Distribution and toxicity evaluation of ZnO dispersion nanoparticles in single intravenously exposed mice

Journal of Medical Investigation

Volumn 62, Issue 1-2, 2015, Pages 45-50

  Fujihara, Junko ^a   Tongu, Miki ^b   Hashimoto, Hideki ^c   Yamada, Takaya ^d   Kimura Kataoka, Kaori ^a   Yasuda, Toshihiro ^e   Fujita, Yasuhisa ^c   Takeshita, Haruo ^a  

^a Department of Legal Medicine ^*  (Japan)

^b Shin Yamanote Hospital   (Japan)

^c SHIMANE UNIVERSITY   (Japan)

^d Department of Experimental Animals Center for Integrated Research in Science   (Japan)

^e UNIVERSITY OF FUKUI   (Japan)

Author keywords

Acute toxicity; Intravenous injection; Nanoparticles; Tissue distribution; ZnO

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ZINC OXIDE NANOPARTICLE; METAL NANOPARTICLE; ZINC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BLOOD LEVEL; CHEMICAL REACTION KINETICS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; LETHAL DOSE; LIVER; LUNG; LUNG EMPHYSEMA; NONHUMAN; OXIDATIVE STRESS; PARTICLE SIZE; PHAGOCYTOSIS; SPLEEN; TISSUE DISTRIBUTION; TOXICITY TESTING; URINE LEVEL; ANIMAL; DNA DAMAGE; DRUG EFFECTS; INSTITUTE FOR CANCER RESEARCH MOUSE; INTRAVENOUS DRUG ADMINISTRATION; LD50; MOUSE;

MUS;

ANIMALS; DNA DAMAGE; FEMALE; INJECTIONS, INTRAVENOUS; LETHAL DOSE 50; METAL NANOPARTICLES; MICE; MICE, INBRED ICR; OXIDATIVE STRESS; TISSUE DISTRIBUTION; ZINC OXIDE;

EID: 84925873280     PISSN: 13431420     EISSN: 13496867     Source Type: Journal    
DOI: 10.2152/jmi.62.45     Document Type: Article

References (28)

