메뉴 건너뛰기




Volumn 7, Issue 3, 2010, Pages 727-737

Toxicity pathway focused gene expression profiling of PEI-based polymers for pulmonary applications

Author keywords

Gene expression profiling; Inflammation; Poly(ethylene imine); Pulmonaryapplication; Toxicity

Indexed keywords

LACTATE DEHYDROGENASE; MACROGOL; MESSENGER RNA; POLYETHYLENEIMINE; POLYMER; PROTEIN; REACTIVE OXYGEN METABOLITE; SILICON DIOXIDE; TUMOR NECROSIS FACTOR; ZINC OXIDE;

EID: 77953303124     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp900278x     Document Type: Article
Times cited : (113)

References (57)
  • 1
    • 76749124750 scopus 로고    scopus 로고
    • Using viral vectors as gene transfer tools (Cell Biology and Toxicology Special Issue: ETCS-UK 1 day meeting on genetic manipulation of cells)
    • Howarth, J. L.; Lee, Y. B.; Uney, J. B. Using viral vectors as gene transfer tools (Cell Biology and Toxicology Special Issue: ETCS-UK 1 day meeting on genetic manipulation of cells) Cell Biol. Toxicol. 2010, 26, 1-20
    • (2010) Cell Biol. Toxicol. , vol.26 , pp. 1-20
    • Howarth, J.L.1    Lee, Y.B.2    Uney, J.B.3
  • 2
    • 50549090204 scopus 로고    scopus 로고
    • Advances in high-capacity extrachromosomal vector technology: Episomal maintenance, vector delivery, and transgene expression
    • Lufino, M. M.; Edser, P. A.; Wade-Martins, R. Advances in high-capacity extrachromosomal vector technology: episomal maintenance, vector delivery, and transgene expression Mol. Ther. 2008, 16 (9) 1525-38
    • (2008) Mol. Ther. , vol.16 , Issue.9 , pp. 1525-38
    • Lufino, M.M.1    Edser, P.A.2    Wade-Martins, R.3
  • 3
    • 19744372388 scopus 로고    scopus 로고
    • Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis
    • Akinc, A.; Thomas, M.; Klibanov, A. M.; Langer, R. Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis J. Gene Med. 2005, 7 (5) 657-63
    • (2005) J. Gene Med. , vol.7 , Issue.5 , pp. 657-63
    • Akinc, A.1    Thomas, M.2    Klibanov, A.M.3    Langer, R.4
  • 4
    • 67249096677 scopus 로고    scopus 로고
    • Nonviral methods for siRNA delivery
    • Gao, K.; Huang, L. Nonviral methods for siRNA delivery Mol. Pharmaceutics 2009, 6 (3) 651-8
    • (2009) Mol. Pharmaceutics , vol.6 , Issue.3 , pp. 651-8
    • Gao, K.1    Huang, L.2
  • 5
    • 9644290900 scopus 로고    scopus 로고
    • Modified polyethylenimines as non-viral gene delivery systems for aerosol gene therapy: Investigations of the complex structure and stability during air-jet and ultrasonic nebulization
    • Kleemann, E.; Dailey, L. A.; Abdelhady, H. G.; Gessler, T.; Schmehl, T.; Roberts, C. J.; Davies, M. C.; Seeger, W.; Kissel, T. Modified polyethylenimines as non-viral gene delivery systems for aerosol gene therapy: investigations of the complex structure and stability during air-jet and ultrasonic nebulization J. Controlled Release 2004, 100 (3) 437-50
    • (2004) J. Controlled Release , vol.100 , Issue.3 , pp. 437-50
    • Kleemann, E.1    Dailey, L.A.2    Abdelhady, H.G.3    Gessler, T.4    Schmehl, T.5    Roberts, C.J.6    Davies, M.C.7    Seeger, W.8    Kissel, T.9
  • 6
    • 0036077937 scopus 로고    scopus 로고
