4783
    • (2010) World J Gastroenterol , vol.16 , pp. 4773-4783
    • Tarantino, G.1    Savastano, S.2    Colao, A.3
  • 12
    • 0027333425 scopus 로고
    • Tumor necrosis factor, other cytokines and disease
    • Tracey KJ, Cerami A. Tumor necrosis factor, other cytokines and disease. Annu Rev Cell Biol 1993; 9: 317-343
    • (1993) Annu Rev Cell Biol , vol.9 , pp. 317-343
    • Tracey, K.J.1    Cerami, A.2
  • 13
    • 79953736773 scopus 로고    scopus 로고
    • Cytokines as therapeutic targets to reduce cardiovascular risk in chronic inflammation
    • Miller AM, McInnes IB. Cytokines as therapeutic targets to reduce cardiovascular risk in chronic inflammation. Curr Pharm Des 2011; 17: 1-8
    • (2011) Curr Pharm Des , vol.17 , pp. 1-8
    • Miller, A.M.1    McInnes, I.B.2
  • 14
    • 33645891172 scopus 로고    scopus 로고
    • Cytokines in atherosclerosis: Pathogenic and regulatory pathways
    • Tedgui A, Mallat Z. Cytokines in atherosclerosis: pathogenic and regulatory pathways. Physiol Rev 2006; 86: 515-581
    • (2006) Physiol Rev , vol.86 , pp. 515-581
    • Tedgui, A.1    Mallat, Z.2
  • 15
    • 0033611515 scopus 로고    scopus 로고
    • Anticytokine therapy--a new era in the treatment of rheumatoid arthritis?
    • O'Dell JR. Anticytokine therapy--a new era in the treatment of rheumatoid arthritis? N Engl J Med 1999; 340: 310-312
    • (1999) N Engl J Med , vol.340 , pp. 310-312
    • O'Dell, J.R.1
  • 16
    • 0034676629 scopus 로고    scopus 로고
    • Cytokines in alcoholic and nonalcoholic steatohepatitis
    • Tilg H, Diehl AM. Cytokines in alcoholic and nonalcoholic steatohepatitis. N Engl J Med 2000; 343: 1467-1476
    • (2000) N Engl J Med , vol.343 , pp. 1467-1476
    • Tilg, H.1    Diehl, A.M.2
  • 17
    • 58249089735 scopus 로고    scopus 로고
    • Does non-alcoholic fatty liver disease (NAFLD) increase cardiovascular risk?
    • Montecucco F, Mach F. Does non-alcoholic fatty liver disease (NAFLD) increase cardiovascular risk? Endocr Metab Immune Disord Drug Targets 2008; 8: 301-307
    • (2008) Endocr Metab Immune Disord Drug Targets , vol.8 , pp. 301-307
    • Montecucco, F.1    Mach, F.2
  • 18
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993; 259: 87-91
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 19
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997; 389: 610-614
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 21
    • 40849106735 scopus 로고    scopus 로고
    • The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet
    • Koca SS, Bahcecioglu IH, Poyrazoglu OK, Ozercan IH, Sahin K, Ustundag B. The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet. Inflammation 2008; 31: 91-98
    • (2008) Inflammation , vol.31 , pp. 91-98
    • Koca, S.S.1    Bahcecioglu, I.H.2    Poyrazoglu, O.K.3    Ozercan, I.H.4    Sahin, K.5    Ustundag, B.6
  • 22
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 1995; 95: 2409-2415
