An in vitro assessment of panel of engineered nanomaterials using a human renal cell line: Cytotoxicity, pro-inflammatory response, oxidative stress and genotoxicity

BMC Nephrology

Volumn 14, Issue 1, 2013, Pages

  Kermanizadeh, Ali ^a   Vranic, Sandra ^b   Boland, Sonja ^b   Moreau, Kevin ^b   Baeza Squiban, Armelle ^b   Gaiser, Birgit K ^a   Andrzejczuk, Livia A ^a   Stone, Vicki ^a  

^a HERIOT WATT UNIVERSITY   (United Kingdom)

^b Groupe Hospitalier Pitié Salpêtrière   (France)

Author keywords

DNA damage; Inflammation; Kidneys; Nanotoxicity; ROS

Indexed keywords

INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; MULTI WALLED NANOTUBE; NANOMATERIAL; REACTIVE OXYGEN METABOLITE; SILVER NANOPARTICLE; TITANIUM DIOXIDE NANOPARTICLE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZINC OXIDE NANOPARTICLE;

ARTICLE; CELL VIABILITY; CLINICAL ASSESSMENT; COMET ASSAY; CONCENTRATION (PARAMETERS); CYTOKINE PRODUCTION; CYTOKINE RELEASE; DNA DAMAGE; DRUG CYTOTOXICITY; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; LD 50; NANOENGINEERING; OXIDATIVE STRESS;

ANIMALS; BIOMEDICAL ENGINEERING; CATTLE; CELL LINE; CELL LINE, TRANSFORMED; CYTOTOXINS; DNA DAMAGE; HUMANS; INFLAMMATION MEDIATORS; KIDNEY; NANOSTRUCTURES; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84876999447     PISSN: None     EISSN: 14712369     Source Type: Journal    
DOI: 10.1186/1471-2369-14-96     Document Type: Article

References (53)