    • Polyethylenimine- graft -poly(ethylene glycol) copolymers: Influence of copolymer block structure on DNA complexation and biological activities as gene delivery system
    • Petersen, H.; Fechner, P. M.; Martin, A. L.; Kunath, K.; Stolnik, S.; Roberts, C. J.; Fischer, D.; Davies, M. C.; Kissel, T. Polyethylenimine- graft -poly(ethylene glycol) copolymers: influence of copolymer block structure on DNA complexation and biological activities as gene delivery system Bioconjugate Chem. 2002, 13 (4) 845-54
    • (2002) Bioconjugate Chem. , vol.13 , Issue.4 , pp. 845-54
    • Petersen, H.1    Fechner, P.M.2    Martin, A.L.3    Kunath, K.4    Stolnik, S.5    Roberts, C.J.6    Fischer, D.7    Davies, M.C.8    Kissel, T.9
  • 7
    • 47749100430 scopus 로고    scopus 로고
    • Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity
    • Zintchenko, A.; Philipp, A.; Dehshahri, A.; Wagner, E. Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity Bioconjugate Chem. 2008, 19 (7) 1448-55
    • (2008) Bioconjugate Chem. , vol.19 , Issue.7 , pp. 1448-55
    • Zintchenko, A.1    Philipp, A.2    Dehshahri, A.3    Wagner, E.4
  • 8
    • 0034219238 scopus 로고    scopus 로고
    • In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers
    • Rudolph, C.; Lausier, J.; Naundorf, S.; Muller, R. H.; Rosenecker, J. In vivo gene delivery to the lung using polyethylenimine and fractured polyamidoamine dendrimers J. Gene Med. 2000, 2 (4) 269-78
    • (2000) J. Gene Med. , vol.2 , Issue.4 , pp. 269-78
    • Rudolph, C.1    Lausier, J.2    Naundorf, S.3    Muller, R.H.4    Rosenecker, J.5
  • 9
    • 65949094345 scopus 로고    scopus 로고
    • Toxicogenomics to improve comprehension of the mechanisms underlying responses of in vitro and in vivo systems to nanomaterials: A review
    • Poma, A.; Di Giorgio, M. L. Toxicogenomics to improve comprehension of the mechanisms underlying responses of in vitro and in vivo systems to nanomaterials: a review Curr. Genomics 2008, 9 (8) 571-85
    • (2008) Curr. Genomics , vol.9 , Issue.8 , pp. 571-85
    • Poma, A.1    Di Giorgio, M.L.2
  • 10
    • 42649099670 scopus 로고    scopus 로고
    • Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways
    • Xia, T.; Kovochich, M.; Liong, M.; Zink, J. I.; Nel, A. E. Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways ACS Nano 2008, 2 (1) 85-96
    • (2008) ACS Nano , vol.2 , Issue.1 , pp. 85-96
    • Xia, T.1    Kovochich, M.2    Liong, M.3    Zink, J.I.4    Nel, A.E.5
  • 11
    • 0346634895 scopus 로고    scopus 로고
    • In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis
    • Fischer, D.; Li, Y.; Ahlemeyer, B.; Krieglstein, J.; Kissel, T. In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis Biomaterials 2003, 24 (7) 1121-31
    • (2003) Biomaterials , vol.24 , Issue.7 , pp. 1121-31
    • Fischer, D.1    Li, Y.2    Ahlemeyer, B.3    Krieglstein, J.4    Kissel, T.5
  • 14
    • 60549086379 scopus 로고    scopus 로고
    • In vitro cytotoxic and immunomodulatory profiling of low molecular weight polyethylenimines for pulmonary application