    • (1995) J Clin Invest , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5
  • 24
    • 68149182338 scopus 로고    scopus 로고
    • Diagnostic value of a group of biochemical markers of liver fibrosis in patients with non-alcoholic steatohepatitis
    • Lesmana CR, Hasan I, Budihusodo U, Gani RA, Krisnuhoni E, Akbar N, Lesmana LA. Diagnostic value of a group of biochemical markers of liver fibrosis in patients with non-alcoholic steatohepatitis. J Dig Dis 2009; 10: 201-206
    • (2009) J Dig Dis , vol.10 , pp. 201-206
    • Lesmana, C.R.1    Hasan, I.2    Budihusodo, U.3    Gani, R.A.4    Krisnuhoni, E.5    Akbar, N.6    Lesmana, L.A.7
  • 30
    • 18744414292 scopus 로고    scopus 로고
    • Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors
    • Müller S, Martin S, Koenig W, Hanifi-Moghaddam P, Rathmann W, Haastert B, Giani G, Illig T, Thorand B, Kolb H. Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors. Diabetologia 2002; 45: 805-812
    • (2002) Diabetologia , vol.45 , pp. 805-812
    • Müller, S.1    Martin, S.2    Koenig, W.3    Hanifi-Moghaddam, P.4    Rathmann, W.5    Haastert, B.6    Giani, G.7    Illig, T.8    Thorand, B.9    Kolb, H.10
  • 31
    • 0037763758 scopus 로고    scopus 로고
    • Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men
    • Bruun JM, Verdich C, Toubro S, Astrup A, Richelsen B. Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men. Eur J Endocrinol 2003; 148: 535-542
    • (2003) Eur J Endocrinol , vol.148 , pp. 535-542
    • Bruun, J.M.1    Verdich, C.2    Toubro, S.3    Astrup, A.4    Richelsen, B.5
  • 32
    • 0029906375 scopus 로고    scopus 로고
    • Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM
    • Ofei F, Hurel S, Newkirk J, Sopwith M, Taylor R. Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM. Diabetes 1996; 45: 881-885
    • (1996) Diabetes , vol.45 , pp. 881-885
    • Ofei, F.1    Hurel, S.2    Newkirk, J.3    Sopwith, M.4    Taylor, R.5
  • 35
    • 77958022236 scopus 로고    scopus 로고
    • TGF- ß in wound healing: A review
    • Douglas HE. TGF- ß in wound healing: a review. J Wound Care 2010; 19: 403-406
    • (2010) J Wound Care , vol.19 , pp. 403-406
    • Douglas, H.E.1
  • 36
    • 70349972775 scopus 로고    scopus 로고
    • Apoptosis and cytokines in non-alcoholic steatohepatitis
    • Syn WK, Choi SS, Diehl AM. Apoptosis and cytokines in non-alcoholic steatohepatitis. Clin Liver Dis 2009; 13: 565-580
    • (2009) Clin Liver Dis , vol.13 , pp. 565-580
    • Syn, W.K.1    Choi, S.S.2    Diehl, A.M.3
  • 37
    • 0032794576 scopus 로고    scopus 로고
    • Cytokines and fibrogenesis
    • Friedman SL. Cytokines and fibrogenesis. Semin Liver Dis 1999; 19: 129-140
    • (1999) Semin Liver Dis , vol.19 , pp. 129-140
    • Friedman, S.L.1
  • 38
    • 2642585736 scopus 로고    scopus 로고
    • How can transforming growth factor beta be targeted usefully to combat liver fibrosis?