1. Tsukazaki A, Kubota M, Ohtomo A, Onuma T, Ohtani K, Ohno H, Cichibu SF, Kawasaki M: Blue light-emitting diode based on ZnO. Jpn J Appl Phys 44: L 643-645, 2005
2. Kim YJ, Yoo J, Kwon BH, Hong YJ, Lee C, Yi G: Positioncontrolled ZnO nanoflower arrays grown on glass substrates for electron emitter application. Nanotechnology 19: 315202, 2008
3. Kotecha M, Veeman W, Roche B, Tausch M: NMR investigations of silane-coated nano sized ZnO particles. Microporous Mesoporous Mat 95: 66-75, 2006
4. Senthilkumar O, Yamauchi K, Senthilkumar K, Yamane T, Fujita Y, Nishimoto N: UV-blue light emission from ZnO nanoparticles. J Korean Phys Soc 53: 46-49, 2008
5. Senthilkumar K, Senthilkumar O, Yamauchi K, Sato M, Morito S, Ohba T, Nakamura M, Fujita Y: Preparation of ZnO nanoparticles for bio-imaging applications. Physica Status Solidi B-Basic Solid State Physics 246: 885-888, 2009
6. Sato M, Harada H, Morito S, Fujita Y, Shimosaki S, Urano T, Nakamura M: Preparation, characterization and properties of novel covalently surface-functionalized zinc oxide nanoparticles. Appl Surface Sci 256: 4497-4501, 2010
7. Sato M, Shimatani K, Iwasaki Y, Morito S, Tanaka H, Fujita Y, Nakamura M: New surface-modified zinc oxide nanoparticles with aminotriethylene oxide chains linked by 1,2,3-triazole ring: Preparation, and visible light-emitting and noncytotoxic properties. Appl Surface Sci 258: 786-790, 2011
8. Gao L, Yang ST, Li S, Meng Y, Wang H, Lei H: Acute toxicity of zinc oxide nanoparticles to the rat olfactory system after intranasal instillation. J Appl Toxicol 33: 1079-1088, 2013
9. Fukui H, Horie M, Endoh S, Kato H, Fujita K, Nishio K, Komaba LK, Maru J, Miyauhi A, Nakamura A, Kinugasa S, Yoshida Y, Hagihara Y, Iwahashi H: Association of zinc ion release and oxidative stress induced by intratracheal instillation of ZnO nanoparticles to rat lung. Chem Biol Interact 198: 29-37, 2012
10. Esmaeillou M, Moharamnejad M, Hsankhani R, Tehrani AA, Maadi H: Toxicity of ZnO nanoparticles in healthy adult mice. Environ Toxicol Pharmacol 35: 67-71, 2013
11. Smijs TG, Bouwstra JA: Focus on skin as a possible port of entry for solid nanoparticles and the toxicological impact. J Biomed Nanotechnol 6: 469-484, 2010
12. Huang CC, Aronstam RS, Chen DR, Huang YW: Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles. Toxicol In Vitro 24: 45-55, 2010
13. Lin W, Xu Y, Huang CC, Ma Y, Shannon K, Chen DR, Huang YW: Toxicity of nano- and micro-sized ZnO particles in human lung epithelial cells. J Nanopart Res 11; 25-39, 2009
14. Honda M, Yamada Y, Tomonaga M, Ichinose H, Kamihira S: Correlation of urinary 8-hydroxy-2’ -deoxyguanosine (8- OHdG), a biomarker of oxidative DNA damage, and clinical features of hematological disorders: a pilot study. Leuk Res 24: 461-468, 2000
15. Litchfield JT, Wilcoxon F: A simplified method of evaluating dose-effect experiments. J Pharmacol 96: 99-113, 1949
16. De Jong WH, Hagens WI, Krystek P, Burger MC, Sips AJAM, Geertsma RE: Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 29: 1912-1919, 2008
17. Lankveld DP, Oomen AG, Krystek P, Neigh A, Troost-de Jong A, Noorlander CW, Van Eijkeren JC, Geertsma RE, De Jong WH: The kinetics of the tissue distribution of silver nanoparticles of different sizes. Biomaterials 31: 8350-8361, 2010
18. Xie G, Wang C, Sun J, Zhong G: Tissue distribution and excretion of intravenously administered titanium dioxide nanoparticles. Toxicol Lett. 205: 55-6, 2011
19. Yang RS, Chang LW, Wu JP, Tsai MH, Wang HJ, Kuo YC, Yeh TK, Yang CS, Lin P: Persistent tissue kinetics and redistribution of nanoparticles, quantum dots 705, in mice: ICPMS quantitative assessment. Environ Health Perspect 115: 1339-1343, 2007
20. Saba TM: Physiological and phusiopathology of the reticuloendthelial system. Arch Intern Med 126: 1031-1052, 1970
21. Opanasopit P, Nishikawa M, Hashida M: Factors affecting drug and gene delivery: effects of interaction with blood components. Crit Rev Ther Drug Carrier Syst 19: 191-233, 2002
22. Baek M, Chung HE, Yu J, Lee JA, Kim TH, Oh JM, Lee WJ, Paek SM, Lee JK, Jeong J, Choy JH, Choi SJ: Pharmacokinetics, tissue distribution, and excretion of zinc oxide nanoparticles. Int J Nanomedicine 7: 3081-3097, 2012
23. Huang CC, Aronstam RS, Chen DR, Huang YW: Oxidative stress, calcium homeostasis, and altered gene expression in human lung epithelial cells exposed to ZnO nanoparticles. Toxicol In Vitro, 24: 45-55, 2010
24. Song W, Zhang J, Guo J, Zhang J, Ding F, Li L, Sun Z: Role of the dissolved zinc ion and reactive oxygen species in cytotoxicity of ZnO nanoparticles. Toxicol Lett 199: 389-397, 2010
25. Xia T, Kovochich M, Liong M, Mädler L, Gilbert B, Shi H, Yeh JI, Zink JI, Nel AE: Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano, 2: 2121-2134, 2008
26. Hwang ES, Kim GH: Biomarkers for oxidative stress status of DNA, lipids, and proteins in vitro and in vivo cancer research. Toxicol 229: 1-10, 2007
27. Ninomiya M, Kajiguchi T, Yamamoto K, Kinoshita T, Emi N, Naoe T: Increased oxidative DNA products in patients with acute promyelocytic leukemia during arsenic therapy. Haematologica 91: 1571-1572, 2006
28. Park EJ, Park K: Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicol Lett 184: 18-25, 2009