    • Beyerle, A.; Hobel, S.; Czubayko, F.; Schulz, H.; Kissel, T.; Aigner, A.; Stoeger, T. In vitro cytotoxic and immunomodulatory profiling of low molecular weight polyethylenimines for pulmonary application Toxicol. in Vitro 2009, 23 (3) 500-8
    • (2009) Toxicol. in Vitro , vol.23 , Issue.3 , pp. 500-8
    • Beyerle, A.1    Hobel, S.2    Czubayko, F.3    Schulz, H.4    Kissel, T.5    Aigner, A.6    Stoeger, T.7
  • 15
    • 0036736960 scopus 로고    scopus 로고
    • Copolymers of ethylene imine and N-(2-hydroxyethyl)-ethylene imine as tools to study effects of polymer structure on physicochemical and biological properties of DNA complexes
    • Fischer, D.; von Harpe, A.; Kunath, K.; Petersen, H.; Li, Y.; Kissel, T. Copolymers of ethylene imine and N-(2-hydroxyethyl)-ethylene imine as tools to study effects of polymer structure on physicochemical and biological properties of DNA complexes Bioconjugate Chem. 2002, 13 (5) 1124-33
    • (2002) Bioconjugate Chem. , vol.13 , Issue.5 , pp. 1124-33
    • Fischer, D.1    Von Harpe, A.2    Kunath, K.3    Petersen, H.4    Li, Y.5    Kissel, T.6
  • 16
    • 31544468071 scopus 로고    scopus 로고
    • Physiochemical properties of low and high molecular weight poly(ethylene glycol)-grafted poly(ethylene imine) copolymers and their complexes with oligonucleotides
    • Glodde, M.; Sirsi, S. R.; Lutz, G. J. Physiochemical properties of low and high molecular weight poly(ethylene glycol)-grafted poly(ethylene imine) copolymers and their complexes with oligonucleotides Biomacromolecules 2006, 7 (1) 347-56
    • (2006) Biomacromolecules , vol.7 , Issue.1 , pp. 347-56
    • Glodde, M.1    Sirsi, S.R.2    Lutz, G.J.3
  • 17
    • 20444441841 scopus 로고    scopus 로고
    • Synthesis, characterization and cytotoxicity of poly(ethylene glycol)- graft -trimethyl chitosan block copolymers
    • Mao, S.; Shuai, X.; Unger, F.; Wittmar, M.; Xie, X.; Kissel, T. Synthesis, characterization and cytotoxicity of poly(ethylene glycol)- graft -trimethyl chitosan block copolymers Biomaterials 2005, 26 (32) 6343-56
    • (2005) Biomaterials , vol.26 , Issue.32 , pp. 6343-56
    • Mao, S.1    Shuai, X.2    Unger, F.3    Wittmar, M.4    Xie, X.5    Kissel, T.6
  • 18
    • 33646152349 scopus 로고    scopus 로고
    • Melittin analogs with high lytic activity at endosomal pH enhance transfection with purified targeted PEI polyplexes
    • Boeckle, S.; Fahrmeir, J.; Roedl, W.; Ogris, M.; Wagner, E. Melittin analogs with high lytic activity at endosomal pH enhance transfection with purified targeted PEI polyplexes J. Controlled Release 2006, 112 (2) 240-8
    • (2006) J. Controlled Release , vol.112 , Issue.2 , pp. 240-8
    • Boeckle, S.1    Fahrmeir, J.2    Roedl, W.3    Ogris, M.4    Wagner, E.5
  • 19
    • 34548653510 scopus 로고    scopus 로고
    • Electrophoretic purification of tumor-targeted polyethylenimine-based polyplexes reduces toxic side effects in vivo
    • Fahrmeir, J.; Gunther, M.; Tietze, N.; Wagner, E.; Ogris, M. Electrophoretic purification of tumor-targeted polyethylenimine-based polyplexes reduces toxic side effects in vivo J. Controlled Release 2007, 122 (3) 236-45
    • (2007) J. Controlled Release , vol.122 , Issue.3 , pp. 236-45