    • Shek FW, Benyon RC. How can transforming growth factor beta be targeted usefully to combat liver fibrosis? Eur J Gastroenterol Hepatol 2004; 16: 123-126
    • (2004) Eur J Gastroenterol Hepatol , vol.16 , pp. 123-126
    • Shek, F.W.1    Benyon, R.C.2
  • 39
    • 0034767501 scopus 로고    scopus 로고
    • Transforming growth factor beta and the liver
    • Bissell DM, Roulot D, George J. Transforming growth factor beta and the liver. Hepatology 2001; 34: 859-867
    • (2001) Hepatology , vol.34 , pp. 859-867
    • Bissell, D.M.1    Roulot, D.2    George, J.3
  • 40
    • 0026600495 scopus 로고
    • Increased transforming growth factor-beta 1 gene expression in human liver disease
    • Annoni G, Weiner FR, Zern MA. Increased transforming growth factor-beta 1 gene expression in human liver disease. J Hepatol 1992; 14: 259-264
    • (1992) J Hepatol , vol.14 , pp. 259-264
    • Annoni, G.1    Weiner, F.R.2    Zern, M.A.3
  • 41
    • 0030992053 scopus 로고    scopus 로고
    • Transforming growth factor-beta gene expression in normal and fibrotic rat liver
    • De Bleser PJ, Niki T, Rogiers V, Geerts A. Transforming growth factor-beta gene expression in normal and fibrotic rat liver. J Hepatol 1997; 26: 886-893
    • (1997) J Hepatol , vol.26 , pp. 886-893
    • de Bleser, P.J.1    Niki, T.2    Rogiers, V.3    Geerts, A.4
  • 44
    • 0025855367 scopus 로고
    • Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy
    • Castilla A, Prieto J, Fausto N. Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alfa therapy. N Engl J Med 1991; 324: 933-940
    • (1991) N Engl J Med , vol.324 , pp. 933-940
    • Castilla, A.1    Prieto, J.2    Fausto, N.3
  • 45
    • 0026320289 scopus 로고
    • Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease
    • Milani S, Herbst H, Schuppan D, Stein H, Surrenti C. Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease. Am J Pathol 1991; 139: 1221-1229
    • (1991) Am J Pathol , vol.139 , pp. 1221-1229
    • Milani, S.1    Herbst, H.2    Schuppan, D.3    Stein, H.4    Surrenti, C.5
  • 46
    • 0141786790 scopus 로고    scopus 로고
    • Oxidative stress, KLF6 and transforming growth factor-beta up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats
    • Stärkel P, Sempoux C, Leclercq I, Herin M, Deby C, Desager JP, Horsmans Y. Oxidative stress, KLF6 and transforming growth factor-beta up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats. J Hepatol 2003; 39: 538-546
    • (2003) J Hepatol , vol.39 , pp. 538-546
    • Stärkel, P.1    Sempoux, C.2    Leclercq, I.3    Herin, M.4    Deby, C.5    Desager, J.P.6    Horsmans, Y.7
  • 47
    • 0034799895 scopus 로고    scopus 로고
    • Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: A pilot study
    • Hasegawa T, Yoneda M, Nakamura K, Makino I, Terano A. Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study. Aliment Pharmacol Ther 2001; 15: 1667-1672
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 1667-1672
    • Hasegawa, T.1    Yoneda, M.2    Nakamura, K.3    Makino, I.4    Terano, A.5
  • 49
    • 77953980528 scopus 로고    scopus 로고
    • IL-6: From its discovery to clinical applications
    • Kishimoto T. IL-6: from its discovery to clinical applications. Int Immunol 2010; 22: 347-352
    • (2010) Int Immunol , vol.22 , pp. 347-352
    • Kishimoto, T.1
  • 51
    • 12744259191 scopus 로고    scopus 로고
    • IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver
    • El-Assal O, Hong F, Kim WH, Radaeva S, Gao B. IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver. Cell Mol Immunol 2004; 1: 205-211
    • (2004) Cell Mol Immunol , vol.1 , pp. 205-211
    • El-Assal, O.1    Hong, F.2    Kim, W.H.3    Radaeva, S.4    Gao, B.5
  • 52
    • 33744941349 scopus 로고    scopus 로고
    • Interleukin-6 is a key mediator of the hepatoprotective and pro-proliferative effects of ischaemic preconditioning in mice
    • Teoh N, Field J, Farrell G. Interleukin-6 is a key mediator of the hepatoprotective and pro-proliferative effects of ischaemic preconditioning in mice. J Hepatol 2006; 45: 20-27
    • (2006) J Hepatol , vol.45 , pp. 20-27
    • Teoh, N.1    Field, J.2    Farrell, G.3
  • 56
    • 0033984744 scopus 로고    scopus 로고
    • Inflammation, obesity, stress and coronary heart disease: Is interleukin-6 the link?
    • Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 2000; 148: 209-214
    • (2000) Atherosclerosis , vol.148 , pp. 209-214
    • Yudkin, J.S.1    Kumari, M.2    Humphries, S.E.3    Mohamed-Ali, V.4
  • 57
    • 23044468612 scopus 로고    scopus 로고
    • Interleukin-6 depletion selectively improves hepatic insulin action in obesity
    • Klover PJ, Clementi AH, Mooney RA. Interleukin-6 depletion selectively improves hepatic insulin action in obesity. Endocrinology 2005; 146: 3417-3427
    • (2005) Endocrinology , vol.146 , pp. 3417-3427
    • Klover, P.J.1    Clementi, A.H.2    Mooney, R.A.3
  • 59
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med 2005; 11: 183-190
    • (2005) Nat Med , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 60
    • 0042265627 scopus 로고    scopus 로고
    • Cytokines and NASH: A pilot study of the effects of lifestyle modification and vitamin
    • Kugelmas M, Hill DB, Vivian B, Marsano L, McClain CJ. Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E. Hepatology 2003; 38: 413-419
    • (2003) E. Hepatology , vol.38 , pp. 413-419
    • Kugelmas, M.1    Hill, D.B.2    Vivian, B.3    Marsano, L.4    McClain, C.J.5
  • 64
    • 77955150888 scopus 로고    scopus 로고
    • Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice
    • Yamaguchi K, Itoh Y, Yokomizo C, Nishimura T, Niimi T, Fujii H, Okanoue T, Yoshikawa T. Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice. Lab Invest 2010; 90: 1169-1178
    • (2010) Lab Invest , vol.90 , pp. 1169-1178
    • Yamaguchi, K.1    Itoh, Y.2    Yokomizo, C.3    Nishimura, T.4    Niimi, T.5    Fujii, H.6    Okanoue, T.7    Yoshikawa, T.8
  • 65
    • 79953176357 scopus 로고    scopus 로고
    • Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice
    • Yamaguchi K, Itoh Y, Yokomizo C, Nishimura T, Niimi T, Umemura A, Fujii H, Okanoue T, Yoshikawa T. Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice. Lab Invest 2011; 91: 609-618
    • (2011) Lab Invest , vol.91 , pp. 609-618
    • Yamaguchi, K.1    Itoh, Y.2    Yokomizo, C.3    Nishimura, T.4    Niimi, T.5    Umemura, A.6    Fujii, H.7    Okanoue, T.8    Yoshikawa, T.9
  • 72
  • 73
    • 32144454172 scopus 로고    scopus 로고
    • The many roles of chemokines and chemokine receptors in inflammation
    • Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 2006; 354: 610-621
    • (2006) N Engl J Med , vol.354 , pp. 610-621
    • Charo, I.F.1    Ransohoff, R.M.2
  • 78
    • 0026075699 scopus 로고
    • Monocyte chemoattractant protein-1 in human atheromatous plaques
    • Nelken NA, Coughlin SR, Gordon D, Wilcox JN. Monocyte chemoattractant protein-1 in human atheromatous plaques. J Clin Invest 1991; 88: 1121-1127
    • (1991) J Clin Invest , vol.88 , pp. 1121-1127
    • Nelken, N.A.1    Coughlin, S.R.2    Gordon, D.3    Wilcox, J.N.4
  • 80
    • 0038809142 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein 1 in obesity and insulin resistance
    • Sartipy P, Loskutoff DJ. Monocyte chemoattractant protein 1 in obesity and insulin resistance. Proc Natl Acad Sci USA 2003; 100: 7265-7270
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 7265-7270
    • Sartipy, P.1    Loskutoff, D.J.2
  • 87
    • 77951146612 scopus 로고    scopus 로고
    • C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis
    • Obstfeld AE, Sugaru E, Thearle M, Francisco AM, Gayet C, Ginsberg HN, Ables EV, Ferrante AW. C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes 2010; 59: 916-925