1. Nanomaterials and nanoparticles: sources and toxicity. Buzea C, Pacheco II, Robbie K, Biointerpahses 2007 2 18 67
2. The benefits of silver in hygiene, personal care and healthcare. Edwards-Jones V, Lett Appl Microbiol 2009 49 147 152 10.1111/j.1472-765X.2009. 02648.x 19515146
3. Health effects of nanomaterials. Tetley TD, Bionanotechnol 2007 35 527 531 (Pubitemid 46975068)
4. Nanoparticles-known and unknown health risks. Hoet PHM, Hohlfeld IB, Salata O, J Nanobiotechnol 2004 2 12 27 10.1186/1477-3155-2-12 (Pubitemid 40230507)
5. Human health implications of nonmaterial exposure. Papp T, Schiffmann D, Weiss D, Castronova V, Vallyathan V, Rahman Q, Nanotoxicology 2008 2 9 27 10.1080/17435390701847935
6. Nanoparticle safety-A perspective from the United States. Maynard AD, Issues in Environ Sci Technol 2007 24 118 131
7. Bio-distribution of 1.4 and 18 nm gold particles in rats. Semmler-Behnke M, Wolfgang KG, Lipka J, Fertsch S, Wenk A, Takeneka S, Schmid G, Brandau W, Small 2008 12 2108 2111
8. Kinetics and tissue distributions of neutron-activated zinc oxide nanoparticles and zinc nitrate in mice: effects of size and particulate nature. Yeh TK, Chen JK, Lin CH, Yang MH, Yang CS, Chou FI, Peir JJ, Wang MY, Chang WH, Tsai MH, Tsai HT, Lin PP, Nanotechnology 2012 8 online access
9. Measurement of plasma volume using fluorescent silica-based nanoparticles. Eisner C, Ow H, Yang TX, Jia ZJ, Dimitriadis E, Li LL, Wang K, Briggs J, Levine M, Schnermann J, Espey MG, J Appl Physiol 2012 112 681 687 10.1152/japplphysiol.01068.2011 22174395
10. An assessment of the methods available to determine nutritional equilibrium in patients with chronic and renal failure. Roberts RG, Louden JD, Goodship THJ, Nephrol Dial Transplant 2000 15 1906 1908 10.1093/ndt/15.12.1906 11096128
11. In vitro effects of nanoparticles on renal cells. L'Azou B, Jorly J, On D, Sellier E, Moisan F, Fluery-Feith J, Cambar J, Brochard P, Ohayon-Courtes C, Part Fibre Toxicol 2008 5 22 10.1186/1743-8977-5-22 19099552
12. 2 particles in cultured human lymphoblastoid cells. Wang JJ, Sanderson BJ, Wang H, Mutat Res 2007 628 99 106 10.1016/j.mrgentox.2006.12.003 17223607 (Pubitemid 46330879)
13. The uptake and intracellular fate of PGLA nanoparticles in epithelial cells. Cartiera MS, Johnson KM, Rajendran V, Caplan MJ, Biomaterials 2009 30 2790 2798 10.1016/j.biomaterials.2009.01.057 19232712
14. In vitro assessment of engineered nanomaterials using C3A cells: cytotoxicity, pro-inflammatory cytokines and function markers. Kermanizadeh A, Pojana G, Gaiser BK, Birkedal R, Bilaničová D, Wallin H, Jensen KA, Sellergren B, Hutchison GR, Marcomini A, Stone V, Nanotoxicology 2012 10.3109/17435390.2011.653416
15. Jacobsen NR, Pojano G, Wallin H, Jensen KA, Nanomaterial dispersion protocol for toxicological studies in ENPRA. Internal ENPRA Project Report The National Research Centre for the Working Environment 2010 available on request
16. Sensitivity of the FPG protein towards alkylation damage in the comet assay. Speit G, Schütz P, Bonzheim I, Trenz K, Hoffmann H, Toxicol Lett 2004 146 151 158 10.1016/j.toxlet.2003.09.010 14643967 (Pubitemid 37487829)
17. Aspects of design and statistical analysis in the Comet assay. Wilklund SJ, Agurelli E, Mutagenesis 2003 2003 18 167 175
18. Role of lysine-57 in the catalytic activities of Escherichia coli formamidopyrimidine-DNA glycosylase (Fpg protein). Sidorkina OM, Laval J, Nucleic Acids Res 1998 26 5351 5357 10.1093/nar/26.23.5351 9826758 (Pubitemid 28542734)
19. Oxidative chemistry of florescent dyes: implications in the detection of reactive oxygen and nitrogen species. Kalyanaraman B, Biochem Soc Trans 2011 39 1221 1225 10.1042/BST0391221 21936793
20. The appearance of renal cells cytoplasm degeneration and nuclear destruction might be an indication of GNPs toxicity. Abdelhalim MAK, Jarrar BM, Lipids Health Dis 2011 10 147 153 10.1186/1476-511X-10-147 21859444