    • Fahrmeir, J.1    Gunther, M.2    Tietze, N.3    Wagner, E.4    Ogris, M.5
  • 20
    • 71049193822 scopus 로고    scopus 로고
    • PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application: Structure-function-relationships
    • Beyerle, A.; Merkel, O. M.; Stoeger, T.; Kissel, T. PEGylation affects cytotoxicity and cell-compatibility of poly(ethylene imine) for lung application: structure-function-relationships Toxicol. Appl. Pharmacol. 2010, 242, 146-54
    • (2010) Toxicol. Appl. Pharmacol. , vol.242 , pp. 146-54
    • Beyerle, A.1    Merkel, O.M.2    Stoeger, T.3    Kissel, T.4
  • 21
    • 64349101066 scopus 로고    scopus 로고
    • Critical role of MARCO in crystalline silica-induced pulmonary inflammation
    • Thakur, S. A.; Beamer, C. A.; Migliaccio, C. T.; Holian, A. Critical role of MARCO in crystalline silica-induced pulmonary inflammation Toxicol. Sci. 2009, 108 (2) 462-71
    • (2009) Toxicol. Sci. , vol.108 , Issue.2 , pp. 462-71
    • Thakur, S.A.1    Beamer, C.A.2    Migliaccio, C.T.3    Holian, A.4
  • 22
    • 4444360520 scopus 로고    scopus 로고
    • Signaling pathways controlling the production of inflammatory mediators in response to crystalline silica exposure: Role of reactive oxygen/nitrogen species
    • Castranova, V. Signaling pathways controlling the production of inflammatory mediators in response to crystalline silica exposure: role of reactive oxygen/nitrogen species Free Radical Biol. Med. 2004, 37 (7) 916-25
    • (2004) Free Radical Biol. Med. , vol.37 , Issue.7 , pp. 916-25
    • Castranova, V.1
  • 23
    • 56049106549 scopus 로고    scopus 로고
    • Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties
    • Xia, T.; Kovochich, M.; Liong, M.; Madler, L.; Gilbert, B.; Shi, H.; Yeh, J. I.; Zink, J. I.; Nel, A. E. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties ACS Nano 2008, 2 (10) 2121-34
    • (2008) ACS Nano , vol.2 , Issue.10 , pp. 2121-34
    • Xia, T.1    Kovochich, M.2    Liong, M.3    Madler, L.4    Gilbert, B.5    Shi, H.6    Yeh, J.I.7    Zink, J.I.8    Nel, A.E.9
  • 24
    • 0027622211 scopus 로고
    • Metal fume fever
    • Gordon, T.; Fine, J. M. Metal fume fever Occup. Med. 1993, 8 (3) 504-17
    • (1993) Occup. Med. , vol.8 , Issue.3 , pp. 504-17
    • Gordon, T.1    Fine, J.M.2
  • 25
    • 0031933162 scopus 로고    scopus 로고
    • Novel aspect on metal fume fever: Zinc stimulates oxygen radical formation in human neutrophils
    • Lindahl, M.; Leanderson, P.; Tagesson, C. Novel aspect on metal fume fever: zinc stimulates oxygen radical formation in human neutrophils Hum. Exp. Toxicol. 1998, 17 (2) 105-10
    • (1998) Hum. Exp. Toxicol. , vol.17 , Issue.2 , pp. 105-10
    • Lindahl, M.1    Leanderson, P.2    Tagesson, C.3
  • 26
    • 41549129392 scopus 로고    scopus 로고
    • The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles
    • Li, N.; Xia, T.; Nel, A. E. The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles Free Radical Biol. Med. 2008, 44 (9) 1689-99
    • (2008) Free Radical Biol. Med. , vol.44 , Issue.9 , pp. 1689-99
    • Li, N.1    Xia, T.2    Nel, A.E.3
  • 27
    • 31944451232 scopus 로고    scopus 로고
