Acute and subacute pulmonary toxicity and mortality in mice after intratracheal instillation of ZnO nanoparticles in three laboratories

Food and Chemical Toxicology

Volumn 85, Issue , 2015, Pages 84-95

  Jacobsen, Nicklas Raun ^a   Stoeger, Tobias ^b   van den Brule, Sybille ^c   Saber, Anne Thoustrup ^a   Beyerle, Andrea ^b   Vietti, Giulia ^c   Mortensen, Alicja ^d   Szarek, Józef ^e   Budtz, Hans Christian ^a   Kermanizadeh, Ali ^f   Banerjee, Atrayee ^g   Ercal, Nuran ^g   Vogel, Ulla ^a,d   Wallin, Håkan ^a,f   Møller, Peter ^f  

^a NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^d TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^e UNIVERSITY OF WARMIA AND MAZURY IN OLSZTYN   (Poland)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

^g MISSOURI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (United States)

Author keywords

Cytotoxicity; DNA damage; Fibrosis; Inflammation; Mortality; Oxidative stress

Indexed keywords

CXCL1 CHEMOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUTATHIONE; GRANULOCYTE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; LACTATE DEHYDROGENASE; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; ZINC OXIDE NANOPARTICLE; BIOLOGICAL MARKER; NANOPARTICLE; ZINC OXIDE;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHOALVEOLAR LAVAGE FLUID; CELL COMPOSITION; CELL MEMBRANE PERMEABILITY; COMET ASSAY; CONTROLLED STUDY; DESQUAMATION; DISEASE SEVERITY; DNA DAMAGE; EPITHELIUM CELL; FEMALE; HISTOPATHOLOGY; LIPID PEROXIDATION; LUNG FIBROSIS; LUNG PARENCHYMA; LUNG TOXICITY; MORTALITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; WEIGHT GAIN; WEIGHT REDUCTION; ADVERSE EFFECTS; ANIMAL; BLOOD; C57BL MOUSE; CHEMICALLY INDUCED; CHEMISTRY; CROSS BREEDING; DOSE RESPONSE; DRUG EFFECTS; EXPOSURE; GERMFREE ANIMAL; IMMUNOLOGY; LIVER; LUNG; METABOLISM; PARTICLE SIZE; PATHOLOGY; PILOT STUDY; RANDOMIZATION; RESPIRATORY TRACT MUCOSA; SURVIVAL ANALYSIS; TOXICITY TESTING;

ANIMALS; BIOMARKERS; CROSSES, GENETIC; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; INHALATION EXPOSURE; LIPID PEROXIDATION; LIVER; LUNG; MICE, INBRED C57BL; NANOPARTICLES; OXIDATIVE STRESS; PARTICLE SIZE; PILOT PROJECTS; PULMONARY FIBROSIS; RANDOM ALLOCATION; RESPIRATORY MUCOSA; SPECIFIC PATHOGEN-FREE ORGANISMS; SURVIVAL ANALYSIS; TOXICITY TESTS, ACUTE; TOXICITY TESTS, SUBACUTE; WEIGHT GAIN; ZINC OXIDE;

EID: 84958598585     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2015.08.008     Document Type: Article

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