Changes in cholesterol homeostasis and acute phase response link pulmonary exposure to multi-walled carbon nanotubes to risk of cardiovascular disease

Toxicology and Applied Pharmacology

Volumn 283, Issue 3, 2015, Pages 210-222

  Poulsen, Sarah S ^a,b   Saber, Anne T ^a   Mortensen, Alicja ^c   Szarek, Józef ^d   Wu, Dongmei ^e   Williams, Andrew ^e   Andersen, Ole ^b   Jacobsen, Nicklas R ^a   Yauk, Carole L ^e   Wallin, Håkan ^a,f   Halappanavar, Sabina ^e   Vogel, Ulla ^a,c  

^a NATIONAL RESEARCH CENTRE FOR THE WORKING ENVIRONMENT   (Denmark)

^b ROSKILDE UNIVERSITY   (Denmark)

^c TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^d UNIVERSITY OF WARMIA AND MAZURY IN OLSZTYN   (Poland)

^e HEALTH CANADA   (Canada)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Acute phase response; Atherosclerosis; Histology; Liver; Nanotoxicology; Toxicogenomics

Indexed keywords

CHOLESTEROL; HAPTOGLOBIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN; MULTI WALLED NANOTUBE; PROTEIN; SAA3 PROTEIN; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN; ACUTE PHASE PROTEIN; AUTACOID; BIOLOGICAL MARKER; CARBON NANOTUBE; MESSENGER RNA;

ACUTE PHASE RESPONSE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; EXPOSURE; FEMALE; GENE EXPRESSION; INFLAMMATION; LIPID BLOOD LEVEL; LIPID COMPOSITION; LIPID HOMEOSTASIS; LIVER; LIVER HISTOLOGY; LUNG; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PLASMA; PROTEIN BLOOD LEVEL; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ADVERSE EFFECTS; ANIMAL; BLOOD; C57BL MOUSE; CARDIOVASCULAR DISEASE; CHEMICALLY INDUCED; COMPARATIVE STUDY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; METABOLISM; PARTICLE SIZE; PATHOLOGY; RISK ASSESSMENT; TIME;

MUS; RODENTIA;

ACUTE-PHASE PROTEINS; ACUTE-PHASE REACTION; ANIMALS; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CHOLESTEROL; FEMALE; GENE EXPRESSION REGULATION; HOMEOSTASIS; INFLAMMATION MEDIATORS; INHALATION EXPOSURE; LIVER; MICE, INBRED C57BL; NANOTUBES, CARBON; PARTICLE SIZE; RISK ASSESSMENT; RNA, MESSENGER; TIME FACTORS;

EID: 84923057093     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2015.01.011     Document Type: Article

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