    • Toxic potential of materials at the nanolevel
    • Nel, A.; Xia, T.; Madler, L.; Li, N. Toxic potential of materials at the nanolevel Science 2006, 311 (5761) 622-7
    • (2006) Science , vol.311 , Issue.5761 , pp. 622-7
    • Nel, A.1    Xia, T.2    Madler, L.3    Li, N.4
  • 28
    • 0037183605 scopus 로고    scopus 로고
    • Synthesis, characterization, and biocompatibility of polyethylenimine- graft -poly(ethylene glycol) block copolymers
    • Petersen, H.; Fechner, P. M.; Fischer, D.; Kissel, T. Synthesis, Characterization, and Biocompatibility of Polyethylenimine- graft -poly(ethylene glycol) Block Copolymers Macromolecules 2002, 35 (18) 6867-6874
    • (2002) Macromolecules , vol.35 , Issue.18 , pp. 6867-6874
    • Petersen, H.1    Fechner, P.M.2    Fischer, D.3    Kissel, T.4
  • 29
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J. Immunol. Methods 1983, 65 (1-2) 55-63
    • (1983) J. Immunol. Methods , vol.65 , Issue.1-2 , pp. 55-63
    • Mosmann, T.1
  • 30
    • 0345367901 scopus 로고    scopus 로고
    • HPMA copolymer bound adriamycin overcomes MDR1 gene encoded resistance in a human ovarian carcinoma cell line
    • Minko, T.; Kopeckova, P.; Pozharov, V.; Kopecek, J. HPMA copolymer bound adriamycin overcomes MDR1 gene encoded resistance in a human ovarian carcinoma cell line J. Controlled Release 1998, 54 (2) 223-33
    • (1998) J. Controlled Release , vol.54 , Issue.2 , pp. 223-33
    • Minko, T.1    Kopeckova, P.2    Pozharov, V.3    Kopecek, J.4
  • 32
    • 33747839466 scopus 로고    scopus 로고
    • CARMAweb: Comprehensive R- and bioconductor-based web service for microarray data analysis
    • WEB SERVER ISSUE
    • Rainer, J.; Sanchez-Cabo, F.; Stocker, G.; Sturn, A.; Trajanoski, Z. CARMAweb: comprehensive R- and bioconductor-based web service for microarray data analysis Nucleic Acids Res. 2006, 34 (Web Server issue) W498-503
    • (2006) Nucleic Acids Res. , vol.34 , pp. 498-503
    • Rainer, J.1    Sanchez-Cabo, F.2    Stocker, G.3    Sturn, A.4    Trajanoski, Z.5
  • 33
    • 4444304469 scopus 로고    scopus 로고
    • Validation and comparative analysis of a multiplexed assay for the simultaneous quantitative measurement of Th1/Th2 cytokines in human serum and human peripheral blood mononuclear cell culture supernatants
    • Prabhakar, U.; Eirikis, E.; Reddy, M.; Silvestro, E.; Spitz, S.; Pendley, C., 2nd; Davis, H. M.; Miller, B. E. Validation and comparative analysis of a multiplexed assay for the simultaneous quantitative measurement of Th1/Th2 cytokines in human serum and human peripheral blood mononuclear cell culture supernatants J. Immunol. Methods 2004, 291 (1-2) 27-38
    • (2004) J. Immunol. Methods , vol.291 , Issue.1-2 , pp. 27-38
    • Prabhakar, U.1    Eirikis, E.2    Reddy, M.3    Silvestro, E.4    Spitz, S.5    Pendley II, C.6    Davis, H.M.7    Miller, B.E.8
  • 34
    • 0032124337 scopus 로고    scopus 로고
    • The quartz hazard: A variable entity
    • Donaldson, K.; Borm, P. J. The quartz hazard: a variable entity Ann. Occup. Hyg. 1998, 42 (5) 287-94
    • (1998) Ann. Occup. Hyg. , vol.42 , Issue.5 , pp. 287-94
    • Donaldson, K.1    Borm, P.J.2
