Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes

Particle and Fibre Toxicology

Volumn 8, Issue , 2011, Pages

  Cho, Wan Seob ^a   Duffin, Rodger ^a   Howie, Sarah E M ^a   Scotton, Chris J ^b   Wallace, William A H ^a   MacNee, William ^a   Bradley, Mark ^a   Megson, Ian L ^c   Donaldson, Ken ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF THE HIGHLANDS AND ISLANDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE ORANGE; ALPHA SMOOTH MUSCLE ACTIN; EOTAXIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; NANOPARTICLE; TRANSFORMING GROWTH FACTOR BETA; ZINC ION; ZINC OXIDE; CYTOKINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BASAL CELL; CELL DEATH; CELL HYPERPLASIA; CELL PROLIFERATION; CLARA CELL; CONTROLLED STUDY; DISEASE SEVERITY; DISSOLUTION; DOSE RESPONSE; DOWN REGULATION; EOSINOPHILIA; FEMALE; FIBROSING ALVEOLITIS; GOBLET CELL; HISTOPATHOLOGY; IMMUNOGLOBULIN BLOOD LEVEL; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; LUNG INJURY; LUNG LAVAGE; LYSOSOME; LYSOSOME MEMBRANE; MACROPHAGE; MYOFIBROBLAST; NEUTROPHIL; NONHUMAN; PH; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY; UPREGULATION; ZETA POTENTIAL; ANIMAL; BAGG ALBINO MOUSE; BLOOD; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYTOLOGY; DISEASE COURSE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPOSURE; HOSPITALIZATION; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; LUNG; METABOLISM; MOUSE; PARTICLE SIZE; PATHOLOGY; SOLUBILITY; SURFACE PROPERTY; WISTAR RAT;

RATTUS;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOHISTOCHEMISTRY; INHALATION EXPOSURE; LUNG; LUNG INJURY; LYSOSOMES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; PARTICLE SIZE; RATS; RATS, WISTAR; SEVERITY OF ILLNESS INDEX; SOLUBILITY; SURFACE PROPERTIES; ZINC OXIDE;

EID: 80052562186     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/1743-8977-8-27     Document Type: Article

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