21. Subchronic oral toxicity of silver nanoparticles. Kim YS, Song MY, Park JD, Song KS, Ryu HR, Chung YH, Chang HK, Lee JH, Oh KH, Kelman BJ, Hwang IK, Yu IJ, Part Fibre Toxicol 2010 7 20 31 10.1186/1743-8977-7-20 20691052
22. HK-2: an immortalized proximal tubule epithelial cell line from normal adult human kidney. Ryan MJ, Johnson G, Kirk J, Fuerstenberg SM, Zager RA, Torok-Storb B, Kidney Int 1994 45 48 57 10.1038/ki.1994.6 8127021 (Pubitemid 24045991)
23. Primary human hepatocytes vs. hepatic cell line-assessing their suitability for in vitro nanotoxicology. Kermanizadeh A, Gaiser BK, Ward MB, Stone V, Nanotoxicology 2012 10.3109/17435390.2012.734341
24. Interspecies comparison on the uptake and toxicity of silver cerium dioxide nanoparticles. Gaiser BK, Fernandes TF, Jepson MA, Lead JR, Tylor CR, Baalousha M, Biswas A, Britton GJ, Cole PA, Johnston BD, Ju-Nam Y, Rosenkranz P, Scown TM, Stone V, Environ Toxicol Chem 2012 31 144 154 10.1002/etc.703 22002553
25. Genotoxic effects of silver nanoparticles stimulated by oxidative stress in human bronchial epithelial (BEAS-2B) cells. Kim HR, Kim MJ, Lee SY, Oh SM, Chung KH, Mutat Res-Gen Toxicol Environ Mutagen 2011 726 129 135 10.1016/j.mrgentox.2011.08.008 23644378
26. Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondrial involved apoptosis. Piao MJ, Kang KA, Lee IK, Kim HS, Kim S, Choi JY, Choi J, Hyun JW, Toxicol Lett 2011 201 92 100 10.1016/j.toxlet.2010.12.010 21182908
27. An in vitro liver model-accessing oxidative stress and genotoxicity following exposure of hepatocytes to a panel of engineered nanoparticles. Kermanizadeh A, Gaiser BK, Hutchison GR, Stone V, Part Fibre Toxicol 2012 9 28 10.1186/1743-8977-9-28 22812506
28. Cytotoxic and genotoxic effects of silver nanoparticles in testicular cells. Asare N, Instanes C, Sandberg WJ, Refsnes M, Schwarze P, Kruszewski M, Brunborg G, Toxicology 2012 291 65 72 10.1016/j.tox.2011.10.022 22085606
29. Cytotoxicity and oxidative stress induced by different metallic nanoparticles on human kidney cells. Pujalté I, Passagne I, Brouillaud B, Tréguer M, Durand E, Ohayon-Courtès C, L'Azou B, Part Fibre Toxicol 2011 8 10 26 10.1186/1743-8977-8-10 21371295
30. Proinflammtory/Profibiotc effects of interlukin 17A on human proximal tubule epithelium. Dudas PL, Sague SL, Elloso MM, Farrell FX, Nephron Exp Nephrol 2011 117 114 123 10.1159/000320177
31. Nutritional compounds influence tissue factor expression and inflammation of chronic kidney patients in vitro. Shing CM, Adams MJ, Fassett RG, Coombes JS, Nutrition 2011 27 967 972 10.1016/j.nut.2010.10.014 21295946
32. Evaluation of toxicity and gene expression changes triggered by oxide nanoparticles. Dua P, Chaudhari KN, Lee CH, Chaudhari NK, Hong SW, Yu JS, Kim S, Lee DK, Bull Korean Chem Soc 2011 32 2051 2057 10.5012/bkcs.2011.32.6.2051
33. Molecular mechanism of hippocampal apoptosis of mice following exposure to titanium dioxide nanoparticles. Hu RP, Zheng L, Zhang T, Gao GD, Cui YL, Cheng Z, Cheng J, Hong MM, Tang M, Hong FS, J Hazard Mater 2011 191 32 40 10.1016/j.jhazmat.2011.04.027 21570177
34. The hepatotoxicity of multi-walled carbon nanotubes in mice. Ji Z, Zhang D, Li L, Shen X, Deng X, Dong L, Wu M, Liu Y, Nanotechnology 2009 20 445101 10.1088/0957-4484/20/44/445101 19801780
35. Cytotoxicity of Titanium dioxide nanoparticles in mouse fibroblast cells. Jin CY, Zhu BS, Wang XF, Lu QH, Chem Res Toxicol 2008 21 1871 1877 10.1021/tx800179f 18680314
36. Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes. Kang SJ, Kim BM, Lee YJ, Chung HW, Environ Mol Mutagen 2008 49 399 405 10.1002/em.20399 18418868 (Pubitemid 351905182)
37. Molecular mechanism of kidney injury of mice caused by exposure to titanium dioxide nanoparticles. Gui S, Zhang Z, Zheng L, Cui Y, Liu X, Li N, Sang X, Sun Q, Gao G, Cheng Z, Wang L, Tang M, Hong F, J Hazard Mater 2011 195 365 370 21907489
38. The pro-inflammatory effects of low toxicity low solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area. Monteiller C, Tran L, MacNee W, Faux S, Jones A, Miller B, Donaldson K, Occup Environ Med 2007 64 609 615 10.1136/oem.2005.024802 17409182 (Pubitemid 47345256)