  • 35
    • 34347234840 scopus 로고    scopus 로고
    • Assessing toxicity of fine and nanoparticles: Comparing in vitro measurements to in vivo pulmonary toxicity profiles
    • Sayes, C. M.; Reed, K. L.; Warheit, D. B. Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles Toxicol. Sci. 2007, 97 (1) 163-80
    • (2007) Toxicol. Sci. , vol.97 , Issue.1 , pp. 163-80
    • Sayes, C.M.1    Reed, K.L.2    Warheit, D.B.3
  • 36
    • 0025830625 scopus 로고
    • Respiratory involvement in metal fume fever
    • Nemery, B.; Demedts, M. Respiratory involvement in metal fume fever Eur. Respir. J. 1991, 4 (6) 764-5
    • (1991) Eur. Respir. J. , vol.4 , Issue.6 , pp. 764-5
    • Nemery, B.1    Demedts, M.2
  • 37
    • 0029789793 scopus 로고    scopus 로고
    • Activation of the complement system by synthetic DNA complexes: A potential barrier for intravenous gene delivery
    • Plank, C.; Mechtler, K.; Szoka, F. C., Jr.; Wagner, E. Activation of the complement system by synthetic DNA complexes: a potential barrier for intravenous gene delivery Hum. Gene Ther. 1996, 7 (12) 1437-46
    • (1996) Hum. Gene Ther. , vol.7 , Issue.12 , pp. 1437-46
    • Plank, C.1    Mechtler, K.2    Szoka Jr., F.C.3    Wagner, E.4
  • 38
    • 0032761712 scopus 로고    scopus 로고
    • Influence of zinc on protein metabolism in various lung cell lines
    • Walthera, U. I.; Fortha, W. Influence of zinc on protein metabolism in various lung cell lines Toxicol. in Vitro 1999, 13 (6) 905-914
    • (1999) Toxicol. in Vitro , vol.13 , Issue.6 , pp. 905-914
    • Walthera, U.I.1    Fortha, W.2
  • 39
    • 0036694663 scopus 로고    scopus 로고
    • Regulation of cytokine signaling and inflammation
    • Hanada, T.; Yoshimura, A. Regulation of cytokine signaling and inflammation Cytokine Growth Factor Rev. 2002, 13 (4-5) 413-21
    • (2002) Cytokine Growth Factor Rev. , vol.13 , Issue.4-5 , pp. 413-21
    • Hanada, T.1    Yoshimura, A.2
  • 40
    • 13144269596 scopus 로고    scopus 로고
    • Life, death and E2F: Linking proliferation control and DNA damage signaling via E2F1
    • Rogoff, H. A.; Kowalik, T. F. Life, death and E2F: linking proliferation control and DNA damage signaling via E2F1 Cell Cycle 2004, 3 (7) 845-6
    • (2004) Cell Cycle , vol.3 , Issue.7 , pp. 845-6
    • Rogoff, H.A.1    Kowalik, T.F.2
  • 42
    • 34548029170 scopus 로고    scopus 로고
    • Involvement of the CDK2-E2F1 pathway in cisplatin cytotoxicity in vitro and in vivo
    • Yu, F.; Megyesi, J.; Safirstein, R. L.; Price, P. M. Involvement of the CDK2-E2F1 pathway in cisplatin cytotoxicity in vitro and in vivo Am. J. Physiol. 2007, 293 (1) F52-9
    • (2007) Am. J. Physiol. , vol.293 , Issue.1 , pp. 52-9
    • Yu, F.1    Megyesi, J.2    Safirstein, R.L.3    Price, P.M.4
  • 43
    • 70450162982 scopus 로고    scopus 로고
    • Differences of inflammatory mechanisms in asthma and COPD
    • Ichinose, M. Differences of inflammatory mechanisms in asthma and COPD Allergol. Int. 2009, 58 (3) 307-13
    • (2009) Allergol. Int. , vol.58 , Issue.3 , pp. 307-13
    • Ichinose, M.1
  • 44
    • 1542511346 scopus 로고    scopus 로고