    • (2010) Diabetes , vol.59 , pp. 916-925
    • Obstfeld, A.E.1    Sugaru, E.2    Thearle, M.3    Francisco, A.M.4    Gayet, C.5    Ginsberg, H.N.6    Ables, E.V.7    Ferrante, A.W.8
  • 89
    • 64149125118 scopus 로고    scopus 로고
    • Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy
    • Yang SJ, IglayReger HB, Kadouh HC, Bodary PF. Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy. Diabetologia 2009; 52: 972-981
    • (2009) Diabetologia , vol.52 , pp. 972-981
    • Yang, S.J.1    Iglayreger, H.B.2    Kadouh, H.C.3    Bodary, P.F.4
  • 91
    • 78649681353 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet
    • Kassel KM, Guo GL, Tawfik O, Luyendyk JP. Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine-choline-deficient diet. Lab Invest 2010; 90: 1794-1804
    • (2010) Lab Invest , vol.90 , pp. 1794-1804
    • Kassel, K.M.1    Guo, G.L.2    Tawfik, O.3    Luyendyk, J.P.4
  • 92
    • 35748972366 scopus 로고    scopus 로고
    • Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects
    • Westerbacka J, Kolak M, Kiviluoto T, Arkkila P, Sirén J, Hamsten A, Fisher RM, Yki-Järvinen H. Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects. Diabetes 2007; 56: 2759-2765
    • (2007) Diabetes , vol.56 , pp. 2759-2765
    • Westerbacka, J.1    Kolak, M.2    Kiviluoto, T.3    Arkkila, P.4    Sirén, J.5    Hamsten, A.6    Fisher, R.M.7    Yki-Järvinen, H.8
  • 96
  • 102
    • 0027601371 scopus 로고
    • The role of interleukin-8 in inflammation and mechanisms of regulation
    • Bickel M. The role of interleukin-8 in inflammation and mechanisms of regulation. J Periodontol 1993; 64: 456-460
    • (1993) J Periodontol , vol.64 , pp. 456-460
    • Bickel, M.1
  • 104
    • 34548126148 scopus 로고    scopus 로고
    • Importance of cytokines, oxidative stress and expression of BCL-2 in the pathogenesis of non-alcoholic steatohepatitis
    • Torer N, Ozenirler S, Yucel A, Bukan N, Erdem O. Importance of cytokines, oxidative stress and expression of BCL-2 in the pathogenesis of non-alcoholic steatohepatitis. Scand J Gastroenterol 2007; 42: 1095-1101
    • (2007) Scand J Gastroenterol , vol.42 , pp. 1095-1101
    • Torer, N.1    Ozenirler, S.2    Yucel, A.3    Bukan, N.4    Erdem, O.5
  • 107
    • 77954481680 scopus 로고    scopus 로고
    • Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity--a tale of conflict and conundrum
    • Müller M, Carter S, Hofer MJ, Campbell IL. Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity--a tale of conflict and conundrum. Neuropathol Appl Neurobiol 2010; 36: 368-387
    • (2010) Neuropathol Appl Neurobiol , vol.36 , pp. 368-387
    • Müller, M.1    Carter, S.2    Hofer, M.J.3    Campbell, I.L.4
  • 108
    • 54449085376 scopus 로고    scopus 로고
    • Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and surface presentation of chemokines
    • Schrage A, Wechsung K, Neumann K, Schumann M, Schulzke JD, Engelhardt B, Zeitz M, Hamann A, Klugewitz K. Enhanced T cell transmigration across the murine liver sinusoidal endothelium is mediated by transcytosis and surface presentation of chemokines. Hepatology 2008; 48: 1262-1272
    • (2008) Hepatology , vol.48 , pp. 1262-1272
    • Schrage, A.1    Wechsung, K.2    Neumann, K.3    Schumann, M.4    Schulzke, J.D.5    Engelhardt, B.6    Zeitz, M.7    Hamann, A.8    Klugewitz, K.9


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