39. Effects of nanoparticle surface charge at the plasma membrane and beyond. Arvizo RR, Miranda OR, Thompson MA, Pabelick CM, Bhattacharya R, Robertson JD, Rotello VM, Prakash YS, Mukherjee P, Nano Lett 2010 10 2543 2548 10.1021/nl101140t 20533851
40. Quantification of the internalization patterns of superparamagnetic iron oxide nanoparticles with opposite charge. Schweiger C, Hartmann R, Zhang F, Parak WJ, Kissel TH, Gil PR, J Nanobiotechnology 2012 10 28 10.1186/1477-3155- 10-28 22781560
41. Effects of surface properties on nanoparticle-cell interactions. Verma A, Stellacci F, Small 2009 6 12 21
42. Impact of agglomeration and different dispersions of titanium dioxide nanoparticles on the human related in vitro cytotoxicity and genotoxicity. Magdolenova Z, Bilanicova D, Pojana G, Fjellsbo LM, Hudecova A, Hasplove K, Marcomini A, Dusinska M, J Environ Monit 2012 14 455 464 10.1039/c2em10746e 22277962
43. 2, SiC nanoparticles and multi-walled carbon nanotubes exposure in several mammalian cell types: an in vitro study. Barillet S, Simon-Deckers A, Herlin-Boime N, Mayne-L'Hermite M, Reynaud C, Cassio D, Gouget B, Carriere M, J Nanopart Res 2010 12 61 73 10.1007/s11051-009-9694-y
44. Assessment of the dermal and ocular irritation potential of multi-walled carbon nanotubes by using in vitro and in vivo methods. Kishore AS, Surekha P, Murthy PB, Toxicol Lett 2009 191 268 274 10.1016/j.toxlet.2009.09.007 19770026
45. Effects of carbon nanotubes on human monocytes. Natural compounds and their role in apoptotic cell signalling pathways. De Nicola M, Nuccitelli S, Gattia DM, Traversa E, Magrini A, Bergamaschi A, Ghibelli L, Ann N Y Acad Sci 2009 1171 600 605 10.1111/j.1749-6632.2009.04892.x 19723110
46. Multi-walled carbon nanotubes injure the plasma membrane of macrophages. Hirano S, Kanno S, Furuyama A, Toxicol Appl Pharmacol 2008 232 244 251 10.1016/j.taap.2008.06.016 18655803
47. Cytotoxicity of metal oxide nanoparticles and multiwalled carbon nanotubes to lung, kidney and liver cells. Simon A, Reynaud C, Mayne M, Herlin N, Desqueyroux H, Gouget B, Carriere M, Met Ions Biol Med 2008 10 310 314
48. Multi walled carbon nanotubes induce oxidative stress and cytotoxicity in human embryonic kidney (HEK293) cells. Reddy ARN, Reddy YN, Krishna DR, Himabindu V, Toxicology 2010 272 11 16 10.1016/j.tox.2010.03.017 20371264
49. Comparative cyto-genotoxicity assessment of functionalized and pristine multi-walled carbon nanotubes on human lung epithelial cells. Ursini CL, Cavallo D, Fresegna AM, Ciervo A, Maiello R, Buresti G, Casciardi S, Tombolini F, Bellucci S, Iavicolli S, Toxicol In Vitro 2012 26 831 840 10.1016/j.tiv.2012.05. 001 22640919
50. Multi-walled carbon nanotubes induce cytotoxicity and genotoxicity in human lung epithelial cells. Cavallo D, Fanizza C, Ursini CL, Casciardi S, Paba E, Ciervo A, Fresegna AM, Buresti G, Tombolini F, Bellucci S, Iavicolli S, J Appl Toxicol 2012 32 454 464 10.1002/jat.2711 22271384
51. Protective effects of tubular liver type fatty acid-binding protein against glomerular damage in murine IgA nephropathy. Zuo N, Suzuki Y, Sugaya T, Osaki K, Kanaguchi Y, Wang LN, Tomino Y, Nephrol Dial Transplant 2011 26 2127 2137 10.1093/ndt/gfq687 21109611
52. The effect of hydroxyethyl starches (HES 130/0.42 and HES 200/0.5) on activated renal tubular epithelial cells. Wittlinger M, Schlapfer M, De Conno E, Zgraggen BR, Reyes L, Booy C, Schimmer RC, Seifert B, Burmeister MA, Spahn DR, Beck-Schimmer B, Anesth Analg 2010 110 531 540 10.1213/ANE.0b013e3181c03c97 19910630
53. Reduction of the vitamin D hormonal system in kidney disease is associated with increased renal inflammation. Zehnder D, Quinkler M, Eardley KS, Bland R, Lepenies J, Hughes SV, Raymond NT, Howie AJ, Cockwell P, Stewart PM, Hewiston M, Kidney Int 2008 74 1343 1353 10.1038/ki.2008.453 18784644