    • Evaluation of generation 2 and 3 poly(propylenimine) dendrimers for the potential cellular delivery of antisense oligonucleotides targeting the epidermal growth factor receptor
    • Hollins, A. J.; Benboubetra, M.; Omidi, Y.; Zinselmeyer, B. H.; Schatzlein, A. G.; Uchegbu, I. F.; Akhtar, S. Evaluation of generation 2 and 3 poly(propylenimine) dendrimers for the potential cellular delivery of antisense oligonucleotides targeting the epidermal growth factor receptor Pharm. Res. 2004, 21 (3) 458-66
    • (2004) Pharm. Res. , vol.21 , Issue.3 , pp. 458-66
    • Hollins, A.J.1    Benboubetra, M.2    Omidi, Y.3    Zinselmeyer, B.H.4    Schatzlein, A.G.5    Uchegbu, I.F.6    Akhtar, S.7
  • 45
    • 33644908033 scopus 로고    scopus 로고
    • Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene delivery
    • Regnstrom, K.; Ragnarsson, E. G.; Fryknas, M.; Koping-Hoggard, M.; Artursson, P. Gene expression profiles in mouse lung tissue after administration of two cationic polymers used for nonviral gene delivery Pharm. Res. 2006, 23 (3) 475-82
    • (2006) Pharm. Res. , vol.23 , Issue.3 , pp. 475-82
    • Regnstrom, K.1    Ragnarsson, E.G.2    Fryknas, M.3    Koping-Hoggard, M.4    Artursson, P.5
  • 46
    • 33847153016 scopus 로고    scopus 로고
    • The gene-silencing effect of siRNA in cationic lipoplexes is enhanced by incorporating pDNA in the complex
    • Tagami, T.; Barichello, J. M.; Kikuchi, H.; Ishida, T.; Kiwada, H. The gene-silencing effect of siRNA in cationic lipoplexes is enhanced by incorporating pDNA in the complex Int. J. Pharm. 2007, 333 (1-2) 62-9
    • (2007) Int. J. Pharm. , vol.333 , pp. 62-9
    • Tagami, T.1    Barichello, J.M.2    Kikuchi, H.3    Ishida, T.4    Kiwada, H.5
  • 47
    • 0347756922 scopus 로고    scopus 로고
    • Toxicogenomics of non-viral vectors for gene therapy: A microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells
    • Omidi, Y.; Hollins, A. J.; Benboubetra, M.; Drayton, R.; Benter, I. F.; Akhtar, S. Toxicogenomics of non-viral vectors for gene therapy: a microarray study of lipofectin- and oligofectamine-induced gene expression changes in human epithelial cells J. Drug Targeting 2003, 11 (6) 311-23
    • (2003) J. Drug Targeting , vol.11 , Issue.6 , pp. 311-23
    • Omidi, Y.1    Hollins, A.J.2    Benboubetra, M.3    Drayton, R.4    Benter, I.F.5    Akhtar, S.6
  • 48
    • 1842586740 scopus 로고    scopus 로고
    • Current hypotheses on the mechanisms of toxicity of ultrafine particles
    • Donaldson, K.; Stone, V. Current hypotheses on the mechanisms of toxicity of ultrafine particles Ann. Ist. Super. Sanita 2003, 39 (3) 405-10
    • (2003) Ann. Ist. Super. Sanita , vol.39 , Issue.3 , pp. 405-10
    • Donaldson, K.1    Stone, V.2
  • 49
    • 33644746349 scopus 로고    scopus 로고
    • Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice
    • Stoeger, T.; Reinhard, C.; Takenaka, S.; Schroeppel, A.; Karg, E.; Ritter, B.; Heyder, J.; Schulz, H. Instillation of six different ultrafine carbon particles indicates a surface area threshold dose for acute lung inflammation in mice Environ. Health Perspect. 2006, 114 (3) 328-33
    • (2006) Environ. Health Perspect. , vol.114 , Issue.3 , pp. 328-33
    • Stoeger, T.1    Reinhard, C.2    Takenaka, S.3    Schroeppel, A.4    Karg, E.5    Ritter, B.6    Heyder, J.7    Schulz, H.8
  • 51
    • 0037289178 scopus 로고    scopus 로고
    • Vermylen josef, nemery benoit. Size effect of intratracheally instilled particles on pulmonary inflammation and vascular thrombosis
    • Nemmar, A. H. M. F.; Hoet Peter, H. M. Vermylen Josef, Nemery Benoit. Size effect of intratracheally instilled particles on pulmonary inflammation and vascular thrombosis Toxicol. Appl. Pharmacol. 2003, 186, 38-45
    • (2003) Toxicol. Appl. Pharmacol. , vol.186 , pp. 38-45
    • Nemmar, A.H.M.F.1    Hoet Peter, H.M.2
  • 52
    • 63449124229 scopus 로고    scopus 로고
    • Cytokine and chemokine expression patterns in lung epithelial cells exposed to components characteristic of particulate air pollution
    • Ovrevik, J.; Lag, M.; Holme, J. A.; Schwarze, P. E.; Refsnes, M. Cytokine and chemokine expression patterns in lung epithelial cells exposed to components characteristic of particulate air pollution Toxicology 2009, 259 (1-2) 46-53
    • (2009) Toxicology , vol.259 , Issue.1-2 , pp. 46-53
    • Ovrevik, J.1    Lag, M.2    Holme, J.A.3    Schwarze, P.E.4    Refsnes, M.5
  • 53
    • 35349019375 scopus 로고    scopus 로고
    • Pulmonary toxicity screening studies in male rats with M5 respirable fibers and particulates
    • Warheit, D. B.; Webb, T. R.; Reed, K. L. Pulmonary toxicity screening studies in male rats with M5 respirable fibers and particulates Inhalation Toxicol. 2007, 19 (11) 951-63
    • (2007) Inhalation Toxicol. , vol.19 , Issue.11 , pp. 951-63
    • Warheit, D.B.1    Webb, T.R.2    Reed, K.L.3
  • 54
    • 24944434257 scopus 로고    scopus 로고
    • Synthetic anticancer gene medicine exploits intrinsic antitumor activity of cationic vector to cure established tumors
    • Dufes, C.; Keith, W. N.; Bilsland, A.; Proutski, I.; Uchegbu, I. F.; Schatzlein, A. G. Synthetic anticancer gene medicine exploits intrinsic antitumor activity of cationic vector to cure established tumors Cancer Res. 2005, 65 (18) 8079-84
    • (2005) Cancer Res. , vol.65 , Issue.18 , pp. 8079-84
    • Dufes, C.1    Keith, W.N.2    Bilsland, A.3    Proutski, I.4    Uchegbu, I.F.5    Schatzlein, A.G.6
  • 55
    • 0015023456 scopus 로고
    • Polycation- treated tumor cells in vivo and in vitro
    • Moroson, H. Polycation- treated tumor cells in vivo and in vitro Cancer Res. 1971, 31 (3) 373-80
    • (1971) Cancer Res. , vol.31 , Issue.3 , pp. 373-80
    • Moroson, H.1
  • 56
    • 33645982602 scopus 로고    scopus 로고
    • Non-viral cancer gene therapy: Beyond delivery
    • Akhtar, S. Non-viral cancer gene therapy: beyond delivery Gene Ther. 2006, 13 (9) 739-40
    • (2006) Gene Ther. , vol.13 , Issue.9 , pp. 739-40
    • Akhtar, S.1
  • 57
    • 0026138425 scopus 로고
    • Synthetic polymers with intrinsic anticancer activity
    • Seymour, L. Synthetic Polymers with Intrinsic Anticancer Activity J. Bioact. Compat. Polym. 1991, 6, 178
    • (1991) J. Bioact. Compat. Polym. , vol.6 , pp. 178
    • Seymour, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.